{"id":"https://openalex.org/W2107488151","doi":"https://doi.org/10.1084/jem.186.5.731","title":"Epstein-Barr Virus Binding to CD21 Activates the Initial Viral Promoter via NF-\u03baB Induction","display_name":"Epstein-Barr Virus Binding to CD21 Activates the Initial Viral Promoter via NF-\u03baB Induction","publication_year":1997,"publication_date":"1997-08-29","ids":{"openalex":"https://openalex.org/W2107488151","doi":"https://doi.org/10.1084/jem.186.5.731","mag":"2107488151","pmid":"https://pubmed.ncbi.nlm.nih.gov/9271588","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2199015"},"language":"en","primary_location":{"id":"doi:10.1084/jem.186.5.731","doi":"https://doi.org/10.1084/jem.186.5.731","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.186.5.731","pdf_url":"https://rupress.org/jem/article-pdf/186/5/731/1685761/97-0468.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://rupress.org/jem/article-pdf/186/5/731/1685761/97-0468.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020834320","display_name":"Naoyuki Sugano","orcid":"https://orcid.org/0000-0001-6798-5463","observed_orcids":["https://orcid.org/0000-0001-6798-5463"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naoyuki Sugano","raw_affiliation_strings":["From the Scripps Research Institute, Department of Immunology, La Jolla, California 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Scripps Research Institute, Department of Immunology, La Jolla, California 92037","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100652326","display_name":"Weiping Chen","orcid":"https://orcid.org/0000-0002-0459-0605","observed_orcids":["https://orcid.org/0000-0002-0459-0605"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weiping Chen","raw_affiliation_strings":["From the Scripps Research Institute, Department of Immunology, La Jolla, California 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Scripps Research Institute, Department of Immunology, La Jolla, California 92037","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109030967","display_name":"M. L. Roberts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Luisa Roberts","raw_affiliation_strings":["From the Scripps Research Institute, Department of Immunology, La Jolla, California 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Scripps Research Institute, Department of Immunology, La Jolla, California 92037","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109049266","display_name":"Neil R. Cooper","orcid":"https://orcid.org/0009-0006-7469-4879","observed_orcids":["https://orcid.org/0009-0006-7469-4879"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neil R. Cooper","raw_affiliation_strings":["From the Scripps Research Institute, Department of Immunology, La Jolla, California 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Scripps Research Institute, Department of Immunology, La Jolla, California 92037","institution_ids":["https://openalex.org/I123431417"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I123431417"],"apc_list":null,"apc_paid":null,"fwci":2.8891,"has_fulltext":true,"cited_by_count":96,"citation_normalized_percentile":{"value":0.91585388,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"186","issue":"5","first_page":"731","last_page":"737"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.8529999852180481,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.8529999852180481,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.11249999701976776,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epstein-barr-virus","display_name":"Epstein-Barr virus","score":1.0},{"id":"https://openalex.org/keywords/cd21","display_name":"CD21","score":0.9959999918937683},{"id":"https://openalex.org/keywords/complement-receptor-2","display_name":"CR2","score":0.8960000276565552},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8199999928474426},{"id":"https://openalex.org/keywords/latent-gene-expression","display_name":"latent gene expression","score":0.675000011920929},{"id":"https://openalex.org/keywords/receptor-binding","display_name":"receptor binding","score":0.4830000102519989},{"id":"https://openalex.org/keywords/intracellular-signaling","display_name":"intracellular signaling","score":0.7149999737739563},{"id":"https://openalex.org/keywords/resting-b-cells","display_name":"resting B cells","score":0.6359999775886536}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6025335192680359},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5884358286857605},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5449879765510559},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4945776164531708},{"id":"https://openalex.org/C2781375147","wikidata":"https://www.wikidata.org/wiki/Q6900","display_name":"Epstein\u2013Barr virus","level":3,"score":0.47886940836906433},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.464033842086792},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4581027030944824},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.453289270401001},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4438214600086212},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4345761239528656},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4076700508594513},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3939092755317688},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.36271828413009644},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10302510857582092},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005814","descriptor_name":"Genes, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009281","descriptor_name":"Naphthalenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011991","descriptor_name":"Receptors, Virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015342","descriptor_name":"DNA Probes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015967","descriptor_name":"Gene Expression Regulation, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017464","descriptor_name":"Receptors, Complement 3d","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019309","descriptor_name":"Epstein-Barr Virus Nuclear Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051841","descriptor_name":"Transcription Factor RelB","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1084/jem.186.5.731","doi":"https://doi.org/10.1084/jem.186.5.731","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.186.5.731","pdf_url":"https://rupress.org/jem/article-pdf/186/5/731/1685761/97-0468.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2199015","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2199015","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Med","raw_type":"Text"},{"id":"pmid:9271588","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9271588","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.334.5622","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.334.5622","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jem.rupress.org/content/186/5/731.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.778.1619","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.778.1619","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/de/8d/97-0468.PMC2199015.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1084/jem.186.5.731","doi":"https://doi.org/10.1084/jem.186.5.731","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.186.5.731","pdf_url":"https://rupress.org/jem/article-pdf/186/5/731/1685761/97-0468.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1655645242","display_name":"GENERAL CLINICAL RESEARCH CENTER","funder_award_id":"M01RR000833","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3380406027","display_name":"CR2, CD19, MEMBRANE IG, AND B-CELL SIGNAL TRANSDUCTION","funder_award_id":"R01AI033244","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6667797187","display_name":"Immunology Training","funder_award_id":"T32AI007244","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2107488151.pdf","grobid_xml":"https://content.openalex.org/works/W2107488151.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W37844384","https://openalex.org/W1483930211","https://openalex.org/W1492606093","https://openalex.org/W1499309587","https://openalex.org/W1524173502","https://openalex.org/W1550109103","https://openalex.org/W1556969558","https://openalex.org/W1568529372","https://openalex.org/W1579336178","https://openalex.org/W1585469912","https://openalex.org/W1668953894","https://openalex.org/W1840693165","https://openalex.org/W1866854460","https://openalex.org/W1888783223","https://openalex.org/W1967776511","https://openalex.org/W1991743392","https://openalex.org/W2010237936","https://openalex.org/W2010484914","https://openalex.org/W2010819361","https://openalex.org/W2028706937","https://openalex.org/W2063380422","https://openalex.org/W2063500485","https://openalex.org/W2066072901","https://openalex.org/W2073993982","https://openalex.org/W2075473225","https://openalex.org/W2082575834","https://openalex.org/W2088094960","https://openalex.org/W2103918307","https://openalex.org/W2107952932","https://openalex.org/W2114530090","https://openalex.org/W2125289493","https://openalex.org/W2132083703","https://openalex.org/W2134971124","https://openalex.org/W2158708535","https://openalex.org/W2159786746","https://openalex.org/W2165289183","https://openalex.org/W2401022224","https://openalex.org/W2421037982","https://openalex.org/W2427880780"],"related_works":["https://openalex.org/W7099710401","https://openalex.org/W2125289493","https://openalex.org/W2042493533","https://openalex.org/W2140282206","https://openalex.org/W2140058638","https://openalex.org/W1525301124","https://openalex.org/W2167643299","https://openalex.org/W7097525270","https://openalex.org/W2159786746","https://openalex.org/W1995171976"],"abstract_inverted_index":{"Epstein-Barr":[0],"virus":[1],"(EBV),":[2],"an":[3,89],"oncogenic":[4],"human":[5,12,51],"herpesvirus,":[6],"binds":[7,63],"to":[8,28,46,64,80],"and":[9,65],"infects":[10],"normal":[11],"B":[13,32,52,86],"lymphocytes":[14],"via":[15],"CD21,":[16],"the":[17,23,56,71],"CR2":[18],"complement":[19],"receptor.":[20],"Studies":[21],"of":[22,40,69],"mechanisms":[24],"that":[25],"enable":[26],"EBV":[27,44,78],"infect":[29],"nonactivated,":[30],"noncycling":[31],"cells":[33,53,87],"provide":[34],"compelling":[35],"evidence":[36],"for":[37,97],"a":[38],"sequence":[39],"events":[41],"in":[42,61],"which":[43,94],"binding":[45,79],"CD21":[47],"on":[48,84],"purified":[49],"resting":[50,85],"rapidly":[54],"activates":[55],"NF-kappaB":[57],"transcription":[58],"factor,":[59],"which,":[60],"turn,":[62],"mediates":[66],"transcriptional":[67],"activation":[68],"Wp,":[70],"initial":[72],"viral":[73],"latent":[74],"gene":[75],"promoter.":[76],"Thus,":[77],"its":[81],"cellular":[82],"receptor":[83],"triggers":[88],"NF-kappaB-dependent":[90],"intracellular":[91],"signaling":[92],"pathway":[93],"is":[95],"required":[96],"infection.":[98]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}