{"id":"https://openalex.org/W2107329942","doi":null,"title":"The clinical use of genetic analyses in colorectal cancer","display_name":"The clinical use of genetic analyses in colorectal cancer","publication_year":2011,"publication_date":"2011-11-22","ids":{"openalex":"https://openalex.org/W2107329942","mag":"2107329942"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/26910802","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/The_clinical_use_of_genetic_analyses_in_colorectal_cancer/26910802","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10616/40824","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075360005","display_name":"S Tumlin Ekelund","orcid":"https://orcid.org/0000-0003-0448-0390","observed_orcids":["https://orcid.org/0000-0003-0448-0390"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"S Tumlin Ekelund","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0448-0390","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5075360005"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.5893999934196472,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.5893999934196472,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.40230000019073486,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/kras-mutation","display_name":"KRAS mutation","score":0.9700000286102295},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.8240000009536743},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8119999766349792},{"id":"https://openalex.org/keywords/anti-egfr-therapy-response","display_name":"anti-EGFR therapy response","score":0.7599999904632568},{"id":"https://openalex.org/keywords/p16-methylation","display_name":"p16 methylation","score":0.8289999961853027},{"id":"https://openalex.org/keywords/mgmt-promoter-methylation","display_name":"MGMT promoter methylation","score":0.9589999914169312},{"id":"https://openalex.org/keywords/loss-of-heterozygosity","display_name":"loss of heterozygosity","score":0.9819999933242798},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.871999979019165},{"id":"https://openalex.org/keywords/stage-ii-colorectal-cancer","display_name":"stage II colorectal cancer","score":0.7170000076293945},{"id":"https://openalex.org/keywords/serum-mirna","display_name":"serum microRNA","score":0.5550000071525574},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.4860000014305115},{"id":"https://openalex.org/keywords/microrna-15a","display_name":"microRNA-15a","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7645994424819946},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6231294274330139},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5757089257240295},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.5698208808898926},{"id":"https://openalex.org/C143589142","wikidata":"https://www.wikidata.org/wiki/Q2617554","display_name":"Loss of heterozygosity","level":4,"score":0.5613672137260437},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5086096525192261},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48373058438301086},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29169994592666626},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16165894269943237},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.13055264949798584},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07255229353904724},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/26910802","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/The_clinical_use_of_genetic_analyses_in_colorectal_cancer/26910802","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:openarchive.ki.se:10616/40824","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/40824","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2107329942","doi":null,"is_oa":false,"landing_page_url":"http://publications.ki.se/xmlui/bitstream/handle/10616/40824/Thesis_Susanne_Tumlin_Ekelund.pdf?sequence=1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:openarchive.ki.se:10616/40824","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/40824","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":112,"referenced_works":["https://openalex.org/W54094404","https://openalex.org/W144423133","https://openalex.org/W162614240","https://openalex.org/W345702292","https://openalex.org/W1245733673","https://openalex.org/W1561373438","https://openalex.org/W1748720947","https://openalex.org/W1935492807","https://openalex.org/W1963853602","https://openalex.org/W1964212603","https://openalex.org/W1965327752","https://openalex.org/W1968588574","https://openalex.org/W1969561516","https://openalex.org/W1970583256","https://openalex.org/W1970706909","https://openalex.org/W1972755526","https://openalex.org/W1974619601","https://openalex.org/W1978802940","https://openalex.org/W1979059536","https://openalex.org/W1979618971","https://openalex.org/W1980269624","https://openalex.org/W1980485834","https://openalex.org/W1981989535","https://openalex.org/W1985029768","https://openalex.org/W1985437593","https://openalex.org/W1988047703","https://openalex.org/W1988050826","https://openalex.org/W1989807712","https://openalex.org/W1989969436","https://openalex.org/W1990261439","https://openalex.org/W1995934753","https://openalex.org/W1999342631","https://openalex.org/W1999360191","https://openalex.org/W1999713736","https://openalex.org/W2000093333","https://openalex.org/W2001258296","https://openalex.org/W2002019030","https://openalex.org/W2002917664","https://openalex.org/W2003930098","https://openalex.org/W2013960424","https://openalex.org/W2014230587","https://openalex.org/W2014610388","https://openalex.org/W2017347636","https://openalex.org/W2025449301","https://openalex.org/W2027616646","https://openalex.org/W2027925091","https://openalex.org/W2028197291","https://openalex.org/W2028674917","https://openalex.org/W2028959640","https://openalex.org/W2032930680","https://openalex.org/W2035213975","https://openalex.org/W2036229577","https://openalex.org/W2037696472","https://openalex.org/W2040602576","https://openalex.org/W2042744474","https://openalex.org/W2049282019","https://openalex.org/W2050079849","https://openalex.org/W2055991307","https://openalex.org/W2056355710","https://openalex.org/W2061460086","https://openalex.org/W2061817133","https://openalex.org/W2065161914","https://openalex.org/W2067089521","https://openalex.org/W2071697240","https://openalex.org/W2073146012","https://openalex.org/W2074845792","https://openalex.org/W2078590818","https://openalex.org/W2078969352","https://openalex.org/W2079245209","https://openalex.org/W2079432915","https://openalex.org/W2079683613","https://openalex.org/W2080308138","https://openalex.org/W2082327705","https://openalex.org/W2085592081","https://openalex.org/W2090375418","https://openalex.org/W2091723114","https://openalex.org/W2095692554","https://openalex.org/W2097709626","https://openalex.org/W2099908487","https://openalex.org/W2100589633","https://openalex.org/W2103414735","https://openalex.org/W2103955948","https://openalex.org/W2106667545","https://openalex.org/W2106787323","https://openalex.org/W2115093090","https://openalex.org/W2120114905","https://openalex.org/W2124924645","https://openalex.org/W2127640925","https://openalex.org/W2127699440","https://openalex.org/W2128059540","https://openalex.org/W2135007926","https://openalex.org/W2135672185","https://openalex.org/W2135836598","https://openalex.org/W2138664009","https://openalex.org/W2146783942","https://openalex.org/W2150625137","https://openalex.org/W2153562609","https://openalex.org/W2155311724","https://openalex.org/W2162102504","https://openalex.org/W2164617114","https://openalex.org/W2164837623","https://openalex.org/W2165496831","https://openalex.org/W2166545599","https://openalex.org/W2167959437","https://openalex.org/W2170226272","https://openalex.org/W2250036631","https://openalex.org/W2327245331","https://openalex.org/W2338315908","https://openalex.org/W2409599271","https://openalex.org/W2414917085","https://openalex.org/W2503604890","https://openalex.org/W2530014580"],"related_works":["https://openalex.org/W2513565870","https://openalex.org/W1983272820","https://openalex.org/W2976742560","https://openalex.org/W2079468689","https://openalex.org/W2055244682","https://openalex.org/W2795721715","https://openalex.org/W2999554008","https://openalex.org/W2085971602","https://openalex.org/W1478128309","https://openalex.org/W4318274231"],"abstract_inverted_index":{"Background:":[0],"Colorectal":[1,686],"cancer":[2],"(CRC)":[3],"is":[4,17,71,99,182,565,628],"a":[5,10,85,100,249,267,456,506,680],"common":[6],"global":[7],"disease,":[8],"with":[9,34,40,288,342,362,382,387,455,485,630,685],"mortality":[11],"rate":[12],"of":[13,29,60,176,206,210,216,231,252,256,269,275,425,430,495,512,523,548,552,591,659,669,683],"almost":[14],"50%.":[15],"Prognosis":[16],"mainly":[18],"based":[19,62],"on":[20,63,67,84,135,157,173,673],"the":[21,27,43,82,120,130,139,149,174,204,229,273,306,316,339,352,378,460,510,515,546,569],"TNM":[22],"classification.":[23],"Surgical":[24],"interventions":[25],"have":[26,54,94],"potential":[28],"being":[30],"curative":[31],"in":[32,47,124,138,142,145,159,162,193,248,334,416,446,459,509,532,561,594,635,676],"patients":[33,190,287,329,341,371,381,386,452,465,516],"stage":[35,48,284,602],"I-III":[36],"CRC.":[37,447],"Adjuvant":[38],"treatment":[39],"chemotherapy":[41],"enhances":[42],"survival":[44,389,435,632],"rate,":[45],"especially":[46],"III":[49],"cancer.":[50,637],"Chemotherapy":[51],"does,":[52],"however,":[53],"significant":[55,507],"side":[56],"effects.":[57],"Therefore,":[58],"refinement":[59],"therapies":[61],"improved":[64],"prognostic":[65,258,408,589],"ability":[66],"an":[68,520],"individual":[69],"level":[70,87,511],"essential.":[72],"One":[73],"way":[74],"to":[75,80,103,180,194,277,313,358,397,433,475,538],"achieve":[76],"this":[77,128,404],"could":[78],"be":[79],"examine":[81],"tumours":[83,160,187,301],"molecular":[86,178],"and":[88,141,161,169,203,212,214,222,234,236,242,246,302,305,311,349,384,427,437,440,443,453,476,490,519,536,545,625,633],"not":[89,498],"just":[90],"histologically.":[91],"Recent":[92],"studies":[93,166],"shown":[95],"that":[96,228,422],"K-ras":[97,207,261,307,324,332,363,564,592],"mutation":[98,262,559],"negative":[101,364],"predictor":[102],"anti-EGFR":[104,279],"(epidermal":[105],"growth":[106],"factor":[107],"receptor)":[108],"therapy.":[109],"MicroRNAs":[110],"were":[111,191,224,293,319,372,390,410,462,483,497],"discovered":[112],"only":[113],"2":[114],"decades":[115],"ago":[116],"but":[117],"are":[118,244],"now":[119],"most":[121],"promising":[122],"biomarkers":[123],"many":[125],"cancers.":[126],"In":[127,165],"thesis,":[129],"first":[131],"two":[132,154],"papers":[133,155,554],"focus":[134,156],"genetic":[136],"changes":[137,179,531],"tumour":[140,502],"lymph":[143,291,299,336,344,365,596],"nodes,":[144,300,345],"particular":[146],"looking":[147],"at":[148,219,238],"oncogene":[150],"K-ras.":[151],"The":[152,492,588,667],"last":[153],"microRNAs":[158,409,482],"blood":[163],"serum.":[164],"2,":[167],"3":[168,481],"4,":[170],"our":[171],"findings":[172],"correlation":[175,528],"some":[177],"prognosis":[181],"described.":[183],"Study":[184,281,367,448],"I:":[185],"17":[186,240],"from":[188,200,298,351,377],"CRC":[189,253,286,370,451],"divided":[192],"small":[195],"cubes.":[196],"DNA":[197,295],"was":[198,296,309,375,472,505,526],"extracted":[199,297,376],"each":[201],"biopsy":[202],"occurrence":[205],"mutations,":[208],"methylation":[209],"p16":[211,233],"MGMT,":[213],"loss":[215],"heterozygosity":[217],"(LOH)":[218],"5q,":[220,239],"17p":[221],"18q":[223,243],"analysed.":[225],"We":[226,420],"found":[227,421],"distribution":[230],"methylated":[232],"MGMT":[235],"LOH":[237],"p":[241],"heterogeneous":[245],"present":[247],"large":[250,457],"majority":[251],"tumours,":[254,317],"thereby":[255],"limited":[257],"value.":[259],"However,":[260],"appears":[263],"more":[264],"homogeneously":[265,566],"spread,":[266],"finding":[268],"clinical":[270],"relevance":[271],"for":[272,323,392,399,558,601],"use":[274],"biopsies":[276],"predict":[278],"response.":[280],"II:":[282],"99":[283],"II":[285,603],"histologically":[289],"normal":[290,303],"nodes":[292,597],"included.":[294,463],"mucosa":[304],"status":[308],"analysed":[310,484],"correlated":[312,432],"prognosis.":[314],"Of":[315,326,338],"34/99":[318],"identified":[320],"as":[321],"positive":[322,343],"mutations.":[325],"these,":[327],"10":[328,340],"also":[330],"expressed":[331,401],"mutations":[333,593],"their":[335],"nodes.":[337,366],"7":[346],"(70%)":[347],"relapsed":[348],"died":[350],"disease":[353,539],"within":[354],"60":[355],"months":[356],"compared":[357],"8/":[359],"24":[360],"(33%)":[361],"III:":[368],"50":[369,418],"studied.":[373],"RNA":[374],"tumours.":[379],"5":[380,385],"short":[383],"long":[388],"selected":[391],"SYBR-green":[393],"quantitative":[394,414],"PCR-based":[395],"array":[396],"screen":[398],"differently":[400],"microRNAs.":[402],"From":[403],"screening,":[405],"6":[406],"candidate":[407],"validated":[411],"using":[412],"TaqMan":[413],"PCR":[415],"all":[417],"patients.":[419],"high":[423],"expression":[424,429],"miR-185":[426,624],"low":[428],"miR-133b":[431,489,513,626],"poor":[434],"(p=0.001":[436],"p=0.028,":[438],"respectively)":[439,445],"metastasis":[441,634],"(p=0.007":[442],"p=0.036,":[444],"IV:":[449],"16":[450],"one":[454],"adenoma":[458],"colon":[461],"All":[464],"underwent":[466],"radical":[467,501,599],"(R0)":[468],"surgery.":[469,480],"Blood":[470],"serum":[471,493,533],"collected":[473],"prior":[474],"30":[477],"days":[478],"after":[479,598],"Taqman":[486],"qPCR":[487],"(miR-21,":[488],"miR-185).":[491],"levels":[494,534,544],"mir-21":[496],"affected":[499],"by":[500],"resection.":[503],"There":[504,525],"decrease":[508],"among":[514],"following":[517],"surgery,":[518],"overall":[521,631],"reduction":[522],"miR-185.":[524],"no":[527],"between":[529,542],"intra-individual":[530],"pre-":[535],"postoperatively":[537],"outcome,":[540],"or":[541],"baseline":[543],"risk":[547],"recurrent":[549],"disease.":[550],"List":[551],"scientific":[553],"I.":[555],"Tissue":[556],"sampling":[557],"analysis":[560],"colorectal":[562,604,636],"cancer:":[563],"distributed":[567],"throughout":[568],"tumor":[570],"tissue.":[571],"Susanne":[572,606,640,688],"Ekelund,":[573,641,690],"Nikos":[574,608],"Papadogiannakis,":[575,609],"Hans":[576,618,653,695],"Olivecrona,":[577,619,654],"Ulrik":[578,620,651,691],"Lindforss.":[579,621],"Oncology":[580],"Reports.":[581],"January":[582],"2011,":[583,662],"pages":[584,663],"253-258.":[585],"https://doi.org/10.3892/or_00001068":[586],"II.":[587],"significance":[590],"regional":[595],"resection":[600],"carcinoma.":[605],"Tumlin-Ekelund,":[607],"Kjell":[610],"Gullberg,":[611],"Leif":[612],"T\u00f6rkvist,":[613],"Greger":[614],"Lindberg,":[615],"Achilleas":[616],"Karkamanis,":[617],"[Submitted]":[622],"III.":[623],"deregulation":[627],"associated":[629],"Pinar":[638],"Akcakaya,":[639],"Iryna":[642],"Kolosenko,":[643],"Stefano":[644],"Caramuta,":[645],"Deniz":[646],"M.":[647],"\u00d6zata,":[648],"Hong":[649],"Xie,":[650],"Lindforss,":[652,692],"Weng-Onn":[655],"Lui.":[656],"International":[657],"Journal":[658],"Oncology.":[660],"August":[661],"311-318.":[664],"https://doi.org/10.3892/ijo.2011.1043":[665],"IV.":[666],"Effect":[668],"Radical":[670],"Tumor":[671],"Resection":[672],"Serum":[674],"MicroRNA":[675],"Cancer":[677],"Patients":[678,684],"\u2013":[679],"Long-term":[681],"Follow-up":[682],"Carcinoma.":[687],"Tumlin":[689],"Mika":[693],"Leinonen,":[694],"Olivecrona.":[696],"[Manuscript]":[697]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
