{"id":"https://openalex.org/W2107555512","doi":"https://doi.org/10.4049/jimmunol.1102294","title":"MicroRNA-Deficient NK Cells Exhibit Decreased Survival but Enhanced Function","display_name":"MicroRNA-Deficient NK Cells Exhibit Decreased Survival but Enhanced Function","publication_year":2012,"publication_date":"2012-03-01","ids":{"openalex":"https://openalex.org/W2107555512","doi":"https://doi.org/10.4049/jimmunol.1102294","mag":"2107555512","pmid":"https://pubmed.ncbi.nlm.nih.gov/22379033","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3311726"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.1102294","doi":"https://doi.org/10.4049/jimmunol.1102294","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.1102294","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3311726","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075847103","display_name":"Ryan P. Sullivan","orcid":"https://orcid.org/0000-0001-5554-7378","observed_orcids":["https://orcid.org/0000-0001-5554-7378"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan P Sullivan","raw_affiliation_strings":["Division of Oncology, Department of Internal Medicine, Washington University School of Medicine , St. Louis, MO 63110","Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncology, Department of Internal Medicine, Washington University School of Medicine , St. Louis, MO 63110","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034007787","display_name":"Jeffrey W. Leong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey W Leong","raw_affiliation_strings":["Division of Oncology, Department of Internal Medicine, Washington University School of Medicine , St. Louis, MO 63110","*Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncology, Department of Internal Medicine, Washington University School of Medicine , St. Louis, MO 63110","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"*Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110; and","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065426246","display_name":"Stephanie Ellyse Schneider","orcid":"https://orcid.org/0000-0001-8239-7272","observed_orcids":["https://orcid.org/0000-0001-8239-7272"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie E Schneider","raw_affiliation_strings":["Division of Oncology, Department of Internal Medicine, Washington University School of Medicine , St. Louis, MO 63110","*Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncology, Department of Internal Medicine, Washington University School of Medicine , St. Louis, MO 63110","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"*Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110; and","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082772492","display_name":"Catherine R. Keppel","orcid":"https://orcid.org/0000-0001-6729-1218","observed_orcids":["https://orcid.org/0000-0001-6729-1218"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine R Keppel","raw_affiliation_strings":["Division of Oncology, Department of Internal Medicine, Washington University School of Medicine , St. Louis, MO 63110","*Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncology, Department of Internal Medicine, Washington University School of Medicine , St. Louis, MO 63110","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"*Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110; and","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000679261","display_name":"Elizabeth Germino","orcid":"https://orcid.org/0000-0003-1396-3722","observed_orcids":["https://orcid.org/0000-0003-1396-3722"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Elizabeth Germino","raw_affiliation_strings":["Division of Oncology, Department of Internal Medicine, Washington University School of Medicine , St. Louis, MO 63110","*Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncology, Department of Internal Medicine, Washington University School of Medicine , St. Louis, MO 63110","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"*Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110; and","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016765171","display_name":"Anthony R. French","orcid":"https://orcid.org/0000-0002-7543-7456","observed_orcids":["https://orcid.org/0000-0002-7543-7456","https://orcid.org/0000-0002-4556-8391"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony R French","raw_affiliation_strings":["\u2020Division of Rheumatology, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020Division of Rheumatology, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016323798","display_name":"Todd A. Fehniger","orcid":"https://orcid.org/0000-0002-8705-2887","observed_orcids":["https://orcid.org/0000-0002-8705-2887"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd A Fehniger","raw_affiliation_strings":["Division of Oncology, Department of Internal Medicine, Washington University School of Medicine , St. Louis, MO 63110","*Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncology, Department of Internal Medicine, Washington University School of Medicine , St. Louis, MO 63110","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"*Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110; and","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5000679261"],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":3.9821,"has_fulltext":false,"cited_by_count":65,"citation_normalized_percentile":{"value":0.94513878,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"188","issue":"7","first_page":"3019","last_page":"3030"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.8799999952316284},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.9010000228881836},{"id":"https://openalex.org/keywords/dicer1","display_name":"DICER1","score":0.9789999723434448},{"id":"https://openalex.org/keywords/microrna-biogenesis","display_name":"microRNA biogenesis","score":0.843999981880188},{"id":"https://openalex.org/keywords/nk-cell-survival","display_name":"NK cell survival","score":0.8370000123977661},{"id":"https://openalex.org/keywords/nk-cell-maturation","display_name":"NK cell maturation","score":0.9350000023841858},{"id":"https://openalex.org/keywords/degranulation","display_name":"degranulation","score":0.878000020980835},{"id":"https://openalex.org/keywords/interferon-gamma-production","display_name":"IFN-gamma production","score":0.925000011920929},{"id":"https://openalex.org/keywords/mcmv-infection","display_name":"MCMV infection","score":0.7739999890327454},{"id":"https://openalex.org/keywords/nk-cell-homeostasis","display_name":"NK cell homeostasis","score":0.781000018119812},{"id":"https://openalex.org/keywords/nk-cell-activation","display_name":"NK cell activation","score":0.4650000035762787}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6860848069190979},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6826245784759521},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5528655052185059},{"id":"https://openalex.org/C2779867133","wikidata":"https://www.wikidata.org/wiki/Q21111297","display_name":"Dicer","level":5,"score":0.47614169120788574},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.45601868629455566},{"id":"https://openalex.org/C49802076","wikidata":"https://www.wikidata.org/wiki/Q5251810","display_name":"Degranulation","level":3,"score":0.4444865882396698},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4319295287132263},{"id":"https://openalex.org/C129374314","wikidata":"https://www.wikidata.org/wiki/Q909381","display_name":"Interleukin 21","level":4,"score":0.4220826029777527},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35779520869255066},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.30989453196525574},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.29697173833847046},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.24182477593421936},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17722925543785095},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.13014328479766846},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10453370213508606}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006566","descriptor_name":"Herpesviridae Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008221","descriptor_name":"Lymphoid Tissue","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008221","descriptor_name":"Lymphoid Tissue","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013047","descriptor_name":"Specific Pathogen-Free Organisms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015550","descriptor_name":"Cell Degranulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018146","descriptor_name":"Muromegalovirus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019409","descriptor_name":"Interleukin-15","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020413","descriptor_name":"3' Untranslated Regions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D043244","descriptor_name":"Ribonuclease III","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D043244","descriptor_name":"Ribonuclease III","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D043244","descriptor_name":"Ribonuclease III","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053487","descriptor_name":"DEAD-box RNA Helicases","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D053487","descriptor_name":"DEAD-box RNA Helicases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053487","descriptor_name":"DEAD-box RNA Helicases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.4049/jimmunol.1102294","doi":"https://doi.org/10.4049/jimmunol.1102294","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.1102294","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:22379033","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22379033","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2610685","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3311726","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3311726","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3311726","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Immunol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2610685","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3311726","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2296472792","display_name":null,"funder_award_id":"T32 HL708836","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3402594117","display_name":"Molecular Mechanisms of Natural Killer Cell Cytokine-Activation","funder_award_id":"K08HL093299","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7009206655","display_name":"REGULATION OF VIRAL-INDUCED NK CELL PROLIFERATION DURING MURINE CMV INFECTION","funder_award_id":"R01AI078994","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000907135","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA091842","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320315130","display_name":"Alvin J. Siteman Cancer Center","ror":"https://ror.org/03jrmgg47"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W69353177","https://openalex.org/W140877157","https://openalex.org/W1899804292","https://openalex.org/W1964265426","https://openalex.org/W1964742561","https://openalex.org/W1966315835","https://openalex.org/W1966427699","https://openalex.org/W1968321644","https://openalex.org/W1969950463","https://openalex.org/W1970563382","https://openalex.org/W1974369317","https://openalex.org/W1979413046","https://openalex.org/W1985563073","https://openalex.org/W1988163167","https://openalex.org/W1990549640","https://openalex.org/W1991366046","https://openalex.org/W1991650736","https://openalex.org/W1997849135","https://openalex.org/W2000115037","https://openalex.org/W2002817805","https://openalex.org/W2014974499","https://openalex.org/W2019689594","https://openalex.org/W2022069273","https://openalex.org/W2025567420","https://openalex.org/W2035918677","https://openalex.org/W2036923470","https://openalex.org/W2040699498","https://openalex.org/W2040914801","https://openalex.org/W2041631804","https://openalex.org/W2050444114","https://openalex.org/W2054218102","https://openalex.org/W2063591664","https://openalex.org/W2068055816","https://openalex.org/W2069594922","https://openalex.org/W2073300038","https://openalex.org/W2089345792","https://openalex.org/W2089684997","https://openalex.org/W2095690828","https://openalex.org/W2096449627","https://openalex.org/W2096882227","https://openalex.org/W2099253285","https://openalex.org/W2103780522","https://openalex.org/W2104610341","https://openalex.org/W2107723355","https://openalex.org/W2109627278","https://openalex.org/W2112192177","https://openalex.org/W2116322544","https://openalex.org/W2117273802","https://openalex.org/W2117391818","https://openalex.org/W2117472344","https://openalex.org/W2119080021","https://openalex.org/W2119197345","https://openalex.org/W2122541507","https://openalex.org/W2125454277","https://openalex.org/W2126022174","https://openalex.org/W2128674168","https://openalex.org/W2128856901","https://openalex.org/W2130979840","https://openalex.org/W2143576416","https://openalex.org/W2146027438","https://openalex.org/W2146482415","https://openalex.org/W2152058349","https://openalex.org/W2406454836","https://openalex.org/W6682150802"],"related_works":["https://openalex.org/W2561884570","https://openalex.org/W2391520642","https://openalex.org/W2099253285","https://openalex.org/W2285069210","https://openalex.org/W1509859064","https://openalex.org/W2113440844","https://openalex.org/W2065291117","https://openalex.org/W1874806502","https://openalex.org/W1967759688","https://openalex.org/W2304302461"],"abstract_inverted_index":{"NK":[0,88,93,102,118,137,163,190,200,209,219,233],"cells":[1,94,103,119,164],"are":[2,19],"innate":[3],"immune":[4],"lymphocytes":[5],"important":[6,197],"for":[7,49,177],"early":[8],"host":[9],"defense":[10],"against":[11],"infectious":[12],"pathogens":[13],"and":[14,52,85,107,123,135],"malignant":[15],"transformation.":[16],"MicroRNAs":[17],"(miRNAs)":[18],"small":[20],"RNA":[21],"molecules":[22],"that":[23,165,184],"regulate":[24],"a":[25,45,57,68,142,174],"wide":[26],"variety":[27],"of":[28,36,39,71,79,87,145,187,214],"cellular":[29],"processes,":[30],"typically":[31],"by":[32,111],"specific":[33,221],"complementary":[34],"targeting":[35],"the":[37,77,83,168,185],"3'UTR":[38],"mRNAs.":[40],"The":[41],"Dicer1":[42,53,73],"gene":[43],"encodes":[44],"conserved":[46],"enzyme":[47],"essential":[48],"miRNA":[50,61,98,229],"processing,":[51],"deficiency":[54],"leads":[55],"to":[56,75,130],"global":[58],"defect":[59],"in":[60,82,126,128,154,162,189,199,217,232],"biogenesis.":[62],"In":[63],"this":[64],"study,":[65],"we":[66],"report":[67],"mouse":[69],"model":[70],"lymphocyte-restricted":[72],"disruption":[74],"evaluate":[76],"role":[78,198],"Dicer1-dependent":[80],"miRNAs":[81,161,188,216],"development":[84],"function":[86,186],"cells.":[89],"As":[90],"expected,":[91],"Dicer1-deficient":[92,117],"had":[95],"decreased":[96],"total":[97],"content.":[99],"Furthermore,":[100],"miRNA-deficient":[101],"exhibited":[104,120],"reduced":[105],"survival":[106],"impaired":[108],"maturation":[109],"defined":[110],"cell":[112,138,191,201,210,220,234],"surface":[113],"phenotypic":[114],"markers.":[115],"However,":[116],"enhanced":[121,178],"degranulation":[122],"IFN-\u03b3":[124,147,170,179],"production":[125],"vitro":[127],"response":[129],"cytokines,":[131],"tumor":[132],"target":[133,167],"cells,":[134],"activating":[136],"receptor":[139],"ligation.":[140],"Moreover,":[141],"similar":[143],"phenotype":[144],"increased":[146],"was":[148],"evident":[149],"during":[150],"acute":[151],"MCMV":[152],"infection":[153],"vivo.":[155],"miRs-15a/15b/16":[156],"were":[157],"identified":[158],"as":[159],"abundant":[160],"directly":[166],"murine":[169],"3'UTR,":[171],"thereby":[172],"providing":[173],"potential":[175],"mechanism":[176],"production.":[180],"These":[181],"data":[182],"suggest":[183],"biology":[192],"is":[193],"complex,":[194],"with":[195],"an":[196,218],"development,":[202],"survival,":[203],"or":[204],"homeostasis,":[205],"while":[206],"tempering":[207],"peripheral":[208],"activation.":[211],"Further":[212],"study":[213],"individual":[215],"fashion":[222],"will":[223],"provide":[224],"insight":[225],"into":[226],"these":[227],"complex":[228],"regulatory":[230],"effects":[231],"biology.":[235]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
