{"id":"https://openalex.org/W2107936006","doi":"https://doi.org/10.1099/vir.0.020990-0","title":"Bovine viral diarrhea virus non-structural protein 5A interacts with NIK- and IKK\u03b2-binding protein","display_name":"Bovine viral diarrhea virus non-structural protein 5A interacts with NIK- and IKK\u03b2-binding protein","publication_year":2010,"publication_date":"2010-05-06","ids":{"openalex":"https://openalex.org/W2107936006","doi":"https://doi.org/10.1099/vir.0.020990-0","mag":"2107936006","pmid":"https://pubmed.ncbi.nlm.nih.gov/20444997"},"language":"en","primary_location":{"id":"doi:10.1099/vir.0.020990-0","doi":"https://doi.org/10.1099/vir.0.020990-0","is_oa":false,"landing_page_url":"https://doi.org/10.1099/vir.0.020990-0","pdf_url":null,"source":{"id":"https://openalex.org/S103035011","display_name":"Journal of General Virology","issn_l":"0022-1317","issn":["0022-1317","1465-2099"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of General Virology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068689865","display_name":"Muhammad Atif Zahoor","orcid":"https://orcid.org/0000-0003-2302-3689","observed_orcids":["https://orcid.org/0000-0003-2302-3689"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Muhammad Atif Zahoor","raw_affiliation_strings":["Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Daisuke Yamane","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Daisuke Yamane","raw_affiliation_strings":["Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008595901","display_name":"Yassir Mahgoub Mohamed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yassir Mahgoub Mohamed","raw_affiliation_strings":["Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019237739","display_name":"Yuto Suda","orcid":"https://orcid.org/0000-0002-7910-7606","observed_orcids":["https://orcid.org/0000-0002-7910-7606"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuto Suda","raw_affiliation_strings":["Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079258411","display_name":"Kyousuke Kobayashi","orcid":"https://orcid.org/0000-0001-5501-8396","observed_orcids":["https://orcid.org/0000-0001-5501-8396"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kyousuke Kobayashi","raw_affiliation_strings":["Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089293101","display_name":"Kentaro Kato","orcid":"https://orcid.org/0000-0003-4890-567X","observed_orcids":["https://orcid.org/0000-0003-4890-567X"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kentaro Kato","raw_affiliation_strings":["Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047758255","display_name":"Yukinobu Tohya","orcid":"https://orcid.org/0000-0002-9385-2274","observed_orcids":["https://orcid.org/0000-0002-9385-2274"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukinobu Tohya","raw_affiliation_strings":["Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113675332","display_name":"Hiroomi Akashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroomi Akashi","raw_affiliation_strings":["Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I74801974"],"apc_list":null,"apc_paid":null,"fwci":4.7736,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.94083815,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"91","issue":"8","first_page":"1939","last_page":"1948"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.8661999702453613,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.8661999702453613,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.05849999934434891,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10494","display_name":"Plant Virus Research Studies","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bovine-viral-diarrhea-virus","display_name":"bovine viral diarrhea virus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ns5a","display_name":"NS5A","score":0.9319999814033508},{"id":"https://openalex.org/keywords/host-virus-protein-interaction","display_name":"host-virus protein interaction","score":0.8149999976158142},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9559999704360962},{"id":"https://openalex.org/keywords/endoplasmic-reticulum","display_name":"endoplasmic reticulum","score":0.9319999814033508},{"id":"https://openalex.org/keywords/viral-replication","display_name":"viral replication","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C2777103181","wikidata":"https://www.wikidata.org/wiki/Q83141840","display_name":"NS5A","level":5,"score":0.9281246662139893},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8437731862068176},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6947623491287231},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5757448077201843},{"id":"https://openalex.org/C132379496","wikidata":"https://www.wikidata.org/wiki/Q83141645","display_name":"NS3","level":4,"score":0.511693000793457},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.505476713180542},{"id":"https://openalex.org/C86295872","wikidata":"https://www.wikidata.org/wiki/Q24779573","display_name":"VP40","level":4,"score":0.4954444169998169},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.48805224895477295},{"id":"https://openalex.org/C2780879997","wikidata":"https://www.wikidata.org/wiki/Q952587","display_name":"Viral protein","level":3,"score":0.476350337266922},{"id":"https://openalex.org/C10852380","wikidata":"https://www.wikidata.org/wiki/Q7933613","display_name":"Viral structural protein","level":5,"score":0.4515770971775055},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.4139867424964905},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36328262090682983},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.36323806643486023},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3271080255508423},{"id":"https://openalex.org/C58475186","wikidata":"https://www.wikidata.org/wiki/Q4118894","display_name":"Viral entry","level":4,"score":0.29340291023254395},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2021212875843048},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1517176628112793},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.14185625314712524},{"id":"https://openalex.org/C2781463415","wikidata":"https://www.wikidata.org/wiki/Q2082778","display_name":"Hepacivirus","level":4,"score":0.13516360521316528}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020798","descriptor_name":"Two-Hybrid System Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030241","descriptor_name":"Diarrhea Virus 1, Bovine Viral","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047468","descriptor_name":"Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1099/vir.0.020990-0","doi":"https://doi.org/10.1099/vir.0.020990-0","is_oa":false,"landing_page_url":"https://doi.org/10.1099/vir.0.020990-0","pdf_url":null,"source":{"id":"https://openalex.org/S103035011","display_name":"Journal of General Virology","issn_l":"0022-1317","issn":["0022-1317","1465-2099"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of General Virology","raw_type":"journal-article"},{"id":"pmid:20444997","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20444997","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of general virology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1493432185","https://openalex.org/W1782518453","https://openalex.org/W1969801155","https://openalex.org/W1974865581","https://openalex.org/W1975922979","https://openalex.org/W1983602795","https://openalex.org/W1995171976","https://openalex.org/W2007008846","https://openalex.org/W2009858209","https://openalex.org/W2012808888","https://openalex.org/W2021574737","https://openalex.org/W2032141002","https://openalex.org/W2035750069","https://openalex.org/W2037352026","https://openalex.org/W2039507753","https://openalex.org/W2042365630","https://openalex.org/W2049685013","https://openalex.org/W2051745043","https://openalex.org/W2062368346","https://openalex.org/W2067015560","https://openalex.org/W2070188098","https://openalex.org/W2072554988","https://openalex.org/W2072698183","https://openalex.org/W2078263624","https://openalex.org/W2081242697","https://openalex.org/W2081933766","https://openalex.org/W2090825777","https://openalex.org/W2094427815","https://openalex.org/W2098710866","https://openalex.org/W2105891409","https://openalex.org/W2115610036","https://openalex.org/W2118120234","https://openalex.org/W2118283523","https://openalex.org/W2121469106","https://openalex.org/W2122275228","https://openalex.org/W2124326956","https://openalex.org/W2132105611","https://openalex.org/W2134148301","https://openalex.org/W2136230169","https://openalex.org/W2147401524","https://openalex.org/W2149025394","https://openalex.org/W2158697492","https://openalex.org/W2159114004","https://openalex.org/W2290936009","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2293346989","https://openalex.org/W2125603161","https://openalex.org/W4308024199","https://openalex.org/W4404066698","https://openalex.org/W7047960666","https://openalex.org/W7154737360","https://openalex.org/W2033819899","https://openalex.org/W2980246699","https://openalex.org/W2132105611","https://openalex.org/W7162115944"],"abstract_inverted_index":{"Bovine":[0],"viral":[1,236],"diarrhea":[2],"virus":[3,10,31,40,216],"(BVDV)":[4],"is":[5,110],"a":[6,36,90,95,99,235,241],"positive-sense,":[7],"single-stranded":[8],"RNA":[9,213],"that":[11,23,73,153,174,205],"causes":[12],"an":[13],"economically":[14],"important":[15],"livestock":[16],"disease":[17],"worldwide.":[18],"Previous":[19],"studies":[20],"have":[21],"suggested":[22],"non-structural":[24],"protein":[25,101,107,113],"5A":[26],"(NS5A)":[27],"from":[28],"hepatitis":[29],"C":[30],"(HCV)":[32],"and":[33,49,81,105,115,135,143,193,234],"BVDV":[34,63,225],"plays":[35],"similar":[37],"role":[38,59],"during":[39,62],"infection.":[41],"Extensive":[42],"reports":[43],"are":[44,146],"available":[45],"on":[46,158],"HCV":[47],"NS5A":[48,61,80,127,154,177,187],"its":[50,86],"interactions":[51],"with":[52,75,128,156,176],"the":[53,58,70,76,147,159,163,169,219,228],"host":[54],"cellular":[55,71,100],"proteins;":[56],"however,":[57],"of":[60,79,126,165,172,186,207,221],"infection":[64],"remains":[65],"largely":[66],"unclear.":[67],"To":[68],"identify":[69],"proteins":[72],"interact":[74,175],"N":[77],"terminus":[78],"could":[82],"be":[83],"involved":[84,111],"in":[85,112,122,133,136,162,191,224],"function,":[87],"we":[88,97],"conducted":[89],"yeast":[91],"two-hybrid":[92],"screening.":[93],"As":[94],"result,":[96],"identified":[98],"termed":[102],"bovine":[103],"NIK-":[104],"IKKbeta-binding":[106],"(NIBP),":[108],"which":[109,151],"trafficking":[114,252],"nuclear":[116],"factor":[117],"kappa":[118],"B":[119],"(NF-kappaB)":[120],"signalling":[121],"cells.":[123,167],"The":[124],"interaction":[125,231],"NIBP":[129,157,173,209,222,233],"was":[130],"confirmed":[131],"both":[132],"vitro":[134],"vivo.":[137],"Complementing":[138],"our":[139],"glutathione":[140],"S-transferase":[141],"pull-down":[142],"immunoprecipitation":[144],"data":[145],"confocal":[148],"immunofluorescence":[149],"results,":[150],"indicate":[152],"colocalized":[155],"endoplasmic":[160],"reticulum":[161],"cytoplasm":[164],"BVDV-infected":[166],"Moreover,":[168],"minimal":[170],"residues":[171],"were":[178],"mapped":[179],"as":[180,196,253,255],"aa":[181],"597-623.":[182],"In":[183],"addition,":[184],"overexpression":[185],"inhibited":[188],"NF-kappaB":[189,256],"activation":[190],"HEK293":[192],"LB9.K":[194],"cells":[195],"determined":[197],"by":[198,210],"luciferase":[199],"reporter-gene":[200],"assay.":[201],"We":[202],"further":[203],"showed":[204],"inhibition":[206],"endogenous":[208],"small":[211],"interfering":[212],"molecules":[214],"enhanced":[215],"replication,":[217],"indicating":[218],"importance":[220],"implications":[223],"pathogenesis.":[226],"Being":[227],"first":[229],"reported":[230],"between":[232],"protein,":[237],"this":[238],"finding":[239],"suggests":[240],"novel":[242],"mechanism":[243],"whereby":[244],"viruses":[245],"may":[246],"subvert":[247],"host-cell":[248],"machinery":[249],"for":[250],"mediating":[251],"well":[254],"signalling.":[257]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
