{"id":"https://openalex.org/W2107328347","doi":null,"title":"Improving oncolytic viral therapy for glioma","display_name":"Improving oncolytic viral therapy for glioma","publication_year":2011,"publication_date":"2011-06-10","ids":{"openalex":"https://openalex.org/W2107328347","mag":"2107328347"},"language":"en","primary_location":{"id":"pmh:oai:dare.ubvu.vu.nl:1871/19781","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1871/19781","pdf_url":"http://hdl.handle.net/1871/19781","source":{"id":"https://openalex.org/S4306400546","display_name":"Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I865915315","host_organization_name":"Vrije Universiteit Amsterdam","host_organization_lineage":["https://openalex.org/I865915315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/1871/19781","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053305431","display_name":"Sander Idema","orcid":"https://orcid.org/0000-0001-7267-0255","observed_orcids":["https://orcid.org/0000-0001-7267-0255"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sander Idema","raw_affiliation_strings":["Neurosurgery"],"raw_orcid":"https://orcid.org/0000-0001-7267-0255","affiliations":[{"raw_affiliation_string":"Neurosurgery","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5053305431"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oncolytic-adenovirus","display_name":"oncolytic adenovirus","score":0.9120000004768372},{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.9909999966621399},{"id":"https://openalex.org/keywords/tumor-spheroids","display_name":"tumor spheroids","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cell-viability-assessment","display_name":"cell viability assessment","score":0.6700000166893005},{"id":"https://openalex.org/keywords/viral-replication","display_name":"viral replication","score":0.6359999775886536},{"id":"https://openalex.org/keywords/cytopathic-effect","display_name":"cytopathic effect","score":0.8989999890327454},{"id":"https://openalex.org/keywords/wst-1-assay","display_name":"WST-1 assay","score":0.8949999809265137},{"id":"https://openalex.org/keywords/crystal-violet-assay","display_name":"crystal violet assay","score":0.8450000286102295},{"id":"https://openalex.org/keywords/patient-derived-spheroids","display_name":"patient-derived spheroids","score":0.6710000038146973}],"concepts":[{"id":"https://openalex.org/C82210918","wikidata":"https://www.wikidata.org/wiki/Q1560099","display_name":"Oncolytic virus","level":3,"score":0.9385451674461365},{"id":"https://openalex.org/C175369904","wikidata":"https://www.wikidata.org/wiki/Q208395","display_name":"Spheroid","level":3,"score":0.8868429660797119},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.802411675453186},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.5956616401672363},{"id":"https://openalex.org/C49744831","wikidata":"https://www.wikidata.org/wiki/Q600121","display_name":"Virotherapy","level":4,"score":0.44054752588272095},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.42441245913505554},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4222542941570282},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37166520953178406},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3428211510181427},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3210337162017822},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.30240598320961},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"pmh:oai:dare.ubvu.vu.nl:1871/19781","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1871/19781","pdf_url":"http://hdl.handle.net/1871/19781","source":{"id":"https://openalex.org/S4306400546","display_name":"Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I865915315","host_organization_name":"Vrije Universiteit Amsterdam","host_organization_lineage":["https://openalex.org/I865915315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/e8d6d9fe-1292-4975-9c52-92ab05ee883e","doi":null,"is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/e8d6d9fe-1292-4975-9c52-92ab05ee883e","pdf_url":"https://pure.amsterdamumc.nl/ws/files/112807701/cover.pdf","source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Idema, S 2011, 'Improving Oncolytic Viral Therapy for Glioma', Doctor of Philosophy, VU Vrije Universiteit.","raw_type":"info:eu-repo/semantics/other"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/d4b87163-2a9a-43c9-b734-60111b9787c1","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/improving-oncolytic-viral-therapy-for-glioma(d4b87163-2a9a-43c9-b734-60111b9787c1).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"pmh:vu:oai:research.vu.nl:publications/3e5d48d4-8dc2-41e3-82f2-8316b55c4dcc","doi":null,"is_oa":true,"landing_page_url":"https://research.vu.nl/en/publications/3e5d48d4-8dc2-41e3-82f2-8316b55c4dcc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"pmh:vumc:oai:pure.atira.dk:publications/10a229b1-57f2-40b6-8afc-2e5492bb46b4","doi":null,"is_oa":true,"landing_page_url":"https://research.vumc.nl/en/publications/10a229b1-57f2-40b6-8afc-2e5492bb46b4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"mag:2107328347","doi":null,"is_oa":false,"landing_page_url":"https://research.vumc.nl/ws/files/823244/cover.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dare.ubvu.vu.nl:1871/19781","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1871/19781","pdf_url":"http://hdl.handle.net/1871/19781","source":{"id":"https://openalex.org/S4306400546","display_name":"Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I865915315","host_organization_name":"Vrije Universiteit Amsterdam","host_organization_lineage":["https://openalex.org/I865915315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2107328347.pdf","grobid_xml":"https://content.openalex.org/works/W2107328347.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W64698069","https://openalex.org/W116280062","https://openalex.org/W1555346784","https://openalex.org/W1558969188","https://openalex.org/W1579265529","https://openalex.org/W1582164157","https://openalex.org/W1781724529","https://openalex.org/W1808107661","https://openalex.org/W1943398466","https://openalex.org/W1958134681","https://openalex.org/W1963654184","https://openalex.org/W1965609218","https://openalex.org/W1965740863","https://openalex.org/W1968377494","https://openalex.org/W1968436602","https://openalex.org/W1983766005","https://openalex.org/W1986880984","https://openalex.org/W1994139105","https://openalex.org/W1998321926","https://openalex.org/W1999160447","https://openalex.org/W2006858976","https://openalex.org/W2007735028","https://openalex.org/W2012191973","https://openalex.org/W2017614842","https://openalex.org/W2027178820","https://openalex.org/W2030834391","https://openalex.org/W2035309695","https://openalex.org/W2043168409","https://openalex.org/W2045179744","https://openalex.org/W2045575161","https://openalex.org/W2049995305","https://openalex.org/W2050265029","https://openalex.org/W2058038884","https://openalex.org/W2061418597","https://openalex.org/W2070292918","https://openalex.org/W2080353653","https://openalex.org/W2091501978","https://openalex.org/W2092888368","https://openalex.org/W2094513009","https://openalex.org/W2096338082","https://openalex.org/W2096947122","https://openalex.org/W2100453275","https://openalex.org/W2101950700","https://openalex.org/W2103803877","https://openalex.org/W2106761285","https://openalex.org/W2109828337","https://openalex.org/W2110592777","https://openalex.org/W2111114047","https://openalex.org/W2112824117","https://openalex.org/W2113822184","https://openalex.org/W2126397856","https://openalex.org/W2130641534","https://openalex.org/W2131308181","https://openalex.org/W2133481877","https://openalex.org/W2135792629","https://openalex.org/W2137837999","https://openalex.org/W2138863592","https://openalex.org/W2141445393","https://openalex.org/W2141473060","https://openalex.org/W2146565047","https://openalex.org/W2147249324","https://openalex.org/W2155140015","https://openalex.org/W2159081397","https://openalex.org/W2159566378","https://openalex.org/W2165565925","https://openalex.org/W2166007074","https://openalex.org/W2168330082","https://openalex.org/W2313228602","https://openalex.org/W2330121938","https://openalex.org/W2399140258","https://openalex.org/W2400281930","https://openalex.org/W2410852615","https://openalex.org/W2413062221"],"related_works":["https://openalex.org/W1989014258","https://openalex.org/W2024662453","https://openalex.org/W2249690945","https://openalex.org/W1965740863","https://openalex.org/W4232296147","https://openalex.org/W2063518850","https://openalex.org/W257351276","https://openalex.org/W2884355981","https://openalex.org/W1998321926","https://openalex.org/W4416266980"],"abstract_inverted_index":{"Multicellular":[0],"tumor":[1],"spheroids":[2,75,111,146,173,183],"are":[3,24,112],"used":[4,19,36,62],"as":[5,50],"a":[6,51,125,178],"model":[7],"to":[8,20,41,59,98,128],"assess":[9,21,129],"the":[10,44,57,66,115,148,169],"efficacy":[11],"of":[12,30,46,53,68,152,162,172,188],"replicating":[13,80],"oncolytic":[14,27,69,138],"adenoviruses.":[15],"As":[16],"most":[17],"assays":[18,63],"cellular":[22],"viability":[23,54,83,136,164],"unsuitable":[25],"for":[26,64,150],"viruses":[28],"because":[29],"ongoing":[31],"viral":[32,139],"replication,":[33],"we":[34],"have":[35],"Positron":[37],"Emission":[38],"Tomography":[39],"(PET)":[40],"sequentially":[42],"determine":[43],"incorporation":[45],"18F-labeled":[47],"deoxyglucose":[48],"(18F-DG),":[49],"measure":[52],"and":[55,74,82,94,135,145],"compared":[56],"results":[58],"more":[60],"commonly":[61],"measuring":[65],"effect":[67,117],"therapy.":[70],"Glioma":[71],"monolayer":[72,143],"cultures":[73,144],"were":[76],"infected":[77,110,120],"with":[78],"wildtype":[79],"adenovirus":[81,109],"was":[84],"measured":[85],"by":[86,114],"18F-DG":[87,122,157],"incorporation,":[88],"WST-1":[89],"assay,":[90],"crystal":[91],"violet":[92],"assay":[93],"spheroid":[95,163],"volume":[96,106],"2":[97],"10":[99],"days":[100],"following":[101,137],"infection.":[102],"Results":[103],"show":[104],"that":[105],"measurements":[107,161],"in":[108,119,132,141],"confounded":[113],"cytopathic":[116],"occurring":[118],"cells.":[121],"PET":[123],"provides":[124],"useful":[126],"method":[127],"small":[130],"differences":[131],"cell":[133],"number":[134,171],"therapy":[140],"glioma":[142],"without":[147],"need":[149],"disintegration":[151],"these":[153],"cultures.":[154],"Moreover,":[155],"using":[156,182],"PET,":[158],"repeated":[159],"sequential":[160],"can":[165],"be":[166],"made,":[167],"decreasing":[168],"required":[170],"per":[174],"experiment.":[175],"This":[176],"is":[177],"valuable":[179],"feature":[180],"when":[181],"derived":[184],"from":[185],"limited":[186],"amounts":[187],"patient":[189],"material.":[190]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}