{"id":"https://openalex.org/W2107768040","doi":"https://doi.org/10.1016/j.exphem.2004.08.001","title":"Senescence and functional failure in hematopoietic stem cells","display_name":"Senescence and functional failure in hematopoietic stem cells","publication_year":2004,"publication_date":"2004-11-01","ids":{"openalex":"https://openalex.org/W2107768040","doi":"https://doi.org/10.1016/j.exphem.2004.08.001","mag":"2107768040","pmid":"https://pubmed.ncbi.nlm.nih.gov/15539079"},"language":"en","primary_location":{"id":"doi:10.1016/j.exphem.2004.08.001","doi":"https://doi.org/10.1016/j.exphem.2004.08.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.exphem.2004.08.001","pdf_url":null,"source":{"id":"https://openalex.org/S72188638","display_name":"Experimental Hematology","issn_l":"0301-472X","issn":["0301-472X","1873-2399"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Hematology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.exphem.2004.08.001","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050700780","display_name":"Jichun Chen","orcid":"https://orcid.org/0000-0002-5158-4814","observed_orcids":["https://orcid.org/0000-0002-5158-4814"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jichun Chen","raw_affiliation_strings":["Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1652, USA. chenji@nhlbi.nih.gov","Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1652, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1652, USA. chenji@nhlbi.nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"raw_affiliation_string":"Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1652, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5050700780"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"],"apc_list":{"value":3250,"currency":"USD","value_usd":3250},"apc_paid":null,"fwci":0.5258,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.45934066,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"32","issue":"11","first_page":"1025","last_page":"1032"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.8838000297546387,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.8838000297546387,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.11429999768733978,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.9710000157356262},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.9769999980926514},{"id":"https://openalex.org/keywords/telomere-shortening","display_name":"telomere shortening","score":0.871999979019165},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.5619999766349792},{"id":"https://openalex.org/keywords/proliferative-arrest","display_name":"proliferative arrest","score":0.6669999957084656},{"id":"https://openalex.org/keywords/chromosomal-loci","display_name":"chromosomal loci","score":0.6480000019073486},{"id":"https://openalex.org/keywords/hematopoiesis","display_name":"hematopoiesis","score":0.6869999766349792},{"id":"https://openalex.org/keywords/stem-cell-maintenance","display_name":"stem cell maintenance","score":0.32600000500679016}],"concepts":[{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.9245215654373169},{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.869686484336853},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7902810573577881},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.7708630561828613},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6964039206504822},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6006914973258972},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5786927938461304},{"id":"https://openalex.org/C2778086970","wikidata":"https://www.wikidata.org/wiki/Q514525","display_name":"Hematopoietic stem cell","level":4,"score":0.47287461161613464},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.4277043640613556},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.424500048160553},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4052457809448242},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38279083371162415},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18492040038108826},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.157362699508667}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016615","descriptor_name":"Telomere","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.exphem.2004.08.001","doi":"https://doi.org/10.1016/j.exphem.2004.08.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.exphem.2004.08.001","pdf_url":null,"source":{"id":"https://openalex.org/S72188638","display_name":"Experimental Hematology","issn_l":"0301-472X","issn":["0301-472X","1873-2399"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Hematology","raw_type":"journal-article"},{"id":"pmid:15539079","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15539079","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental hematology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.exphem.2004.08.001","doi":"https://doi.org/10.1016/j.exphem.2004.08.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.exphem.2004.08.001","pdf_url":null,"source":{"id":"https://openalex.org/S72188638","display_name":"Experimental Hematology","issn_l":"0301-472X","issn":["0301-472X","1873-2399"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Hematology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W37377977","https://openalex.org/W388446501","https://openalex.org/W1507274883","https://openalex.org/W1509263437","https://openalex.org/W1509946101","https://openalex.org/W1510398656","https://openalex.org/W1510708869","https://openalex.org/W1513797878","https://openalex.org/W1539203900","https://openalex.org/W1542558044","https://openalex.org/W1551544315","https://openalex.org/W1557431901","https://openalex.org/W1570758035","https://openalex.org/W1575507552","https://openalex.org/W1608329801","https://openalex.org/W1656975248","https://openalex.org/W1883938059","https://openalex.org/W1965578312","https://openalex.org/W1973035870","https://openalex.org/W1973213472","https://openalex.org/W1973577066","https://openalex.org/W1977336549","https://openalex.org/W1983002658","https://openalex.org/W1983851163","https://openalex.org/W1985801522","https://openalex.org/W1987790226","https://openalex.org/W1992235404","https://openalex.org/W1999009002","https://openalex.org/W2004314923","https://openalex.org/W2004516409","https://openalex.org/W2007593927","https://openalex.org/W2007673671","https://openalex.org/W2011221227","https://openalex.org/W2014013625","https://openalex.org/W2014600438","https://openalex.org/W2019953864","https://openalex.org/W2039007181","https://openalex.org/W2040609191","https://openalex.org/W2046169969","https://openalex.org/W2047330128","https://openalex.org/W2048182519","https://openalex.org/W2070587656","https://openalex.org/W2073272642","https://openalex.org/W2081396834","https://openalex.org/W2083067420","https://openalex.org/W2083632015","https://openalex.org/W2085184588","https://openalex.org/W2088820015","https://openalex.org/W2089653991","https://openalex.org/W2093264415","https://openalex.org/W2099787297","https://openalex.org/W2108177762","https://openalex.org/W2109708361","https://openalex.org/W2110859973","https://openalex.org/W2111759041","https://openalex.org/W2113343307","https://openalex.org/W2115154817","https://openalex.org/W2124086016","https://openalex.org/W2124701488","https://openalex.org/W2131958173","https://openalex.org/W2141138595","https://openalex.org/W2152006444","https://openalex.org/W2158335485","https://openalex.org/W2158800860","https://openalex.org/W2166001805","https://openalex.org/W2166846044","https://openalex.org/W2259941570","https://openalex.org/W2291689896","https://openalex.org/W2313480125","https://openalex.org/W2350069970","https://openalex.org/W2401607170","https://openalex.org/W2407144049","https://openalex.org/W2439014038","https://openalex.org/W3112311983","https://openalex.org/W4239596684","https://openalex.org/W6601543293"],"related_works":["https://openalex.org/W2042160143","https://openalex.org/W2072546363","https://openalex.org/W7143482730","https://openalex.org/W1601152296","https://openalex.org/W2010641214","https://openalex.org/W2018675740","https://openalex.org/W1531414518","https://openalex.org/W2152296355","https://openalex.org/W2358097366","https://openalex.org/W2372962097"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}