{"id":"https://openalex.org/W2107433464","doi":"https://doi.org/10.1073/pnas.0913574107","title":"MicroRNA miR-125a controls hematopoietic stem cell number","display_name":"MicroRNA miR-125a controls hematopoietic stem cell number","publication_year":2010,"publication_date":"2010-07-08","ids":{"openalex":"https://openalex.org/W2107433464","doi":"https://doi.org/10.1073/pnas.0913574107","mag":"2107433464","pmid":"https://pubmed.ncbi.nlm.nih.gov/20616003","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2922532"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0913574107","doi":"https://doi.org/10.1073/pnas.0913574107","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0913574107","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2922532","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072320963","display_name":"Shangqin Guo","orcid":"https://orcid.org/0000-0003-1157-0423","observed_orcids":["https://orcid.org/0000-0003-1157-0423"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210157861","display_name":"Harvard Stem Cell Institute","ror":"https://ror.org/04kj1hn59","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shangqin Guo","raw_affiliation_strings":["Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114;","Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138;","Harvard Stem Cell Institute, Cambridge, MA 02138;","Yale Stem Cell Center, Department of Genetics, Yale University, New Haven, CT 06520","Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138;","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Stem Cell Institute, Cambridge, MA 02138;","institution_ids":["https://openalex.org/I4210157861"]},{"raw_affiliation_string":"Yale Stem Cell Center, Department of Genetics, Yale University, New Haven, CT 06520","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009882164","display_name":"Jun L\u00fc","orcid":"https://orcid.org/0000-0003-2726-7613","observed_orcids":["https://orcid.org/0000-0003-2726-7613"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Lu","raw_affiliation_strings":["Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142;","Department of Pediatric Oncology, Dana-Farber Cancer Institute, and","Yale Stem Cell Center, Department of Genetics, Yale University, New Haven, CT 06520","Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142;","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I136199984","https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Pediatric Oncology, Dana-Farber Cancer Institute, and","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Yale Stem Cell Center, Department of Genetics, Yale University, New Haven, CT 06520","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049131731","display_name":"Rita Schlanger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210157861","display_name":"Harvard Stem Cell Institute","ror":"https://ror.org/04kj1hn59","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rita Schlanger","raw_affiliation_strings":["Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114;","Harvard Stem Cell Institute, Cambridge, MA 02138;","Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA","Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard Stem Cell Institute, Cambridge, MA 02138;","institution_ids":["https://openalex.org/I4210157861"]},{"raw_affiliation_string":"Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA","institution_ids":["https://openalex.org/I4210157861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100396959","display_name":"Hao Zhang","orcid":"https://orcid.org/0000-0002-7971-2646","observed_orcids":["https://orcid.org/0000-0002-7971-2646"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hao Zhang","raw_affiliation_strings":["Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142;","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I136199984","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003823455","display_name":"Judy Y. Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Judy Y. Wang","raw_affiliation_strings":["Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142;","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I136199984","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061321370","display_name":"Michelle C. Fox","orcid":"https://orcid.org/0009-0004-4668-0408","observed_orcids":["https://orcid.org/0009-0004-4668-0408"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210157861","display_name":"Harvard Stem Cell Institute","ror":"https://ror.org/04kj1hn59","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle C. Fox","raw_affiliation_strings":["Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114;","Harvard Stem Cell Institute, Cambridge, MA 02138;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard Stem Cell Institute, Cambridge, MA 02138;","institution_ids":["https://openalex.org/I4210157861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087291616","display_name":"Louise E. Purton","orcid":"https://orcid.org/0000-0001-6593-3168","observed_orcids":["https://orcid.org/0000-0001-6593-3168"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210157861","display_name":"Harvard Stem Cell Institute","ror":"https://ror.org/04kj1hn59","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Louise E. Purton","raw_affiliation_strings":["Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114;","Harvard Stem Cell Institute, Cambridge, MA 02138;","Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA","Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard Stem Cell Institute, Cambridge, MA 02138;","institution_ids":["https://openalex.org/I4210157861"]},{"raw_affiliation_string":"Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA","institution_ids":["https://openalex.org/I4210157861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052097356","display_name":"Heather E. Fleming","orcid":"https://orcid.org/0000-0002-5286-3794","observed_orcids":["https://orcid.org/0000-0002-5286-3794"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210157861","display_name":"Harvard Stem Cell Institute","ror":"https://ror.org/04kj1hn59","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather H. Fleming","raw_affiliation_strings":["Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114;","Harvard Stem Cell Institute, Cambridge, MA 02138;","Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA","Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard Stem Cell Institute, Cambridge, MA 02138;","institution_ids":["https://openalex.org/I4210157861"]},{"raw_affiliation_string":"Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA","institution_ids":["https://openalex.org/I4210157861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012461176","display_name":"Bradley S. Cobb","orcid":"https://orcid.org/0000-0001-6783-0509","observed_orcids":["https://orcid.org/0000-0001-6783-0509"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Bradley Cobb","raw_affiliation_strings":["Lymphocyte Development Group, Medical Research Center Clinical Sciences Centre, Imperial College London, London W12 0NN, United Kingdom; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lymphocyte Development Group, Medical Research Center Clinical Sciences Centre, Imperial College London, London W12 0NN, United Kingdom; and","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073285869","display_name":"Matthias Merkenschlager","orcid":"https://orcid.org/0000-0003-2889-3288","observed_orcids":["https://orcid.org/0000-0003-2889-3288"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Matthias Merkenschlager","raw_affiliation_strings":["Lymphocyte Development Group, Medical Research Center Clinical Sciences Centre, Imperial College London, London W12 0NN, United Kingdom; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lymphocyte Development Group, Medical Research Center Clinical Sciences Centre, Imperial College London, London W12 0NN, United Kingdom; and","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001449157","display_name":"Todd R. Golub","orcid":"https://orcid.org/0000-0003-0113-2403","observed_orcids":["https://orcid.org/0000-0003-0113-2403"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd R. Golub","raw_affiliation_strings":["Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142;","The Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115;","Yale Stem Cell Center, Department of Genetics, Yale University, New Haven, CT 06520","Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA","Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142;","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I136199984","https://openalex.org/I63966007"]},{"raw_affiliation_string":"The Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115;","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Yale Stem Cell Center, Department of Genetics, Yale University, New Haven, CT 06520","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083648953","display_name":"David T. Scadden","orcid":"https://orcid.org/0000-0001-9821-7133","observed_orcids":["https://orcid.org/0000-0001-9821-7133"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210157861","display_name":"Harvard Stem Cell Institute","ror":"https://ror.org/04kj1hn59","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David T. Scadden","raw_affiliation_strings":["Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114;","Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138;","Harvard Stem Cell Institute, Cambridge, MA 02138;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138;","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Stem Cell Institute, Cambridge, MA 02138;","institution_ids":["https://openalex.org/I4210157861"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":9.2506,"has_fulltext":false,"cited_by_count":330,"citation_normalized_percentile":{"value":0.98606005,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"107","issue":"32","first_page":"14229","last_page":"14234"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.6410999894142151,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.6410999894142151,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.3537999987602234,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-125a","display_name":"miR-125a","score":0.9959999918937683},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.7680000066757202},{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.9399999976158142},{"id":"https://openalex.org/keywords/dicer","display_name":"Dicer","score":0.7549999952316284},{"id":"https://openalex.org/keywords/stem-cell-apoptosis","display_name":"stem cell apoptosis","score":0.5740000009536743},{"id":"https://openalex.org/keywords/hematopoietic-stem-and-progenitor-cells","display_name":"hematopoietic stem and progenitor cells","score":0.8640000224113464},{"id":"https://openalex.org/keywords/bak1","display_name":"BAK1","score":0.8029999732971191},{"id":"https://openalex.org/keywords/let-7e","display_name":"let-7e","score":0.75},{"id":"https://openalex.org/keywords/mir-99b","display_name":"miR-99b","score":0.9980000257492065},{"id":"https://openalex.org/keywords/microrna-cluster","display_name":"miRNA clusters","score":0.7850000262260437},{"id":"https://openalex.org/keywords/long-term-hematopoietic-stem-cells","display_name":"long-term hematopoietic stem cells","score":0.8629999756813049},{"id":"https://openalex.org/keywords/hematopoietic-differentiation","display_name":"hematopoietic differentiation","score":0.6840000152587891},{"id":"https://openalex.org/keywords/conditional-gene-deletion","display_name":"conditional gene deletion","score":0.4620000123977661}],"concepts":[{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.7817819118499756},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.765249490737915},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.7042113542556763},{"id":"https://openalex.org/C2779867133","wikidata":"https://www.wikidata.org/wiki/Q21111297","display_name":"Dicer","level":5,"score":0.7026225328445435},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.648060142993927},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6277393102645874},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6195530891418457},{"id":"https://openalex.org/C2778086970","wikidata":"https://www.wikidata.org/wiki/Q514525","display_name":"Hematopoietic stem cell","level":4,"score":0.5815200805664062},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.48236793279647827},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20961815118789673},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.19224566221237183},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10373762249946594},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.07578852772712708},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004722","descriptor_name":"Endoribonucleases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D043244","descriptor_name":"Ribonuclease III","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050998","descriptor_name":"bcl-2 Homologous Antagonist-Killer Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053487","descriptor_name":"DEAD-box RNA Helicases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1073/pnas.0913574107","doi":"https://doi.org/10.1073/pnas.0913574107","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0913574107","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2922532","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2922532","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:20616003","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20616003","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:dash.harvard.edu:1/4341695","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:4341695","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:researchonline.rvc.ac.uk:6239","doi":null,"is_oa":true,"landing_page_url":"http://researchonline.rvc.ac.uk/id/eprint/6239/","pdf_url":null,"source":{"id":"https://openalex.org/S4306402069","display_name":"RVC Research Online (Royal Veterinary College)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I133836048","host_organization_name":"Royal Veterinary College","host_organization_lineage":["https://openalex.org/I133836048"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2922532","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2922532","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"score":0.766700029373169,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1916491745","https://openalex.org/W1953301620","https://openalex.org/W1964631913","https://openalex.org/W1969822495","https://openalex.org/W1972064898","https://openalex.org/W1974595624","https://openalex.org/W1989543257","https://openalex.org/W1991021907","https://openalex.org/W1996441871","https://openalex.org/W2011059916","https://openalex.org/W2014974499","https://openalex.org/W2021050536","https://openalex.org/W2024421175","https://openalex.org/W2024704386","https://openalex.org/W2025567420","https://openalex.org/W2026570544","https://openalex.org/W2026873116","https://openalex.org/W2026990179","https://openalex.org/W2038970416","https://openalex.org/W2052904272","https://openalex.org/W2057403210","https://openalex.org/W2062133747","https://openalex.org/W2062378348","https://openalex.org/W2109336877","https://openalex.org/W2109377963","https://openalex.org/W2113440844","https://openalex.org/W2116322544","https://openalex.org/W2117472344","https://openalex.org/W2117991391","https://openalex.org/W2118694755","https://openalex.org/W2120279642","https://openalex.org/W2130979840","https://openalex.org/W2140254135","https://openalex.org/W2145185496","https://openalex.org/W2158556487","https://openalex.org/W2161693225","https://openalex.org/W2166179294","https://openalex.org/W2166887786"],"related_works":["https://openalex.org/W1983841935","https://openalex.org/W2160943450","https://openalex.org/W2915810902","https://openalex.org/W2057676422","https://openalex.org/W2483627127","https://openalex.org/W7096052550","https://openalex.org/W3132513162","https://openalex.org/W1991663093","https://openalex.org/W3112888908","https://openalex.org/W3199511066"],"abstract_inverted_index":{"MicroRNAs":[0],"influence":[1],"hematopoietic":[2,48,92,105,127,149],"differentiation,":[3],"but":[4],"little":[5],"is":[6,25],"known":[7],"about":[8],"their":[9],"effects":[10],"on":[11],"the":[12,20,39,42,62,102,168],"stem":[13,28,43,93,106,169],"cell":[14,29,44,50,170],"state.":[15],"Here,":[16],"we":[17],"report":[18],"that":[19],"microRNA":[21,80,159,164],"processing":[22],"enzyme":[23],"Dicer":[24,56],"essential":[26],"for":[27,61],"persistence":[30],"in":[31,66,74,90,108,125,151],"vivo":[32,109],"and":[33,85,141,160],"a":[34,67,119,144,162],"specific":[35],"microRNA,":[36],"miR-125a,":[37],"controls":[38],"size":[40],"of":[41,55,100,104,123,143],"population":[45,65],"by":[46,110,139,158],"regulating":[47],"stem/progenitor":[49],"(HSPC)":[51],"apoptosis.":[52],"Conditional":[53],"deletion":[54],"revealed":[57],"an":[58],"absolute":[59],"dependence":[60],"multipotent":[63],"HSPC":[64,72],"cell-autonomous":[68],"manner,":[69],"with":[70],"increased":[71],"apoptosis":[73,124],"mutant":[75],"animals.":[76],"An":[77],"evolutionarily":[78],"conserved":[79],"cluster":[81],"containing":[82],"miR-99b,":[83],"let-7e,":[84],"miR-125a":[86,96,140],"was":[87,98,116,136],"preferentially":[88],"expressed":[89],"long-term":[91],"cells.":[94],"MicroRNA":[95],"alone":[97],"capable":[99],"increasing":[101],"number":[103],"cells":[107],"more":[111],"than":[112],"8-fold.":[113],"This":[114],"result":[115],"accomplished":[117],"through":[118,130],"differentiation":[120],"stage-specific":[121],"reduction":[122],"immature":[126],"progenitors,":[128],"possibly":[129],"targeting":[131],"multiple":[132],"proapoptotic":[133],"genes.":[134],"Bak1":[135,146],"directly":[137],"down-regulated":[138],"expression":[142],"3'UTR-less":[145],"blocked":[147],"miR-125a-induced":[148],"expansion":[150],"vivo.":[152],"These":[153],"data":[154],"demonstrate":[155],"cell-state-specific":[156],"regulation":[157],"identify":[161],"unique":[163],"functioning":[165],"to":[166],"regulate":[167],"pool":[171],"size.":[172]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":21},{"year":2019,"cited_by_count":22},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":23},{"year":2016,"cited_by_count":25},{"year":2015,"cited_by_count":29},{"year":2014,"cited_by_count":37},{"year":2013,"cited_by_count":32},{"year":2012,"cited_by_count":38}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
