{"id":"https://openalex.org/W2107792664","doi":"https://doi.org/10.2337/diab.38.10.1329","title":"Macrophage-Mediated Islet Cell Cytotoxicity in BB Rats","display_name":"Macrophage-Mediated Islet Cell Cytotoxicity in BB Rats","publication_year":1989,"publication_date":"1989-10-01","ids":{"openalex":"https://openalex.org/W2107792664","doi":"https://doi.org/10.2337/diab.38.10.1329","mag":"2107792664","pmid":"https://pubmed.ncbi.nlm.nih.gov/2676662"},"language":"en","primary_location":{"id":"doi:10.2337/diab.38.10.1329","doi":"https://doi.org/10.2337/diab.38.10.1329","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diab.38.10.1329","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"M Varsanyi Nagy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Varsanyi Nagy","raw_affiliation_strings":["Diabetes Research Program, Department of Medicine, University of California\u2008Irvine, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes Research Program, Department of Medicine, University of California\u2008Irvine, California","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103687563","display_name":"Eve K. Chan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eve K Chan","raw_affiliation_strings":["Diabetes Research Program, Department of Medicine, University of California\u2008Irvine, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes Research Program, Department of Medicine, University of California\u2008Irvine, California","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109994434","display_name":"Masanori Teruya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masanori Teruya","raw_affiliation_strings":["Diabetes Research Program, Department of Medicine, University of California\u2008Irvine, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes Research Program, Department of Medicine, University of California\u2008Irvine, California","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079258813","display_name":"Luette E Forrest","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luette E Forrest","raw_affiliation_strings":["Diabetes Research Program, Department of Medicine, University of California\u2008Irvine, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes Research Program, Department of Medicine, University of California\u2008Irvine, California","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112146180","display_name":"Vilas V. Likhite","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vilas Likhite","raw_affiliation_strings":["Diabetes Research Program, Department of Medicine, University of California\u2008Irvine, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes Research Program, Department of Medicine, University of California\u2008Irvine, California","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042260144","display_name":"M. Arthur Charles","orcid":"https://orcid.org/0000-0002-4614-9084","observed_orcids":["https://orcid.org/0000-0002-4614-9084"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Arthur Charles","raw_affiliation_strings":["Diabetes Research Program, Department of Medicine, University of California\u2008Irvine, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes Research Program, Department of Medicine, University of California\u2008Irvine, California","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204250578"],"apc_list":null,"apc_paid":null,"fwci":2.2003,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.87716816,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"38","issue":"10","first_page":"1329","last_page":"1331"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.016100000590085983,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8600000143051147},{"id":"https://openalex.org/keywords/bb-rat","display_name":"BB rat","score":0.671999990940094},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.7289999723434448},{"id":"https://openalex.org/keywords/insulitis","display_name":"insulitis","score":0.9459999799728394},{"id":"https://openalex.org/keywords/splenic-macrophages","display_name":"splenic macrophages","score":0.8579999804496765},{"id":"https://openalex.org/keywords/diabetes-onset","display_name":"diabetes onset","score":0.6159999966621399},{"id":"https://openalex.org/keywords/islet-destruction","display_name":"islet damage","score":0.6620000004768372},{"id":"https://openalex.org/keywords/cell-mediated-autoimmunity","display_name":"cell-mediated autoimmunity","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C2779511750","wikidata":"https://www.wikidata.org/wiki/Q922215","display_name":"Insulitis","level":4,"score":0.9217935800552368},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.9214605093002319},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6276456713676453},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5870336294174194},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5824970602989197},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5801548361778259},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5342459082603455},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.5149300694465637},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4801849126815796},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.43359264731407166},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39516472816467285},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3767606019973755},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0692274272441864},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0369735062122345}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011913","descriptor_name":"Rats, Inbred BB","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2337/diab.38.10.1329","doi":"https://doi.org/10.2337/diab.38.10.1329","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diab.38.10.1329","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"doi:10.2337/diabetes.38.10.1329","doi":"https://doi.org/10.2337/diabetes.38.10.1329","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diabetes.38.10.1329","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"pmid:2676662","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2676662","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7799999713897705,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1547936079","https://openalex.org/W1590384635","https://openalex.org/W1990009191","https://openalex.org/W1991846489","https://openalex.org/W1994232119","https://openalex.org/W2003933970","https://openalex.org/W2007997802","https://openalex.org/W2024670462","https://openalex.org/W2026987834","https://openalex.org/W2070551583","https://openalex.org/W2079932743","https://openalex.org/W2082707055","https://openalex.org/W2087967870","https://openalex.org/W2131798470","https://openalex.org/W2132327589","https://openalex.org/W2196240791","https://openalex.org/W2433435863"],"related_works":["https://openalex.org/W2013831740","https://openalex.org/W2078505376","https://openalex.org/W1966362059","https://openalex.org/W1991846489","https://openalex.org/W2050564398","https://openalex.org/W2024670462","https://openalex.org/W1989358278","https://openalex.org/W1873730442","https://openalex.org/W2007997802","https://openalex.org/W2066235027"],"abstract_inverted_index":{"Islet":[0,112],"cell":[1],"killing":[2,22,81,205],"mediated":[3],"by":[4],"natural":[5,221],"killer":[6,222],"cells":[7,37,48,223],"and":[8,13,72,122,135,215,224,232],"T-lymphocytes":[9],"in":[10,56,139,174,208,218,243],"diabetes-prone":[11],"(DP)":[12],"diabetic":[14,169],"BB":[15,57],"rats":[16,58,67,132,153,166],"has":[17],"been":[18],"described,":[19],"but":[20],"other":[21],"mechanisms":[23],"may":[24,195],"also":[25],"be":[26],"involved.":[27],"Histopathologic":[28],"studies":[29],"suggest":[30],"that":[31,154,182],"macrophages":[32,44,63,194],"are":[33,45,226,234],"the":[34,46,149,175,237],"first":[35,47,238],"immune":[36],"to":[38,148,156,220,241],"infiltrate":[39],"islets.":[40],"To":[41],"determine":[42],"if":[43],"mediating":[49],"islet":[50,80,184,200,204,230,244],"damage,":[51],"macrophage-mediated":[52,203],"cytotoxicity":[53,136],"was":[54,94,114,137],"evaluated":[55],"of":[59,75,125,128,141,151,162,171,177],"different":[60],"ages.":[61],"Splenic":[62],"isolated":[64],"from":[65,188],"DP":[66,131,152,165],"at":[68,87,116],"33,":[69],"100,":[70],"120,":[71],"140":[73,123],"days":[74,124],"age":[76],"showed":[77,168],"no":[78],"enhanced":[79],"compared":[82,100],"with":[83,101],"diabetes-resistant":[84,103],"rats.":[85],"Killing":[86],"diabetes":[88,190,213],"onset":[89],"(121":[90],"+/-":[91,98,106],"14":[92],"days)":[93],"markedly":[95],"increased":[96,138],"(43":[97],"9.3%)":[99],"age-matched":[102],"controls":[104],"(19":[105],"8.3%,":[107],"P":[108],"less":[109],"than":[110],".001).":[111],"inflammation":[113,185],"monitored":[115],"all":[117,209],"time":[118],"points.":[119],"At":[120,158],"120":[121],"age,":[126],"9":[127],"11":[129,142],"(82%)":[130],"had":[133],"insulitis,":[134],"6":[140,163],"(55%)":[143],"rats,":[144],"which":[145],"is":[146,186,206],"similar":[147],"number":[150],"progress":[155],"diabetes.":[157],"100":[159],"days,":[160],"3":[161],"(50%)":[164],"again":[167],"levels":[170],"killing,":[172],"even":[173],"absence":[176],"insulitis.":[178],"These":[179],"data":[180],"indicate":[181],"1)":[183],"dissociated":[187],"clinical":[189],"onset,":[191,214],"2)":[192],"splenic":[193],"have":[196],"islet-killing":[197],"potential":[198],"before":[199],"inflammation,":[201],"3)":[202],"elevated":[207],"animals":[210],"immediately":[211],"after":[212],"4)":[216],"macrophages,":[217],"addition":[219],"T-lymphocytes,":[225],"responsible":[227],"for":[228,236],"cell-mediated":[229],"destruction":[231],"thus":[233],"candidates":[235],"cellular":[239],"effector":[240],"result":[242],"killing.":[245]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}