{"id":"https://openalex.org/W2107658298","doi":"https://doi.org/10.1002/bjs.8732","title":"Critical appraisal of the \u2018wait and see\u2019 approach in rectal cancer for clinical complete responders after chemoradiation","display_name":"Critical appraisal of the \u2018wait and see\u2019 approach in rectal cancer for clinical complete responders after chemoradiation","publication_year":2012,"publication_date":"2012-04-27","ids":{"openalex":"https://openalex.org/W2107658298","doi":"https://doi.org/10.1002/bjs.8732","mag":"2107658298","pmid":"https://pubmed.ncbi.nlm.nih.gov/22539154"},"language":"en","primary_location":{"id":"doi:10.1002/bjs.8732","doi":"https://doi.org/10.1002/bjs.8732","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bjs.8732","pdf_url":null,"source":{"id":"https://openalex.org/S61740008","display_name":"British journal of surgery","issn_l":"0007-1323","issn":["0007-1323","1365-2168"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Surgery","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2107658298"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054217604","display_name":"Rob Glynne\u2010Jones","orcid":"https://orcid.org/0000-0002-6742-222X","observed_orcids":["https://orcid.org/0000-0002-6742-222X"]},"institutions":[{"id":"https://openalex.org/I2801038905","display_name":"Mount Vernon Hospital","ror":"https://ror.org/04am5a125","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799786270","https://openalex.org/I2801038905"]},{"id":"https://openalex.org/I4210108939","display_name":"Mount Vernon Cancer Centre","ror":"https://ror.org/01wwv4x50","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210108939","https://openalex.org/I4210122718"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"R Glynne-Jones","raw_affiliation_strings":["Centre for Cancer Treatment, Mount Vernon Hospital, Northwood HA6 2RN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Cancer Treatment, Mount Vernon Hospital, Northwood HA6 2RN, UK","institution_ids":["https://openalex.org/I2801038905","https://openalex.org/I4210108939"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031837479","display_name":"Rob Hughes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801038905","display_name":"Mount Vernon Hospital","ror":"https://ror.org/04am5a125","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799786270","https://openalex.org/I2801038905"]},{"id":"https://openalex.org/I4210108939","display_name":"Mount Vernon Cancer Centre","ror":"https://ror.org/01wwv4x50","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210108939","https://openalex.org/I4210122718"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R Hughes","raw_affiliation_strings":["Centre for Cancer Treatment, Mount Vernon Hospital, Northwood HA6 2RN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Cancer Treatment, Mount Vernon Hospital, Northwood HA6 2RN, UK","institution_ids":["https://openalex.org/I2801038905","https://openalex.org/I4210108939"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5054217604"],"corresponding_institution_ids":["https://openalex.org/I2801038905","https://openalex.org/I4210108939"],"apc_list":{"value":3797,"currency":"GBP","value_usd":5007},"apc_paid":null,"fwci":3.4905,"has_fulltext":true,"cited_by_count":256,"citation_normalized_percentile":{"value":0.95992714,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"99","issue":"7","first_page":"897","last_page":"909"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13110","display_name":"Colorectal and Anal Carcinomas","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rectal-cancer","display_name":"rectal cancer","score":0.9359999895095825},{"id":"https://openalex.org/keywords/watch-and-wait-strategy","display_name":"watch-and-wait strategy","score":0.7919999957084656},{"id":"https://openalex.org/keywords/clinical-complete-response","display_name":"clinical complete response","score":0.8130000233650208},{"id":"https://openalex.org/keywords/pathological-complete-response","display_name":"pathological complete response","score":0.9440000057220459},{"id":"https://openalex.org/keywords/neoadjuvant-chemoradiotherapy","display_name":"neoadjuvant chemoradiotherapy","score":0.9089999794960022},{"id":"https://openalex.org/keywords/conservative-treatment","display_name":"conservative treatment","score":0.6579999923706055},{"id":"https://openalex.org/keywords/locoregional-failure","display_name":"locoregional failure","score":0.7699999809265137},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.972000002861023},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9879999756813049},{"id":"https://openalex.org/keywords/tumor-resection","display_name":"tumor resection","score":0.5889999866485596},{"id":"https://openalex.org/keywords/low-rectal-cancer","display_name":"low rectal cancer","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9618638753890991},{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.6744563579559326},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6156440377235413},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5401015281677246},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4936174154281616},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.4205940365791321},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4129118025302887},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3650965094566345}],"mesh":[{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D011300","descriptor_name":"Preoperative Care","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012004","descriptor_name":"Rectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012004","descriptor_name":"Rectal Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016879","descriptor_name":"Salvage Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057832","descriptor_name":"Watchful Waiting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059248","descriptor_name":"Chemoradiotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/bjs.8732","doi":"https://doi.org/10.1002/bjs.8732","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bjs.8732","pdf_url":null,"source":{"id":"https://openalex.org/S61740008","display_name":"British journal of surgery","issn_l":"0007-1323","issn":["0007-1323","1365-2168"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Surgery","raw_type":"journal-article"},{"id":"pmid:22539154","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22539154","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of surgery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":84,"referenced_works":["https://openalex.org/W270233768","https://openalex.org/W1497096495","https://openalex.org/W1526104698","https://openalex.org/W1553624849","https://openalex.org/W1596817535","https://openalex.org/W1851891531","https://openalex.org/W1921512623","https://openalex.org/W1963653242","https://openalex.org/W1964759750","https://openalex.org/W1969991447","https://openalex.org/W1973101195","https://openalex.org/W1975544941","https://openalex.org/W1976176418","https://openalex.org/W1979009297","https://openalex.org/W1979238043","https://openalex.org/W1980625813","https://openalex.org/W1985262661","https://openalex.org/W1986352900","https://openalex.org/W1992316669","https://openalex.org/W1998587149","https://openalex.org/W2005483787","https://openalex.org/W2006698274","https://openalex.org/W2010920121","https://openalex.org/W2012658101","https://openalex.org/W2014355159","https://openalex.org/W2021182753","https://openalex.org/W2025144588","https://openalex.org/W2030757814","https://openalex.org/W2034850050","https://openalex.org/W2037887298","https://openalex.org/W2042189302","https://openalex.org/W2043352332","https://openalex.org/W2043507415","https://openalex.org/W2044852602","https://openalex.org/W2045503238","https://openalex.org/W2047758064","https://openalex.org/W2048115066","https://openalex.org/W2063023627","https://openalex.org/W2067668691","https://openalex.org/W2069453354","https://openalex.org/W2069682731","https://openalex.org/W2071971830","https://openalex.org/W2074862179","https://openalex.org/W2078780440","https://openalex.org/W2082441739","https://openalex.org/W2084844489","https://openalex.org/W2095439981","https://openalex.org/W2097719906","https://openalex.org/W2100238773","https://openalex.org/W2106014206","https://openalex.org/W2108083343","https://openalex.org/W2113353705","https://openalex.org/W2119479963","https://openalex.org/W2120304479","https://openalex.org/W2123432691","https://openalex.org/W2124173257","https://openalex.org/W2124297369","https://openalex.org/W2124732991","https://openalex.org/W2124886112","https://openalex.org/W2125452425","https://openalex.org/W2125701475","https://openalex.org/W2127326400","https://openalex.org/W2130482832","https://openalex.org/W2132385434","https://openalex.org/W2137332632","https://openalex.org/W2142818315","https://openalex.org/W2144717403","https://openalex.org/W2152474423","https://openalex.org/W2154772456","https://openalex.org/W2159691094","https://openalex.org/W2159919969","https://openalex.org/W2161581516","https://openalex.org/W2164281685","https://openalex.org/W2170854632","https://openalex.org/W2171573992","https://openalex.org/W2332766403","https://openalex.org/W2399744559","https://openalex.org/W2405607619","https://openalex.org/W2416980100","https://openalex.org/W2439817102","https://openalex.org/W2496710861","https://openalex.org/W2529616653","https://openalex.org/W2944549795","https://openalex.org/W6959622373"],"related_works":["https://openalex.org/W1851891531","https://openalex.org/W2178788967","https://openalex.org/W266747182","https://openalex.org/W1596817535","https://openalex.org/W2317312851","https://openalex.org/W2574818791","https://openalex.org/W2146036216","https://openalex.org/W3081155273","https://openalex.org/W2330328778","https://openalex.org/W4307725198"],"abstract_inverted_index":{"BACKGROUND:":[0],"Some":[1,24],"10-20":[2],"per":[3,131,144],"cent":[4,145],"of":[5,35,49,57,65,129,140,178,190,228,244],"patients":[6,66,204],"with":[7,133,194,198,274],"locally":[8],"advanced":[9,263],"rectal":[10,58,249],"cancer":[11,59],"achieve":[12],"a":[13,26,84,124,152,213,229,240],"pathological":[14],"complete":[15,29],"response":[16,30],"(pCR)":[17],"at":[18],"surgery":[19],"following":[20],"preoperative":[21],"chemoradiation":[22],"(CRT).":[23],"demonstrate":[25],"sustained":[27],"clinical":[28,252],"(cCR),":[31],"defined":[32],"as":[33],"absence":[34],"clinically":[36],"detectable":[37],"residual":[38],"tumour":[39,223],"after":[40,60,87,180],"CRT,":[41,61,181],"and":[42,62,93,95,114,136,142,176,231],"do":[43],"not":[44,257],"undergo":[45,221],"resection.":[46,224],"The":[47,99,118,188,200,226],"aim":[48],"this":[50],"review":[51],"was":[52,103,192],"to":[53,211,261,281],"evaluate":[54,282],"non-operative":[55,85],"treatment":[56],"the":[63,185,283],"outcome":[64,101,106],"observed":[67],"without":[68],"radical":[69],"surgery.":[70],"METHODS:":[71],"A":[72],"systematic":[73],"computerized":[74],"search":[75],"identified":[76],"30":[77],"publications":[78],"(9":[79],"series,":[80],"650":[81],"patients)":[82],"evaluating":[83],"approach":[86],"CRT.":[88],"Original":[89],"data":[90],"were":[91,149,168],"extracted":[92],"tabulated,":[94],"study":[96,174],"quality":[97],"evaluated.":[98],"primary":[100],"measure":[102],"cCR.":[104],"Secondary":[105],"measures":[107],"included":[108],"locoregional":[109,126],"failure":[110,127],"rate,":[111],"disease-free":[112,137],"survival":[113,138],"overall":[115,135],"survival.":[116],"RESULTS:":[117],"most":[119],"recent":[120],"Habr-Gama":[121],"series":[122,160],"reported":[123],"low":[125,248],"rate":[128],"4\u00b76":[130],"cent,":[132],"5-year":[134],"rates":[139],"96":[141],"72":[143],"respectively.":[146],"These":[147],"findings":[148],"supported":[150],"by":[151],"small":[153,247],"prospective":[154,271],"Dutch":[155],"study.":[156],"However,":[157],"other":[158],"retrospective":[159,237],"have":[161],"described":[162],"higher":[163],"recurrence":[164],"rates.":[165],"All":[166],"studies":[167,273],"heterogeneous":[169],"in":[170,246],"staging,":[171],"inclusion":[172,277],"criteria,":[173],"design":[175],"rigour":[177],"follow-up":[179],"which":[182],"might":[183],"explain":[184],"different":[186],"outcomes.":[187],"definition":[189],"cCR":[191],"inconsistent,":[193],"only":[195],"partial":[196],"concordance":[197],"pCR.":[199],"results":[201],"suggested":[202],"that":[203],"who":[205,220],"are":[206,279],"observed,":[207],"but":[208],"subsequently":[209],"fail":[210],"sustain":[212],"cCR,":[214],"may":[215],"fare":[216],"worse":[217],"than":[218],"those":[219],"immediate":[222],"CONCLUSION:":[225],"rationale":[227],"'wait":[230],"see'":[232],"policy":[233],"relies":[234],"mainly":[235],"on":[236],"observations":[238],"from":[239],"single":[241],"series.":[242],"Proof":[243],"principle":[245],"cancers,":[250],"where":[251,265],"assessment":[253],"is":[254,268],"easy,":[255],"should":[256],"be":[258],"extrapolated":[259],"uncritically":[260],"more":[262,275],"cancers":[264],"nodal":[266],"involvement":[267],"common.":[269],"Long-term":[270],"observational":[272],"uniform":[276],"criteria":[278],"required":[280],"risk":[284],"versus":[285],"benefit.":[286]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":19},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":23},{"year":2016,"cited_by_count":30},{"year":2015,"cited_by_count":33},{"year":2014,"cited_by_count":32},{"year":2013,"cited_by_count":24},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}