{"id":"https://openalex.org/W2107465172","doi":"https://doi.org/10.1002/pst.138","title":"Mixture and mixture\u2013process variable experiments for pharmaceutical applications","display_name":"Mixture and mixture\u2013process variable experiments for pharmaceutical applications","publication_year":2004,"publication_date":"2004-10-01","ids":{"openalex":"https://openalex.org/W2107465172","doi":"https://doi.org/10.1002/pst.138","mag":"2107465172"},"language":"en","primary_location":{"id":"doi:10.1002/pst.138","doi":"https://doi.org/10.1002/pst.138","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pst.138","pdf_url":null,"source":{"id":"https://openalex.org/S141766756","display_name":"Pharmaceutical Statistics","issn_l":"1539-1604","issn":["1539-1604","1539-1612"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical Statistics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035506669","display_name":"Christine M. Anderson\u2010Cook","orcid":"https://orcid.org/0000-0002-0165-5565","observed_orcids":["https://orcid.org/0000-0002-0165-5565"]},"institutions":[{"id":"https://openalex.org/I1343871089","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I4210120050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine M. Anderson\u2010Cook","raw_affiliation_strings":["Los Alamos National Laboratory, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Los Alamos National Laboratory, USA","institution_ids":["https://openalex.org/I1343871089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109568772","display_name":"Heidi B. Goldfarb","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Heidi B. Goldfarb","raw_affiliation_strings":["The Dial Corporation, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Dial Corporation, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014160766","display_name":"Connie M. Borror","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I2801919071","display_name":"University of Illinois System","ror":"https://ror.org/05e94g991","country_code":"US","type":"education","lineage":["https://openalex.org/I2801919071"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Connie M. Borror","raw_affiliation_strings":["University of Illinois, USA","Univ. of Illinois, USA#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Illinois, USA","institution_ids":["https://openalex.org/I157725225","https://openalex.org/I2801919071"]},{"raw_affiliation_string":"Univ. of Illinois, USA#TAB#","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027046322","display_name":"Douglas C. Montgomery","orcid":"https://orcid.org/0000-0002-8959-134X","observed_orcids":["https://orcid.org/0000-0002-8959-134X"]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Douglas C. Montgomery","raw_affiliation_strings":["Arizona State University, USA","Arizona State University, USA#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arizona State University, USA","institution_ids":["https://openalex.org/I55732556"]},{"raw_affiliation_string":"Arizona State University, USA#TAB#","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073720913","display_name":"Kelly G. Canter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly G. Canter","raw_affiliation_strings":["Pfizer Corporation, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Corporation, USA","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003634135","display_name":"John N. Twist","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159288","display_name":"Mylan (United States)","ror":"https://ror.org/04nsw4151","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159288","https://openalex.org/I4387153459"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John N. Twist","raw_affiliation_strings":["Mylan Pharmaceuticals, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mylan Pharmaceuticals, USA","institution_ids":["https://openalex.org/I4210159288"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5027046322"],"corresponding_institution_ids":["https://openalex.org/I55732556"],"apc_list":{"value":4880,"currency":"USD","value_usd":4880},"apc_paid":null,"fwci":0.5253,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.75521583,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"3","issue":"4","first_page":"247","last_page":"260"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11798","display_name":"Optimal Experimental Design Methods","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1803","display_name":"Management Science and Operations Research"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11798","display_name":"Optimal Experimental Design Methods","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1803","display_name":"Management Science and Operations Research"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11901","display_name":"Bayesian Methods and Mixture Models","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mixture-experiments","display_name":"mixture experiments","score":0.9829999804496765},{"id":"https://openalex.org/keywords/experimental-design","display_name":"experimental design","score":0.753000020980835},{"id":"https://openalex.org/keywords/tablet-formulation","display_name":"tablet formulation","score":0.8930000066757202},{"id":"https://openalex.org/keywords/pharmaceutical-research-and-development","display_name":"pharmaceutical R&D","score":0.8230000138282776},{"id":"https://openalex.org/keywords/process-factors","display_name":"process factors","score":0.5019999742507935}],"concepts":[{"id":"https://openalex.org/C34559072","wikidata":"https://www.wikidata.org/wiki/Q2334061","display_name":"Design of experiments","level":2,"score":0.5564435720443726},{"id":"https://openalex.org/C2780589914","wikidata":"https://www.wikidata.org/wiki/Q10675206","display_name":"Ingredient","level":2,"score":0.5063973665237427},{"id":"https://openalex.org/C45904493","wikidata":"https://www.wikidata.org/wiki/Q912807","display_name":"Active ingredient","level":2,"score":0.4805029630661011},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.47558271884918213},{"id":"https://openalex.org/C182365436","wikidata":"https://www.wikidata.org/wiki/Q50701","display_name":"Variable (mathematics)","level":2,"score":0.45149654150009155},{"id":"https://openalex.org/C61224824","wikidata":"https://www.wikidata.org/wiki/Q2260434","display_name":"Mixture model","level":2,"score":0.430764377117157},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4021461009979248},{"id":"https://openalex.org/C21880701","wikidata":"https://www.wikidata.org/wiki/Q2144042","display_name":"Process engineering","level":1,"score":0.38402023911476135},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.37911054491996765},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.30028849840164185},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.28935307264328003},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1887507438659668},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.09310165047645569},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07955262064933777},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.05772542953491211},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/pst.138","doi":"https://doi.org/10.1002/pst.138","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pst.138","pdf_url":null,"source":{"id":"https://openalex.org/S141766756","display_name":"Pharmaceutical Statistics","issn_l":"1539-1604","issn":["1539-1604","1539-1612"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical Statistics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W7853605","https://openalex.org/W1518301943","https://openalex.org/W1558966030","https://openalex.org/W1983118771","https://openalex.org/W2007495522","https://openalex.org/W2033525158","https://openalex.org/W2044771513","https://openalex.org/W2071890004","https://openalex.org/W2078751722","https://openalex.org/W2141216374","https://openalex.org/W2160460989","https://openalex.org/W2395988252","https://openalex.org/W4235977256"],"related_works":["https://openalex.org/W2062277543","https://openalex.org/W4401372398","https://openalex.org/W2479500192","https://openalex.org/W2141216374","https://openalex.org/W3006354414","https://openalex.org/W2110971461","https://openalex.org/W598798292","https://openalex.org/W1993037051","https://openalex.org/W3048738378","https://openalex.org/W4246026110"],"abstract_inverted_index":{"Abstract":[0],"Many":[1],"experiments":[2,16],"in":[3,7,17,117],"research":[4,119],"and":[5,28,79,94,120],"development":[6],"the":[8,19,23,29,36,47,58,81,92],"pharmaceutical":[9,118],"industry":[10],"involve":[11],"mixture":[12,27,48,59,82],"components.":[13],"These":[14],"are":[15,22,64],"which":[18],"experimental":[20],"factors":[21,70],"ingredients":[24,49],"of":[25,35,39,57,76,80,96,99,114],"a":[26,33,86],"response":[30],"variable":[31,88],"is":[32,109],"function":[34],"relative":[37],"proportion":[38],"each":[40,77],"ingredient,":[41],"not":[42],"its":[43],"absolute":[44],"amount.":[45],"Thus":[46],"cannot":[50],"be":[51,73],"varied":[52,74],"independently.":[53],"A":[54],"common":[55],"variation":[56],"experiment":[60],"occurs":[61],"when":[62],"there":[63],"also":[65],"one":[66],"or":[67],"more":[68],"process":[69],"that":[71],"can":[72],"independently":[75],"other":[78],"components,":[83],"leading":[84],"to":[85,110],"mixture\u2013process":[87],"experiment.":[89],"We":[90],"discuss":[91],"design":[93],"analysis":[95],"these":[97,115],"types":[98],"experiments,":[100],"using":[101],"tablet":[102],"formulation":[103],"as":[104],"an":[105],"example.":[106],"Our":[107],"objective":[108],"encourage":[111],"greater":[112],"utilization":[113],"techniques":[116],"development.":[121],"Copyright":[122],"\u00a9":[123],"2004":[124],"John":[125],"Wiley":[126],"&":[127],"Sons":[128],"Ltd.":[129]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
