{"id":"https://openalex.org/W2107464441","doi":"https://doi.org/10.2337/diabetes.47.11.1671","title":"Removal of adenosine decreases the responsiveness of muscle glucose transport to insulin and contractions.","display_name":"Removal of adenosine decreases the responsiveness of muscle glucose transport to insulin and contractions.","publication_year":1998,"publication_date":"1998-11-01","ids":{"openalex":"https://openalex.org/W2107464441","doi":"https://doi.org/10.2337/diabetes.47.11.1671","mag":"2107464441","pmid":"https://pubmed.ncbi.nlm.nih.gov/9792534"},"language":"en","primary_location":{"id":"doi:10.2337/diabetes.47.11.1671","doi":"https://doi.org/10.2337/diabetes.47.11.1671","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diabetes.47.11.1671","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"D H Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D H Han","raw_affiliation_strings":["Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027247460","display_name":"Polly A. Hansen","orcid":"https://orcid.org/0000-0002-2095-2493","observed_orcids":["https://orcid.org/0000-0002-2095-2493"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P A Hansen","raw_affiliation_strings":["Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111734905","display_name":"Lorraine A. Nolte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L A Nolte","raw_affiliation_strings":["Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110844716","display_name":"John O. Holloszy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J O Holloszy","raw_affiliation_strings":["Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":null,"apc_paid":null,"fwci":3.0705,"has_fulltext":false,"cited_by_count":92,"citation_normalized_percentile":{"value":0.92155756,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"47","issue":"11","first_page":"1671","last_page":"1675"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.5396000146865845,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.5396000146865845,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.4458000063896179,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adenosine","display_name":"adenosine","score":0.9869999885559082},{"id":"https://openalex.org/keywords/skeletal-muscle-glucose-transport","display_name":"skeletal muscle glucose transport","score":0.9160000085830688},{"id":"https://openalex.org/keywords/insulin-stimulated-glucose-transport","display_name":"insulin-stimulated glucose transport","score":0.9459999799728394},{"id":"https://openalex.org/keywords/muscle-contraction","display_name":"muscle contraction","score":0.6800000071525574},{"id":"https://openalex.org/keywords/glut4-translocation","display_name":"GLUT4 translocation","score":0.7419999837875366},{"id":"https://openalex.org/keywords/adenosine-deaminase","display_name":"adenosine deaminase","score":0.8899999856948853},{"id":"https://openalex.org/keywords/adenosine-receptors","display_name":"adenosine receptors","score":0.7080000042915344},{"id":"https://openalex.org/keywords/epitrochlearis-muscle","display_name":"epitrochlearis muscle","score":0.9039999842643738},{"id":"https://openalex.org/keywords/soleus-muscle","display_name":"soleus muscle","score":1.0},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.7820000052452087},{"id":"https://openalex.org/keywords/extracellular-adenosine","display_name":"extracellular adenosine","score":0.7860000133514404}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8494424819946289},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8122656345367432},{"id":"https://openalex.org/C2776188179","wikidata":"https://www.wikidata.org/wiki/Q24768727","display_name":"GLUT4","level":4,"score":0.7755274772644043},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.7653486728668213},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6620988845825195},{"id":"https://openalex.org/C34628245","wikidata":"https://www.wikidata.org/wiki/Q356093","display_name":"Adenosine deaminase","level":3,"score":0.5943855047225952},{"id":"https://openalex.org/C161573976","wikidata":"https://www.wikidata.org/wiki/Q420277","display_name":"Glucose transporter","level":3,"score":0.5698858499526978},{"id":"https://openalex.org/C182683403","wikidata":"https://www.wikidata.org/wiki/Q14888579","display_name":"Adenosine A1 receptor","level":5,"score":0.48921728134155273},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.45554935932159424},{"id":"https://openalex.org/C2777866211","wikidata":"https://www.wikidata.org/wiki/Q5572349","display_name":"Glucose uptake","level":3,"score":0.4508858919143677},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42640814185142517},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.41209641098976135},{"id":"https://openalex.org/C67907053","wikidata":"https://www.wikidata.org/wiki/Q356147","display_name":"Adenosine receptor","level":4,"score":0.39407116174697876},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36336004734039307},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19011154770851135},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1711178421974182},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.07301676273345947}],"mesh":[{"descriptor_ui":"D000067956","descriptor_name":"Adenylyl Cyclase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000243","descriptor_name":"Adenosine Deaminase","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009004","descriptor_name":"Monosaccharide Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009124","descriptor_name":"Muscle Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014970","descriptor_name":"Xanthines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018047","descriptor_name":"Receptors, Purinergic P1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051275","descriptor_name":"Glucose Transporter Type 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2337/diabetes.47.11.1671","doi":"https://doi.org/10.2337/diabetes.47.11.1671","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diabetes.47.11.1671","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"pmid:9792534","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9792534","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G507895129","display_name":null,"funder_award_id":"AG 00078","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8100243051","display_name":"Carbohydrate and Fat Metabolism During Exercise","funder_award_id":"R01DK018986","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1554235282","https://openalex.org/W1577804997","https://openalex.org/W1599097515","https://openalex.org/W1963599442","https://openalex.org/W2086611782","https://openalex.org/W2122460963","https://openalex.org/W2151763612","https://openalex.org/W2168808578","https://openalex.org/W2279574053","https://openalex.org/W2296784018","https://openalex.org/W2405919402","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2028643546","https://openalex.org/W2146405130","https://openalex.org/W1963599442","https://openalex.org/W7095642481","https://openalex.org/W2254172940","https://openalex.org/W1786671386","https://openalex.org/W1978337194","https://openalex.org/W2199355155","https://openalex.org/W2004918519","https://openalex.org/W2087976139"],"abstract_inverted_index":{"Adenosine":[0],"in":[1,9,16,31,51,93,99,105,113,134,140,145,151,166,173,194],"the":[2,13,27,67,74,97,102,114,118,143,171,176,181],"extracellular":[3],"space":[4],"modulates":[5],"stimulated":[6],"glucose":[7,21,46,77,148,164],"transport":[8,78,149,165],"striated":[10],"muscle.":[11],"In":[12],"heart":[14],"and":[15,41,54,88,91,162,179],"adipocytes,":[17],"adenosine":[18,30,58,60,68,124,152,159,185],"potentiates":[19,160],"insulin-stimulated":[20,45,147],"transport.":[22,47],"There":[23],"is":[24],"controversy":[25],"regarding":[26],"effect":[28,40],"of":[29,36,76,96],"skeletal":[32,167],"muscle,":[33,116],"with":[34,59,66],"reports":[35],"both":[37],"an":[38],"inhibitory":[39],"no":[42],"effect,":[43],"on":[44],"We":[48],"found":[49],"that,":[50],"rat":[52],"epitrochlearis":[53,115],"soleus":[55],"muscles,":[56],"removing":[57],"deaminase":[61,125],"or":[62,187],"blocking":[63],"its":[64],"action":[65,188],"receptor":[69],"blocker":[70],"CPDPX":[71],"markedly":[72,127],"reduces":[73,128],"responsiveness":[75],"to":[79,107,142],"stimulation":[80],"by":[81,169],"1)":[82],"insulin":[83,90,111,195],"alone,":[84,87],"2)":[85],"contractions":[86,92],"3)":[89],"combination.":[94],"Measurement":[95],"increase":[98,172],"GLUT4":[100,130,136,174],"at":[101,175],"cell":[103,177],"surface":[104,178],"response":[106],"a":[108,191],"maximally":[109,146],"effective":[110],"stimulus":[112],"using":[117],"exofacial":[119],"label":[120],"ATB-[3H]BMPA,":[121],"showed":[122],"that":[123,158,183],"treatment":[126],"cell-surface":[129,135],"labeling.":[131],"The":[132],"reduction":[133],"labeling":[137],"was":[138],"similar":[139],"magnitude":[141],"decrease":[144],"activity":[150],"deaminase-treated":[153],"muscles.":[154],"These":[155],"results":[156],"show":[157],"insulin-":[161],"contraction-stimulated":[163],"muscle":[168],"enhancing":[170],"raise":[180],"possibility":[182],"decreased":[184],"production":[186],"could":[189],"play":[190],"causative":[192],"role":[193],"resistance.":[196]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}