{"id":"https://openalex.org/W2107923742","doi":"https://doi.org/10.1016/0003-9861(87)90410-3","title":"Generation of radical anions of nitrofurantoin, misonidazole, and metronidazole by ascorbate","display_name":"Generation of radical anions of nitrofurantoin, misonidazole, and metronidazole by ascorbate","publication_year":1987,"publication_date":"1987-06-01","ids":{"openalex":"https://openalex.org/W2107923742","doi":"https://doi.org/10.1016/0003-9861(87)90410-3","mag":"2107923742","pmid":"https://pubmed.ncbi.nlm.nih.gov/3036006"},"language":"en","primary_location":{"id":"doi:10.1016/0003-9861(87)90410-3","doi":"https://doi.org/10.1016/0003-9861(87)90410-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0003-9861(87)90410-3","pdf_url":null,"source":{"id":"https://openalex.org/S153476765","display_name":"Archives of Biochemistry and Biophysics","issn_l":"0003-9861","issn":["0003-9861","1096-0384"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Biochemistry and Biophysics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"D.N.Ramakrishna Rao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"D.N.Ramakrishna Rao","raw_affiliation_strings":["Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, North Carolina 27709 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, North Carolina 27709 USA","institution_ids":["https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077878822","display_name":"Laura S. Harman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Harman","raw_affiliation_strings":["Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, North Carolina 27709 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, North Carolina 27709 USA","institution_ids":["https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058595303","display_name":"Ann G. Motten","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann Motten","raw_affiliation_strings":["Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, North Carolina 27709 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, North Carolina 27709 USA","institution_ids":["https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J\u00f6rg Schreiber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J\u00f6rg Schreiber","raw_affiliation_strings":["Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, North Carolina 27709 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, North Carolina 27709 USA","institution_ids":["https://openalex.org/I4210095140"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015414029","display_name":"Ronald Paul Mason","orcid":"https://orcid.org/0000-0002-1859-9109","observed_orcids":["https://orcid.org/0000-0002-1859-9109"]},"institutions":[{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald P. Mason","raw_affiliation_strings":["Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, North Carolina 27709 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, North Carolina 27709 USA","institution_ids":["https://openalex.org/I4210095140"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210095140"],"apc_list":{"value":3170,"currency":"USD","value_usd":3170},"apc_paid":null,"fwci":8.1058,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.98955622,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"255","issue":"2","first_page":"419","last_page":"427"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13013","display_name":"Free Radicals and Antioxidants","score":0.9458000063896179,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13013","display_name":"Free Radicals and Antioxidants","score":0.9458000063896179,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.018400000408291817,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.013399999588727951,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitrofurantoin","display_name":"nitrofurantoin","score":0.9049999713897705},{"id":"https://openalex.org/keywords/misonidazole","display_name":"misonidazole","score":0.9990000128746033},{"id":"https://openalex.org/keywords/metronidazole","display_name":"metronidazole","score":1.0},{"id":"https://openalex.org/keywords/ascorbate-reduction","display_name":"ascorbate reduction","score":0.871999979019165},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.8500000238418579},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.984000027179718},{"id":"https://openalex.org/keywords/oxygen-consumption","display_name":"oxygen consumption","score":0.9240000247955322},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.9769999980926514},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.9919999837875366},{"id":"https://openalex.org/keywords/anaerobic-reduction","display_name":"anaerobic reduction","score":0.6269999742507935},{"id":"https://openalex.org/keywords/ph-dependence","display_name":"pH dependence","score":0.3709999918937683}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.90190589427948},{"id":"https://openalex.org/C139066938","wikidata":"https://www.wikidata.org/wiki/Q185056","display_name":"Radical","level":2,"score":0.8349367380142212},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.6942658424377441},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.6733192205429077},{"id":"https://openalex.org/C2781305896","wikidata":"https://www.wikidata.org/wiki/Q6875874","display_name":"Misonidazole","level":3,"score":0.6731513738632202},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.6344031095504761},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.6088350415229797},{"id":"https://openalex.org/C533411734","wikidata":"https://www.wikidata.org/wiki/Q171877","display_name":"Hydrogen peroxide","level":2,"score":0.6072949767112732},{"id":"https://openalex.org/C2780639532","wikidata":"https://www.wikidata.org/wiki/Q7041427","display_name":"Nitro","level":3,"score":0.5157046914100647},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.502464771270752},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.39374762773513794},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.39233729243278503},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.350178062915802},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.2720378041267395},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.14507609605789185},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13393160700798035},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.08038672804832458},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C2780263894","wikidata":"https://www.wikidata.org/wiki/Q335268","display_name":"Alkyl","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000693","descriptor_name":"Anaerobiosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000838","descriptor_name":"Anions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001205","descriptor_name":"Ascorbic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004578","descriptor_name":"Electron Spin Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008795","descriptor_name":"Metronidazole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008920","descriptor_name":"Misonidazole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009582","descriptor_name":"Nitrofurantoin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0003-9861(87)90410-3","doi":"https://doi.org/10.1016/0003-9861(87)90410-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0003-9861(87)90410-3","pdf_url":null,"source":{"id":"https://openalex.org/S153476765","display_name":"Archives of Biochemistry and Biophysics","issn_l":"0003-9861","issn":["0003-9861","1096-0384"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Biochemistry and Biophysics","raw_type":"journal-article"},{"id":"pmid:3036006","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3036006","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of biochemistry and biophysics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation","score":0.7699999809265137}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W186045281","https://openalex.org/W219011801","https://openalex.org/W1569494491","https://openalex.org/W1970823424","https://openalex.org/W1979281692","https://openalex.org/W1979931416","https://openalex.org/W1992398525","https://openalex.org/W1996811700","https://openalex.org/W2009371242","https://openalex.org/W2037320205","https://openalex.org/W2042808140","https://openalex.org/W2047140336","https://openalex.org/W2048195510","https://openalex.org/W2053941895","https://openalex.org/W2056659011","https://openalex.org/W2068423670","https://openalex.org/W2069496794","https://openalex.org/W2069764248","https://openalex.org/W2080476230","https://openalex.org/W2080501796","https://openalex.org/W2085306532","https://openalex.org/W2088696325","https://openalex.org/W2100050744","https://openalex.org/W2104866202","https://openalex.org/W2136908233","https://openalex.org/W2144921023","https://openalex.org/W2163946974","https://openalex.org/W2231666798","https://openalex.org/W2241698647","https://openalex.org/W2335572613","https://openalex.org/W2954379768"],"related_works":["https://openalex.org/W2248486206","https://openalex.org/W128823262","https://openalex.org/W2039504221","https://openalex.org/W1991775006","https://openalex.org/W2045960922","https://openalex.org/W2060651560","https://openalex.org/W2145057798","https://openalex.org/W2341210692","https://openalex.org/W2056659011","https://openalex.org/W1979931416"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}