{"id":"https://openalex.org/W2107367266","doi":"https://doi.org/10.1128/iai.62.8.3184-3188.1994","title":"Interaction of the two components of leukocidin from Staphylococcus aureus with human polymorphonuclear leukocyte membranes: sequential binding and subsequent activation","display_name":"Interaction of the two components of leukocidin from Staphylococcus aureus with human polymorphonuclear leukocyte membranes: sequential binding and subsequent activation","publication_year":1994,"publication_date":"1994-08-01","ids":{"openalex":"https://openalex.org/W2107367266","doi":"https://doi.org/10.1128/iai.62.8.3184-3188.1994","mag":"2107367266","pmid":"https://pubmed.ncbi.nlm.nih.gov/8039887","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/302944"},"language":"en","primary_location":{"id":"doi:10.1128/iai.62.8.3184-3188.1994","doi":"https://doi.org/10.1128/iai.62.8.3184-3188.1994","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.62.8.3184-3188.1994","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC302944","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103500681","display_name":"Didier Andr\u00e9 Colin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"D A Colin","raw_affiliation_strings":["Laboratoire de Toxinologie Bact\u00e9rienne, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Louis Pasteur, Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Toxinologie Bact\u00e9rienne, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Louis Pasteur, Strasbourg, France","institution_ids":["https://openalex.org/I68947357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088654204","display_name":"Isabelle Mazurier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"I Mazurier","raw_affiliation_strings":["Laboratoire de Toxinologie Bact\u00e9rienne, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Louis Pasteur, Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Toxinologie Bact\u00e9rienne, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Louis Pasteur, Strasbourg, France","institution_ids":["https://openalex.org/I68947357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108505703","display_name":"St\u00e9phane Sire","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"S Sire","raw_affiliation_strings":["Laboratoire de Toxinologie Bact\u00e9rienne, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Louis Pasteur, Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Toxinologie Bact\u00e9rienne, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Louis Pasteur, Strasbourg, France","institution_ids":["https://openalex.org/I68947357"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021189230","display_name":"Viviane Finck\u2010Barban\u00e7on","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"V Finck-Barban\u00e7on","raw_affiliation_strings":["Laboratoire de Toxinologie Bact\u00e9rienne, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Louis Pasteur, Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Toxinologie Bact\u00e9rienne, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Louis Pasteur, Strasbourg, France","institution_ids":["https://openalex.org/I68947357"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I68947357"],"apc_list":null,"apc_paid":null,"fwci":2.4782,"has_fulltext":false,"cited_by_count":120,"citation_normalized_percentile":{"value":0.89134698,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"62","issue":"8","first_page":"3184","last_page":"3188"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.7724999785423279,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.7724999785423279,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.10490000247955322,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.030500000342726707,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leukocidin","display_name":"leukocidin","score":0.9110000133514404},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9950000047683716},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.9190000295639038},{"id":"https://openalex.org/keywords/sequential-binding","display_name":"sequential binding","score":0.8130000233650208},{"id":"https://openalex.org/keywords/neutrophil-activation","display_name":"neutrophil activation","score":0.8519999980926514},{"id":"https://openalex.org/keywords/lysozyme","display_name":"lysozyme","score":0.8619999885559082},{"id":"https://openalex.org/keywords/hexosaminidase","display_name":"hexosaminidase","score":0.9900000095367432},{"id":"https://openalex.org/keywords/calcium-dependent-binding","display_name":"calcium-dependent binding","score":0.6660000085830688}],"concepts":[{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.7154564261436462},{"id":"https://openalex.org/C2776966407","wikidata":"https://www.wikidata.org/wiki/Q24779410","display_name":"Lysozyme","level":2,"score":0.6244058012962341},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.5663907527923584},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.5513080954551697},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.5484907031059265},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5473957657814026},{"id":"https://openalex.org/C2777805791","wikidata":"https://www.wikidata.org/wiki/Q16889545","display_name":"Leukocidin","level":5,"score":0.5062867403030396},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.48384323716163635},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4763776957988739},{"id":"https://openalex.org/C2777983669","wikidata":"https://www.wikidata.org/wiki/Q223143","display_name":"Granulocyte","level":2,"score":0.47175484895706177},{"id":"https://openalex.org/C49760210","wikidata":"https://www.wikidata.org/wiki/Q5596727","display_name":"Granule (geology)","level":2,"score":0.420940101146698},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33570337295532227},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.22230765223503113},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.20723319053649902},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C2777052132","wikidata":"https://www.wikidata.org/wiki/Q595158","display_name":"Methicillin-resistant Staphylococcus aureus","level":4,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007956","descriptor_name":"Leukocidins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007956","descriptor_name":"Leukocidins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1128/iai.62.8.3184-3188.1994","doi":"https://doi.org/10.1128/iai.62.8.3184-3188.1994","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.62.8.3184-3188.1994","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:89871","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC302944","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:302944","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/302944","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Immun","raw_type":"Text"},{"id":"pmid:8039887","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8039887","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and immunity","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.606.3242","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.606.3242","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://iai.highwire.org/content/62/8/3184.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:89871","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC302944","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1486635927","https://openalex.org/W1880713856","https://openalex.org/W1897911390","https://openalex.org/W1913839795","https://openalex.org/W1920303758","https://openalex.org/W1963573942","https://openalex.org/W1999463130","https://openalex.org/W2031576809","https://openalex.org/W2041195097","https://openalex.org/W2050036543","https://openalex.org/W2069600053","https://openalex.org/W2076509125","https://openalex.org/W2084203394","https://openalex.org/W2093951251","https://openalex.org/W2112151664","https://openalex.org/W2164239930","https://openalex.org/W2219373567","https://openalex.org/W2269547579","https://openalex.org/W2338852652","https://openalex.org/W2419462913","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W7098848801","https://openalex.org/W1920303758","https://openalex.org/W1958248975","https://openalex.org/W2254558301","https://openalex.org/W2148907437","https://openalex.org/W2572566025","https://openalex.org/W2086839948","https://openalex.org/W1964160281","https://openalex.org/W2081668908","https://openalex.org/W1880713856"],"abstract_inverted_index":{"The":[0,53,81],"sequential":[1],"interaction":[2],"between":[3],"the":[4,16,26,42,50,93,105,124,129,132,138,170,174],"two":[5],"components":[6,60,112],"S":[7,51,109,133,171],"and":[8,15,75,100,110,154,161],"F":[9,43,111,139],"of":[10,18,28,41,49,56,58,83,86,92,108,123,131,137,158],"leukocidin":[11,87],"from":[12],"Staphylococcus":[13],"aureus":[14],"membrane":[17],"human":[19,114],"polymorphonuclear":[20,115,159],"neutrophils":[21,116,160],"has":[22,36],"been":[23,37],"investigated":[24],"in":[25,173],"presence":[27],"1":[29],"mM":[30],"Ca2+.":[31],"With":[32],"125I-labeled":[33],"components,":[34],"it":[35],"shown":[38],"that":[39,136,144],"binding":[40,48,57,147,153,167],"component":[44,134,172],"occurred":[45],"only":[46,127],"after":[47],"component.":[52,140],"kinetic":[54],"constants":[55],"both":[59,76],"were":[61,79],"not":[62],"statistically":[63],"different":[64],"(Kd,":[65],"approximately":[66,70],"5":[67],"nM;":[68],"Bm,":[69],"35,000":[71],"molecules":[72],"per":[73],"cell),":[74],"Hill":[77],"coefficients":[78],"1.":[80],"application":[82],"increasing":[84],"concentrations":[85],"provoked":[88],"a":[89,119,149,165],"dose-dependent":[90],"secretion":[91,122],"granule":[94],"content,":[95],"as":[96],"determined":[97],"by":[98],"hexosaminidase":[99],"lysozyme":[101],"activity":[102],"measurements.":[103],"Furthermore,":[104],"separate":[106],"perfusion":[107,130],"on":[113,118],"deposited":[117],"filter":[120],"induced":[121],"granules":[125],"content":[126],"when":[128],"preceded":[135],"We":[141],"conclude,":[142],"therefore,":[143],"(i)":[145],"S-component":[146],"is":[148,164],"prerequisite":[150],"for":[151,155,169],"F-component":[152],"subsequent":[156],"activation":[157],"(ii)":[162],"there":[163],"specific":[166],"site":[168],"plasma":[175],"membrane.":[176]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}