{"id":"https://openalex.org/W2107549015","doi":"https://doi.org/10.1111/j.1600-051x.1995.tb00809.x","title":"Effects of Porphyromonas gingivalis culture products on the morphology of peripheral blood polymorphonuclear leucocytes from periodontitis patients and healthy subjects","display_name":"Effects of Porphyromonas gingivalis culture products on the morphology of peripheral blood polymorphonuclear leucocytes from periodontitis patients and healthy subjects","publication_year":1995,"publication_date":"1995-08-01","ids":{"openalex":"https://openalex.org/W2107549015","doi":"https://doi.org/10.1111/j.1600-051x.1995.tb00809.x","mag":"2107549015","pmid":"https://pubmed.ncbi.nlm.nih.gov/8583013"},"language":"en","primary_location":{"id":"doi:10.1111/j.1600-051x.1995.tb00809.x","doi":"https://doi.org/10.1111/j.1600-051x.1995.tb00809.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-051x.1995.tb00809.x","pdf_url":null,"source":{"id":"https://openalex.org/S61859066","display_name":"Journal Of Clinical Periodontology","issn_l":"0303-6979","issn":["0303-6979","1600-051X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Periodontology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071377489","display_name":"Margaret A. Scragg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"M.A. Scragg","raw_affiliation_strings":["Department of Oral Pathology, London Hospital Medical College, UK","Department of Oral Pathology, The London Hospital Medical College, Turner Street, London E1 2AD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Pathology, London Hospital Medical College, UK","institution_ids":["https://openalex.org/I166337079"]},{"raw_affiliation_string":"Department of Oral Pathology, The London Hospital Medical College, Turner Street, London E1 2AD, UK","institution_ids":["https://openalex.org/I166337079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069613212","display_name":"L.R. Turton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"L.R. Turton","raw_affiliation_strings":["Department of Oral Pathology, The London Hospital Medical College, Turner Street, London E1 2AD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Pathology, The London Hospital Medical College, Turner Street, London E1 2AD, UK","institution_ids":["https://openalex.org/I166337079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003901401","display_name":"Hubert N. Newman","orcid":"https://orcid.org/0000-0001-7610-6010","observed_orcids":["https://orcid.org/0000-0001-7610-6010"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H.N. Newman","raw_affiliation_strings":["Department of Periodontology. Eastman Dental Institute, 256 Gray's Inn Road, London WC1X 8LD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology. Eastman Dental Institute, 256 Gray's Inn Road, London WC1X 8LD, UK","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013259507","display_name":"David Michael Williams","orcid":"https://orcid.org/0000-0001-9472-6168","observed_orcids":["https://orcid.org/0000-0001-9472-6168"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D.M. Williams","raw_affiliation_strings":["Department of Oral Pathology, The London Hospital Medical College, Turner Street, London E1 2AD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Pathology, The London Hospital Medical College, Turner Street, London E1 2AD, UK","institution_ids":["https://openalex.org/I166337079"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5071377489"],"corresponding_institution_ids":["https://openalex.org/I166337079"],"apc_list":{"value":5510,"currency":"USD","value_usd":5510},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.21227956,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"22","issue":"8","first_page":"585","last_page":"590"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13768","display_name":"Oral and gingival health research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3611","display_name":"Pharmacy"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/porphyromonas-gingivalis","display_name":"Porphyromonas gingivalis","score":1.0},{"id":"https://openalex.org/keywords/periodontitis","display_name":"periodontitis","score":0.902999997138977},{"id":"https://openalex.org/keywords/rapidly-progressive-periodontitis","display_name":"rapidly progressive periodontitis","score":0.8899999856948853},{"id":"https://openalex.org/keywords/aggressive-periodontitis","display_name":"aggressive periodontitis","score":0.996999979019165},{"id":"https://openalex.org/keywords/polymorphonuclear-leukocytes","display_name":"polymorphonuclear leukocytes","score":0.9279999732971191},{"id":"https://openalex.org/keywords/leukocyte-morphology","display_name":"leukocyte morphology","score":0.8600000143051147},{"id":"https://openalex.org/keywords/culture-supernatant","display_name":"culture supernatant","score":0.8790000081062317},{"id":"https://openalex.org/keywords/avirulent-mutants","display_name":"avirulent mutants","score":0.7319999933242798},{"id":"https://openalex.org/keywords/bacterial-virulence","display_name":"bacterial virulence","score":0.5580000281333923}],"concepts":[{"id":"https://openalex.org/C2780183776","wikidata":"https://www.wikidata.org/wiki/Q3214147","display_name":"Porphyromonas gingivalis","level":3,"score":0.9480262994766235},{"id":"https://openalex.org/C2780385504","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontitis","level":2,"score":0.7984864711761475},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4531377851963043},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.41257476806640625},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.39933115243911743},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3490784168243408},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32935190200805664},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2834312617778778},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2820497751235962}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010518","descriptor_name":"Periodontitis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D010518","descriptor_name":"Periodontitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010520","descriptor_name":"Aggressive Periodontitis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010520","descriptor_name":"Aggressive Periodontitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016966","descriptor_name":"Porphyromonas gingivalis","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D016966","descriptor_name":"Porphyromonas gingivalis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016966","descriptor_name":"Porphyromonas gingivalis","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D048429","descriptor_name":"Cell Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1600-051x.1995.tb00809.x","doi":"https://doi.org/10.1111/j.1600-051x.1995.tb00809.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-051x.1995.tb00809.x","pdf_url":null,"source":{"id":"https://openalex.org/S61859066","display_name":"Journal Of Clinical Periodontology","issn_l":"0303-6979","issn":["0303-6979","1600-051X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Periodontology","raw_type":"journal-article"},{"id":"pmid:8583013","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8583013","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical periodontology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1928718299","https://openalex.org/W1956236905","https://openalex.org/W1964937681","https://openalex.org/W1979100295","https://openalex.org/W2000630510","https://openalex.org/W2001784811","https://openalex.org/W2012626831","https://openalex.org/W2017793777","https://openalex.org/W2035900327","https://openalex.org/W2037835080","https://openalex.org/W2042450805","https://openalex.org/W2043838926","https://openalex.org/W2066891402","https://openalex.org/W2074968150","https://openalex.org/W2075188186","https://openalex.org/W2082305741","https://openalex.org/W2083401612","https://openalex.org/W2084540497","https://openalex.org/W2087715055","https://openalex.org/W2094749758","https://openalex.org/W2111950448","https://openalex.org/W2115337964","https://openalex.org/W2161113906","https://openalex.org/W2161696386","https://openalex.org/W2313102622","https://openalex.org/W2328247822","https://openalex.org/W2486891872","https://openalex.org/W4242617047"],"related_works":["https://openalex.org/W7046917129","https://openalex.org/W2398903144","https://openalex.org/W2066891402","https://openalex.org/W2000630510","https://openalex.org/W2001784811","https://openalex.org/W2035900327","https://openalex.org/W2089668353","https://openalex.org/W2365212790","https://openalex.org/W2325207650","https://openalex.org/W2053156639"],"abstract_inverted_index":{"The":[0,130],"effects":[1],"of":[2,68,80,143],"Porphyromonas":[3],"gingivalis":[4,156],"culture":[5,17,157],"supernatant":[6,75],"from":[7,27,43,135,141],"strain":[8],"W50,":[9],"its":[10],"avirulent":[11],"variant":[12],"(W50/BE1)":[13],"and":[14,63,73,88,108,115,118],"sterile":[15],"BM":[16],"medium":[18],"on":[19],"the":[20,94,147],"morphological":[21],"changes":[22,149],"in":[23,56,93,146],"polymorphonuclear":[24],"leucocytes":[25],"(PMN)":[26],"10":[28,44],"patients":[29,57,136],"with":[30,41,71,113,137],"periodontitis":[31,138],"(3":[32],"juvenile":[33],"periodontitis,":[34],"7":[35],"rapidly":[36],"progressive":[37],"periodontitis)":[38],"were":[39,54,91,103],"compared":[40],"those":[42,142],"healthy":[45,144],"controls.":[46],"Large":[47],"non-polar":[48,82,101],"cells":[49,83,90,102,125],"(":[50,84],">":[51],"160":[52],"microns2)":[53,87],"increased":[55],"to":[58,127,154],"182.8%":[59],"(p":[60,65,105,110,120],"=":[61,66,106,111,121],"0.0076)":[62],"245.5%":[64],"0.0002)":[67],"control":[69],"values":[70],"W50":[72,114,128],"W50/BE1":[74],"respectively.":[76],"In":[77],"contrast,":[78],"numbers":[79],"small":[81,100],"<":[85],"80":[86],"polarised":[89,124],"decreased":[92],"patient":[95],"group.":[96],"Patient/control":[97],"ratios":[98],"for":[99,123],"30.3%":[104],"0.0007)":[107],"33.6%":[109],"0.0005)":[112],"W50/BE1,":[116],"respectively,":[117],"38.2%":[119],"0.0147)":[122],"exposed":[126],"supernatant.":[129,158],"data":[131],"indicate":[132],"that":[133],"PMN":[134],"differ":[139],"significantly":[140],"controls":[145],"shape":[148],"which":[150],"occur":[151],"after":[152],"exposure":[153],"P.":[155]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}