{"id":"https://openalex.org/W2107610593","doi":"https://doi.org/10.1093/ndt/gfn280","title":"Heart rate variability in patients with end-stage renal disease: an emerging predictive tool for sudden cardiac death?","display_name":"Heart rate variability in patients with end-stage renal disease: an emerging predictive tool for sudden cardiac death?","publication_year":2008,"publication_date":"2008-05-24","ids":{"openalex":"https://openalex.org/W2107610593","doi":"https://doi.org/10.1093/ndt/gfn280","mag":"2107610593","pmid":"https://pubmed.ncbi.nlm.nih.gov/18503010"},"language":"en","primary_location":{"id":"doi:10.1093/ndt/gfn280","doi":"https://doi.org/10.1093/ndt/gfn280","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ndt/gfn280","pdf_url":null,"source":{"id":"https://openalex.org/S186113128","display_name":"Nephrology Dialysis Transplantation","issn_l":"0931-0509","issn":["0931-0509","1460-2385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology Dialysis Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020996643","display_name":"Christopher T. Chan","orcid":"https://orcid.org/0000-0002-0947-7273","observed_orcids":["https://orcid.org/0000-0002-0947-7273"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801845744","display_name":"Toronto General Hospital","ror":"https://ror.org/026pg9j08","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2801845744"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"C. T. Chan","raw_affiliation_strings":["Division of Nephrology, Department of Medicine, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Medicine, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750","https://openalex.org/I2801845744"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5020996643"],"corresponding_institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750","https://openalex.org/I2801845744"],"apc_list":{"value":3474,"currency":"EUR","value_usd":3926},"apc_paid":null,"fwci":1.6972,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.86208295,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"23","issue":"10","first_page":"3061","last_page":"3062"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-rate-variability","display_name":"heart rate variability","score":1.0},{"id":"https://openalex.org/keywords/end-stage-renal-disease","display_name":"end-stage renal disease","score":0.9929999709129333},{"id":"https://openalex.org/keywords/sudden-cardiac-death","display_name":"sudden cardiac death","score":0.9869999885559082},{"id":"https://openalex.org/keywords/dialysis-patients","display_name":"dialysis patients","score":0.6629999876022339},{"id":"https://openalex.org/keywords/parasympathetic-modulation","display_name":"parasympathetic modulation","score":0.7229999899864197},{"id":"https://openalex.org/keywords/sympathetic-nervous-system","display_name":"sympathetic nervous system","score":0.7710000276565552},{"id":"https://openalex.org/keywords/cardiac-arrhythmia","display_name":"cardiac arrhythmias","score":0.5640000104904175},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.4300000071525574},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6449999809265137},{"id":"https://openalex.org/keywords/lf-hf-ratio","display_name":"LF/HF ratio","score":0.671999990940094},{"id":"https://openalex.org/keywords/hrv-spectral-analysis","display_name":"spectral analysis of HRV","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9556198120117188},{"id":"https://openalex.org/C2775935837","wikidata":"https://www.wikidata.org/wiki/Q202837","display_name":"Sudden cardiac death","level":2,"score":0.6733322143554688},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.652336597442627},{"id":"https://openalex.org/C3019040382","wikidata":"https://www.wikidata.org/wiki/Q476921","display_name":"End stage renal disease","level":3,"score":0.6432472467422485},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6327547430992126},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.4847566783428192},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.47297894954681396},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4007885456085205}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016757","descriptor_name":"Death, Sudden, Cardiac","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D016757","descriptor_name":"Death, Sudden, Cardiac","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/ndt/gfn280","doi":"https://doi.org/10.1093/ndt/gfn280","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ndt/gfn280","pdf_url":null,"source":{"id":"https://openalex.org/S186113128","display_name":"Nephrology Dialysis Transplantation","issn_l":"0931-0509","issn":["0931-0509","1460-2385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology Dialysis Transplantation","raw_type":"journal-article"},{"id":"pmid:18503010","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18503010","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association","raw_type":"Editorial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8700000047683716}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1976721331","https://openalex.org/W1979920872","https://openalex.org/W1995381509","https://openalex.org/W2033192729","https://openalex.org/W2043798744","https://openalex.org/W2082227074","https://openalex.org/W2087002715","https://openalex.org/W2091594768","https://openalex.org/W2098541838","https://openalex.org/W2117260072","https://openalex.org/W2139573429","https://openalex.org/W2142513501","https://openalex.org/W2146213028","https://openalex.org/W2153926185","https://openalex.org/W2158976222","https://openalex.org/W2162292872","https://openalex.org/W2163051958","https://openalex.org/W2164826114","https://openalex.org/W2166904705","https://openalex.org/W2171788381"],"related_works":["https://openalex.org/W2146213028","https://openalex.org/W7096421328","https://openalex.org/W7100448755","https://openalex.org/W7100729906","https://openalex.org/W2804379546","https://openalex.org/W2070913196","https://openalex.org/W186819349","https://openalex.org/W2406100950","https://openalex.org/W2097753092","https://openalex.org/W2159259090"],"abstract_inverted_index":{"Patients":[0],"with":[1,84],"end-stage":[2],"renal":[3],"disease":[4],"(ESRD)":[5],"have":[6,125,151,177,235,257],"an":[7,190],"elevated":[8,96],"cardiovascular":[9,51],"mortality.":[10],"Although":[11],"much":[12],"interest":[13],"has":[14,33],"been":[15,152,258],"focused":[16],"on":[17],"the":[18,21,36,56,89,105,118,126,139,179,200,208,216,262,275],"understanding":[19],"of":[20,24,40,59,91,104,121,168,192,195,202,207,219,246,251,265,274],"accelerated":[22],"nature":[23],"their":[25],"coronary":[26],"artery":[27],"disease,":[28],"sudden":[29],"cardiac":[30,41],"death":[31,42,94],"(SCD)":[32],"emerged":[34],"as":[35,130,189,255],"single":[37],"largest":[38],"cause":[39],"in":[43,99,107,138,147,224,237,239],"our":[44,81],"patient":[45],"population.":[46,141],"Multiple":[47],"traditional":[48],"and":[49,76,86,97,123,134,162,175],"novel":[50],"risk":[52,90],"factors":[53],"contribute":[54],"to":[55,128,214,260,270],"particular":[57],"vulnerability":[58],"dialysis":[60],"patients":[61],"towards":[62],"SCD,":[63],"including":[64],"myocardial":[65],"ischaemia,":[66],"left":[67],"ventricular":[68],"hypertrophy/dilatation,":[69],"electrolytes":[70],"abnormalities,":[71],"volume":[72],"overload,":[73],"sleep":[74],"apnoea":[75],"sympathetic":[77,227],"overactivity":[78],"[1].":[79],"Despite":[80],"best":[82],"efforts":[83],"revascularization":[85],"medical":[87],"therapy,":[88],"arrhythmically":[92],"mediated":[93],"remains":[95],"uncorrected":[98],"ESRD":[100,140],"[2].":[101],"Careful":[102],"examination":[103],"impairments":[106],"heart":[108,196],"rate":[109,197],"variability":[110],"(HRV)":[111],"may":[112,124],"allow":[113],"for":[114,181],"better":[115],"insights":[116],"into":[117],"\u2018non-ischemic\u2019":[119],"contributors":[120],"SCD":[122],"potential":[127],"serve":[129],"both":[131],"a":[132,135],"monitoring":[133],"prognostic":[136],"tool":[137],"There":[142],"are":[143],"multiple":[144],"validated":[145],"methods":[146],"quantifying":[148],"HRV,":[149],"which":[150],"reviewed":[153],"previously":[154],"[3\u20135].":[155],"Commonly":[156],"used":[157,259],"techniques":[158],"include":[159],"time":[160],"domain":[161,166],"spectral":[163],"or":[164,204],"frequency":[165,184,241],"analysis":[167],"HRV.":[169,220,266],"Basic":[170],"pharmacological":[171],"studies":[172,277],"using":[173],"animals":[174],"humans":[176],"formed":[178],"rationale":[180],"identifying":[182],"high":[183],"(HF)":[185],"power":[186,245],"[>0.15":[187],"Hz]":[188,244],"indicator":[191],"parasympathetic":[193,209],"modulation":[194],"given":[198],"that":[199,272],"administration":[201],"atropine":[203],"other":[205],"blockers":[206],"nervous":[210],"system":[211],"was":[212],"able":[213],"abolish":[215],"HF":[217],"component":[218],"Similarly,":[221],"classical":[222],"manoeuvres":[223],"augmenting":[225],"central":[226],"outflow":[228],"(e.g.":[229],"tilt,":[230],"lower":[231],"body":[232],"negative":[233],"pressure)":[234],"resulted":[236],"increases":[238],"low":[240],"(LF)":[242],"[0.05\u20130.15":[243],"HRV":[247],"[6].":[248],"Further":[249],"refinements":[250],"normalized":[252],"ratios":[253],"such":[254],"LF/HF":[256],"estimate":[261],"sympathetic/vagal":[263],"influence":[264],"It":[267],"is":[268],"important":[269],"note":[271],"most":[273],"validation":[276]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}