{"id":"https://openalex.org/W2107929514","doi":null,"title":"Interleukin 10 (IL-10) inhibition of primary human prostate cell-induced angiogenesis: IL-10 stimulation of tissue inhibitor of metalloproteinase-1 and inhibition of matrix metalloproteinase (MMP)-2/MMP-9 secretion.","display_name":"Interleukin 10 (IL-10) inhibition of primary human prostate cell-induced angiogenesis: IL-10 stimulation of tissue inhibitor of metalloproteinase-1 and inhibition of matrix metalloproteinase (MMP)-2/MMP-9 secretion.","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W2107929514","mag":"2107929514","pmid":"https://pubmed.ncbi.nlm.nih.gov/9918218"},"language":"en","primary_location":{"id":"pmid:9918218","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9918218","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111797055","display_name":"Mark E. Stearns","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M E Stearns","raw_affiliation_strings":["Department of Pathology and Laboratory Sciences, Medical College of Pennsylvania and Hahnemann University, Philadelphia 19102-1192, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Sciences, Medical College of Pennsylvania and Hahnemann University, Philadelphia 19102-1192, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010174521","display_name":"J S Rhim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Rhim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5004528129","display_name":"M Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.4051,"has_fulltext":false,"cited_by_count":126,"citation_normalized_percentile":{"value":0.95193705,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"5","issue":"1","first_page":"189","last_page":"96"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.06849999725818634,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9129999876022339},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.8460000157356262},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.7829999923706055},{"id":"https://openalex.org/keywords/timp-1","display_name":"TIMP-1","score":0.968999981880188},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.9580000042915344},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":1.0},{"id":"https://openalex.org/keywords/timp-2","display_name":"TIMP-2","score":0.8700000047683716},{"id":"https://openalex.org/keywords/bone-marrow-endothelial-cells","display_name":"bone marrow endothelial cells","score":0.890999972820282},{"id":"https://openalex.org/keywords/microvessel-formation","display_name":"microvessel formation","score":0.9390000104904175},{"id":"https://openalex.org/keywords/il-10-receptor","display_name":"IL-10 receptor","score":0.7860000133514404},{"id":"https://openalex.org/keywords/extracellular-matrix-degradation","display_name":"extracellular matrix degradation","score":0.5009999871253967}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7476049661636353},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.6810027360916138},{"id":"https://openalex.org/C2775965246","wikidata":"https://www.wikidata.org/wiki/Q4531845","display_name":"Tissue inhibitor of metalloproteinase","level":3,"score":0.5829752087593079},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.47987690567970276},{"id":"https://openalex.org/C2775958869","wikidata":"https://www.wikidata.org/wiki/Q16966320","display_name":"Matrix metalloproteinase inhibitor","level":3,"score":0.4780583679676056},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44970226287841797},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41914287209510803},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.40661874413490295},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.37852752208709717},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.358331561088562},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32624882459640503},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20800086855888367},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12433421611785889}],"mesh":[{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017364","descriptor_name":"Collagenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018093","descriptor_name":"Gelatinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018093","descriptor_name":"Gelatinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019715","descriptor_name":"Tissue Inhibitor of Metalloproteinase-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020778","descriptor_name":"Matrix Metalloproteinase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061965","descriptor_name":"Matrix Metalloproteinase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9918218","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9918218","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"mag:2107929514","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9918218","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1494870272","https://openalex.org/W1550859266","https://openalex.org/W1571977158","https://openalex.org/W1756614403","https://openalex.org/W1872258297","https://openalex.org/W1964632069","https://openalex.org/W1968476315","https://openalex.org/W2000000541","https://openalex.org/W2016068460","https://openalex.org/W2038613403","https://openalex.org/W2054979979","https://openalex.org/W2098305726","https://openalex.org/W2098400443","https://openalex.org/W2118785471","https://openalex.org/W2122418128","https://openalex.org/W2128635872","https://openalex.org/W2137849418","https://openalex.org/W2242679990","https://openalex.org/W2400348936","https://openalex.org/W2414537042","https://openalex.org/W2419112487","https://openalex.org/W2419541271"],"related_works":["https://openalex.org/W2122940508","https://openalex.org/W2419112487","https://openalex.org/W2414537042","https://openalex.org/W2003642195","https://openalex.org/W7096648663","https://openalex.org/W7098553457","https://openalex.org/W2139250878","https://openalex.org/W2159133324","https://openalex.org/W2062467422","https://openalex.org/W7098573889"],"abstract_inverted_index":{"In":[0,105,171],"in":[1,31,167,209],"vitro":[2],"angiogenesis":[3,208],"assays,":[4],"aggregates":[5,51],"of":[6,57,64,88,91,103,112,122,164,191,195,207],"human":[7,12,21],"papilloma":[8],"virus":[9],"(HPV)-18-immortalized":[10],"primary":[11],"prostate":[13,201],"cancer":[14],"cells":[15,25,83,108,203],"(HPCA-5aHPV-18":[16],"or":[17],"HPCA-10aHPV-18":[18,107,153],"cells)":[19,27],"induced":[20,134],"bone":[22],"marrow":[23],"endothelial":[24],"(HBMCE-1":[26],"to":[28,48,72],"form":[29],"microvessels":[30,45,66],"three-dimensional":[32],"collagen":[33],"I":[34],"gels":[35],"after":[36],"1-2":[37],"days":[38],"incubation":[39],"at":[40],"37":[41],"degrees":[42],"C.":[43],"The":[44,60,185],"aligned":[46],"perpendicular":[47],"the":[49,55,58,65,81,150,168],"tumor":[50,202],"and":[52,62,97,114,124,143,152,158,176,182,193,197],"abutted":[53],"on":[54],"edges":[56],"aggregates.":[59],"number":[61],"length":[63],"increased":[67],"significantly":[68],"from":[69],"day":[70],"1":[71],"2":[73],"(i.e.,":[74],"by":[75,149,200],"approximately":[76],"30%).":[77],"ELISAs":[78],"showed":[79],"that":[80,188],"HPCA-5aHPV-18":[82,151],"normally":[84],"secreted":[85,109],"low":[86,120],"levels":[87,102,111,121],"tissue":[89],"inhibitor":[90],"metalloproteinase":[92,95],"(TIMP)-2,":[93],"matrix":[94],"(MMP)-2,":[96],"MMP-9":[98,115,144,198],"but":[99,119,140],"relatively":[100],"high":[101,110],"TIMP-1.":[104],"contrast,":[106,172],"MMP-2":[113,142,196],"(>40":[116],"pg/microg":[117,127,138,147],"protein)":[118,139,148],"TIMP-1":[123,135,177,192],"TIMP-2":[125],"(<5":[126,146],"protein).":[128],"Interleukin":[129],"10":[130],"(IL-10)":[131],"(15":[132,156],"ng/ml)":[133,157],"production":[136],"(>15":[137],"reduced":[141],"secretion":[145,199],"cells.":[154],"IL-10":[155,173,189],"MMP-9/MMP-2":[159],"antibodies":[160,175,178],"all":[161],"blocked":[162],"induction":[163,206],"microvessel":[165],"formation":[166],"coculture":[169],"experiments.":[170],"receptor":[174],"countered":[179],"IL-10's":[180],"effects":[181],"promoted":[183],"angiogenesis.":[184],"data":[186],"demonstrated":[187],"stimulation":[190],"inhibition":[194],"can":[204],"control":[205],"vitro.":[210]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}