{"id":"https://openalex.org/W2107959641","doi":null,"title":"Structure of eukaryotic DNA polymerase epsilon and lesion bypass capability","display_name":"Structure of eukaryotic DNA polymerase epsilon and lesion bypass capability","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2107959641","mag":"2107959641"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:umu-1477","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1477","pdf_url":null,"source":{"id":"https://openalex.org/S4306400361","display_name":"DiVA at Ume\u00e5 University (Ume\u00e5 University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I90267481","host_organization_name":"Ume\u00e5 University","host_organization_lineage":["https://openalex.org/I90267481"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1477","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054275086","display_name":"Nasim Sabouri","orcid":"https://orcid.org/0000-0002-4541-7702","observed_orcids":["https://orcid.org/0000-0002-4541-7702"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Nasim Sabouri","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4541-7702","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5054275086"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-polymerase-epsilon","display_name":"DNA polymerase epsilon","score":0.9729999899864197},{"id":"https://openalex.org/keywords/dna-polymerase-delta","display_name":"DNA polymerase delta","score":0.9810000061988831},{"id":"https://openalex.org/keywords/dna-replication","display_name":"DNA replication","score":0.6470000147819519},{"id":"https://openalex.org/keywords/okazaki-fragment-processing","display_name":"Okazaki fragment processing","score":0.7329999804496765},{"id":"https://openalex.org/keywords/fen1","display_name":"FEN1","score":0.9100000262260437},{"id":"https://openalex.org/keywords/dna-ligase-i","display_name":"DNA ligase I","score":0.8600000143051147},{"id":"https://openalex.org/keywords/lagging-strand-synthesis","display_name":"lagging strand synthesis","score":0.8999999761581421},{"id":"https://openalex.org/keywords/dna-polymerase-structure","display_name":"DNA polymerase structure","score":0.49399998784065247},{"id":"https://openalex.org/keywords/translesion-synthesis","display_name":"translesion synthesis","score":0.9129999876022339},{"id":"https://openalex.org/keywords/abasic-sites","display_name":"abasic sites","score":0.6769999861717224},{"id":"https://openalex.org/keywords/8-oxoguanine","display_name":"8-oxoguanine","score":0.9599999785423279},{"id":"https://openalex.org/keywords/dna-damage-tolerance","display_name":"DNA damage tolerance","score":0.45899999141693115},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.4099999964237213},{"id":"https://openalex.org/keywords/yeast","display_name":"yeast","score":0.34299999475479126},{"id":"https://openalex.org/keywords/proofreading-exonuclease","display_name":"proofreading exonuclease","score":0.6880000233650208}],"concepts":[{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.557715654373169},{"id":"https://openalex.org/C2756471","wikidata":"https://www.wikidata.org/wiki/Q206286","display_name":"DNA polymerase","level":3,"score":0.5250838994979858},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.4859005808830261},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4744875431060791},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44926708936691284},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.44214317202568054},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4196377396583557},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41948214173316956},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4004397690296173},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3855084180831909},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21237412095069885}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:umu-1477","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1477","pdf_url":null,"source":{"id":"https://openalex.org/S4306400361","display_name":"DiVA at Ume\u00e5 University (Ume\u00e5 University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I90267481","host_organization_name":"Ume\u00e5 University","host_organization_lineage":["https://openalex.org/I90267481"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2107959641","doi":null,"is_oa":false,"landing_page_url":"http://umu.diva-portal.org/smash/get/diva2:141190/FULLTEXT01.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:umu-1477","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1477","pdf_url":null,"source":{"id":"https://openalex.org/S4306400361","display_name":"DiVA at Ume\u00e5 University (Ume\u00e5 University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I90267481","host_organization_name":"Ume\u00e5 University","host_organization_lineage":["https://openalex.org/I90267481"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":121,"referenced_works":["https://openalex.org/W47123523","https://openalex.org/W206882731","https://openalex.org/W1485247673","https://openalex.org/W1515096181","https://openalex.org/W1516514485","https://openalex.org/W1522788044","https://openalex.org/W1531823089","https://openalex.org/W1556770656","https://openalex.org/W1559981481","https://openalex.org/W1568134298","https://openalex.org/W1581236180","https://openalex.org/W1680634601","https://openalex.org/W1840855988","https://openalex.org/W1963876890","https://openalex.org/W1965582223","https://openalex.org/W1966219094","https://openalex.org/W1968946850","https://openalex.org/W1972743742","https://openalex.org/W1972909843","https://openalex.org/W1974394081","https://openalex.org/W1974631593","https://openalex.org/W1975057185","https://openalex.org/W1976279799","https://openalex.org/W1977000365","https://openalex.org/W1982453626","https://openalex.org/W1983478738","https://openalex.org/W1984459901","https://openalex.org/W1987749465","https://openalex.org/W1988122022","https://openalex.org/W1990751478","https://openalex.org/W1992650062","https://openalex.org/W1993705842","https://openalex.org/W1994051286","https://openalex.org/W1994204938","https://openalex.org/W1997002747","https://openalex.org/W1997892688","https://openalex.org/W1998657111","https://openalex.org/W1999624888","https://openalex.org/W2000826427","https://openalex.org/W2003928652","https://openalex.org/W2012914676","https://openalex.org/W2014717496","https://openalex.org/W2018179063","https://openalex.org/W2020309820","https://openalex.org/W2020982275","https://openalex.org/W2021508107","https://openalex.org/W2023218302","https://openalex.org/W2026686404","https://openalex.org/W2033139694","https://openalex.org/W2034206561","https://openalex.org/W2036285677","https://openalex.org/W2037909746","https://openalex.org/W2038174431","https://openalex.org/W2044290089","https://openalex.org/W2047388928","https://openalex.org/W2049136565","https://openalex.org/W2052079265","https://openalex.org/W2052424743","https://openalex.org/W2054615119","https://openalex.org/W2056590571","https://openalex.org/W2058337905","https://openalex.org/W2059184834","https://openalex.org/W2059535670","https://openalex.org/W2059594509","https://openalex.org/W2062487397","https://openalex.org/W2063240589","https://openalex.org/W2064154094","https://openalex.org/W2065286203","https://openalex.org/W2065999793","https://openalex.org/W2067463001","https://openalex.org/W2067786302","https://openalex.org/W2068309168","https://openalex.org/W2068668716","https://openalex.org/W2069757035","https://openalex.org/W2071843243","https://openalex.org/W2074566613","https://openalex.org/W2078734222","https://openalex.org/W2079955502","https://openalex.org/W2080245011","https://openalex.org/W2080408680","https://openalex.org/W2081804926","https://openalex.org/W2084695608","https://openalex.org/W2085866527","https://openalex.org/W2087752365","https://openalex.org/W2088085545","https://openalex.org/W2088850807","https://openalex.org/W2093703127","https://openalex.org/W2095437328","https://openalex.org/W2099367992","https://openalex.org/W2100637641","https://openalex.org/W2102972000","https://openalex.org/W2103646786","https://openalex.org/W2107520545","https://openalex.org/W2110487265","https://openalex.org/W2118873017","https://openalex.org/W2119301405","https://openalex.org/W2119344497","https://openalex.org/W2121550117","https://openalex.org/W2122748184","https://openalex.org/W2122763703","https://openalex.org/W2125636072","https://openalex.org/W2127144937","https://openalex.org/W2130937328","https://openalex.org/W2134814213","https://openalex.org/W2135333576","https://openalex.org/W2135511433","https://openalex.org/W2139949200","https://openalex.org/W2140230014","https://openalex.org/W2146851796","https://openalex.org/W2147899637","https://openalex.org/W2152115601","https://openalex.org/W2153835493","https://openalex.org/W2154518311","https://openalex.org/W2156211930","https://openalex.org/W2159531864","https://openalex.org/W2161248815","https://openalex.org/W2168581769","https://openalex.org/W2169950973","https://openalex.org/W2171540539","https://openalex.org/W2281048538","https://openalex.org/W7098416052"],"related_works":["https://openalex.org/W122811541","https://openalex.org/W57506128","https://openalex.org/W2053213954","https://openalex.org/W2120401129","https://openalex.org/W3040576751","https://openalex.org/W2030571538","https://openalex.org/W2559125989","https://openalex.org/W2036519418","https://openalex.org/W1741215583","https://openalex.org/W4401397206"],"abstract_inverted_index":{"To":[0,105],"transfer":[1],"the":[2,5,13,74,96,116,121,124,147,166,198,239,250,271,280,283,318,333,336,345,348,369,387,407,416,435,440,465],"information":[3],"in":[4,41,102,182,299,317,368,386,408,411,422,486],"genome":[6,75],"from":[7],"mother":[8],"cell":[9,30],"to":[10,28,89,137,164,168,206,222,263,399,461],"daughter":[11],"cell,":[12],"DNA":[14,38,42,45,50,52,58,98,103,119,155,292,355,391,427,448,452,478],"replication":[15,43],"must":[16],"be":[17,264,384,420],"carried":[18],"out":[19,208],"only":[20],"once":[21],"and":[22,57,72,126,170,244,255,286,338,358,410,468],"with":[23,76,146,173,187,347,353],"very":[24,78],"high":[25,79,272],"fidelity":[26],"prior":[27],"every":[29],"division.":[31],"In":[32,158,393,433],"yeast":[33],"there":[34,481],"are":[35,482],"several":[36],"different":[37,297],"polymerases":[39,363,382,418],"involved":[40,181],"and/or":[44],"repair.":[46],"The":[47,83,212,257,327,450],"two":[48,258],"replicative":[49,291,381,417,451],"polymerases,":[51],"polymerase":[53,59,99,453],"delta":[54,112,134,196],"(Pol":[55,61],"delta)":[56],"epsilon":[60,100,109,161,178,205,216,229,277,295,306,396,455,472],"epsilon),":[62],"which":[63],"both":[64],"include":[65],"a":[66,77,91,139,151,223,233,245,267,290,313,341,354,445],"proofreading":[67],"3\u00b4\u21925\u00b4exonuclease":[68],"activity,":[69],"can":[70,307,456],"replicate":[71],"proofread":[73],"degree":[80],"of":[81,85,94,118,128,214,225,232,238,249,275,320,332,344,360,371,374,389,424,444],"accuracy.":[82],"aim":[84],"this":[86],"thesis":[87],"was":[88,131,135,162,192,217,302,330,397],"gain":[90],"better":[92],"understanding":[93],"how":[95],"enigmatic":[97],"participates":[101],"transactions.":[104],"investigate":[106],"whether":[107],"Pol":[108,111,133,160,177,195,204,215,228,276,294,305,395,454,471],"or":[110],"is":[113,179,197,230],"responsible":[114],"for":[115,154],"synthesis":[117,310,459],"on":[120,279,335,340],"lagging":[122,200],"strand,":[123],"processing":[125,183],"assembly":[127],"Okazaki":[129,184],"fragments":[130],"studied.":[132],"found":[136,163,262,398],"have":[138],"unique":[140],"property":[141],"called":[142],"\u201cidling\u201d":[143],"which,":[144],"together":[145],"flap-endonuclease":[148],"(FEN1),":[149],"maintained":[150],"ligatable":[152],"nick":[153],"ligase":[156],"I.":[157],"contrast,":[159],"lack":[165],"ability":[167],"\u201cidle\u201d":[169],"interact":[171],"functionally":[172],"FEN-1,":[174],"indicating":[175],"that":[176,194,304,380,415],"not":[180],"fragments.":[185],"Together":[186],"previous":[188],"genetic":[189,377],"studies,":[190],"it":[191],"concluded":[193],"preferred":[199],"strand":[201],"polymerase,":[202,293],"leaving":[203],"carry":[207],"some":[209,390],"other":[210],"function.":[211],"structure":[213,437],"determined":[218],"by":[219,266],"cryo-electron":[220],"microscopy,":[221],"resolution":[224],"~20":[226],"\u00c5.":[227],"composed":[231],"globular":[234],"\u201chead\u201d":[235],"domain":[236,285,467],"consisting":[237,248],"large":[240],"catalytic":[241],"subunit":[242],"Pol2p,":[243],"\u201ctail\u201d":[246],"domain,":[247],"small":[251],"subunits":[252],"Dpb2p,":[253],"Dpb3p,":[254],"Dpb4p.":[256],"separable":[259],"domains":[260],"were":[261],"connected":[265],"flexible":[268],"hinge.":[269],"Interestingly,":[270],"intrinsic":[273],"processivity":[274,322],"depends":[278],"interaction":[281,343,463],"between":[282,464],"tail":[284,466],"double-stranded":[287,469],"DNA.":[288,300,470],"As":[289],"encounters":[296],"lesions":[298,428,479],"It":[301],"shown":[303],"perform":[308,457],"translesion":[309,458],"(TLS)":[311],"through":[312],"model":[314],"abasic":[315],"site":[316],"absence":[319],"external":[321],"clamps":[323],"under":[324],"single-hit":[325],"conditions.":[326],"lesion":[328],"bypass":[329,388,400,423,475],"dependent":[331],"sequence":[334],"template":[337],"also":[339,474],"proper":[342],"\u201ctail\u201ddomain":[346],"primer-template.":[349],"Yeast":[350],"cells":[351],"treated":[352],"damaging":[356],"agent":[357],"devoid":[359],"all":[361],"TLS":[362],"showed":[364],"improved":[365],"survival":[366],"rates":[367],"presence":[370],"elevated":[372,403,430,483],"levels":[373],"dNTPs.":[375],"These":[376],"results":[378,413],"suggested":[379],"may":[383,419,473],"engaged":[385,421],"lesions.":[392],"vitro,":[394],"8-OxoG":[401],"at":[402,429],"dNTP":[404,431,484],"levels.":[405,432],"Together,":[406],"vitro":[409],"vivo":[412],"suggest":[414],"less":[425,476],"bulky":[426,477],"conclusion,":[434],"low-resolution":[436],"presented":[438],"represents":[439],"first":[441],"structural":[442],"characterization":[443],"eukaryotic":[446],"multi-subunit":[447],"polymerase.":[449],"due":[460],"an":[462],"when":[480],"concentrations":[485],"vivo.":[487]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}