{"id":"https://openalex.org/W2107783538","doi":"https://doi.org/10.1155/2016/1239629","title":"Caffeine-Induced Suppression of GABAergic Inhibition and Calcium-Independent Metaplasticity","display_name":"Caffeine-Induced Suppression of GABAergic Inhibition and Calcium-Independent Metaplasticity","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2107783538","doi":"https://doi.org/10.1155/2016/1239629","mag":"2107783538","pmid":"https://pubmed.ncbi.nlm.nih.gov/26998364","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4779589"},"language":"lv","primary_location":{"id":"doi:10.1155/2016/1239629","doi":"https://doi.org/10.1155/2016/1239629","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2016/1239629","pdf_url":"http://downloads.hindawi.com/journals/np/2016/1239629.pdf","source":{"id":"https://openalex.org/S185020647","display_name":"Neural Plasticity","issn_l":"1687-5443","issn":["1687-5443","2090-5904"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural Plasticity","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://downloads.hindawi.com/journals/np/2016/1239629.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103257872","display_name":"Masako Isokawa","orcid":"https://orcid.org/0000-0001-7304-3552","observed_orcids":["https://orcid.org/0000-0001-7304-3552"]},"institutions":[{"id":"https://openalex.org/I2802326326","display_name":"The University of Texas Rio Grande Valley","ror":"https://ror.org/02p5xjf12","country_code":"US","type":"education","lineage":["https://openalex.org/I2802326326"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Masako Isokawa","raw_affiliation_strings":["Department of Health and Biomedical Sciences, The University of Texas Rio Grande Valley, One West University Boulevard, Brownsville, TX 78520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health and Biomedical Sciences, The University of Texas Rio Grande Valley, One West University Boulevard, Brownsville, TX 78520, USA","institution_ids":["https://openalex.org/I2802326326"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5103257872"],"corresponding_institution_ids":["https://openalex.org/I2802326326"],"apc_list":{"value":2830,"currency":"USD","value_usd":2830},"apc_paid":{"value":2830,"currency":"USD","value_usd":2830},"fwci":2.0561,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.84647259,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"2016","issue":null,"first_page":"1","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caffeine","display_name":"caffeine","score":1.0},{"id":"https://openalex.org/keywords/gabaergic-inhibition","display_name":"GABAergic inhibition","score":0.9950000047683716},{"id":"https://openalex.org/keywords/metaplasticity","display_name":"metaplasticity","score":0.8999999761581421},{"id":"https://openalex.org/keywords/depolarization-induced-suppression-of-inhibition","display_name":"depolarization-induced suppression of inhibition","score":0.8980000019073486},{"id":"https://openalex.org/keywords/inhibitory-postsynaptic-currents","display_name":"inhibitory postsynaptic currents","score":0.921999990940094},{"id":"https://openalex.org/keywords/ca1-pyramidal-neurons","display_name":"CA1 pyramidal neurons","score":0.9240000247955322},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.7009999752044678},{"id":"https://openalex.org/keywords/endocannabinoids","display_name":"endocannabinoids","score":0.6880000233650208},{"id":"https://openalex.org/keywords/calcium-store-release","display_name":"calcium store release","score":0.5210000276565552},{"id":"https://openalex.org/keywords/ruthenium-red","display_name":"ruthenium red","score":0.7910000085830688},{"id":"https://openalex.org/keywords/plasma-membrane-channels","display_name":"plasma membrane channels","score":0.7519999742507935},{"id":"https://openalex.org/keywords/inward-current","display_name":"inward current","score":0.3659999966621399}],"concepts":[{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.4231046438217163},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.25308090448379517}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002110","descriptor_name":"Caffeine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053444","descriptor_name":"Inhibitory Postsynaptic Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1155/2016/1239629","doi":"https://doi.org/10.1155/2016/1239629","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2016/1239629","pdf_url":"http://downloads.hindawi.com/journals/np/2016/1239629.pdf","source":{"id":"https://openalex.org/S185020647","display_name":"Neural Plasticity","issn_l":"1687-5443","issn":["1687-5443","2090-5904"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural Plasticity","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3765881","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4779589","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4779589","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4779589","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural Plast","raw_type":"Text"},{"id":"pmid:26998364","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26998364","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural plasticity","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:2b6c7621d005462dadc66f7ed7512128","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2b6c7621d005462dadc66f7ed7512128","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neural Plasticity, Vol 2016 (2016)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/2016/1239629","doi":"https://doi.org/10.1155/2016/1239629","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2016/1239629","pdf_url":"http://downloads.hindawi.com/journals/np/2016/1239629.pdf","source":{"id":"https://openalex.org/S185020647","display_name":"Neural Plasticity","issn_l":"1687-5443","issn":["1687-5443","2090-5904"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural Plasticity","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2552244536","display_name":null,"funder_award_id":"SC1GM 081179/DA029329","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G2621984751","display_name":"Cannabinoid mobilization in neurons (R15DA021683)","funder_award_id":"R15DA021683","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G5806795442","display_name":"Caffeine-induced modulation of GABAergic transmission","funder_award_id":"SC1DA029329","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G8277392922","display_name":"Caffeine-induced modulation of GABAergic transmission","funder_award_id":"SC1GM081179","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2107783538.pdf","grobid_xml":"https://content.openalex.org/works/W2107783538.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1601627343","https://openalex.org/W1717986312","https://openalex.org/W1894814115","https://openalex.org/W1970706920","https://openalex.org/W1973401628","https://openalex.org/W1976709166","https://openalex.org/W1980972634","https://openalex.org/W1995190911","https://openalex.org/W1996024251","https://openalex.org/W2014100516","https://openalex.org/W2022599378","https://openalex.org/W2027025579","https://openalex.org/W2029668693","https://openalex.org/W2030195151","https://openalex.org/W2034692024","https://openalex.org/W2059067548","https://openalex.org/W2079054696","https://openalex.org/W2088093088","https://openalex.org/W2094381233","https://openalex.org/W2098094063","https://openalex.org/W2100465045","https://openalex.org/W2116562654","https://openalex.org/W2127039578","https://openalex.org/W2130661432","https://openalex.org/W2134325626","https://openalex.org/W2141260882","https://openalex.org/W2145758516","https://openalex.org/W2164438705","https://openalex.org/W2342037587"],"related_works":["https://openalex.org/W2027025579","https://openalex.org/W878562380","https://openalex.org/W2075044108","https://openalex.org/W1967874164","https://openalex.org/W2095033319","https://openalex.org/W2164438705","https://openalex.org/W1949292176","https://openalex.org/W2342037587","https://openalex.org/W2339247815","https://openalex.org/W2091422939"],"abstract_inverted_index":{"GABAergic":[0,51,69,199],"inhibition":[1,200],"plays":[2],"a":[3,39,100,116,173,193],"critical":[4],"role":[5],"in":[6,112],"the":[7,24,35,83,113,136,158,170,186],"regulation":[8],"of":[9,26,41,60,80,86,92,108,115,121,138,145,152,160,163,172,180],"neuron":[10],"excitability;":[11],"thus,":[12],"it":[13],"is":[14,184],"subject":[15],"to":[16,62,134],"modulations":[17],"by":[18,53,74,95,156,204],"many":[19],"factors.":[20],"Recent":[21],"evidence":[22],"suggests":[23],"elevation":[25],"intracellular":[27,44,131],"calcium":[28,42,128,147],"([Ca(2+)]i)":[29],"and":[30,82,123,201],"calcium-dependent":[31],"signaling":[32],"molecules":[33],"underlie":[34],"modulations.":[36],"Caffeine":[37],"induces":[38],"release":[40,129],"from":[43,130],"stores.":[45],"We":[46],"tested":[47],"whether":[48],"caffeine":[49,61,191],"modulated":[50],"transmission":[52],"increasing":[54],"[Ca(2+)]i.":[55],"A":[56],"brief":[57],"local":[58],"puff-application":[59],"hippocampal":[63],"CA1":[64],"pyramidal":[65],"cells":[66],"transiently":[67],"suppressed":[68],"inhibitory":[70,196],"postsynaptic":[71],"currents":[72],"(IPSCs)":[73],"73.2":[75],"\u00b1":[76],"6.98%.":[77],"Time":[78],"course":[79],"suppression":[81,91,107],"subsequent":[84],"recovery":[85],"IPSCs":[87,109],"resembled":[88],"DSI":[89],"(depolarization-induced":[90],"inhibition),":[93],"mediated":[94],"endogenous":[96],"cannabinoids":[97],"that":[98,190],"require":[99],"[Ca(2+)]i":[101,117],"rise.":[102,118],"However,":[103],"unlike":[104],"DSI,":[105],"caffeine-induced":[106,127],"(CSI)":[110],"persisted":[111],"absence":[114],"Intracellular":[119],"applications":[120],"BAPTA":[122],"ryanodine":[124],"(which":[125],"blocks":[126],"stores)":[132],"failed":[133],"prevent":[135],"generation":[137,171],"CSI.":[139],"Surprisingly,":[140],"ruthenium":[141],"red,":[142],"an":[143],"inhibitor":[144],"multiple":[146],"permeable/release":[148],"channels":[149],"including":[150],"those":[151],"stores,":[153],"induced":[154],"metaplasticity":[155,166,203],"amplifying":[157],"magnitude":[159],"CSI":[161],"independently":[162],"calcium.":[164],"This":[165],"was":[167],"accompanied":[168],"with":[169],"large":[174],"inward":[175,182],"current.":[176],"Although":[177],"ionic":[178],"basis":[179],"this":[181],"current":[183],"undetermined,":[185],"present":[187],"result":[188],"demonstrates":[189],"has":[192],"robust":[194],"Ca(2+)-independent":[195],"action":[197],"on":[198],"causes":[202],"opening":[205],"plasma":[206],"membrane":[207],"channels.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":7},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}