{"id":"https://openalex.org/W2107546292","doi":null,"title":"THE EFFECTS OF GROWTH AND EXERCISE ON PROTEIN TURNOVER AND SENSITIVITY TO TESTOSTERONE ADMINISTRATION IN SKELETAL MUSCLE OF PREPUBERTAL RATS","display_name":"THE EFFECTS OF GROWTH AND EXERCISE ON PROTEIN TURNOVER AND SENSITIVITY TO TESTOSTERONE ADMINISTRATION IN SKELETAL MUSCLE OF PREPUBERTAL RATS","publication_year":1985,"publication_date":"1985-01-01","ids":{"openalex":"https://openalex.org/W2107546292","mag":"2107546292"},"language":"en","primary_location":{"id":"pmh:oai:summit.sfu.ca:5925","doi":null,"is_oa":true,"landing_page_url":"http://summit.sfu.ca/item/5925","pdf_url":"http://summit.sfu.ca/item/5925","source":{"id":"https://openalex.org/S4306400490","display_name":"Summit (Simon Fraser University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I18014758","host_organization_name":"Simon Fraser University","host_organization_lineage":["https://openalex.org/I18014758"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://summit.sfu.ca/item/5925","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012805849","display_name":"Susan A. Malcolm","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Susan Malcolm","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5012805849"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/skeletal-muscle-protein-turnover","display_name":"skeletal muscle protein turnover","score":0.9120000004768372},{"id":"https://openalex.org/keywords/protein-synthesis","display_name":"protein synthesis","score":0.8159999847412109},{"id":"https://openalex.org/keywords/testosterone-propionate","display_name":"testosterone propionate","score":0.7839999794960022},{"id":"https://openalex.org/keywords/exhaustive-exercise","display_name":"exhaustive exercise","score":0.9729999899864197},{"id":"https://openalex.org/keywords/detraining","display_name":"detraining","score":0.875},{"id":"https://openalex.org/keywords/muscle-growth","display_name":"muscle growth","score":0.5609999895095825},{"id":"https://openalex.org/keywords/prepubertal-rats","display_name":"prepubertal rats","score":0.8330000042915344},{"id":"https://openalex.org/keywords/soleus-muscle","display_name":"soleus muscle","score":0.9290000200271606},{"id":"https://openalex.org/keywords/gastrocnemius-muscle","display_name":"gastrocnemius","score":0.9990000128746033},{"id":"https://openalex.org/keywords/succinate-dehydrogenase","display_name":"succinate dehydrogenase","score":0.8759999871253967},{"id":"https://openalex.org/keywords/leucine-uptake","display_name":"leucine uptake","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7454425096511841},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7437553405761719},{"id":"https://openalex.org/C195580219","wikidata":"https://www.wikidata.org/wiki/Q7251511","display_name":"Protein turnover","level":3,"score":0.7389513850212097},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.6904946565628052},{"id":"https://openalex.org/C119406331","wikidata":"https://www.wikidata.org/wiki/Q419763","display_name":"Acclimatization","level":2,"score":0.5568698048591614},{"id":"https://openalex.org/C2781115071","wikidata":"https://www.wikidata.org/wiki/Q10354588","display_name":"Testosterone propionate","level":4,"score":0.5210949182510376},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47032630443573},{"id":"https://openalex.org/C2779572773","wikidata":"https://www.wikidata.org/wiki/Q4862551","display_name":"Protein metabolism","level":3,"score":0.4672277867794037},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.43978893756866455},{"id":"https://openalex.org/C2776104385","wikidata":"https://www.wikidata.org/wiki/Q1954164","display_name":"Soleus muscle","level":3,"score":0.4381254017353058},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.42027169466018677},{"id":"https://openalex.org/C26077564","wikidata":"https://www.wikidata.org/wiki/Q1910318","display_name":"Turnover","level":2,"score":0.41678160429000854},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3590241074562073},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.34622782468795776},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28662437200546265},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19771993160247803},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.14249363541603088},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.12153860926628113},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C187736073","wikidata":"https://www.wikidata.org/wiki/Q2920921","display_name":"Management","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:summit.sfu.ca:5925","doi":null,"is_oa":true,"landing_page_url":"http://summit.sfu.ca/item/5925","pdf_url":"http://summit.sfu.ca/item/5925","source":{"id":"https://openalex.org/S4306400490","display_name":"Summit (Simon Fraser University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I18014758","host_organization_name":"Simon Fraser University","host_organization_lineage":["https://openalex.org/I18014758"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:oai:summit.sfu.ca:node-5925","doi":null,"is_oa":true,"landing_page_url":"https://summit.sfu.ca/_flysystem/fedora/sfu_migrate/5925/b15304723.pdf","pdf_url":"https://summit.sfu.ca/_flysystem/fedora/sfu_migrate/5925/b15304723.pdf","source":{"id":"https://openalex.org/S4306400490","display_name":"Summit (Simon Fraser University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I18014758","host_organization_name":"Simon Fraser University","host_organization_lineage":["https://openalex.org/I18014758"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:2107546292","doi":null,"is_oa":false,"landing_page_url":"http://summit.sfu.ca/system/files/iritems1/5925/b15304723.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:summit.sfu.ca:5925","doi":null,"is_oa":true,"landing_page_url":"http://summit.sfu.ca/item/5925","pdf_url":"http://summit.sfu.ca/item/5925","source":{"id":"https://openalex.org/S4306400490","display_name":"Summit (Simon Fraser University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I18014758","host_organization_name":"Simon Fraser University","host_organization_lineage":["https://openalex.org/I18014758"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2107546292.pdf","grobid_xml":"https://content.openalex.org/works/W2107546292.grobid-xml"},"referenced_works_count":145,"referenced_works":["https://openalex.org/W5160150","https://openalex.org/W9763234","https://openalex.org/W16548684","https://openalex.org/W17781183","https://openalex.org/W34311502","https://openalex.org/W58658442","https://openalex.org/W77676294","https://openalex.org/W84529627","https://openalex.org/W92064158","https://openalex.org/W126350244","https://openalex.org/W132112035","https://openalex.org/W152338347","https://openalex.org/W180374030","https://openalex.org/W187713099","https://openalex.org/W277249932","https://openalex.org/W291220406","https://openalex.org/W1485332384","https://openalex.org/W1491317952","https://openalex.org/W1544423740","https://openalex.org/W1555482102","https://openalex.org/W1555901525","https://openalex.org/W1558857728","https://openalex.org/W1570319355","https://openalex.org/W1580439180","https://openalex.org/W1590420180","https://openalex.org/W1601658610","https://openalex.org/W1660531963","https://openalex.org/W1757594464","https://openalex.org/W1766155663","https://openalex.org/W1775749144","https://openalex.org/W1799879229","https://openalex.org/W1805148815","https://openalex.org/W1816636001","https://openalex.org/W1819130013","https://openalex.org/W1831614231","https://openalex.org/W1904089165","https://openalex.org/W1914574115","https://openalex.org/W1963860016","https://openalex.org/W1966225856","https://openalex.org/W1968638990","https://openalex.org/W1971884276","https://openalex.org/W1973061385","https://openalex.org/W1976830639","https://openalex.org/W1976890482","https://openalex.org/W1982069648","https://openalex.org/W1985143437","https://openalex.org/W1986824447","https://openalex.org/W1987780028","https://openalex.org/W1991210021","https://openalex.org/W1992283742","https://openalex.org/W1995729727","https://openalex.org/W1995888665","https://openalex.org/W1998090296","https://openalex.org/W2005745170","https://openalex.org/W2006557585","https://openalex.org/W2007218645","https://openalex.org/W2008827505","https://openalex.org/W2009009538","https://openalex.org/W2011583617","https://openalex.org/W2012183901","https://openalex.org/W2013562913","https://openalex.org/W2014364890","https://openalex.org/W2015471616","https://openalex.org/W2021542197","https://openalex.org/W2022696374","https://openalex.org/W2023318912","https://openalex.org/W2023846617","https://openalex.org/W2025711379","https://openalex.org/W2028255838","https://openalex.org/W2034096672","https://openalex.org/W2035458364","https://openalex.org/W2035731143","https://openalex.org/W2036905121","https://openalex.org/W2037643750","https://openalex.org/W2041738917","https://openalex.org/W2042111232","https://openalex.org/W2048588515","https://openalex.org/W2050930381","https://openalex.org/W2056953110","https://openalex.org/W2060833247","https://openalex.org/W2064616045","https://openalex.org/W2065695713","https://openalex.org/W2067093550","https://openalex.org/W2067623925","https://openalex.org/W2070676317","https://openalex.org/W2073267621","https://openalex.org/W2073319510","https://openalex.org/W2073951292","https://openalex.org/W2075257421","https://openalex.org/W2075268950","https://openalex.org/W2077732889","https://openalex.org/W2080365596","https://openalex.org/W2080607015","https://openalex.org/W2082020558","https://openalex.org/W2084690309","https://openalex.org/W2086914553","https://openalex.org/W2089106954","https://openalex.org/W2089787504","https://openalex.org/W2091587238","https://openalex.org/W2091733217","https://openalex.org/W2095102539","https://openalex.org/W2096708891","https://openalex.org/W2112003048","https://openalex.org/W2127569884","https://openalex.org/W2153281506","https://openalex.org/W2158882750","https://openalex.org/W2165655337","https://openalex.org/W2176423605","https://openalex.org/W2177354961","https://openalex.org/W2194940061","https://openalex.org/W2258050857","https://openalex.org/W2258326667","https://openalex.org/W2259666366","https://openalex.org/W2266929766","https://openalex.org/W2268428790","https://openalex.org/W2275941921","https://openalex.org/W2276001110","https://openalex.org/W2280358576","https://openalex.org/W2287719822","https://openalex.org/W2297905482","https://openalex.org/W2319829950","https://openalex.org/W2337638159","https://openalex.org/W2338144558","https://openalex.org/W2403332392","https://openalex.org/W2403794256","https://openalex.org/W2405924462","https://openalex.org/W2409112036","https://openalex.org/W2410541488","https://openalex.org/W2411228761","https://openalex.org/W2411460444","https://openalex.org/W2411978917","https://openalex.org/W2414823949","https://openalex.org/W2415104947","https://openalex.org/W2416773318","https://openalex.org/W2417369146","https://openalex.org/W2417692374","https://openalex.org/W2418297250","https://openalex.org/W2424800975","https://openalex.org/W2436848085","https://openalex.org/W2442777489","https://openalex.org/W2461397370","https://openalex.org/W2476047789","https://openalex.org/W2491523732","https://openalex.org/W2897677445","https://openalex.org/W4297820770"],"related_works":["https://openalex.org/W2946965002","https://openalex.org/W598919639","https://openalex.org/W2166150852","https://openalex.org/W1973373340","https://openalex.org/W1979905323","https://openalex.org/W7217095146","https://openalex.org/W1016389496","https://openalex.org/W69501696","https://openalex.org/W2061692238","https://openalex.org/W2595883994"],"abstract_inverted_index":{"The":[0],"effects":[1,44],"of":[2,40,52,95,113,123,154,170,180,203,209,230,246,266,333],"growth,":[3],"exercise":[4,9,67],"acclimatization":[5,184],"(AC)":[6],"and":[7,17,31,37,58,76,98,117,147,191,200,244,258,286,319],"exhaustive":[8,312,339],"(A)":[10],"on":[11],"skeletal":[12],"muscle":[13],"protein":[14,148,189,198,204,217,242,268,288,317,336],"sythesis,":[15],"turnover":[16,137,159,218],"sensitivity":[18],"to":[19,49,64,86,91,109,134,167,235,270,277,300],"testosterone":[20,124,271,307,328],"administration":[21,234],"(T)":[22],"were":[23,45,62,100,321],"studied":[24],"in":[25,35,54,161,176,186,213,220,240,254,290,297,303,316],"the":[26,88,177,207,221,227,264,267,314],"homogenate":[27],"(HOM),":[28],"mitochondria1":[29,285],"(MIT)":[30],"sarcoplasmic":[32,287],"(SAR)":[33],"fractions":[34],"soleus":[36,181],"gastrocnemius":[38],"muscles":[39,163,292],"prepubescent":[41],"rats.":[42],"Growth":[43],"monitored":[46],"from":[47,165],"five":[48,69,166],"six":[50,168],"weeks":[51,169],"age":[53],"sedentary":[55,236],"animals":[56,61,96,114,223],"(C5":[57],"C6).":[59],"Exercised":[60],"acclimatized":[63,73],"mild":[65],"treadmill":[66],"for":[68,226,331],"days":[70],"after":[71],"which":[72],"groups":[74,94,112,256],"(AC":[75],"ACT)":[77],"rested":[78],"7":[79],"2":[80,102,130],"hours":[81,104,132,281],".":[82],"i":[83],"In":[84],"order":[85],"study":[87],"acute":[89],"response":[90,212,269],"exercise,":[92,284,313],"two":[93],"(A.Ac":[97],"A.ACT)":[99,118],"sacrificed":[101],"4":[103,131],"'":[105],"following":[106,282,311,338],"a":[107,143,210],"run":[108],"exhaustion.":[110],"Three":[111],"(C~T,":[115],"ACT":[116,257],"received":[119],"an":[120,249],"intraperitoneal":[121],"injection":[122],"propionate":[125],"(10":[126],"mg/kg":[127],"body":[128],"weight)":[129],"prior":[133,275],"sacrifice.":[135],"Protein":[136,158,172],"was":[138,174,252,272,293,308],"assessed":[139],"-in":[140,151],"vivo":[141,152],"using":[142],"double":[144],"isotope":[145],"method":[146],"synthesis":[149,199,318],"by":[150,274],"uptake":[153],"radioactively":[155],"labelled":[156],"leucine.":[157],"rates":[160,202,219,245],"both":[162,255,291],"fell":[164],"age.":[171],"concentration":[173,190,243,289],"increased":[175,187],"HOM":[178,188],"fraction":[179],"muscle.":[182],"Exercise":[183],"resulted":[185,239],"elevated":[192,201],"succinate":[193],"dehydrogenase":[194],"(SDH)":[195],"activity.":[196],"Reduced":[197],"degradation":[205],"suggest":[206],"onset":[208,229],"detraining":[211],"these":[214],"animals.":[215,305],"High":[216],"young":[222],"may":[224],"account":[225],"early":[228],"this":[231],"response.":[232],"Testosterone":[233],"rats":[237],"(C6T)":[238],"reduced":[241],"synthesis.":[247],"As":[248],"opposite":[250],"effect":[251],"observed":[253],"A.AcT":[259],"it":[260,324],"is":[261,296,325,329],"suggested":[262],"that":[263,327],"direction":[265],"mediated":[273],"exposure":[276],"exercise.":[278,340],"Twenty":[279],"four":[280],"severe":[283],"diminished.":[294],"This":[295],"direct":[298],"contrast":[299],"usual":[301],"observations":[302],"adult":[304],"When":[306],"administered":[309],"immediately":[310],"changes":[315],"content":[320],"reversed.":[322],"Therefore":[323],"hypothesized":[326],"required":[330],"supression":[332],"glucocorticoid":[334],"induced":[335],"catabolism":[337]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
