{"id":"https://openalex.org/W2107445688","doi":null,"title":"Early clinical cancer trials: Proof of concept and beyond","display_name":"Early clinical cancer trials: Proof of concept and beyond","publication_year":2011,"publication_date":"2011-02-04","ids":{"openalex":"https://openalex.org/W2107445688","mag":"2107445688"},"language":"en","primary_location":{"id":"pmh:eur:oai:pure.eur.nl:publications/82e6ee39-1269-4b44-85b9-8625132d7593","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/82e6ee39-1269-4b44-85b9-8625132d7593","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pure.eur.nl/en/publications/82e6ee39-1269-4b44-85b9-8625132d7593","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103026138","display_name":"Inge R. H. M. Konings","orcid":"https://orcid.org/0000-0002-9574-4023","observed_orcids":["https://orcid.org/0000-0002-9574-4023","https://orcid.org/0000-0002-2798-704X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Inge R. Konings","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9574-4023","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5103026138"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10582","display_name":"Ethics in Clinical Research","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13656","display_name":"Science, Research, and Medicine","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proof-of-concept","display_name":"proof of concept","score":0.8339999914169312},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.7670000195503235},{"id":"https://openalex.org/keywords/clinical-trial-design","display_name":"clinical trial design","score":0.5889999866485596},{"id":"https://openalex.org/keywords/tumor-biology","display_name":"tumor biology","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.6669993996620178},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6547720432281494},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5381271839141846},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.43843555450439453},{"id":"https://openalex.org/C3019816032","wikidata":"https://www.wikidata.org/wiki/Q2575340","display_name":"Cancer treatment","level":3,"score":0.4171265661716461},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3538033366203308},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.22141563892364502},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20143452286720276},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:eur:oai:pure.eur.nl:publications/82e6ee39-1269-4b44-85b9-8625132d7593","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/82e6ee39-1269-4b44-85b9-8625132d7593","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"pmh:eur:oai:repub.eur.nl:22796","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1765/22796","pdf_url":null,"source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"pmh:oai:repub.eur.nl:22796","doi":null,"is_oa":false,"landing_page_url":"https://repub.eur.nl/pub/22796","pdf_url":null,"source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2107445688","doi":null,"is_oa":false,"landing_page_url":"https://repub.eur.nl/pub/22796/110204_Konings, Ingeborg Regina Huberta Maria.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:eur:oai:pure.eur.nl:publications/82e6ee39-1269-4b44-85b9-8625132d7593","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/82e6ee39-1269-4b44-85b9-8625132d7593","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":164,"referenced_works":["https://openalex.org/W12110721","https://openalex.org/W29865278","https://openalex.org/W33710999","https://openalex.org/W167816258","https://openalex.org/W1417844963","https://openalex.org/W1509578301","https://openalex.org/W1557142436","https://openalex.org/W1566849814","https://openalex.org/W1569610737","https://openalex.org/W1571264139","https://openalex.org/W1579641819","https://openalex.org/W1593019308","https://openalex.org/W1599727238","https://openalex.org/W1634760965","https://openalex.org/W1639582946","https://openalex.org/W1660048993","https://openalex.org/W1875373156","https://openalex.org/W1885232396","https://openalex.org/W1943068165","https://openalex.org/W1963581413","https://openalex.org/W1964493635","https://openalex.org/W1967280935","https://openalex.org/W1968960893","https://openalex.org/W1970434896","https://openalex.org/W1971837077","https://openalex.org/W1972568719","https://openalex.org/W1973296923","https://openalex.org/W1974693247","https://openalex.org/W1974952755","https://openalex.org/W1974969947","https://openalex.org/W1975672959","https://openalex.org/W1975787992","https://openalex.org/W1977024706","https://openalex.org/W1980588823","https://openalex.org/W1980637733","https://openalex.org/W1981453711","https://openalex.org/W1985553251","https://openalex.org/W1989484851","https://openalex.org/W1992408996","https://openalex.org/W1993016882","https://openalex.org/W1995152152","https://openalex.org/W2001693787","https://openalex.org/W2006198477","https://openalex.org/W2006426893","https://openalex.org/W2007882332","https://openalex.org/W2011364372","https://openalex.org/W2013453542","https://openalex.org/W2013988606","https://openalex.org/W2015940235","https://openalex.org/W2016206649","https://openalex.org/W2017018900","https://openalex.org/W2017082986","https://openalex.org/W2017605860","https://openalex.org/W2020538864","https://openalex.org/W2022517233","https://openalex.org/W2023945227","https://openalex.org/W2024192845","https://openalex.org/W2025137878","https://openalex.org/W2027928529","https://openalex.org/W2029882446","https://openalex.org/W2031520822","https://openalex.org/W2032022098","https://openalex.org/W2041928869","https://openalex.org/W2048131754","https://openalex.org/W2050089788","https://openalex.org/W2051839343","https://openalex.org/W2055662495","https://openalex.org/W2055827129","https://openalex.org/W2057195209","https://openalex.org/W2058237771","https://openalex.org/W2066233960","https://openalex.org/W2071013022","https://openalex.org/W2073051869","https://openalex.org/W2076426678","https://openalex.org/W2076627331","https://openalex.org/W2077173862","https://openalex.org/W2079251713","https://openalex.org/W2084303847","https://openalex.org/W2087812126","https://openalex.org/W2088201493","https://openalex.org/W2088363975","https://openalex.org/W2089257078","https://openalex.org/W2090354608","https://openalex.org/W2091130738","https://openalex.org/W2093216555","https://openalex.org/W2093469424","https://openalex.org/W2098176107","https://openalex.org/W2099088585","https://openalex.org/W2102769930","https://openalex.org/W2107055927","https://openalex.org/W2107134343","https://openalex.org/W2110444464","https://openalex.org/W2111101616","https://openalex.org/W2112001957","https://openalex.org/W2112064092","https://openalex.org/W2112893608","https://openalex.org/W2113365503","https://openalex.org/W2114281628","https://openalex.org/W2115100370","https://openalex.org/W2116996913","https://openalex.org/W2118333556","https://openalex.org/W2118677643","https://openalex.org/W2121117803","https://openalex.org/W2121554308","https://openalex.org/W2122816286","https://openalex.org/W2125496066","https://openalex.org/W2126358767","https://openalex.org/W2126446022","https://openalex.org/W2127930047","https://openalex.org/W2128328462","https://openalex.org/W2128923437","https://openalex.org/W2130522735","https://openalex.org/W2131597845","https://openalex.org/W2132027537","https://openalex.org/W2132128791","https://openalex.org/W2135726947","https://openalex.org/W2137063143","https://openalex.org/W2137405846","https://openalex.org/W2139248078","https://openalex.org/W2141061207","https://openalex.org/W2142364508","https://openalex.org/W2143645520","https://openalex.org/W2143782771","https://openalex.org/W2147156144","https://openalex.org/W2147394591","https://openalex.org/W2147761753","https://openalex.org/W2148842373","https://openalex.org/W2149218373","https://openalex.org/W2150937214","https://openalex.org/W2151709942","https://openalex.org/W2153491150","https://openalex.org/W2153493705","https://openalex.org/W2153867442","https://openalex.org/W2154108823","https://openalex.org/W2154502317","https://openalex.org/W2157262448","https://openalex.org/W2159500653","https://openalex.org/W2160363302","https://openalex.org/W2160573271","https://openalex.org/W2162233545","https://openalex.org/W2162749413","https://openalex.org/W2162957857","https://openalex.org/W2164977235","https://openalex.org/W2165264849","https://openalex.org/W2165836181","https://openalex.org/W2166550586","https://openalex.org/W2167873388","https://openalex.org/W2169689529","https://openalex.org/W2225644272","https://openalex.org/W2231000545","https://openalex.org/W2240403613","https://openalex.org/W2244727579","https://openalex.org/W2249698993","https://openalex.org/W2270901686","https://openalex.org/W2277470516","https://openalex.org/W2277765299","https://openalex.org/W2286186015","https://openalex.org/W2409698846","https://openalex.org/W2589337990","https://openalex.org/W2591123310","https://openalex.org/W2601485429","https://openalex.org/W2604239337","https://openalex.org/W2942054879","https://openalex.org/W3022312776"],"related_works":["https://openalex.org/W1995661057","https://openalex.org/W2077078015","https://openalex.org/W3203503329","https://openalex.org/W3144462144","https://openalex.org/W2601615883","https://openalex.org/W4231828022","https://openalex.org/W2168548734","https://openalex.org/W6989056837","https://openalex.org/W1974298534","https://openalex.org/W4378832498"],"abstract_inverted_index":{"Over":[0],"the":[1,30,36],"last":[2],"few":[3],"decades":[4],"clinical":[5],"cancer":[6,40,89],"research":[7,41],"has":[8],"developed":[9],"at":[10,78],"accelerating":[11],"speed,\\\\nresulting":[12],"in":[13,63,72,75,86,91,94,100],"a":[14,50],"tremendous":[15],"increase":[16],"of":[17,33,39,53],"knowledge":[18],"with":[19,26,49],"regard":[20],"to":[21,43,83],"tumour":[22,27],"biology,":[23],"hypotheses\\\\nto":[24],"interfere":[25],"growth":[28],"and":[29,66,74,104],"subsequent":[31],"development":[32],"anticancer":[34,56],"therapies.\\\\nObviously,":[35],"ultimate":[37],"aim":[38],"is":[42],"identify":[44],"treatment":[45],"approaches\\\\nimproving":[46],"overall":[47],"survival":[48],"good":[51],"quality":[52],"life.":[54],"Novel":[55],"therapies":[57,90],"mostly\\\\narise":[58],"from":[59],"scientifi":[60],"c":[61],"insights":[62],"preclinical":[64],"studies,":[65],"provided":[67],"that":[68],"they":[69,81],"have":[70,82],"looked\\\\npromising":[71],"vitro":[73],"animal":[76],"models,":[77],"one":[79],"point":[80],"be":[84],"tested":[85],"humans.\\\\nTesting":[87],"new":[88],"patients":[92],"occurs":[93],"diff":[95],"erent":[96],"stages,":[97],"i.e.":[98],"successively":[99],"phase\\\\nI,":[101],"phase":[102,105],"II":[103],"III":[106],"trials.":[107]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
