{"id":"https://openalex.org/W2107944939","doi":"https://doi.org/10.1161/01.str.0000177891.15082.b9","title":"Association of Apolipoprotein E4 and Haplotypes of the Apolipoprotein E Gene With Lobar Intracerebral Hemorrhage","display_name":"Association of Apolipoprotein E4 and Haplotypes of the Apolipoprotein E Gene With Lobar Intracerebral Hemorrhage","publication_year":2005,"publication_date":"2005-08-12","ids":{"openalex":"https://openalex.org/W2107944939","doi":"https://doi.org/10.1161/01.str.0000177891.15082.b9","mag":"2107944939","pmid":"https://pubmed.ncbi.nlm.nih.gov/16100021"},"language":"en","primary_location":{"id":"doi:10.1161/01.str.0000177891.15082.b9","doi":"https://doi.org/10.1161/01.str.0000177891.15082.b9","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.str.0000177891.15082.b9","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010722813","display_name":"Daniel Woo","orcid":"https://orcid.org/0000-0002-2466-7155","observed_orcids":["https://orcid.org/0000-0002-2466-7155"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Woo","raw_affiliation_strings":["From the University of Cincinnati (D.W., R.K., R.C., M.H., P.S., B.K., A.P., E.J., D.K., M.F., A.S., P.K., L.S., J.B.), and Children\u2019s Hospital Medical Center (J.W.), Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the University of Cincinnati (D.W., R.K., R.C., M.H., P.S., B.K., A.P., E.J., D.K., M.F., A.S., P.K., L.S., J.B.), and Children\u2019s Hospital Medical Center (J.W.), Cincinnati, Ohio","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052192860","display_name":"Ritesh D. Kaushal","orcid":"https://orcid.org/0000-0001-6695-784X","observed_orcids":["https://orcid.org/0000-0001-6695-784X"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ritesh Kaushal","raw_affiliation_strings":["From the University of Cincinnati (D.W., R.K., R.C., M.H., P.S., B.K., A.P., E.J., D.K., M.F., A.S., P.K., L.S., J.B.), and Children\u2019s Hospital Medical Center (J.W.), Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the University of Cincinnati (D.W., R.K., R.C., M.H., P.S., B.K., A.P., E.J., D.K., M.F., A.S., P.K., L.S., J.B.), and Children\u2019s Hospital Medical Center (J.W.), Cincinnati, Ohio","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108105495","display_name":"Ranajit Chakraborty","orcid":"https://orcid.org/0000-0001-9576-916X","observed_orcids":["https://orcid.org/0000-0001-9576-916X"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ranajit Chakraborty","raw_affiliation_strings":["From the University of Cincinnati (D.W., R.K., R.C., M.H., P.S., B.K., A.P., E.J., D.K., M.F., A.S., P.K., L.S., J.B.), and Children\u2019s Hospital Medical Center (J.W.), Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the University of Cincinnati (D.W., R.K., R.C., M.H., P.S., B.K., A.P., E.J., D.K., M.F., A.S., P.K., L.S., J.B.), and Children\u2019s Hospital Medical Center (J.W.), Cincinnati, Ohio","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071319528","display_name":"Jessica Graus Woo","orcid":"https://orcid.org/0000-0003-3644-8432","observed_orcids":["https://orcid.org/0000-0003-3644-8432"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Woo","raw_affiliation_strings":["From the University of Cincinnati (D.W., R.K., R.C., M.H., P.S., B.K., A.P., E.J., D.K., M.F., A.S., P.K., L.S., J.B.), and Children\u2019s Hospital Medical Center (J.W.), Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the University of Cincinnati (D.W., R.K., R.C., M.H., P.S., B.K., A.P., E.J., D.K., M.F., A.S., P.K., L.S., J.B.), and Children\u2019s Hospital Medical Center (J.W.), Cincinnati, Ohio","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004125795","display_name":"Mary A. Haverbusch","orcid":"https://orcid.org/0000-0002-1017-1036","observed_orcids":["https://orcid.org/0000-0002-1017-1036"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Haverbusch","raw_affiliation_strings":["From the University of Cincinnati (D.W., R.K., R.C., M.H., P.S., B.K., A.P., E.J., D.K., M.F., A.S., P.K., L.S., J.B.), and Children\u2019s Hospital Medical Center (J.W.), Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the University of Cincinnati (D.W., R.K., R.C., M.H., P.S., B.K., A.P., E.J., D.K., M.F., A.S., P.K., L.S., J.B.), and Children\u2019s Hospital Medical Center (J.W.), Cincinnati, Ohio","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059680007","display_name":"Padmini Sekar","orcid":"https://orcid.org/0000-0002-3734-5075","observed_orcids":["https://orcid.org/0000-0002-3734-5075"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Padmini Sekar","raw_affiliation_strings":["From the University of Cincinnati (D.W., R.K., R.C., M.H., P.S., B.K., A.P., E.J., D.K., M.F., A.S., P.K., L.S., J.B.), and Children\u2019s Hospital Medical Center (J.W.), Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the University of Cincinnati (D.W., R.K., R.C., M.H., P.S., B.K., A.P., E.J., D.K., M.F., A.S., P.K., L.S., J.B.), and Children\u2019s Hospital Medical Center (J.W.), Cincinnati, Ohio","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075585875","display_name":"Brett M. Kissela M. D","orcid":"https://orcid.org/0000-0002-9773-4013","observed_orcids":["https://orcid.org/0000-0002-9773-4013","https://orcid.org/0000-0002-4839-3814"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brett Kissela","raw_affiliation_strings":["From the University of Cincinnati (D.W., R.K., R.C., M.H., P.S., B.K., A.P., E.J., D.K., M.F., A.S., P.K., L.S., J.B.), and Children\u2019s Hospital Medical Center (J.W.), Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the University of Cincinnati (D.W., R.K., R.C., M.H., P.S., B.K., A.P., E.J., D.K., M.F., A.S., P.K., L.S., J.B.), and Children\u2019s Hospital Medical Center (J.W.), Cincinnati, Ohio","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086708867","display_name":"Arthur Pancioli","orcid":"https://orcid.org/0000-0001-6146-8051","observed_orcids":["https://orcid.org/0000-0001-6146-8051"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arthur Pancioli","raw_affiliation_strings":["From the University of Cincinnati (D.W., R.K., R.C., M.H., P.S., B.K., A.P., E.J., D.K., M.F., A.S., P.K., L.S., J.B.), and Children\u2019s Hospital Medical Center (J.W.), Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the University of Cincinnati (D.W., R.K., R.C., M.H., P.S., B.K., A.P., E.J., D.K., M.F., A.S., P.K., L.S., J.B.), and Children\u2019s Hospital Medical Center (J.W.), Cincinnati, Ohio","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079582489","display_name":"Edward C. Jauch","orcid":"https://orcid.org/0000-0002-3533-4364","observed_orcids":["https://orcid.org/0000-0002-3533-4364"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward Jauch","raw_affiliation_strings":["From the University of Cincinnati (D.W., R.K., R.C., M.H., P.S., B.K., A.P., E.J., D.K., M.F., A.S., P.K., L.S., J.B.), and Children\u2019s Hospital Medical Center (J.W.), Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the University of Cincinnati (D.W., R.K., R.C., M.H., P.S., B.K., A.P., E.J., D.K., M.F., A.S., P.K., L.S., J.B.), and Children\u2019s Hospital Medical Center (J.W.), Cincinnati, Ohio","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006246283","display_name":"Dawn Kleindorfer","orcid":"https://orcid.org/0000-0003-1361-3693","observed_orcids":["https://orcid.org/0000-0003-1361-3693"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dawn Kleindorfer","raw_affiliation_strings":["From the University of Cincinnati (D.W., R.K., R.C., M.H., P.S., B.K., A.P., E.J., D.K., M.F., A.S., P.K., L.S., J.B.), and Children\u2019s Hospital Medical Center (J.W.), Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the University of Cincinnati (D.W., R.K., R.C., M.H., P.S., B.K., A.P., E.J., D.K., M.F., A.S., P.K., L.S., J.B.), and Children\u2019s Hospital Medical Center (J.W.), Cincinnati, Ohio","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024175492","display_name":"Matthew L. Flaherty","orcid":"https://orcid.org/0000-0002-6247-010X","observed_orcids":["https://orcid.org/0000-0002-6247-010X"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Flaherty","raw_affiliation_strings":["From the University of Cincinnati (D.W., R.K., R.C., M.H., P.S., B.K., A.P., E.J., D.K., M.F., A.S., P.K., L.S., J.B.), and Children\u2019s Hospital Medical Center (J.W.), Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the University of Cincinnati (D.W., R.K., R.C., M.H., P.S., B.K., A.P., E.J., D.K., M.F., A.S., P.K., L.S., J.B.), and Children\u2019s Hospital Medical Center (J.W.), Cincinnati, Ohio","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111539255","display_name":"Alexander T. Schneider","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Schneider","raw_affiliation_strings":["From the University of Cincinnati (D.W., R.K., R.C., M.H., P.S., B.K., A.P., E.J., D.K., M.F., A.S., P.K., L.S., J.B.), and Children\u2019s Hospital Medical Center (J.W.), Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the University of Cincinnati (D.W., R.K., R.C., M.H., P.S., B.K., A.P., E.J., D.K., M.F., A.S., P.K., L.S., J.B.), and Children\u2019s Hospital Medical Center (J.W.), Cincinnati, Ohio","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079955678","display_name":"Pooja Khatri","orcid":"https://orcid.org/0000-0002-7344-8266","observed_orcids":["https://orcid.org/0000-0002-7344-8266"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pooja Khatri","raw_affiliation_strings":["From the University of Cincinnati (D.W., R.K., R.C., M.H., P.S., B.K., A.P., E.J., D.K., M.F., A.S., P.K., L.S., J.B.), and Children\u2019s Hospital Medical Center (J.W.), Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the University of Cincinnati (D.W., R.K., R.C., M.H., P.S., B.K., A.P., E.J., D.K., M.F., A.S., P.K., L.S., J.B.), and Children\u2019s Hospital Medical Center (J.W.), Cincinnati, Ohio","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084626172","display_name":"Laura R. Sauerbeck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Sauerbeck","raw_affiliation_strings":["From the University of Cincinnati (D.W., R.K., R.C., M.H., P.S., B.K., A.P., E.J., D.K., M.F., A.S., P.K., L.S., J.B.), and Children\u2019s Hospital Medical Center (J.W.), Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the University of Cincinnati (D.W., R.K., R.C., M.H., P.S., B.K., A.P., E.J., D.K., M.F., A.S., P.K., L.S., J.B.), and Children\u2019s Hospital Medical Center (J.W.), Cincinnati, Ohio","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068433832","display_name":"Jane C. Khoury","orcid":"https://orcid.org/0000-0002-8064-6404","observed_orcids":["https://orcid.org/0000-0002-8064-6404"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jane Khoury","raw_affiliation_strings":["From the University of Cincinnati (D.W., R.K., R.C., M.H., P.S., B.K., A.P., E.J., D.K., M.F., A.S., P.K., L.S., J.B.), and Children\u2019s Hospital Medical Center (J.W.), Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the University of Cincinnati (D.W., R.K., R.C., M.H., P.S., B.K., A.P., E.J., D.K., M.F., A.S., P.K., L.S., J.B.), and Children\u2019s Hospital Medical Center (J.W.), Cincinnati, Ohio","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047807086","display_name":"Ranjan Deka","orcid":"https://orcid.org/0000-0003-2680-1159","observed_orcids":["https://orcid.org/0000-0003-2680-1159"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ranjan Deka","raw_affiliation_strings":["From the University of Cincinnati (D.W., R.K., R.C., M.H., P.S., B.K., A.P., E.J., D.K., M.F., A.S., P.K., L.S., J.B.), and Children\u2019s Hospital Medical Center (J.W.), Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the University of Cincinnati (D.W., R.K., R.C., M.H., P.S., B.K., A.P., E.J., D.K., M.F., A.S., P.K., L.S., J.B.), and Children\u2019s Hospital Medical Center (J.W.), Cincinnati, Ohio","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083232394","display_name":"Joseph P. Broderick","orcid":"https://orcid.org/0000-0002-7323-7709","observed_orcids":["https://orcid.org/0000-0002-7323-7709"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Broderick","raw_affiliation_strings":["From the University of Cincinnati (D.W., R.K., R.C., M.H., P.S., B.K., A.P., E.J., D.K., M.F., A.S., P.K., L.S., J.B.), and Children\u2019s Hospital Medical Center (J.W.), Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the University of Cincinnati (D.W., R.K., R.C., M.H., P.S., B.K., A.P., E.J., D.K., M.F., A.S., P.K., L.S., J.B.), and Children\u2019s Hospital Medical Center (J.W.), Cincinnati, Ohio","institution_ids":["https://openalex.org/I63135867"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I63135867"],"apc_list":null,"apc_paid":null,"fwci":5.7386,"has_fulltext":false,"cited_by_count":78,"citation_normalized_percentile":{"value":0.962593,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"36","issue":"9","first_page":"1874","last_page":"1879"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.9390000104904175},{"id":"https://openalex.org/keywords/apoe-epsilon4","display_name":"APOE \u03b54","score":0.8550000190734863},{"id":"https://openalex.org/keywords/lobar-intracerebral-hemorrhage","display_name":"lobar intracerebral hemorrhage","score":0.9589999914169312},{"id":"https://openalex.org/keywords/haplotype-association","display_name":"haplotype association","score":0.6420000195503235},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.902999997138977},{"id":"https://openalex.org/keywords/genetic-risk-factors","display_name":"genetic risk factors","score":0.7450000047683716},{"id":"https://openalex.org/keywords/untreated-hypertension","display_name":"untreated hypertension","score":0.8980000019073486},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.8899999856948853},{"id":"https://openalex.org/keywords/anticoagulant-use","display_name":"anticoagulant use","score":0.9620000123977661},{"id":"https://openalex.org/keywords/educational-attainment","display_name":"educational attainment","score":0.5490000247955322},{"id":"https://openalex.org/keywords/hemorrhagic-stroke","display_name":"hemorrhagic stroke","score":0.7940000295639038}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.839174211025238},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.7439566254615784},{"id":"https://openalex.org/C2777094939","wikidata":"https://www.wikidata.org/wiki/Q1368943","display_name":"Intracerebral hemorrhage","level":3,"score":0.689035952091217},{"id":"https://openalex.org/C35605836","wikidata":"https://www.wikidata.org/wiki/Q2064311","display_name":"Linkage disequilibrium","level":5,"score":0.6036058068275452},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6012065410614014},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5494056940078735},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.5439394116401672},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.4794815480709076},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.46457916498184204},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.4456362724304199},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4269174039363861},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2696017622947693},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17017534375190735},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08568421006202698},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.08497953414916992},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C2777736543","wikidata":"https://www.wikidata.org/wiki/Q693442","display_name":"Subarachnoid hemorrhage","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002543","descriptor_name":"Cerebral Hemorrhage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002543","descriptor_name":"Cerebral Hemorrhage","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002543","descriptor_name":"Cerebral Hemorrhage","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007438","descriptor_name":"Introns","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044383","descriptor_name":"Black People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044465","descriptor_name":"White People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053327","descriptor_name":"Apolipoprotein E4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1161/01.str.0000177891.15082.b9","doi":"https://doi.org/10.1161/01.str.0000177891.15082.b9","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.str.0000177891.15082.b9","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"},{"id":"pmid:16100021","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16100021","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1321548795","display_name":"Genetic and Environmental Risk Factors for Hemorrhagic Stroke","funder_award_id":"R01NS036695","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G2266511478","display_name":"Cerebrovascular Fellowship Training Program","funder_award_id":"T32NS047996","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G302433295","display_name":null,"funder_award_id":"R-01- ES 06096","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G393493647","display_name":"Center for Environmental Genetics","funder_award_id":"P30ES006096","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G4080943098","display_name":"Genetic and Environmental Risk Factors for Hemorrhagic Stroke","funder_award_id":"U01NS036695","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320308349","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78"},{"id":"https://openalex.org/F4320323155","display_name":"Chinese Academy of Agricultural Sciences","ror":"https://ror.org/0313jb750"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W143151133","https://openalex.org/W519910993","https://openalex.org/W1551600243","https://openalex.org/W1674692411","https://openalex.org/W1963669299","https://openalex.org/W1966030100","https://openalex.org/W1966360257","https://openalex.org/W1968954730","https://openalex.org/W1998358467","https://openalex.org/W2010796941","https://openalex.org/W2011640156","https://openalex.org/W2024191170","https://openalex.org/W2033938435","https://openalex.org/W2038693585","https://openalex.org/W2054931992","https://openalex.org/W2055763065","https://openalex.org/W2068394373","https://openalex.org/W2068808615","https://openalex.org/W2072178955","https://openalex.org/W2074747084","https://openalex.org/W2091924214","https://openalex.org/W2109678076","https://openalex.org/W2117001236","https://openalex.org/W2125858955","https://openalex.org/W2149626290","https://openalex.org/W2169851819","https://openalex.org/W2338858604","https://openalex.org/W3205926832"],"related_works":["https://openalex.org/W2997812053","https://openalex.org/W1579435968","https://openalex.org/W2911364139","https://openalex.org/W2885346286","https://openalex.org/W2056353399","https://openalex.org/W2116109446","https://openalex.org/W2911419914","https://openalex.org/W2085393839","https://openalex.org/W6980065677","https://openalex.org/W2061923387"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"PURPOSE:":[2],"Conflicting":[3],"reports":[4],"in":[5,30],"the":[6,12,31,40,85,105,212,240],"literature":[7],"exist":[8],"with":[9,56,62,90,154,174,183,190,197,216,231,246],"regard":[10],"to":[11,78,95,116,141],"association":[13,49,145,205,210],"of":[14,39,84,129,133,193,201,211,239],"apolipoprotein":[15],"E":[16,42,214,242],"(apo":[17],"E)":[18],"alleles":[19],"and":[20,36,44,47,59,69,82,107,110,124,176,222],"lobar":[21,101,137,162,202,217,232,247,256],"intracerebral":[22],"hemorrhage":[23],"(ICH).":[24],"We":[25,52],"genotyped":[26],"12":[27],"single-nucleotide":[28],"polymorphisms":[29],"5'":[32],"upstream":[33],"regulatory,":[34],"exonic,":[35],"intronic":[37],"regions":[38],"apo":[41,149,165,213,241],"gene":[43,215,243],"performed":[45],"genotype":[46,106],"haplotype":[48,108],"analyses.":[50],"METHODS:":[51],"prospectively":[53],"enrolled":[54],"subjects":[55],"hemorrhagic":[57],"stroke":[58],"matched":[60,140],"them":[61],"2":[63],"controls":[64],"based":[65],"on":[66],"age,":[67],"race,":[68],"sex.":[70],"Each":[71],"case":[72,80],"was":[73,93,146,195],"reviewed":[74],"by":[75],"a":[76,171,198,208,252],"physician":[77],"determine":[79,96],"status":[81],"location":[83],"ICH.":[86,102,156,203,237,248,257],"Multivariate":[87],"logistic-regression":[88],"modeling":[89],"backward":[91],"elimination":[92],"used":[94],"significant":[97,158,209],"risk":[98,159,200,253],"factors":[99,160],"for":[100,148,161,255],"Associations":[103],"at":[104],"levels":[109],"linkage":[111],"disequilibrium":[112],"were":[113,131,136],"conducted":[114],"according":[115],"standard":[117],"statistical":[118],"methods.":[119],"RESULTS:":[120],"Between":[121],"May":[122],"1997":[123],"December":[125],"2002,":[126],"315":[127],"cases":[128,139],"ICH":[130,138,163,218,233],"recruited,":[132],"whom":[134],"107":[135],"205":[142],"controls.":[143],"No":[144],"found":[147],"E2,":[150],"E3,":[151],"or":[152,178],"E4":[153,227],"nonlobar":[155,236],"Independent,":[157],"included":[164],"E4,":[166],"untreated":[167],"hypertension,":[168],"anticoagulant":[169],"use,":[170],"first-degree":[172],"relative":[173],"ICH,":[175],"<":[177],"=high":[179],"school":[180,185],"education":[181],"(compared":[182],">high":[184],"education).":[186],"Treated":[187],"hypercholesterolemia":[188],"compared":[189],"\"no":[191],"history":[192],"hypercholesterolemia\"":[194],"associated":[196,230,245],"decreased":[199],"Haplotype":[204],"analysis":[206],"demonstrated":[207],"among":[219],"whites":[220],"(P<0.0001)":[221],"blacks":[223],"(P=0.0024).":[224],"CONCLUSIONS:":[225],"Apo":[226],"is":[228,251],"independently":[229],"but":[234],"not":[235],"Haplotypes":[238],"are":[244],"Untreated":[249],"hypertension":[250],"factor":[254]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}