{"id":"https://openalex.org/W2107933249","doi":"https://doi.org/10.3389/fcimb.2013.00002","title":"Management of familial Mediterranean fever by colchicine does not normalize the altered profile of microbial long chain fatty acids in the human metabolome","display_name":"Management of familial Mediterranean fever by colchicine does not normalize the altered profile of microbial long chain fatty acids in the human metabolome","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2107933249","doi":"https://doi.org/10.3389/fcimb.2013.00002","mag":"2107933249","pmid":"https://pubmed.ncbi.nlm.nih.gov/23373011","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3556566"},"language":"en","primary_location":{"id":"doi:10.3389/fcimb.2013.00002","doi":"https://doi.org/10.3389/fcimb.2013.00002","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2013.00002","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcimb.2013.00002/pdf","source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2107933249"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fcimb.2013.00002/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065262974","display_name":"Zhanna A. Ktsoyan","orcid":"https://orcid.org/0000-0001-7246-2579","observed_orcids":["https://orcid.org/0000-0001-7246-2579"]},"institutions":[{"id":"https://openalex.org/I4210133976","display_name":"Institute of Molecular Biology","ror":"https://ror.org/03t8mqd25","country_code":"AM","type":"facility","lineage":["https://openalex.org/I4210133976","https://openalex.org/I99064381"]},{"id":"https://openalex.org/I99064381","display_name":"National Academy of Sciences of Armenia","ror":"https://ror.org/04mczx267","country_code":"AM","type":"government","lineage":["https://openalex.org/I99064381"]}],"countries":["AM"],"is_corresponding":false,"raw_author_name":"Zhanna A. Ktsoyan","raw_affiliation_strings":["Institute of Molecular Biology, National Academy of Sciences, Yerevan, Republic of Armenia","Institute of Molecular Biology, Yerevan, Armenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology, National Academy of Sciences, Yerevan, Republic of Armenia","institution_ids":["https://openalex.org/I4210133976","https://openalex.org/I99064381"]},{"raw_affiliation_string":"Institute of Molecular Biology, Yerevan, Armenia","institution_ids":["https://openalex.org/I4210133976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048039887","display_name":"Beloborodova Nv","orcid":"https://orcid.org/0000-0003-2328-1610","observed_orcids":["https://orcid.org/0000-0003-2328-1610"]},"institutions":[{"id":"https://openalex.org/I4210120300","display_name":"V.A. Negovsky Scientific Research Institute of General Reanimatology","ror":"https://ror.org/01w84qj32","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210120300"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Natalia V. Beloborodova","raw_affiliation_strings":["Research Institute of General Reanimatology, Russian Academy of Medical Sciences, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of General Reanimatology, Russian Academy of Medical Sciences, Moscow, Russia","institution_ids":["https://openalex.org/I4210120300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077859121","display_name":"Anahit Sedrakyan","orcid":"https://orcid.org/0000-0001-9013-3103","observed_orcids":["https://orcid.org/0000-0001-9013-3103"]},"institutions":[{"id":"https://openalex.org/I4210133976","display_name":"Institute of Molecular Biology","ror":"https://ror.org/03t8mqd25","country_code":"AM","type":"facility","lineage":["https://openalex.org/I4210133976","https://openalex.org/I99064381"]}],"countries":["AM"],"is_corresponding":false,"raw_author_name":"Anahit M. Sedrakyan","raw_affiliation_strings":["Institute of Molecular Biology, Yerevan, Armenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology, Yerevan, Armenia","institution_ids":["https://openalex.org/I4210133976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107791563","display_name":"George A. Osipov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801984088","display_name":"Bakulev Scientific Center for Cardiovascular Surgery Russian Academy of Medical Sciences","ror":"https://ror.org/03c94bc04","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I2801984088","https://openalex.org/I4210110862"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"George A. Osipov","raw_affiliation_strings":["Scientific Center of Cardiovascular Surgery, Russian Academy of Medical Sciences, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scientific Center of Cardiovascular Surgery, Russian Academy of Medical Sciences, Moscow, Russia","institution_ids":["https://openalex.org/I2801984088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050061648","display_name":"Zaruhi Khachatryan","orcid":"https://orcid.org/0000-0001-8357-5181","observed_orcids":["https://orcid.org/0000-0001-8357-5181"]},"institutions":[{"id":"https://openalex.org/I4210133976","display_name":"Institute of Molecular Biology","ror":"https://ror.org/03t8mqd25","country_code":"AM","type":"facility","lineage":["https://openalex.org/I4210133976","https://openalex.org/I99064381"]}],"countries":["AM"],"is_corresponding":false,"raw_author_name":"Zaruhi A. Khachatryan","raw_affiliation_strings":["Institute of Molecular Biology, Yerevan, Armenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology, Yerevan, Armenia","institution_ids":["https://openalex.org/I4210133976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035577625","display_name":"Gayane P. Manukyan","orcid":"https://orcid.org/0000-0001-7541-5743","observed_orcids":["https://orcid.org/0000-0001-7541-5743"]},"institutions":[{"id":"https://openalex.org/I4210133976","display_name":"Institute of Molecular Biology","ror":"https://ror.org/03t8mqd25","country_code":"AM","type":"facility","lineage":["https://openalex.org/I4210133976","https://openalex.org/I99064381"]}],"countries":["AM"],"is_corresponding":false,"raw_author_name":"Gayane P. Manukyan","raw_affiliation_strings":["Institute of Molecular Biology, Yerevan, Armenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology, Yerevan, Armenia","institution_ids":["https://openalex.org/I4210133976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087141857","display_name":"Karine A. Arakelova","orcid":"https://orcid.org/0009-0001-2202-2476","observed_orcids":["https://orcid.org/0009-0001-2202-2476"]},"institutions":[{"id":"https://openalex.org/I4210133976","display_name":"Institute of Molecular Biology","ror":"https://ror.org/03t8mqd25","country_code":"AM","type":"facility","lineage":["https://openalex.org/I4210133976","https://openalex.org/I99064381"]}],"countries":["AM"],"is_corresponding":false,"raw_author_name":"Karine A. Arakelova","raw_affiliation_strings":["Institute of Molecular Biology, Yerevan, Armenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology, Yerevan, Armenia","institution_ids":["https://openalex.org/I4210133976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019408412","display_name":"Alvard I. Hovhannisyan","orcid":"https://orcid.org/0000-0002-7867-1395","observed_orcids":["https://orcid.org/0000-0002-7867-1395"]},"institutions":[{"id":"https://openalex.org/I4210133976","display_name":"Institute of Molecular Biology","ror":"https://ror.org/03t8mqd25","country_code":"AM","type":"facility","lineage":["https://openalex.org/I4210133976","https://openalex.org/I99064381"]}],"countries":["AM"],"is_corresponding":false,"raw_author_name":"Alvard I. Hovhannisyan","raw_affiliation_strings":["Institute of Molecular Biology, Yerevan, Armenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology, Yerevan, Armenia","institution_ids":["https://openalex.org/I4210133976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052114174","display_name":"Arsen Arakelyan","orcid":"https://orcid.org/0000-0002-6851-1056","observed_orcids":["https://orcid.org/0000-0002-6851-1056"]},"institutions":[{"id":"https://openalex.org/I4210133976","display_name":"Institute of Molecular Biology","ror":"https://ror.org/03t8mqd25","country_code":"AM","type":"facility","lineage":["https://openalex.org/I4210133976","https://openalex.org/I99064381"]}],"countries":["AM"],"is_corresponding":false,"raw_author_name":"Arsen A. Arakelyan","raw_affiliation_strings":["Institute of Molecular Biology, Yerevan, Armenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology, Yerevan, Armenia","institution_ids":["https://openalex.org/I4210133976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018395516","display_name":"Karine A. Ghazaryan","orcid":"https://orcid.org/0009-0005-1614-7650","observed_orcids":["https://orcid.org/0009-0005-1614-7650"]},"institutions":[{"id":"https://openalex.org/I4210133976","display_name":"Institute of Molecular Biology","ror":"https://ror.org/03t8mqd25","country_code":"AM","type":"facility","lineage":["https://openalex.org/I4210133976","https://openalex.org/I99064381"]}],"countries":["AM"],"is_corresponding":false,"raw_author_name":"Karine A. Ghazaryan","raw_affiliation_strings":["Institute of Molecular Biology, Yerevan, Armenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology, Yerevan, Armenia","institution_ids":["https://openalex.org/I4210133976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091639808","display_name":"Magdalina K. Zakaryan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133976","display_name":"Institute of Molecular Biology","ror":"https://ror.org/03t8mqd25","country_code":"AM","type":"facility","lineage":["https://openalex.org/I4210133976","https://openalex.org/I99064381"]}],"countries":["AM"],"is_corresponding":false,"raw_author_name":"Magdalina K. Zakaryan","raw_affiliation_strings":["Institute of Molecular Biology, Yerevan, Armenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology, Yerevan, Armenia","institution_ids":["https://openalex.org/I4210133976"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068142157","display_name":"Rustam Irekovitch Aminov","orcid":"https://orcid.org/0000-0002-5811-8322","observed_orcids":["https://orcid.org/0000-0002-5811-8322"]},"institutions":[{"id":"https://openalex.org/I4210129319","display_name":"University of the West Indies","ror":"https://ror.org/03fkc8c64","country_code":"JM","type":"education","lineage":["https://openalex.org/I137799390","https://openalex.org/I4210129319"]}],"countries":["JM"],"is_corresponding":true,"raw_author_name":"Rustam I. Aminov","raw_affiliation_strings":["University of the West Indies, Faculty of Medical Sciences, Mona campus, Kingston, 7, Jamaica"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of the West Indies, Faculty of Medical Sciences, Mona campus, Kingston, 7, Jamaica","institution_ids":["https://openalex.org/I4210129319"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5068142157"],"corresponding_institution_ids":["https://openalex.org/I4210129319"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.2016,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.43995416,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"3","issue":null,"first_page":"2","last_page":"2"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.8550000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.8550000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.1316000074148178,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/familial-mediterranean-fever","display_name":"familial Mediterranean fever","score":1.0},{"id":"https://openalex.org/keywords/colchicine","display_name":"colchicine","score":0.9419999718666077},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.8859999775886536},{"id":"https://openalex.org/keywords/human-metabolome","display_name":"human metabolome","score":0.8790000081062317},{"id":"https://openalex.org/keywords/autoinflammatory-disease","display_name":"autoinflammatory disease","score":0.9509999752044678},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.4129999876022339}],"concepts":[{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.908008337020874},{"id":"https://openalex.org/C2776636253","wikidata":"https://www.wikidata.org/wiki/Q326224","display_name":"Colchicine","level":2,"score":0.858611524105072},{"id":"https://openalex.org/C2779537928","wikidata":"https://www.wikidata.org/wiki/Q1144618","display_name":"Familial Mediterranean fever","level":3,"score":0.8416875600814819},{"id":"https://openalex.org/C3020382795","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Long chain","level":2,"score":0.5120835304260254},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42907679080963135},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.41712820529937744},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.35371461510658264},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3503853678703308},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24588239192962646},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21230319142341614},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.18453115224838257},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.11386457085609436},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09587985277175903},{"id":"https://openalex.org/C126348684","wikidata":"https://www.wikidata.org/wiki/Q3456979","display_name":"Polymer science","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003078","descriptor_name":"Colchicine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010505","descriptor_name":"Familial Mediterranean Fever","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D010505","descriptor_name":"Familial Mediterranean Fever","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010505","descriptor_name":"Familial Mediterranean Fever","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.3389/fcimb.2013.00002","doi":"https://doi.org/10.3389/fcimb.2013.00002","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2013.00002","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcimb.2013.00002/pdf","source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2562150","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3556566","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:23373011","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23373011","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cellular and infection microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3556566","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3556566/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cell Infect Microbiol","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.817.5506","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.817.5506","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/27/d1/fcimb-03-00002.PMC3556566.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:04615fc47f744633b8648a819cac3599","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/04615fc47f744633b8648a819cac3599","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cellular and Infection Microbiology, Vol 3 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcimb.2013.00002","doi":"https://doi.org/10.3389/fcimb.2013.00002","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2013.00002","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcimb.2013.00002/pdf","source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2107933249.pdf","grobid_xml":"https://content.openalex.org/works/W2107933249.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W111771087","https://openalex.org/W1547959173","https://openalex.org/W1583820135","https://openalex.org/W1880966689","https://openalex.org/W1964119225","https://openalex.org/W1980442164","https://openalex.org/W1980914602","https://openalex.org/W1983972858","https://openalex.org/W1986933064","https://openalex.org/W1988455358","https://openalex.org/W1999822725","https://openalex.org/W2005376832","https://openalex.org/W2014299676","https://openalex.org/W2025114863","https://openalex.org/W2029911121","https://openalex.org/W2036873956","https://openalex.org/W2039359833","https://openalex.org/W2046445387","https://openalex.org/W2051551464","https://openalex.org/W2060485250","https://openalex.org/W2062073449","https://openalex.org/W2071371593","https://openalex.org/W2090925778","https://openalex.org/W2091421604","https://openalex.org/W2095491650","https://openalex.org/W2097875133","https://openalex.org/W2100906891","https://openalex.org/W2101271919","https://openalex.org/W2106829739","https://openalex.org/W2125826054","https://openalex.org/W2137725057","https://openalex.org/W2140276493","https://openalex.org/W2149243769","https://openalex.org/W2151088711","https://openalex.org/W2156145269","https://openalex.org/W2162647701","https://openalex.org/W2242165656","https://openalex.org/W2624936342","https://openalex.org/W4251129201","https://openalex.org/W6832545341"],"related_works":["https://openalex.org/W4383186146","https://openalex.org/W7166094704","https://openalex.org/W7165728072","https://openalex.org/W120958231","https://openalex.org/W7139005561","https://openalex.org/W2774421047","https://openalex.org/W4412173820","https://openalex.org/W2014359667","https://openalex.org/W4220887398"],"abstract_inverted_index":{"In":[0],"our":[1,63],"previous":[2],"works":[3],"we":[4],"established":[5],"that":[6,120],"in":[7,25,37,76,92,109,135,143],"an":[8],"autoinflammatory":[9],"condition,":[10],"familial":[11],"Mediterranean":[12],"fever":[13],"(FMF),":[14],"the":[15,26,38,45,72,77,82,93,106,116,121,124,129,132,139,144],"gut":[16,136],"microbial":[17,30,73,98,141],"diversity":[18],"is":[19,47],"specifically":[20],"restructured,":[21],"which":[22,101],"also":[23],"results":[24,91],"altered":[27],"profiles":[28,75],"of":[29,44,52,95],"long":[31],"chain":[32],"fatty":[33],"acids":[34],"(LCFAs)":[35],"present":[36],"systemic":[39],"metabolome.":[40,145],"The":[41],"mainstream":[42],"management":[43],"disease":[46],"based":[48],"on":[49],"oral":[50],"administration":[51],"colchicine":[53],"to":[54,66],"suppress":[55],"clinical":[56],"signs":[57],"and":[58,62,112,138],"extend":[59],"remission":[60],"periods":[61],"aim":[64],"was":[65],"determine":[67],"whether":[68],"this":[69],"therapy":[70,122],"normalizes":[71],"LCFA":[74,99],"metabolome":[78],"as":[79],"well.":[80],"Unexpectedly,":[81],"treatment":[83],"does":[84],"not":[85],"normalize":[86],"these":[87],"profiles.":[88],"Moreover,":[89],"it":[90],"formation":[94],"new":[96],"distinct":[97],"clusters,":[100],"are":[102],"well":[103],"separated":[104],"from":[105],"corresponding":[107,140],"values":[108],"healthy":[110],"controls":[111],"FMF":[113],"patients":[114],"without":[115],"therapy.":[117],"We":[118],"hypothesize":[119],"alters":[123],"proinflammatory":[125],"network":[126],"specific":[127],"for":[128],"disease,":[130],"with":[131],"concomitant":[133],"changes":[134],"microbiota":[137],"LCFAs":[142]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}