{"id":"https://openalex.org/W2107544447","doi":"https://doi.org/10.1017/s0967199411000645","title":"Role of phospholipase A2pathway in regulating activation ofBufo arenarumoocytes","display_name":"Role of phospholipase A2pathway in regulating activation ofBufo arenarumoocytes","publication_year":2012,"publication_date":"2012-02-02","ids":{"openalex":"https://openalex.org/W2107544447","doi":"https://doi.org/10.1017/s0967199411000645","mag":"2107544447","pmid":"https://pubmed.ncbi.nlm.nih.gov/22300896"},"language":"en","primary_location":{"id":"doi:10.1017/s0967199411000645","doi":"https://doi.org/10.1017/s0967199411000645","is_oa":false,"landing_page_url":"https://doi.org/10.1017/s0967199411000645","pdf_url":null,"source":{"id":"https://openalex.org/S99576920","display_name":"Zygote","issn_l":"0967-1994","issn":["0967-1994","1469-8730"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zygote","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063370421","display_name":"Mar\u00eda Teresa Ajmat","orcid":"https://orcid.org/0000-0002-0639-1407","observed_orcids":["https://orcid.org/0000-0002-0639-1407"]},"institutions":[{"id":"https://openalex.org/I127019355","display_name":"National University of Tucum\u00e1n","ror":"https://ror.org/04chzd762","country_code":"AR","type":"education","lineage":["https://openalex.org/I127019355"]},{"id":"https://openalex.org/I4210091080","display_name":"Instituto Superior de Investigaciones Biol\u00f3gicas","ror":"https://ror.org/00bv27459","country_code":"AR","type":"facility","lineage":["https://openalex.org/I127019355","https://openalex.org/I151201029","https://openalex.org/I4210091080","https://openalex.org/I4210123736","https://openalex.org/I4210128307","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"M.T. Ajmat","raw_affiliation_strings":["Instituto Superior de Investigaciones Biol\u00f3gicas (INSIBIO) Universidad Nacional de Tucum\u00e1n Chacabuco 461 (4000) S.M. de Tucum\u00e1n. Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Superior de Investigaciones Biol\u00f3gicas (INSIBIO) Universidad Nacional de Tucum\u00e1n Chacabuco 461 (4000) S.M. de Tucum\u00e1n. Argentina","institution_ids":["https://openalex.org/I127019355","https://openalex.org/I4210091080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027737195","display_name":"Federico Bonilla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127019355","display_name":"National University of Tucum\u00e1n","ror":"https://ror.org/04chzd762","country_code":"AR","type":"education","lineage":["https://openalex.org/I127019355"]},{"id":"https://openalex.org/I4210091080","display_name":"Instituto Superior de Investigaciones Biol\u00f3gicas","ror":"https://ror.org/00bv27459","country_code":"AR","type":"facility","lineage":["https://openalex.org/I127019355","https://openalex.org/I151201029","https://openalex.org/I4210091080","https://openalex.org/I4210123736","https://openalex.org/I4210128307","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"F. Bonilla","raw_affiliation_strings":["Instituto Superior de Investigaciones Biol\u00f3gicas (INSIBIO) Universidad Nacional de Tucum\u00e1n Chacabuco 461 (4000) S.M. de Tucum\u00e1n. Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Superior de Investigaciones Biol\u00f3gicas (INSIBIO) Universidad Nacional de Tucum\u00e1n Chacabuco 461 (4000) S.M. de Tucum\u00e1n. Argentina","institution_ids":["https://openalex.org/I127019355","https://openalex.org/I4210091080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006627385","display_name":"P.C. Hermosilla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127019355","display_name":"National University of Tucum\u00e1n","ror":"https://ror.org/04chzd762","country_code":"AR","type":"education","lineage":["https://openalex.org/I127019355"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"P.C. Hermosilla","raw_affiliation_strings":["Instituto de Biolog\u00eda, Facultad de Bioqu\u00edmica, Qu\u00edmica y Farmacia, Universidad Nacional de Tucum\u00e1n, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Biolog\u00eda, Facultad de Bioqu\u00edmica, Qu\u00edmica y Farmacia, Universidad Nacional de Tucum\u00e1n, Argentina","institution_ids":["https://openalex.org/I127019355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069360128","display_name":"Liliana Isabel Zelaray\u00e1n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127019355","display_name":"National University of Tucum\u00e1n","ror":"https://ror.org/04chzd762","country_code":"AR","type":"education","lineage":["https://openalex.org/I127019355"]},{"id":"https://openalex.org/I4210091080","display_name":"Instituto Superior de Investigaciones Biol\u00f3gicas","ror":"https://ror.org/00bv27459","country_code":"AR","type":"facility","lineage":["https://openalex.org/I127019355","https://openalex.org/I151201029","https://openalex.org/I4210091080","https://openalex.org/I4210123736","https://openalex.org/I4210128307","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"L. Zelaray\u00e1n","raw_affiliation_strings":["Instituto Superior de Investigaciones Biol\u00f3gicas (INSIBIO) Universidad Nacional de Tucum\u00e1n Chacabuco 461 (4000) S.M. de Tucum\u00e1n. Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Superior de Investigaciones Biol\u00f3gicas (INSIBIO) Universidad Nacional de Tucum\u00e1n Chacabuco 461 (4000) S.M. de Tucum\u00e1n. Argentina","institution_ids":["https://openalex.org/I127019355","https://openalex.org/I4210091080"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111659718","display_name":"Marta In\u00e9s B\u00fchler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091080","display_name":"Instituto Superior de Investigaciones Biol\u00f3gicas","ror":"https://ror.org/00bv27459","country_code":"AR","type":"facility","lineage":["https://openalex.org/I127019355","https://openalex.org/I151201029","https://openalex.org/I4210091080","https://openalex.org/I4210123736","https://openalex.org/I4210128307","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":true,"raw_author_name":"M.I. B\u00fchler","raw_affiliation_strings":["Departamento de Biolog\u00eda del Desarrollo (INSIBIO), Chacabuco 461, 4000- San Miguel de Tucum\u00e1n, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Biolog\u00eda del Desarrollo (INSIBIO), Chacabuco 461, 4000- San Miguel de Tucum\u00e1n, Argentina","institution_ids":["https://openalex.org/I4210091080"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5111659718"],"corresponding_institution_ids":["https://openalex.org/I4210091080"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":1.2437,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.76440654,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"21","issue":"3","first_page":"214","last_page":"220"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.23569999635219574,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.23569999635219574,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.23510000109672546,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.10719999670982361,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phospholipase-a2","display_name":"phospholipase A2","score":0.8650000095367432},{"id":"https://openalex.org/keywords/bufo-arenarum","display_name":"Bufo arenarum","score":0.9070000052452087},{"id":"https://openalex.org/keywords/oocyte-activation","display_name":"oocyte activation","score":0.968999981880188},{"id":"https://openalex.org/keywords/arachidonic-acid","display_name":"arachidonic acid","score":0.8690000176429749},{"id":"https://openalex.org/keywords/melittin","display_name":"melittin","score":0.9570000171661377},{"id":"https://openalex.org/keywords/ip3-receptor","display_name":"IP3 receptor","score":0.9319999814033508},{"id":"https://openalex.org/keywords/ryanodine-receptor","display_name":"ryanodine receptor","score":1.0},{"id":"https://openalex.org/keywords/intracellular-calcium-release","display_name":"intracellular calcium release","score":0.9089999794960022},{"id":"https://openalex.org/keywords/calcium-homeostasis","display_name":"calcium homeostasis","score":0.9139999747276306},{"id":"https://openalex.org/keywords/fertilisation-biology","display_name":"fertilisation (biology)","score":0.6869999766349792}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6017969846725464},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5788020491600037},{"id":"https://openalex.org/C179265757","wikidata":"https://www.wikidata.org/wiki/Q7095247","display_name":"Oocyte activation","level":4,"score":0.48178789019584656},{"id":"https://openalex.org/C2778597717","wikidata":"https://www.wikidata.org/wiki/Q420248","display_name":"Phospholipase C","level":3,"score":0.46675896644592285},{"id":"https://openalex.org/C2776690073","wikidata":"https://www.wikidata.org/wiki/Q3246226","display_name":"Oocyte","level":3,"score":0.342754989862442},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2559027373790741},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25019344687461853},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23153617978096008},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.10462793707847595}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002022","descriptor_name":"Bufo arenarum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008555","descriptor_name":"Melitten","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011796","descriptor_name":"Quinacrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016718","descriptor_name":"Arachidonic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016718","descriptor_name":"Arachidonic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019837","descriptor_name":"Ryanodine Receptor Calcium Release Channel","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053496","descriptor_name":"Inositol 1,4,5-Trisphosphate Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054467","descriptor_name":"Phospholipases A2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054510","descriptor_name":"Phospholipases A2, Cytosolic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1017/s0967199411000645","doi":"https://doi.org/10.1017/s0967199411000645","is_oa":false,"landing_page_url":"https://doi.org/10.1017/s0967199411000645","pdf_url":null,"source":{"id":"https://openalex.org/S99576920","display_name":"Zygote","issn_l":"0967-1994","issn":["0967-1994","1469-8730"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zygote","raw_type":"journal-article"},{"id":"pmid:22300896","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22300896","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zygote (Cambridge, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W14044937","https://openalex.org/W1497597518","https://openalex.org/W1524196422","https://openalex.org/W1986605032","https://openalex.org/W1999421897","https://openalex.org/W2001589067","https://openalex.org/W2006265135","https://openalex.org/W2007278837","https://openalex.org/W2012485812","https://openalex.org/W2013446928","https://openalex.org/W2026452617","https://openalex.org/W2026571586","https://openalex.org/W2028335574","https://openalex.org/W2028971323","https://openalex.org/W2031180111","https://openalex.org/W2031416023","https://openalex.org/W2044575298","https://openalex.org/W2046875322","https://openalex.org/W2047204395","https://openalex.org/W2048894874","https://openalex.org/W2051958752","https://openalex.org/W2058348515","https://openalex.org/W2062984300","https://openalex.org/W2071757955","https://openalex.org/W2072410964","https://openalex.org/W2089992191","https://openalex.org/W2090611949","https://openalex.org/W2105305126","https://openalex.org/W2106896608","https://openalex.org/W2113126328","https://openalex.org/W2129032725","https://openalex.org/W2129391636","https://openalex.org/W2133759741","https://openalex.org/W2138517958","https://openalex.org/W2142181236","https://openalex.org/W2149968029","https://openalex.org/W2167367897","https://openalex.org/W2169209842","https://openalex.org/W2186033591","https://openalex.org/W2319169701","https://openalex.org/W2324141539","https://openalex.org/W2345557679","https://openalex.org/W2394776735","https://openalex.org/W2469557233","https://openalex.org/W3156754755"],"related_works":["https://openalex.org/W2066128960","https://openalex.org/W2319169701","https://openalex.org/W2068990208","https://openalex.org/W1596536567","https://openalex.org/W2022037486","https://openalex.org/W1849208354","https://openalex.org/W2153539273","https://openalex.org/W7097908027","https://openalex.org/W2041622964","https://openalex.org/W2019774786"],"abstract_inverted_index":{"Transient":[0],"increases":[1],"in":[2,131,152,187,210,240],"the":[3,34,40,49,55,86,93,110,123,126,132,140,148,153,157,176],"concentration":[4],"of":[5,51,73,85,112,125,134,144,166,193,218,228,246],"cytosolic":[6,75],"Ca(2+)":[7,16],"are":[8],"essential":[9],"for":[10,236],"triggering":[11],"egg":[12,213],"activation":[13,138,185],"events.":[14],"Increased":[15],"results":[17],"from":[18,22,83,92,156,230],"its":[19,63,104,145,201,222],"rapid":[20],"release":[21,155],"intracellular":[23,31,158,231],"stores,":[24],"mainly":[25],"mediated":[26],"by":[27,197],"one":[28],"or":[29],"both":[30,167,244],"calcium":[32,67,154,229,238],"channels:":[33],"inositol":[35],"trisphosphate":[36],"receptor":[37,42],"(IP3R)":[38],"and":[39,139,147,173,195,200,206,233],"ryanodine":[41],"(RyR).":[43],"Several":[44],"regulatory":[45],"pathways":[46],"that":[47,100,164,242],"tailor":[48],"response":[50],"these":[52,118],"channels":[53,150],"to":[54,108,183],"specific":[56],"cell":[57],"type":[58],"have":[59,98,121],"been":[60],"proposed.":[61],"Among":[62],"many":[64],"modulatory":[65],"actions,":[66],"can":[68],"serve":[69],"as":[70,89,91],"an":[71],"activator":[72],"a":[74,169,188],"phospholipase":[76,127],"A(2)":[77,128],"(cPLA2),":[78],"which":[79],"releases":[80],"arachidonic":[81,101,174,198,207,219],"acid":[82,102,199,208,220],"phospholipids":[84],"endoplasmic":[87],"reticulum":[88],"well":[90],"nuclear":[94],"envelope.":[95],"Previous":[96],"studies":[97],"suggested":[99],"and/or":[103,221],"metabolites":[105,146,223],"were":[106],"able":[107,182],"modulate":[109],"activity":[111],"several":[113],"ion":[114,149],"channels.":[115],"Based":[116],"on":[117],"findings,":[119],"we":[120],"studied":[122],"participation":[124],"(PLA(2))":[129],"pathway":[130],"process":[133],"Bufo":[135,211],"arenarum":[136,212],"oocyte":[137],"interrelation":[141],"between":[142],"any":[143],"involved":[151],"reservoirs":[159,232],"at":[160],"fertilization.":[161],"We":[162],"found":[163],"addition":[165],"melittin,":[168],"potent":[170],"PLA(2)":[171,178],"activator,":[172],"acid,":[175],"main":[177],"reaction":[179],"metabolite,":[180],"was":[181],"induce":[184],"events":[186],"bell-shaped":[189],"manner.":[190],"Differential":[191],"regulation":[192],"IP3Rs":[194],"RyRs":[196],"products":[202],"could":[203,224],"explain":[204],"melittin":[205],"behaviour":[209],"activation.":[214],"The":[215],"concerted":[216],"action":[217],"provide":[225],"controlled":[226],"mobilization":[227],"useful":[234],"tools":[235],"understanding":[237],"homeostasis":[239],"eggs":[241],"express":[243],"types":[245],"receptors.":[247]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
