{"id":"https://openalex.org/W2107936470","doi":null,"title":"Adjunctive osteopathic manipulative treatment in women with depression: a pilot study.","display_name":"Adjunctive osteopathic manipulative treatment in women with depression: a pilot study.","publication_year":2001,"publication_date":"2001-09-01","ids":{"openalex":"https://openalex.org/W2107936470","mag":"2107936470","pmid":"https://pubmed.ncbi.nlm.nih.gov/11575038"},"language":"en","primary_location":{"id":"pmid:11575038","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11575038","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of the American Osteopathic Association","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023432627","display_name":"Balbina J. Plotkin","orcid":"https://orcid.org/0000-0002-0564-3975","observed_orcids":["https://orcid.org/0000-0002-0564-3975"]},"institutions":[{"id":"https://openalex.org/I128902783","display_name":"Midwestern University","ror":"https://ror.org/046yatd98","country_code":"US","type":"education","lineage":["https://openalex.org/I128902783"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B J Plotkin","raw_affiliation_strings":["Department of Microbiology, Chicago College of Osteopathic Medicine of Midwestern University, USA. Bplotk@Midwestern.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Chicago College of Osteopathic Medicine of Midwestern University, USA. Bplotk@Midwestern.edu","institution_ids":["https://openalex.org/I128902783"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005138527","display_name":"J J Rodos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J J Rodos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058666079","display_name":"R E Kappler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Kappler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087278192","display_name":"Marco Schrage","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Schrage","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047195918","display_name":"K Freydl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Freydl","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"S Hasegawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Hasegawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021269234","display_name":"E Hennegan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Hennegan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074397873","display_name":"C Hilchie-Schmidt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Hilchie-Schmidt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112839937","display_name":"Debbie Hines","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Hines","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"J Iwata","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Iwata","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"C Mok","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Mok","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5091311473","display_name":"D Raffaelli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Raffaelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5849,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.68352113,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"101","issue":"9","first_page":"517","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.36010000109672546,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.36010000109672546,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10902","display_name":"Complementary and Alternative Medicine Studies","score":0.2329999953508377,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11334","display_name":"Psychosomatic Disorders and Their Treatments","score":0.10869999974966049,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteopathic-manipulative-treatment","display_name":"osteopathic manipulative treatment","score":0.9980000257492065},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.9300000071525574},{"id":"https://openalex.org/keywords/women","display_name":"women","score":0.8259999752044678},{"id":"https://openalex.org/keywords/adjunctive-therapy","display_name":"adjunctive therapy","score":0.8799999952316284},{"id":"https://openalex.org/keywords/paroxetine","display_name":"paroxetine","score":0.8529999852180481},{"id":"https://openalex.org/keywords/psychotherapy","display_name":"psychotherapy","score":0.7129999995231628},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.8289999961853027},{"id":"https://openalex.org/keywords/herpes-simplex-virus-antibodies","display_name":"herpes simplex virus antibodies","score":0.6069999933242798},{"id":"https://openalex.org/keywords/epstein-barr-virus-antibodies","display_name":"Epstein-Barr virus antibodies","score":0.9869999885559082},{"id":"https://openalex.org/keywords/premenopausal-women","display_name":"premenopausal women","score":0.9319999814033508}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9408820867538452},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.7213296890258789},{"id":"https://openalex.org/C2777828372","wikidata":"https://www.wikidata.org/wiki/Q408471","display_name":"Paroxetine","level":4,"score":0.5587361454963684},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.549387514591217},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.485811710357666},{"id":"https://openalex.org/C100480397","wikidata":"https://www.wikidata.org/wiki/Q7836899","display_name":"Treatment and control groups","level":2,"score":0.483634352684021},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.4561258554458618},{"id":"https://openalex.org/C3018162438","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Adjunctive treatment","level":2,"score":0.4195810854434967},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000534","qualifier_name":"rehabilitation","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008349","descriptor_name":"Manipulation, Orthopedic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010021","descriptor_name":"Osteopathic Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D010808","descriptor_name":"Physical Examination","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011594","descriptor_name":"Psychometrics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011613","descriptor_name":"Psychotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017374","descriptor_name":"Paroxetine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018687","descriptor_name":"Antidepressive Agents, Second-Generation","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11575038","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11575038","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of the American Osteopathic Association","raw_type":"Clinical Trial"},{"id":"mag:2107936470","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11575038","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W14150217","https://openalex.org/W186261144","https://openalex.org/W1589251200","https://openalex.org/W1783512343","https://openalex.org/W1970866729","https://openalex.org/W1985248606","https://openalex.org/W2004388116","https://openalex.org/W2010029732","https://openalex.org/W2032457845","https://openalex.org/W2162103053","https://openalex.org/W2170332928","https://openalex.org/W2268530164","https://openalex.org/W2298277034","https://openalex.org/W2325767108","https://openalex.org/W2398839848","https://openalex.org/W2412922546","https://openalex.org/W3202697100","https://openalex.org/W4229848608","https://openalex.org/W4234746122","https://openalex.org/W4251503174"],"related_works":["https://openalex.org/W3200576435","https://openalex.org/W2301020777","https://openalex.org/W3206807190","https://openalex.org/W7223633447","https://openalex.org/W2969438876","https://openalex.org/W7153850138","https://openalex.org/W4416448327","https://openalex.org/W2581907048","https://openalex.org/W2371628057","https://openalex.org/W4392237864"],"abstract_inverted_index":{"The":[0,146],"authors":[1],"assessed":[2],"the":[3,54,91,98,140],"impact":[4],"of":[5,17,53,84,90,97,117,129,148],"osteopathic":[6,141],"manipulative":[7,142],"treatment":[8,16,41,93,160],"(OMT)":[9],"as":[10],"an":[11],"adjunct":[12],"to":[13,30,71,139],"standard":[14],"psychiatric":[15],"women":[18,22],"with":[19,23],"depression.":[20],"Premenopausal":[21],"newly":[24],"diagnosed":[25],"depression":[26,163],"were":[27,69,111],"randomly":[28],"assigned":[29],"either":[31],"control":[32,99],"(osteopathic":[33],"structural":[34,143],"examination":[35],"only;":[36],"n":[37,44],"=":[38,45],"9)":[39],"or":[40,82,109,126],"group":[42,72,94,100],"(OMT;":[43],"8).":[46],"Both":[47],"groups":[48,79,114],"received":[49],"conventional":[50],"therapy":[51],"consisting":[52],"antidepressant":[55],"paroxetine":[56],"(Paxil)":[57],"hydrochloride":[58],"plus":[59],"weekly":[60],"psychotherapy":[61],"for":[62,80,161],"8":[63,87],"weeks.":[64],"Attending":[65],"psychiatrists":[66],"and":[67,95,124,132],"psychologists":[68],"blinded":[70],"assignments.":[73],"No":[74,106],"significant":[75,107],"differences":[76,108],"existed":[77],"between":[78,113],"age":[81],"severity":[83],"disease.":[85],"After":[86],"weeks,":[88],"100%":[89],"OMT":[92,154],"33%":[96],"tested":[101],"normal":[102],"by":[103],"psychometric":[104],"evaluation.":[105],"trends":[110],"observed":[112],"in":[115,127,164],"levels":[116,128],"cytokine":[118],"production":[119],"(IL-1,":[120],"IL-10,":[121],"IL-2,":[122],"IL-4,":[123],"IL-6)":[125],"anti-HSV-1,":[130],"anti-HSV-2,":[131],"anti-EBV":[133],"antibody.":[134],"There":[135],"was":[136],"no":[137],"pattern":[138],"dysfunctions":[144],"recorded.":[145],"findings":[147],"this":[149],"pilot":[150],"study":[151],"indicate":[152],"that":[153],"may":[155],"be":[156],"a":[157],"useful":[158],"adjunctive":[159],"alleviating":[162],"women.":[165]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}