{"id":"https://openalex.org/W2107922680","doi":"https://doi.org/10.1152/ajpcell.00050.2004","title":"Overexpression of human KCNA5 increases IK(V) and enhances apoptosis","display_name":"Overexpression of human KCNA5 increases IK(V) and enhances apoptosis","publication_year":2004,"publication_date":"2004-05-18","ids":{"openalex":"https://openalex.org/W2107922680","doi":"https://doi.org/10.1152/ajpcell.00050.2004","mag":"2107922680","pmid":"https://pubmed.ncbi.nlm.nih.gov/15140747"},"language":"en","primary_location":{"id":"doi:10.1152/ajpcell.00050.2004","doi":"https://doi.org/10.1152/ajpcell.00050.2004","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpcell.00050.2004","pdf_url":null,"source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044765705","display_name":"Elena E. Brevnova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elena E. Brevnova","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, Dept. of Medicine, Medical Teaching Facility, University of California-San Diego, #0725, 9500 Gilman Drive, La Jolla, CA 92093-0725, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Dept. of Medicine, Medical Teaching Facility, University of California-San Diego, #0725, 9500 Gilman Drive, La Jolla, CA 92093-0725, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003629788","display_name":"Oleksandr Platoshyn","orcid":"https://orcid.org/0000-0001-6529-6752","observed_orcids":["https://orcid.org/0000-0001-6529-6752"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oleksandr Platoshyn","raw_affiliation_strings":["","Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Diego, La Jolla, California 92093-0725"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Diego, La Jolla, California 92093-0725","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100354196","display_name":"Shen Zhang","orcid":"https://orcid.org/0000-0002-6429-8008","observed_orcids":["https://orcid.org/0000-0002-6429-8008"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shen Zhang","raw_affiliation_strings":["","Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Diego, La Jolla, California 92093-0725"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Diego, La Jolla, California 92093-0725","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034938550","display_name":"Jason X.\u2010J. Yuan","orcid":"https://orcid.org/0000-0002-0685-4862","observed_orcids":["https://orcid.org/0000-0002-0685-4862"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason X.-J. Yuan","raw_affiliation_strings":["","Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Diego, La Jolla, California 92093-0725"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Diego, La Jolla, California 92093-0725","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":null,"apc_paid":null,"fwci":2.4411,"has_fulltext":false,"cited_by_count":92,"citation_normalized_percentile":{"value":0.895258,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":98},"biblio":{"volume":"287","issue":"3","first_page":"C715","last_page":"C722"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.7935000061988831,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.7935000061988831,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.18410000205039978,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kv1-5","display_name":"Kv1.5","score":1.0},{"id":"https://openalex.org/keywords/delayed-rectifier-potassium-channel","display_name":"delayed rectifier potassium channel","score":0.8389999866485596},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9399999976158142},{"id":"https://openalex.org/keywords/pulmonary-artery-smooth-muscle-cells","display_name":"pulmonary artery smooth muscle cells","score":0.8119999766349792},{"id":"https://openalex.org/keywords/pulmonary-hypertension","display_name":"pulmonary hypertension","score":0.5989999771118164},{"id":"https://openalex.org/keywords/idiopathic-pulmonary-arterial-hypertension","display_name":"idiopathic pulmonary arterial hypertension","score":0.9049999713897705},{"id":"https://openalex.org/keywords/staurosporine","display_name":"staurosporine","score":0.8460000157356262},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.996999979019165},{"id":"https://openalex.org/keywords/4-aminopyridine","display_name":"4-aminopyridine","score":0.9269999861717224},{"id":"https://openalex.org/keywords/gene-overexpression","display_name":"gene overexpression","score":0.6539999842643738},{"id":"https://openalex.org/keywords/potassium-efflux","display_name":"potassium efflux","score":0.781000018119812}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.8267266750335693},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.7232773900032043},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4591400623321533},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.4108430743217468},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35121220350265503},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34950414299964905},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33885249495506287},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.24163547158241272},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23167073726654053},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20758703351020813},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11727997660636902}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015761","descriptor_name":"4-Aminopyridine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019311","descriptor_name":"Staurosporine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024642","descriptor_name":"Potassium Channels, Voltage-Gated","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D024642","descriptor_name":"Potassium Channels, Voltage-Gated","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D026902","descriptor_name":"Potassium Channel Blockers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpcell.00050.2004","doi":"https://doi.org/10.1152/ajpcell.00050.2004","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpcell.00050.2004","pdf_url":null,"source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},{"id":"pmid:15140747","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15140747","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Cell physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1426602300","display_name":null,"funder_award_id":"HL 54043","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G378154135","display_name":"Calcium Signaling in Pulmonary Arterial Hypertension: Role of CaSR and TRPC6","funder_award_id":"R01HL066012","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4201175642","display_name":"Autonomic Pharmacodynamic Pharmacogenomics","funder_award_id":"U01HL069758","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7583591397","display_name":"Cellular Mechanisms of PPH: Role of K+ Channels","funder_award_id":"R01HL064945","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8018442451","display_name":"Discovery and Development of Therapeutic Genes for CHF","funder_award_id":"P01HL066941","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W204164459","https://openalex.org/W1745634660","https://openalex.org/W1973824723","https://openalex.org/W1976429299","https://openalex.org/W1977777133","https://openalex.org/W1978575240","https://openalex.org/W1980619986","https://openalex.org/W1991870376","https://openalex.org/W1994807255","https://openalex.org/W1998248849","https://openalex.org/W2006911187","https://openalex.org/W2008479667","https://openalex.org/W2010171666","https://openalex.org/W2014609720","https://openalex.org/W2015717266","https://openalex.org/W2016417151","https://openalex.org/W2050099786","https://openalex.org/W2053003352","https://openalex.org/W2054818418","https://openalex.org/W2070908828","https://openalex.org/W2071026795","https://openalex.org/W2071666526","https://openalex.org/W2080561371","https://openalex.org/W2081136116","https://openalex.org/W2082490296","https://openalex.org/W2091965408","https://openalex.org/W2100867769","https://openalex.org/W2114696344","https://openalex.org/W2119800239","https://openalex.org/W2121294357","https://openalex.org/W2124462138","https://openalex.org/W2145070342","https://openalex.org/W2148965526","https://openalex.org/W2152501741","https://openalex.org/W2155920800","https://openalex.org/W2158326731","https://openalex.org/W2162908585","https://openalex.org/W2166431337","https://openalex.org/W2166985476","https://openalex.org/W2170961323","https://openalex.org/W2181344473","https://openalex.org/W2184358523","https://openalex.org/W2188714410","https://openalex.org/W2221719760","https://openalex.org/W2224021986","https://openalex.org/W2262658406","https://openalex.org/W2266973650","https://openalex.org/W2342230037","https://openalex.org/W2396389971","https://openalex.org/W2418256718","https://openalex.org/W2419424321"],"related_works":["https://openalex.org/W2135875385","https://openalex.org/W2081414376","https://openalex.org/W3030896273","https://openalex.org/W2188714410","https://openalex.org/W2419360290","https://openalex.org/W1499833703","https://openalex.org/W7097596058","https://openalex.org/W2387856814","https://openalex.org/W2103424889","https://openalex.org/W7100108819"],"abstract_inverted_index":{"Apoptotic":[0],"cell":[1,163],"shrinkage,":[2],"an":[3,137,236],"early":[4],"hallmark":[5],"of":[6,35,45,55,73,117,145,179,200,225,243],"apoptosis,":[7,153],"is":[8],"regulated":[9],"by":[10,229],"K+":[11,14,21,62,66,186,206,209],"efflux":[12,210],"and":[13,19,40,68,85,100,114,171,177,191,221,248],"channel":[15,82,92],"activity.":[16],"Inhibited":[17],"apoptosis":[18,120,126,194,226],"downregulated":[20],"channels":[22,181,190],"in":[23,33,80,90,98,111,151,154,168,195,227],"pulmonary":[24,36,41,244,254],"artery":[25],"smooth":[26],"muscle":[27],"cells":[28,118,134,170],"(PASMC)":[29],"have":[30],"been":[31],"implicated":[32],"development":[34],"vascular":[37,245],"medial":[38],"hypertrophy":[39],"hypertension.":[42],"The":[43],"objective":[44],"this":[46],"study":[47],"was":[48,130,165],"to":[49,77,87,156],"test":[50],"the":[51,115,201,241],"hypothesis":[52],"that":[53],"overexpression":[54],"KCNA5,":[56,176],"which":[57],"encodes":[58],"a":[59],"delayed-rectifier":[60],"voltage-gated":[61],"(Kv)":[63],"channel,":[64],"increases":[65,110,205,218],"currents":[67,187,207],"enhances":[69],"apoptosis.":[70,159,223],"Transient":[71],"transfection":[72,144],"KCNA5":[74,81,146,180,189,203,230],"caused":[75,148],"25-":[76],"34-fold":[78],"increase":[79,89,150],"protein":[83],"level":[84],"24-":[86],"29-fold":[88],"Kv":[91],"current":[93],"(I(K(V)))":[94],"at":[95],"+60":[96],"mV":[97],"COS-7":[99,106,169,197],"rat":[101,141,172],"PASMC,":[102,142],"respectively.":[103],"In":[104,140],"KCNA5-transfected":[105,196],"cells,":[107],"staurosporine":[108],"(ST)-mediated":[109],"caspase-3":[112,219],"activity":[113],"percentage":[116],"undergoing":[119],"were":[121],"both":[122],"enhanced,":[123],"whereas":[124],"basal":[125,152],"(without":[127],"ST":[128],"stimulation)":[129],"unchanged":[131],"compared":[132],"with":[133,136,175,182,252],"transfected":[135,174],"empty":[138],"vector.":[139],"however,":[143],"alone":[147],"marked":[149],"addition":[155],"enhancing":[157],"ST-mediated":[158],"Furthermore,":[160],"ST-induced":[161,193],"apoptotic":[162,214],"shrinkage":[164],"significantly":[166],"accelerated":[167],"PASMC":[173,228],"blockade":[178],"4-aminopyridine":[183],"(4-AP)":[184],"reduced":[185],"through":[188],"inhibited":[192],"cells.":[198],"Overexpression":[199],"human":[202],"gene":[204,231],"(i.e.,":[208],"or":[211],"loss),":[212],"accelerates":[213],"volume":[215],"decrease":[216],"(AVD),":[217],"activity,":[220],"induces":[222],"Induction":[224],"transfer":[232],"may":[233],"serve":[234],"as":[235],"important":[237],"strategy":[238],"for":[239,249],"preventing":[240],"progression":[242],"wall":[246],"thickening":[247],"treating":[250],"patients":[251],"idiopathic":[253],"arterial":[255],"hypertension":[256],"(IPAH).":[257]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}