{"id":"https://openalex.org/W2107935973","doi":"https://doi.org/10.1002/cmdc.201200316","title":"Effect of Oxime Ether Incorporation in Acyl Indole Derivatives on PPAR Subtype Selectivity","display_name":"Effect of Oxime Ether Incorporation in Acyl Indole Derivatives on PPAR Subtype Selectivity","publication_year":2012,"publication_date":"2012-10-09","ids":{"openalex":"https://openalex.org/W2107935973","doi":"https://doi.org/10.1002/cmdc.201200316","mag":"2107935973","pmid":"https://pubmed.ncbi.nlm.nih.gov/23047286"},"language":"en","primary_location":{"id":"doi:10.1002/cmdc.201200316","doi":"https://doi.org/10.1002/cmdc.201200316","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cmdc.201200316","pdf_url":null,"source":{"id":"https://openalex.org/S136164820","display_name":"ChemMedChem","issn_l":"1860-7179","issn":["1860-7179","1860-7187"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111895480","display_name":"Morgan Le Naour","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59807433","display_name":"Universit\u00e9 Lille Nord de France","ror":"https://ror.org/03btvgn05","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970","https://openalex.org/I59807433"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Morgan Le\u2005Naour","raw_affiliation_strings":["Laboratoire de Chimie Therapeutique, EA4481, Universit\u00e9 Lille-Nord de France, Facult\u00e9 des Sciences Pharmaceutiques et Biologiques de Lille, 3 rue du Prof. Laguesse, BP83, 59006 Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Chimie Therapeutique, EA4481, Universit\u00e9 Lille-Nord de France, Facult\u00e9 des Sciences Pharmaceutiques et Biologiques de Lille, 3 rue du Prof. Laguesse, BP83, 59006 Lille, France","institution_ids":["https://openalex.org/I59807433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062840295","display_name":"V\u00e9ronique Leclerc","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59807433","display_name":"Universit\u00e9 Lille Nord de France","ror":"https://ror.org/03btvgn05","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970","https://openalex.org/I59807433"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Veronique Leclerc","raw_affiliation_strings":["Laboratoire de Chimie Therapeutique, EA4481, Universit\u00e9 Lille-Nord de France, Facult\u00e9 des Sciences Pharmaceutiques et Biologiques de Lille, 3 rue du Prof. Laguesse, BP83, 59006 Lille (France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Chimie Therapeutique, EA4481, Universit\u00e9 Lille-Nord de France, Facult\u00e9 des Sciences Pharmaceutiques et Biologiques de Lille, 3 rue du Prof. Laguesse, BP83, 59006 Lille (France)","institution_ids":["https://openalex.org/I59807433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087813979","display_name":"Amaury Farce","orcid":"https://orcid.org/0000-0003-3992-9629","observed_orcids":["https://orcid.org/0000-0003-3992-9629"]},"institutions":[{"id":"https://openalex.org/I59807433","display_name":"Universit\u00e9 Lille Nord de France","ror":"https://ror.org/03btvgn05","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970","https://openalex.org/I59807433"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Amaury Farce","raw_affiliation_strings":["Laboratoire de Chimie Therapeutique, EA4481, Universit\u00e9 Lille-Nord de France, Facult\u00e9 des Sciences Pharmaceutiques et Biologiques de Lille, 3 rue du Prof. Laguesse, BP83, 59006 Lille (France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Chimie Therapeutique, EA4481, Universit\u00e9 Lille-Nord de France, Facult\u00e9 des Sciences Pharmaceutiques et Biologiques de Lille, 3 rue du Prof. Laguesse, BP83, 59006 Lille (France)","institution_ids":["https://openalex.org/I59807433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075639539","display_name":"Daniel\u2010Henri Caignard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268767","display_name":"Institut de Recherches Internationales Servier (France)","ror":"https://ror.org/01zej3n42","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405268767"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Daniel\u2010Henri Caignard","raw_affiliation_strings":["Etudes Ext\u00e9rieures et Alliances strat\u00e9giques Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy sur Seine (France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Etudes Ext\u00e9rieures et Alliances strat\u00e9giques Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy sur Seine (France)","institution_ids":["https://openalex.org/I4405268767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013140552","display_name":"Nathalie Hennuyer","orcid":"https://orcid.org/0000-0003-0303-7258","observed_orcids":["https://orcid.org/0000-0003-0303-7258"]},"institutions":[{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]},{"id":"https://openalex.org/I4210157332","display_name":"R\u00e9cepteurs Nucl\u00e9aires, Maladies M\u00e9taboliques et Cardiovasculaires","ror":"https://ror.org/05xanhp90","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4210157332"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nathalie Hennuyer","raw_affiliation_strings":["D\u00e9partement d'Ath\u00e9roscl\u00e9rose, U1011 Institut Pasteur de Lille, 1 Rue du Pr. Calmette, 59019 Lille Cedex (France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement d'Ath\u00e9roscl\u00e9rose, U1011 Institut Pasteur de Lille, 1 Rue du Pr. Calmette, 59019 Lille Cedex (France)","institution_ids":["https://openalex.org/I2800921988","https://openalex.org/I4210157332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001127450","display_name":"Bart Staels","orcid":"https://orcid.org/0000-0002-3784-1503","observed_orcids":["https://orcid.org/0000-0002-3784-1503","https://orcid.org/0000-0002-0028-5988"]},"institutions":[{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]},{"id":"https://openalex.org/I4210157332","display_name":"R\u00e9cepteurs Nucl\u00e9aires, Maladies M\u00e9taboliques et Cardiovasculaires","ror":"https://ror.org/05xanhp90","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4210157332"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bart Staels","raw_affiliation_strings":["D\u00e9partement d'Ath\u00e9roscl\u00e9rose, U1011 Institut Pasteur de Lille, 1 Rue du Pr. Calmette, 59019 Lille Cedex (France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement d'Ath\u00e9roscl\u00e9rose, U1011 Institut Pasteur de Lille, 1 Rue du Pr. Calmette, 59019 Lille Cedex (France)","institution_ids":["https://openalex.org/I2800921988","https://openalex.org/I4210157332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007183018","display_name":"Val\u00e9rie Audinot","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Val\u00e9rie Audinot\u2010Bouchez","raw_affiliation_strings":["Division de Recherche Pharmacologie Mol\u00e9culaire et Cellulaire, 125 Chemin de Ronde, 78290 Croissy sur Seine (France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division de Recherche Pharmacologie Mol\u00e9culaire et Cellulaire, 125 Chemin de Ronde, 78290 Croissy sur Seine (France)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021383328","display_name":"Jean Albert Boutin","orcid":"https://orcid.org/0000-0003-0068-7204","observed_orcids":["https://orcid.org/0000-0003-0068-7204"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean\u2010Albert Boutin","raw_affiliation_strings":["Division de Recherche Pharmacologie Mol\u00e9culaire et Cellulaire, 125 Chemin de Ronde, 78290 Croissy sur Seine (France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division de Recherche Pharmacologie Mol\u00e9culaire et Cellulaire, 125 Chemin de Ronde, 78290 Croissy sur Seine (France)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031278901","display_name":"Michel Lonchampt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268767","display_name":"Institut de Recherches Internationales Servier (France)","ror":"https://ror.org/01zej3n42","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405268767"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Michel Lonchampt","raw_affiliation_strings":["Division de Recherche Maladies M\u00e9taboliques, Institut de Recherches Servier, 11 Rue des Moulineaux, 92150 Suresnes (France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division de Recherche Maladies M\u00e9taboliques, Institut de Recherches Servier, 11 Rue des Moulineaux, 92150 Suresnes (France)","institution_ids":["https://openalex.org/I4405268767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087807982","display_name":"Catherine Dacquet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268767","display_name":"Institut de Recherches Internationales Servier (France)","ror":"https://ror.org/01zej3n42","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405268767"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Catherine Dacquet","raw_affiliation_strings":["Division de Recherche Maladies M\u00e9taboliques, Institut de Recherches Servier, 11 Rue des Moulineaux, 92150 Suresnes (France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division de Recherche Maladies M\u00e9taboliques, Institut de Recherches Servier, 11 Rue des Moulineaux, 92150 Suresnes (France)","institution_ids":["https://openalex.org/I4405268767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065222707","display_name":"Alain Ktorza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268767","display_name":"Institut de Recherches Internationales Servier (France)","ror":"https://ror.org/01zej3n42","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405268767"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alain Ktorza","raw_affiliation_strings":["Division de Recherche Maladies M\u00e9taboliques, Institut de Recherches Servier, 11 Rue des Moulineaux, 92150 Suresnes (France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division de Recherche Maladies M\u00e9taboliques, Institut de Recherches Servier, 11 Rue des Moulineaux, 92150 Suresnes (France)","institution_ids":["https://openalex.org/I4405268767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109956088","display_name":"Pascal Berthelot","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59807433","display_name":"Universit\u00e9 Lille Nord de France","ror":"https://ror.org/03btvgn05","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970","https://openalex.org/I59807433"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pascal Berthelot","raw_affiliation_strings":["Laboratoire de Chimie Therapeutique, EA4481, Universit\u00e9 Lille-Nord de France, Facult\u00e9 des Sciences Pharmaceutiques et Biologiques de Lille, 3 rue du Prof. Laguesse, BP83, 59006 Lille (France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Chimie Therapeutique, EA4481, Universit\u00e9 Lille-Nord de France, Facult\u00e9 des Sciences Pharmaceutiques et Biologiques de Lille, 3 rue du Prof. Laguesse, BP83, 59006 Lille (France)","institution_ids":["https://openalex.org/I59807433"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040085998","display_name":"Nicolas Leb\u00e8gue","orcid":"https://orcid.org/0000-0003-4245-2833","observed_orcids":["https://orcid.org/0000-0003-4245-2833"]},"institutions":[{"id":"https://openalex.org/I59807433","display_name":"Universit\u00e9 Lille Nord de France","ror":"https://ror.org/03btvgn05","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970","https://openalex.org/I59807433"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nicolas Lebegue","raw_affiliation_strings":["Laboratoire de Chimie Therapeutique, EA4481, Universit\u00e9 Lille-Nord de France, Facult\u00e9 des Sciences Pharmaceutiques et Biologiques de Lille, 3 rue du Prof. Laguesse, BP83, 59006 Lille (France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Chimie Therapeutique, EA4481, Universit\u00e9 Lille-Nord de France, Facult\u00e9 des Sciences Pharmaceutiques et Biologiques de Lille, 3 rue du Prof. Laguesse, BP83, 59006 Lille (France)","institution_ids":["https://openalex.org/I59807433"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.315,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.52676409,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"7","issue":"12","first_page":"2179","last_page":"2193"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pparalpha-gamma-dual-agonist","display_name":"PPAR\u03b1/\u03b3 dual agonist","score":0.8999999761581421},{"id":"https://openalex.org/keywords/oxime-ethers","display_name":"oxime ethers","score":0.9580000042915344},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9200000166893005},{"id":"https://openalex.org/keywords/dyslipidemia","display_name":"dyslipidemia","score":0.9929999709129333},{"id":"https://openalex.org/keywords/weight-gain","display_name":"weight gain","score":0.7739999890327454},{"id":"https://openalex.org/keywords/ob-ob-mice","display_name":"ob/ob mice","score":0.7770000100135803},{"id":"https://openalex.org/keywords/rosiglitazone","display_name":"rosiglitazone","score":0.890999972820282},{"id":"https://openalex.org/keywords/tesaglitazar","display_name":"tesaglitazar","score":0.9409999847412109},{"id":"https://openalex.org/keywords/structure-activity-optimization","display_name":"structure-activity optimization","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C2780152017","wikidata":"https://www.wikidata.org/wiki/Q424771","display_name":"Rosiglitazone","level":3,"score":0.7943771481513977},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7362772822380066},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.654346227645874},{"id":"https://openalex.org/C127078168","wikidata":"https://www.wikidata.org/wiki/Q138639","display_name":"Peroxisome","level":3,"score":0.6144068837165833},{"id":"https://openalex.org/C192527728","wikidata":"https://www.wikidata.org/wiki/Q1465700","display_name":"Indole test","level":2,"score":0.5119200944900513},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.4959467351436615},{"id":"https://openalex.org/C2779648554","wikidata":"https://www.wikidata.org/wiki/Q182738","display_name":"Oxime","level":2,"score":0.4555834233760834},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4503324627876282},{"id":"https://openalex.org/C118792377","wikidata":"https://www.wikidata.org/wiki/Q108584245","display_name":"Selectivity","level":3,"score":0.41852331161499023},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4066981375217438},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33381322026252747},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2787249684333801},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11463838815689087},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010091","descriptor_name":"Oximes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010091","descriptor_name":"Oximes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010091","descriptor_name":"Oximes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011422","descriptor_name":"Propionates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011422","descriptor_name":"Propionates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011422","descriptor_name":"Propionates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015430","descriptor_name":"Weight Gain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047493","descriptor_name":"PPAR alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047493","descriptor_name":"PPAR alpha","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D050171","descriptor_name":"Dyslipidemias","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D050171","descriptor_name":"Dyslipidemias","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D050171","descriptor_name":"Dyslipidemias","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/cmdc.201200316","doi":"https://doi.org/10.1002/cmdc.201200316","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cmdc.201200316","pdf_url":null,"source":{"id":"https://openalex.org/S136164820","display_name":"ChemMedChem","issn_l":"1860-7179","issn":["1860-7179","1860-7187"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"journal-article"},{"id":"pmid:23047286","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23047286","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W36311596","https://openalex.org/W53497458","https://openalex.org/W1567127662","https://openalex.org/W1971193699","https://openalex.org/W1976175204","https://openalex.org/W1977508102","https://openalex.org/W1979761686","https://openalex.org/W1994904833","https://openalex.org/W1995754186","https://openalex.org/W1997430803","https://openalex.org/W2001800835","https://openalex.org/W2002008049","https://openalex.org/W2002438078","https://openalex.org/W2003856834","https://openalex.org/W2006112045","https://openalex.org/W2024074798","https://openalex.org/W2027324370","https://openalex.org/W2029729619","https://openalex.org/W2035393250","https://openalex.org/W2050456292","https://openalex.org/W2055943486","https://openalex.org/W2060678630","https://openalex.org/W2066092624","https://openalex.org/W2084060595","https://openalex.org/W2092363805","https://openalex.org/W2094229974","https://openalex.org/W2142769796","https://openalex.org/W2161239029","https://openalex.org/W2165640401","https://openalex.org/W2166179667","https://openalex.org/W2326184045","https://openalex.org/W2949247831","https://openalex.org/W2950970623","https://openalex.org/W2951415224"],"related_works":["https://openalex.org/W2078477203","https://openalex.org/W1991308074","https://openalex.org/W2041333875","https://openalex.org/W2012818636","https://openalex.org/W2002189685","https://openalex.org/W2067226163","https://openalex.org/W2083166170","https://openalex.org/W1995822558","https://openalex.org/W7156668969","https://openalex.org/W2002008049"],"abstract_inverted_index":{"Compounds":[0],"that":[1,140],"simultaneously":[2],"activate":[3],"peroxisome":[4],"proliferator-activated":[5],"receptor":[6],"(PPAR)":[7],"subtypes":[8],"\u03b1":[9],"and":[10,19,42,72,120,136,143],"\u03b3":[11],"have":[12],"the":[13,69,92,96,101,114],"potential":[14],"to":[15,47,56,106,139,183],"effectively":[16],"treat":[17],"dyslipidemia":[18],"type":[20],"2":[21],"diabetes":[22],"(T2D)":[23],"in":[24,129,150,179],"a":[25,75,147,162,177],"single":[26],"pharmaceutically":[27],"active":[28],"molecule.":[29],"The":[30,86],"frequently":[31],"observed":[32],"side":[33],"effects":[34],"of":[35,74,78,88,95,134,141],"selective":[36],"PPAR\u03b3":[37],"agonists,":[38],"such":[39],"as":[40,112,161,174],"edema":[41],"weight":[43,152,181],"gain,":[44],"were":[45],"expected":[46],"be":[48],"overcome":[49],"by":[50],"using":[51],"additive":[52],"PPAR\u03b1":[53],"activity,":[54],"leading":[55],"dual":[57,163],"PPAR\u03b1/\u03b3":[58,102,164],"agonists":[59],"with":[60,146],"balanced":[61],"activity":[62],"for":[63,116],"both":[64],"subtypes.":[65],"Herein":[66],"we":[67],"report":[68],"discovery,":[70],"synthesis,":[71],"optimization":[73],"new":[76],"series":[77],"\u03b1-ethoxyphenylpropionic":[79],"acid":[80],"bearing":[81],"5-":[82],"or":[83,107],"6-substituted":[84],"indoles.":[85],"incorporation":[87],"oxime":[89],"ethers":[90],"on":[91],"carbonyl":[93],"portion":[94],"benzoyl":[97],"group":[98],"can":[99],"bring":[100],"potency":[103],"ratio":[104],"equal":[105],"slightly":[108],"greater":[109],"than":[110,166],"one,":[111],"is":[113],"case":[115],"compounds":[117],"20":[118,124,167],"c":[119,125],"21":[121,157],"a.":[122],"Compound":[123],"shows":[126],"high":[127],"efficacy":[128],"an":[130,170],"ob/ob":[131],"mouse":[132],"model":[133],"T2D":[135],"dyslipidemia,":[137],"similar":[138],"rosiglitazone":[142],"tesaglitazar,":[144],"but":[145],"significant":[148],"increase":[149],"body":[151,180],"gain.":[153],"In":[154],"contrast,":[155],"compound":[156],"a,":[158],"less":[159],"potent":[160],"activator":[165],"c,":[168],"showed":[169],"interesting":[171],"pharmacological":[172],"profile,":[173],"it":[175],"elicits":[176],"decrease":[178],"relative":[182],"reference":[184],"compounds.":[185]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}