{"id":"https://openalex.org/W2107923114","doi":"https://doi.org/10.1136/bjo.2008.138479","title":"Characteristics of severe intraocular inflammation following intravitreal injection of bevacizumab (Avastin)","display_name":"Characteristics of severe intraocular inflammation following intravitreal injection of bevacizumab (Avastin)","publication_year":2008,"publication_date":"2008-11-25","ids":{"openalex":"https://openalex.org/W2107923114","doi":"https://doi.org/10.1136/bjo.2008.138479","mag":"2107923114","pmid":"https://pubmed.ncbi.nlm.nih.gov/19033289"},"language":"en","primary_location":{"id":"doi:10.1136/bjo.2008.138479","doi":"https://doi.org/10.1136/bjo.2008.138479","is_oa":false,"landing_page_url":"https://doi.org/10.1136/bjo.2008.138479","pdf_url":null,"source":{"id":"https://openalex.org/S79587146","display_name":"British Journal of Ophthalmology","issn_l":"0007-1161","issn":["0007-1161","1468-2079"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Ophthalmology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038462897","display_name":"Michael Georgopoulos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"M Georgopoulos","raw_affiliation_strings":["Department of Ophthalmology, Medical University of, Vienna, Spitalgasse 23, A-1090 Vienna, Austria. ursula.schmidt-erfurth@meduniwien.ac.at","Department of Ophthalmology, Medical University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Medical University of, Vienna, Spitalgasse 23, A-1090 Vienna, Austria. ursula.schmidt-erfurth@meduniwien.ac.at","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"Department of Ophthalmology, Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031412911","display_name":"Kaija Polak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"K Polak","raw_affiliation_strings":["Department of Ophthalmology, Medical University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063581584","display_name":"Franz Prager","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"F Prager","raw_affiliation_strings":["Department of Ophthalmology, Medical University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110956109","display_name":"Christian F. Pr\u00fcnte","orcid":"https://orcid.org/0000-0002-8405-8933","observed_orcids":["https://orcid.org/0000-0002-8405-8933"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"C Prunte","raw_affiliation_strings":["Department of Ophthalmology, Medical University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053563726","display_name":"Ursula Margarethe Schmidt-Erfurth","orcid":"https://orcid.org/0000-0002-7788-7311","observed_orcids":["https://orcid.org/0000-0002-7788-7311"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"U Schmidt-Erfurth","raw_affiliation_strings":["Department of Ophthalmology, Medical University of, Vienna, Spitalgasse 23, A-1090 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Medical University of, Vienna, Spitalgasse 23, A-1090 Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5053563726"],"corresponding_institution_ids":["https://openalex.org/I76134821"],"apc_list":null,"apc_paid":null,"fwci":10.1462,"has_fulltext":false,"cited_by_count":124,"citation_normalized_percentile":{"value":0.98609282,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"93","issue":"4","first_page":"457","last_page":"462"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.015699999406933784,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.011699999682605267,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.984000027179718},{"id":"https://openalex.org/keywords/intravitreal-injection-complications","display_name":"intravitreal injection complications","score":0.9070000052452087},{"id":"https://openalex.org/keywords/intraocular-inflammation","display_name":"intraocular inflammation","score":0.8889999985694885},{"id":"https://openalex.org/keywords/uveitis","display_name":"uveitis","score":0.9160000085830688},{"id":"https://openalex.org/keywords/vitreitis","display_name":"vitritis","score":0.6790000200271606},{"id":"https://openalex.org/keywords/anterior-chamber-reaction","display_name":"anterior chamber reaction","score":0.824999988079071},{"id":"https://openalex.org/keywords/endophthalmitis","display_name":"endophthalmitis","score":0.8090000152587891},{"id":"https://openalex.org/keywords/vitreous-hemorrhage","display_name":"vitreous hemorrhage","score":0.9850000143051147},{"id":"https://openalex.org/keywords/corticosteroid-therapy","display_name":"corticosteroid therapy","score":0.843999981880188},{"id":"https://openalex.org/keywords/anti-vegf-therapy","display_name":"anti-VEGF therapy","score":0.8090000152587891}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9663671255111694},{"id":"https://openalex.org/C2777235844","wikidata":"https://www.wikidata.org/wiki/Q1294912","display_name":"Endophthalmitis","level":2,"score":0.8161508440971375},{"id":"https://openalex.org/C2781403741","wikidata":"https://www.wikidata.org/wiki/Q1638140","display_name":"Hypopyon","level":3,"score":0.7942377328872681},{"id":"https://openalex.org/C2776194053","wikidata":"https://www.wikidata.org/wiki/Q280027","display_name":"Uveitis","level":2,"score":0.6310333609580994},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.6202759742736816},{"id":"https://openalex.org/C113520495","wikidata":"https://www.wikidata.org/wiki/Q2359854","display_name":"Posterior segment of eyeball","level":2,"score":0.5496559739112854},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.5409446954727173},{"id":"https://openalex.org/C2778257484","wikidata":"https://www.wikidata.org/wiki/Q555066","display_name":"Visual acuity","level":2,"score":0.47377490997314453},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.42233896255493164},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.18186861276626587}],"mesh":[{"descriptor_ui":"D000068258","descriptor_name":"Bevacizumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D003937","descriptor_name":"Diagnosis, Differential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007267","descriptor_name":"Injections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009877","descriptor_name":"Endophthalmitis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D009877","descriptor_name":"Endophthalmitis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014792","descriptor_name":"Visual Acuity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014822","descriptor_name":"Vitreous Body","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1136/bjo.2008.138479","doi":"https://doi.org/10.1136/bjo.2008.138479","is_oa":false,"landing_page_url":"https://doi.org/10.1136/bjo.2008.138479","pdf_url":null,"source":{"id":"https://openalex.org/S79587146","display_name":"British Journal of Ophthalmology","issn_l":"0007-1161","issn":["0007-1161","1468-2079"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Ophthalmology","raw_type":"journal-article"},{"id":"pmid:19033289","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19033289","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of ophthalmology","raw_type":"Case Reports"},{"id":"pmh:oai:open-archive.highwire.org:bjophthalmol:bjo.2008.138479v1","doi":null,"is_oa":false,"landing_page_url":"http://bjo.bmj.com/cgi/content/short/bjo.2008.138479v1","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1214250537","https://openalex.org/W1493672163","https://openalex.org/W1513613431","https://openalex.org/W1522421496","https://openalex.org/W1966884742","https://openalex.org/W1968609549","https://openalex.org/W1976409243","https://openalex.org/W1995708259","https://openalex.org/W2004882123","https://openalex.org/W2018352429","https://openalex.org/W2033245558","https://openalex.org/W2039446733","https://openalex.org/W2039654078","https://openalex.org/W2059265707","https://openalex.org/W2093730001","https://openalex.org/W2094418307","https://openalex.org/W2124415048","https://openalex.org/W2130245376","https://openalex.org/W2139499737","https://openalex.org/W2151129590"],"related_works":["https://openalex.org/W2089838877","https://openalex.org/W2168910208","https://openalex.org/W2081275070","https://openalex.org/W1998470576","https://openalex.org/W2052892208","https://openalex.org/W2057394405","https://openalex.org/W2057196912","https://openalex.org/W1969016833","https://openalex.org/W2078028176","https://openalex.org/W2127262139"],"abstract_inverted_index":{"BACKGROUND/AIMS:":[0],"To":[1],"report":[2],"a":[3,21,47,74,122,137,187],"series":[4,52],"of":[5,13,53,63,72,76,158,168,204],"severe":[6,57,87],"intraocular":[7,31,35,58,88],"inflammatory":[8],"events":[9],"following":[10,131],"intravitreal":[11,61,91],"injections":[12,78],"bevacizumab":[14,64,209],"(Avastin).":[15],"This":[16,45],"procedure":[17],"is":[18,46],"performed":[19,79],"on":[20],"rapidly":[22],"increasing":[23],"number":[24],"worldwide,":[25],"and":[26,109,116,145,196,243,252],"rare":[27],"complications":[28],"such":[29],"as":[30,192],"inflammation,":[32],"endophthalmitis":[33,245],"or":[34,223,230],"haemorrhage":[36,242],"are":[37],"gaining":[38],"in":[39,41,80,125,194,218],"importance":[40],"clinical":[42,165],"routine.":[43],"METHODS:":[44],"single-centre":[48],"retrospective":[49],"interventional":[50],"case":[51],"eight":[54],"patients":[55,135],"with":[56,142,175,215,234],"inflammation":[59,89,206],"after":[60,90],"injection":[62,92,210],"at":[65],"one":[66],"referral":[67],"centre":[68],"consecutively":[69],"seen":[70,193],"out":[71],"approximately":[73],"total":[75],"2500":[77],"that":[81],"time":[82,250],"period.":[83],"Patients":[84,120,226],"who":[85],"developed":[86],"were":[93,173,197],"evaluated":[94],"clinically,":[95],"including":[96],"slit-lamp":[97,104],"examination,":[98],"best-corrected":[99],"Snellen":[100],"visual":[101],"acuity":[102],"(VA),":[103],"photography,":[105],"optical":[106],"coherence":[107],"tomography":[108],"fluorescein":[110],"angiography":[111],"prior":[112],"to":[113,128,162,228],"the":[114,132,179],"event":[115],"during":[117],"follow-up.":[118],"RESULTS:":[119],"noticed":[121],"painless":[123,216],"drop":[124],"VA":[126,219],"up":[127],"2":[129],"days":[130],"injection.":[133,225],"All":[134],"had":[136],"marked":[138],"anterior":[139],"chamber":[140],"reaction":[141],"increased":[143],"flare":[144],"cells,":[146],"but":[147,178,237],"no":[148],"hypopyon.":[149],"Typical":[150],"posterior":[151],"segment":[152],"findings":[153],"included":[154],"vitreous":[155,190],"cellular":[156],"infiltrates":[157],"pseudogranulomatous":[159,189],"aspect.":[160],"Due":[161],"their":[163],"initial":[164],"aspect":[166],"suspicious":[167],"an":[169,205,212],"endophthalmitis,":[170],"three":[171],"cases":[172,185],"treated":[174,198],"systemic":[176,229],"antibiotics,":[177],"final":[180],"diagnosis":[181],"was":[182],"uveitis.":[183],"Five":[184],"showed":[186],"characteristic":[188],"infiltration":[191],"vitritis":[195],"only":[199],"topically.":[200],"CONCLUSIONS:":[201],"Characteristic":[202],"features":[203],"induced":[207],"by":[208,249],"include":[211],"early":[213],"onset":[214],"loss":[217],"mostly":[220],"without":[221,238],"conjunctival":[222],"ciliary":[224],"respond":[227],"topical":[231],"cortisone":[232],"treatment":[233],"slow":[235],"recovery":[236],"permanent":[239],"damage.":[240],"Vitreous":[241],"infectious":[244],"might":[246],"be":[247],"differentiated":[248],"course":[251],"symptoms.":[253]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
