{"id":"https://openalex.org/W2107931459","doi":"https://doi.org/10.1371/journal.pone.0102133","title":"Disruption of Ion-Trafficking System in the Cochlear Spiral Ligament Prior to Permanent Hearing Loss Induced by Exposure to Intense Noise: Possible Involvement of 4-Hydroxy-2-Nonenal as a Mediator of Oxidative Stress","display_name":"Disruption of Ion-Trafficking System in the Cochlear Spiral Ligament Prior to Permanent Hearing Loss Induced by Exposure to Intense Noise: Possible Involvement of 4-Hydroxy-2-Nonenal as a Mediator of Oxidative Stress","publication_year":2014,"publication_date":"2014-07-11","ids":{"openalex":"https://openalex.org/W2107931459","doi":"https://doi.org/10.1371/journal.pone.0102133","mag":"2107931459","pmid":"https://pubmed.ncbi.nlm.nih.gov/25013956","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4094500"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0102133","doi":"https://doi.org/10.1371/journal.pone.0102133","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0102133","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0102133&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0102133&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102500736","display_name":"Taro Yamaguchi","orcid":"https://orcid.org/0000-0001-5779-8496","observed_orcids":["https://orcid.org/0000-0001-5779-8496"]},"institutions":[{"id":"https://openalex.org/I102826571","display_name":"Setsunan University","ror":"https://ror.org/0418a3v02","country_code":"JP","type":"education","lineage":["https://openalex.org/I102826571"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taro Yamaguchi","raw_affiliation_strings":["Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka, Japan","institution_ids":["https://openalex.org/I102826571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068305721","display_name":"Reiko Nagashima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102826571","display_name":"Setsunan University","ror":"https://ror.org/0418a3v02","country_code":"JP","type":"education","lineage":["https://openalex.org/I102826571"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Reiko Nagashima","raw_affiliation_strings":["Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka, Japan","institution_ids":["https://openalex.org/I102826571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103136168","display_name":"Masanori Yoneyama","orcid":"https://orcid.org/0000-0002-3313-3171","observed_orcids":["https://orcid.org/0000-0002-3313-3171"]},"institutions":[{"id":"https://openalex.org/I102826571","display_name":"Setsunan University","ror":"https://ror.org/0418a3v02","country_code":"JP","type":"education","lineage":["https://openalex.org/I102826571"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masanori Yoneyama","raw_affiliation_strings":["Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka, Japan","institution_ids":["https://openalex.org/I102826571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047594974","display_name":"Tatsuo Shiba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102826571","display_name":"Setsunan University","ror":"https://ror.org/0418a3v02","country_code":"JP","type":"education","lineage":["https://openalex.org/I102826571"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuo Shiba","raw_affiliation_strings":["Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka, Japan","institution_ids":["https://openalex.org/I102826571"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083134882","display_name":"Kiyokazu Ogita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102826571","display_name":"Setsunan University","ror":"https://ror.org/0418a3v02","country_code":"JP","type":"education","lineage":["https://openalex.org/I102826571"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kiyokazu Ogita","raw_affiliation_strings":["Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka, Japan","institution_ids":["https://openalex.org/I102826571"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5083134882"],"corresponding_institution_ids":["https://openalex.org/I102826571"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.4783,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.76951037,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"9","issue":"7","first_page":"e102133","last_page":"e102133"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10283","display_name":"Hearing Loss and Rehabilitation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3616","display_name":"Speech and Hearing"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/noise-induced-hearing-loss","display_name":"noise-induced hearing loss","score":0.9990000128746033},{"id":"https://openalex.org/keywords/spiral-ligament-fibrocytes","display_name":"spiral ligament fibrocytes","score":0.9620000123977661},{"id":"https://openalex.org/keywords/4-hydroxynonenal","display_name":"4-hydroxynonenal","score":0.9169999957084656},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9929999709129333},{"id":"https://openalex.org/keywords/connexin-26","display_name":"connexin 26","score":0.9269999861717224},{"id":"https://openalex.org/keywords/connexin-30","display_name":"connexin 30","score":0.9980000257492065},{"id":"https://openalex.org/keywords/na-k-atpase","display_name":"Na+/K+-ATPase","score":0.9309999942779541},{"id":"https://openalex.org/keywords/endocochlear-potential","display_name":"endocochlear potential","score":0.925000011920929},{"id":"https://openalex.org/keywords/gap-junctional-intercellular-communication","display_name":"gap junctional intercellular communication","score":0.7129999995231628},{"id":"https://openalex.org/keywords/acoustic-overstimulation","display_name":"acoustic overstimulation","score":0.7979999780654907},{"id":"https://openalex.org/keywords/free-radical-scavenging-activity","display_name":"free radical scavenging","score":0.7979999780654907},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9649999737739563}],"concepts":[{"id":"https://openalex.org/C2780408329","wikidata":"https://www.wikidata.org/wiki/Q16976591","display_name":"Spiral ligament","level":4,"score":0.9308367371559143},{"id":"https://openalex.org/C2779152698","wikidata":"https://www.wikidata.org/wiki/Q3095145","display_name":"Spiral ganglion","level":3,"score":0.6181658506393433},{"id":"https://openalex.org/C2780921233","wikidata":"https://www.wikidata.org/wiki/Q5376300","display_name":"Endocochlear potential","level":3,"score":0.5632489323616028},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.4811869263648987},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4711053967475891},{"id":"https://openalex.org/C2780130748","wikidata":"https://www.wikidata.org/wiki/Q317857","display_name":"Cochlea","level":2,"score":0.4141026735305786},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41302576661109924},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4056057631969452},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40419483184814453},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3636409640312195},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3298228979110718},{"id":"https://openalex.org/C2780659331","wikidata":"https://www.wikidata.org/wiki/Q1128309","display_name":"Organ of Corti","level":3,"score":0.3023908734321594},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.16687893867492676},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1553647220134735}],"mesh":[{"descriptor_ui":"D000072259","descriptor_name":"Connexin 26","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000075302","descriptor_name":"Connexin 30","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000254","descriptor_name":"Sodium-Potassium-Exchanging ATPase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000254","descriptor_name":"Sodium-Potassium-Exchanging ATPase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000254","descriptor_name":"Sodium-Potassium-Exchanging ATPase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000447","descriptor_name":"Aldehydes","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000447","descriptor_name":"Aldehydes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006317","descriptor_name":"Hearing Loss, Noise-Induced","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006317","descriptor_name":"Hearing Loss, Noise-Induced","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006317","descriptor_name":"Hearing Loss, Noise-Induced","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006317","descriptor_name":"Hearing Loss, Noise-Induced","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009622","descriptor_name":"Noise","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013316","descriptor_name":"Stria Vascularis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013316","descriptor_name":"Stria Vascularis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013316","descriptor_name":"Stria Vascularis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016166","descriptor_name":"Free Radical Scavengers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017136","descriptor_name":"Ion Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017630","descriptor_name":"Connexins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017630","descriptor_name":"Connexins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017630","descriptor_name":"Connexins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019331","descriptor_name":"NG-Nitroarginine Methyl Ester","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052248","descriptor_name":"Nitric Oxide Synthase Type I","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D052248","descriptor_name":"Nitric Oxide Synthase Type I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D052248","descriptor_name":"Nitric Oxide Synthase Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055493","descriptor_name":"Spiral Ligament of Cochlea","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D055493","descriptor_name":"Spiral Ligament of Cochlea","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055493","descriptor_name":"Spiral Ligament of Cochlea","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D061251","descriptor_name":"Primary Cell Culture","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0102133","doi":"https://doi.org/10.1371/journal.pone.0102133","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0102133","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0102133&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3067895","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4094500","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:25013956","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25013956","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4094500","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4094500/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.772.7240","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.772.7240","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/ed/bf/pone.0102133.PMC4094500.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:2972883ba47c40ba8967e2b4950d1d53","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2972883ba47c40ba8967e2b4950d1d53","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 9, Iss 7, p e102133 (2014)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0102133","doi":"https://doi.org/10.1371/journal.pone.0102133","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0102133","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0102133&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G605416360","display_name":"Regulation of neuroregeneration by endogenous reactive oxygen spices after granule cell loss in the adult hippocampal dentate gyrus.","funder_award_id":"24590130","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2107931459.pdf","grobid_xml":"https://content.openalex.org/works/W2107931459.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W107230004","https://openalex.org/W1972563179","https://openalex.org/W1976882461","https://openalex.org/W1981530141","https://openalex.org/W1989832881","https://openalex.org/W1993936979","https://openalex.org/W2000858861","https://openalex.org/W2008896071","https://openalex.org/W2009277491","https://openalex.org/W2014469165","https://openalex.org/W2016376034","https://openalex.org/W2017645261","https://openalex.org/W2021476963","https://openalex.org/W2023298477","https://openalex.org/W2030167054","https://openalex.org/W2030943241","https://openalex.org/W2031323872","https://openalex.org/W2055275392","https://openalex.org/W2061220576","https://openalex.org/W2070326831","https://openalex.org/W2071014369","https://openalex.org/W2076471795","https://openalex.org/W2080097561","https://openalex.org/W2089641851","https://openalex.org/W2091355057","https://openalex.org/W2107313757","https://openalex.org/W2109557790","https://openalex.org/W2114794549","https://openalex.org/W2136350602","https://openalex.org/W2136855026","https://openalex.org/W2146130931","https://openalex.org/W2153794151","https://openalex.org/W2165400940","https://openalex.org/W2183747868","https://openalex.org/W2290507695","https://openalex.org/W2414075395","https://openalex.org/W2600279133"],"related_works":["https://openalex.org/W7095483053","https://openalex.org/W3010868540","https://openalex.org/W1954465503","https://openalex.org/W2906895389","https://openalex.org/W2136855026","https://openalex.org/W2016737611","https://openalex.org/W4403167013","https://openalex.org/W1995296555","https://openalex.org/W2038257168","https://openalex.org/W2601603448"],"abstract_inverted_index":{"Noise-induced":[0],"hearing":[1,148,261],"loss":[2,149,262],"is":[3,15,67,241],"at":[4,111,254],"least":[5,255],"in":[6,30,42,46,53,58,91,124,130,140,143,152,190,198,217,237,246,256,259,275,282],"part":[7,257],"due":[8],"to":[9,64,105,193,272],"disruption":[10,232],"of":[11,61,70,103,188,202,219,233],"endocochlear":[12],"potential,":[13],"which":[14,66],"maintained":[16],"by":[17,163,243,264],"various":[18],"K(+)":[19],"transport":[20],"apparatuses":[21],"including":[22],"Na(+),":[23,85,158,205,211,250,279],"K(+)-ATPase":[24,86,132,159,206,212,251,280],"and":[25,75,95,121,129,150,157,204,214,249,253,278],"gap":[26],"junction-mediated":[27],"intercellular":[28,221],"communication":[29,222],"the":[31,40,43,47,81,92,125,144,153,199,220,224,234,238,244,273,283],"lateral":[32,285],"wall":[33,286],"structures.":[34,287],"In":[35,185],"this":[36],"study,":[37],"we":[38],"examined":[39],"changes":[41],"ion-trafficking-related":[44],"proteins":[45],"spiral":[48,82,96],"ligament":[49],"fibrocytes":[50],"(SLFs)":[51],"following":[52],"vivo":[54],"acoustic":[55],"overstimulation":[56],"or":[57,174],"vitro":[59,186],"exposure":[60,102,187],"cultured":[62],"SLFs":[63,189,240],"4-hydroxy-2-nonenal,":[65],"a":[68,112,137,164,168,176,196],"mediator":[69],"oxidative":[71],"stress.":[72],"Connexin":[73],"(Cx)26":[74],"Cx30":[76,141],"were":[77,161],"ubiquitously":[78],"expressed":[79],"throughout":[80],"ligament,":[83],"whereas":[84],"\u03b11":[87],"was":[88],"predominantly":[89],"detected":[90],"stria":[93],"vascularis":[94],"prominence":[97],"(type":[98],"2":[99],"SLFs).":[100],"One-hour":[101],"mice":[104],"8":[106],"kHz":[107],"octave":[108],"band":[109],"noise":[110],"110":[113],"dB":[114],"sound":[115],"pressure":[116],"level":[117,128,156,248],"produced":[118,195],"an":[119],"immediate":[120],"prolonged":[122],"decrease":[123,139,151,197,245,274],"Cx26":[126,154,203],"expression":[127,142],"Na+,":[131],"activity,":[133,213,252],"as":[134,136,208,210],"well":[135,209],"delayed":[138],"SLFs.":[145,225],"The":[146],"noise-induced":[147],"protein":[155,200],"activity":[160,281],"abolished":[162],"systemic":[165],"treatment":[166],"with":[167,175],"free":[169],"radical-scavenging":[170],"agent,":[171],"4-hydroxy-2,2,6,6-tetramethylpiperidine":[172],"1-oxyl,":[173],"nitric":[177],"oxide":[178],"synthase":[179],"inhibitor,":[180],"N(\u03c9)-nitro-L-arginine":[181],"methyl":[182],"ester":[183],"hydrochloride.":[184],"primary":[191],"culture":[192],"4-hydroxy-2-nonenal":[194],"levels":[201],"\u03b11,":[207],"also":[215],"resulted":[216],"dysfunction":[218],"between":[223],"Taken":[226],"together,":[227],"our":[228],"data":[229],"suggest":[230],"that":[231],"ion-trafficking":[235],"system":[236],"cochlear":[239,284],"caused":[242],"Cxs":[247,276],"involved":[258],"permanent":[260],"induced":[263],"intense":[265],"noise.":[266],"Oxidative":[267],"stress-mediated":[268],"products":[269],"might":[270],"contribute":[271],"content":[277]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
