{"id":"https://openalex.org/W2107616379","doi":null,"title":"A world in one dimension: Linus Pauling, Francis Crick and the central dogma of molecular biology.","display_name":"A world in one dimension: Linus Pauling, Francis Crick and the central dogma of molecular biology.","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2107616379","mag":"2107616379","pmid":"https://pubmed.ncbi.nlm.nih.gov/18351048"},"language":"en","primary_location":{"id":"pmid:18351048","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18351048","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"History and philosophy of the life sciences","raw_type":"Biography"},"volume":null,"type":"other","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004158395","display_name":"Bruno J. Strasser","orcid":"https://orcid.org/0000-0002-2773-6670","observed_orcids":["https://orcid.org/0000-0002-2773-6670"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bruno J Strasser","raw_affiliation_strings":["Program in the History of Science and Medicine, Yale University, New Haven, CT 06520-8015, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in the History of Science and Medicine, Yale University, New Haven, CT 06520-8015, USA","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5004158395"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"28","issue":"4","first_page":"491","last_page":"512"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10778","display_name":"Philosophy and History of Science","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1207","display_name":"History and Philosophy of Science"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10778","display_name":"Philosophy and History of Science","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1207","display_name":"History and Philosophy of Science"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T14475","display_name":"History of Science and Medicine","score":0.01679999940097332,"subfield":{"id":"https://openalex.org/subfields/1207","display_name":"History and Philosophy of Science"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/central-dogma","display_name":"central dogma","score":0.7089999914169312},{"id":"https://openalex.org/keywords/francis-crick","display_name":"Francis Crick","score":0.9580000042915344},{"id":"https://openalex.org/keywords/linus-pauling","display_name":"Linus Pauling","score":1.0},{"id":"https://openalex.org/keywords/protein-synthesis","display_name":"protein synthesis","score":0.9129999876022339},{"id":"https://openalex.org/keywords/gene-action","display_name":"gene action","score":0.9399999976158142},{"id":"https://openalex.org/keywords/nucleic-acid-sequences","display_name":"nucleic acid sequences","score":0.777999997138977},{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.6639999747276306},{"id":"https://openalex.org/keywords/macromolecular-structure","display_name":"macromolecular structure","score":0.6589999794960022},{"id":"https://openalex.org/keywords/history-of-molecular-biology","display_name":"history of molecular biology","score":0.8960000276565552}],"concepts":[{"id":"https://openalex.org/C180182882","wikidata":"https://www.wikidata.org/wiki/Q1028964","display_name":"Philosophy of biology","level":3,"score":0.6078277826309204},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.5485367774963379},{"id":"https://openalex.org/C110099512","wikidata":"https://www.wikidata.org/wiki/Q59115","display_name":"Philosophy of science","level":2,"score":0.4992051124572754},{"id":"https://openalex.org/C190161988","wikidata":"https://www.wikidata.org/wiki/Q231218","display_name":"Abiogenesis","level":2,"score":0.46700605750083923},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.45470908284187317},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.4164179265499115},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3524605631828308},{"id":"https://openalex.org/C33332235","wikidata":"https://www.wikidata.org/wiki/Q18362","display_name":"Theoretical physics","level":1,"score":0.3322884142398834},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2879207134246826},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2484116554260254}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008967","descriptor_name":"Molecular Biology","qualifier_ui":"Q000266","qualifier_name":"history","is_major_topic":true},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D034462","descriptor_name":"Dissent and Disputes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049673","descriptor_name":"History, 20th Century","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:18351048","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18351048","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"History and philosophy of the life sciences","raw_type":"Biography"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":77,"referenced_works":["https://openalex.org/W79627341","https://openalex.org/W80078525","https://openalex.org/W81399258","https://openalex.org/W98867491","https://openalex.org/W124231724","https://openalex.org/W146172273","https://openalex.org/W170687535","https://openalex.org/W595843285","https://openalex.org/W606757019","https://openalex.org/W625946490","https://openalex.org/W631723770","https://openalex.org/W1486903749","https://openalex.org/W1508225465","https://openalex.org/W1512592100","https://openalex.org/W1575652119","https://openalex.org/W1581009174","https://openalex.org/W1597579132","https://openalex.org/W1691896390","https://openalex.org/W1786216877","https://openalex.org/W1969009135","https://openalex.org/W1982251587","https://openalex.org/W1983566072","https://openalex.org/W1983590645","https://openalex.org/W1989138976","https://openalex.org/W1990117546","https://openalex.org/W1991092571","https://openalex.org/W1993627813","https://openalex.org/W1997188014","https://openalex.org/W2009761034","https://openalex.org/W2010745676","https://openalex.org/W2020700266","https://openalex.org/W2023403121","https://openalex.org/W2027816595","https://openalex.org/W2028764882","https://openalex.org/W2029396052","https://openalex.org/W2044033727","https://openalex.org/W2055214702","https://openalex.org/W2061184407","https://openalex.org/W2064008537","https://openalex.org/W2069175085","https://openalex.org/W2070569568","https://openalex.org/W2071511112","https://openalex.org/W2071603139","https://openalex.org/W2078467581","https://openalex.org/W2083389189","https://openalex.org/W2087577318","https://openalex.org/W2089819802","https://openalex.org/W2091571793","https://openalex.org/W2094566646","https://openalex.org/W2095791446","https://openalex.org/W2142802046","https://openalex.org/W2148890723","https://openalex.org/W2157051765","https://openalex.org/W2171582839","https://openalex.org/W2171984569","https://openalex.org/W2320102768","https://openalex.org/W2326282683","https://openalex.org/W2327883350","https://openalex.org/W2328086914","https://openalex.org/W2333090580","https://openalex.org/W2395571530","https://openalex.org/W2395815119","https://openalex.org/W2402564691","https://openalex.org/W2405778248","https://openalex.org/W2418686086","https://openalex.org/W2439046800","https://openalex.org/W2442318243","https://openalex.org/W2470691407","https://openalex.org/W2479775521","https://openalex.org/W2484538081","https://openalex.org/W2489482269","https://openalex.org/W2504456230","https://openalex.org/W2566493721","https://openalex.org/W2768895118","https://openalex.org/W2798883080","https://openalex.org/W2799149404","https://openalex.org/W3205183712"],"related_works":["https://openalex.org/W2020700266","https://openalex.org/W1965992130","https://openalex.org/W2419559495","https://openalex.org/W927149776","https://openalex.org/W1506646996","https://openalex.org/W4234580107","https://openalex.org/W4220837759","https://openalex.org/W1549294461","https://openalex.org/W2265248309","https://openalex.org/W3166580992"],"abstract_inverted_index":{"In":[0,75],"1957,":[1],"Francis":[2],"Crick":[3,146],"outlined":[4],"a":[5,62,106,121],"startling":[6],"vision":[7,35],"of":[8,15,19,27,39,52,65,91,108,129,142],"life":[9],"in":[10,23,36,72,112,123,151],"which":[11,68,124,145],"the":[12,24,37,40,50,89,125,140],"great":[13],"diversity":[14],"forms":[16,126],"and":[17,45,83,127],"shapes":[18,128],"macromolecules":[20,130],"was":[21,96,103,117,147],"encoded":[22],"one-dimensional":[25],"sequence":[26],"nucleic":[28],"acids.":[29],"This":[30],"paper":[31],"situates":[32],"Crick's":[33,53],"new":[34],"debates":[38],"1950s":[41],"about":[42],"protein":[43,66,143],"synthesis":[44,67,144],"gene":[46],"action.":[47],"After":[48],"exploring":[49],"reception":[51],"ideas,":[54],"it":[55,95],"shows":[56],"how":[57],"they":[58],"differed":[59],"radically":[60],"from":[61,133],"different":[63,113],"model":[64,122],"enjoyed":[69],"wide":[70],"currency":[71],"that":[73],"decade.":[74],"this":[76,101],"alternative":[77],"model,":[78],"advocated":[79],"by":[80,105,120],"Linus":[81],"Pauling":[82],"other":[84],"luminaries,":[85],"three-dimensional":[86],"templates":[87],"directed":[88],"folding":[90],"proteins.":[92],"Even":[93],"though":[94],"always":[97],"considered":[98],"somewhat":[99],"speculative,":[100],"theory":[102],"supported":[104],"number":[107],"empirical":[109],"results":[110],"originating":[111],"experimental":[114],"systems.":[115],"It":[116],"eventually":[118],"replaced":[119],"resulted":[131],"solely":[132],"their":[134],"amino":[135],"acid":[136],"sequence,":[137],"dramatically":[138],"simplifying":[139],"problem":[141],"attempting":[148],"to":[149],"solve":[150],"1957.":[152]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
