{"id":"https://openalex.org/W2107327233","doi":null,"title":"Effect of interleukin (IL)-4 cytotoxin on breast tumor growth after in vivo gene transfer of IL-4 receptor alpha chain.","display_name":"Effect of interleukin (IL)-4 cytotoxin on breast tumor growth after in vivo gene transfer of IL-4 receptor alpha chain.","publication_year":2003,"publication_date":"2003-05-01","ids":{"openalex":"https://openalex.org/W2107327233","mag":"2107327233","pmid":"https://pubmed.ncbi.nlm.nih.gov/12738741"},"language":"en","primary_location":{"id":"pmid:12738741","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12738741","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037731704","display_name":"Koji Kawakami","orcid":"https://orcid.org/0000-0002-7477-4071","observed_orcids":["https://orcid.org/0000-0002-7477-4071"]},"institutions":[{"id":"https://openalex.org/I1318287680","display_name":"Center for Biologics Evaluation and Research","ror":"https://ror.org/02nr3fr97","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1318287680","https://openalex.org/I1320320070"]},{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Koji Kawakami","raw_affiliation_strings":["Laboratory of Molecular Tumor Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Tumor Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA","institution_ids":["https://openalex.org/I1318287680","https://openalex.org/I1320320070"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110301884","display_name":"Mariko Kawakami","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mariko Kawakami","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110475180","display_name":"Syed Rafat Husain","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Syed R Husain","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5067972591","display_name":"Raj K. Puri","orcid":"https://orcid.org/0000-0003-2548-346X","observed_orcids":["https://orcid.org/0000-0003-2548-346X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raj K Puri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1038,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.41961807,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"9","issue":"5","first_page":"1826","last_page":"36"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.7914999723434448,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.7914999723434448,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.09799999743700027,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.027499999850988388,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9430000185966492},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.5619999766349792},{"id":"https://openalex.org/keywords/plasmid-mediated-gene-transfer","display_name":"plasmid-mediated gene transfer","score":0.9100000262260437},{"id":"https://openalex.org/keywords/intratumoral-injection","display_name":"intratumoral injection","score":0.746999979019165},{"id":"https://openalex.org/keywords/liposomal-drug-delivery","display_name":"liposomal drug delivery","score":0.6179999709129333},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.7490000128746033},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.9160000085830688},{"id":"https://openalex.org/keywords/tumor-infiltrating-macrophages","display_name":"tumor-infiltrating macrophages","score":0.7129999995231628},{"id":"https://openalex.org/keywords/tumor-infiltrating-neutrophils","display_name":"tumor-infiltrating neutrophils","score":0.9520000219345093},{"id":"https://openalex.org/keywords/innate-immune-cells","display_name":"innate immune cells","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5737007856369019},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5488985180854797},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5431912541389465},{"id":"https://openalex.org/C2777371288","wikidata":"https://www.wikidata.org/wiki/Q410130","display_name":"Interleukin 2","level":3,"score":0.4888603091239929},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4834500253200531},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4342501759529114},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.4223559498786926},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41182634234428406},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4077448844909668},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3672182261943817},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.36447709798812866},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.35928797721862793},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.358442097902298},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28763651847839355},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20657294988632202},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000922","descriptor_name":"Immunotoxins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008262","descriptor_name":"Macrophage Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011869","descriptor_name":"Radioligand Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015552","descriptor_name":"Injections, Intralesional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019948","descriptor_name":"Receptors, Interleukin-4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019948","descriptor_name":"Receptors, Interleukin-4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:12738741","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12738741","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"mag:2107327233","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12738741","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W116096765","https://openalex.org/W191480925","https://openalex.org/W575678561","https://openalex.org/W1240277104","https://openalex.org/W1487848976","https://openalex.org/W1494753294","https://openalex.org/W1534106804","https://openalex.org/W1541033317","https://openalex.org/W1543909608","https://openalex.org/W1583283620","https://openalex.org/W1598843567","https://openalex.org/W1673454808","https://openalex.org/W1821781403","https://openalex.org/W1958440406","https://openalex.org/W1973114143","https://openalex.org/W1977758857","https://openalex.org/W1980694674","https://openalex.org/W1983844193","https://openalex.org/W1990997298","https://openalex.org/W1991036896","https://openalex.org/W2012738581","https://openalex.org/W2014707230","https://openalex.org/W2023931058","https://openalex.org/W2029102977","https://openalex.org/W2029428013","https://openalex.org/W2033734753","https://openalex.org/W2037342239","https://openalex.org/W2043784957","https://openalex.org/W2044573147","https://openalex.org/W2044673785","https://openalex.org/W2045575773","https://openalex.org/W2051699993","https://openalex.org/W2052605623","https://openalex.org/W2053870688","https://openalex.org/W2054351138","https://openalex.org/W2068785423","https://openalex.org/W2070629020","https://openalex.org/W2073537725","https://openalex.org/W2077498864","https://openalex.org/W2079323372","https://openalex.org/W2083776767","https://openalex.org/W2086659607","https://openalex.org/W2098678529","https://openalex.org/W2100033342","https://openalex.org/W2107308295","https://openalex.org/W2115759102","https://openalex.org/W2116937898","https://openalex.org/W2118638089","https://openalex.org/W2132024010","https://openalex.org/W2135757997","https://openalex.org/W2142622103","https://openalex.org/W2144120552","https://openalex.org/W2146124563","https://openalex.org/W2149200346","https://openalex.org/W2151778057","https://openalex.org/W2156539373","https://openalex.org/W2157353407","https://openalex.org/W2159127194","https://openalex.org/W2161321534","https://openalex.org/W2173500887","https://openalex.org/W2177651721","https://openalex.org/W2181523762","https://openalex.org/W2190356106","https://openalex.org/W2255965873","https://openalex.org/W2320365343","https://openalex.org/W2415660346","https://openalex.org/W2420340547"],"related_works":["https://openalex.org/W2098678529","https://openalex.org/W1487848976","https://openalex.org/W2286752153","https://openalex.org/W1969921119","https://openalex.org/W2029376715","https://openalex.org/W2083776767","https://openalex.org/W2318637375","https://openalex.org/W4244559924","https://openalex.org/W1487819464","https://openalex.org/W2101278500"],"abstract_inverted_index":{"Although":[0],"human":[1,97],"breast":[2,25,92,98,199],"cancer":[3,46,99],"cells":[4,56,100],"express":[5],"interleukin-4":[6],"receptors":[7],"(IL-4Rs),":[8],"a":[9,32,192],"recombinant":[10],"fusion":[11],"protein,":[12,36],"IL-4":[13,34,44,64,86,132,141,187],"cytotoxin,":[14],"did":[15],"not":[16],"mediate":[17],"desirable":[18],"antitumor":[19,83],"activity":[20,84],"in":[21,45,54,66,75,88,101],"tumor":[22,55,169],"models":[23,90],"of":[24,51,63,72,85,91,104,115,140,147,175,198],"cancer.":[26,200],"Recent":[27],"studies":[28],"have":[29],"identified":[30],"that":[31,177],"primary":[33],"binding":[35,42],"IL-4Ralpha":[37,53,73,117,148,179],"chain,":[38],"is":[39],"internalized":[40],"after":[41],"to":[43,59,164],"cells.":[47],"The":[48],"consequent":[49],"expression":[50],"high-level":[52],"sensitizes":[57],"them":[58],"the":[60,145,167,196],"cytotoxic":[61],"effect":[62],"cytotoxin":[65,87,133,142,188],"vitro.":[67],"To":[68],"assess":[69],"whether":[70],"overexpression":[71],"chain":[74],"vivo":[76],"by":[77,131,183],"plasmid-mediated":[78],"gene":[79],"transfer":[80],"can":[81],"enhance":[82],"mouse":[89],"tumor,":[93],"we":[94],"injected":[95],"MDA-MB-231":[96,150],"both":[102],"flanks":[103],"athymic":[105],"nude":[106],"mice.":[107],"Animals":[108],"then":[109],"received":[110],"three":[111],"intratumoral":[112],"(i.t.)":[113],"injections":[114],"either":[116],"encoding":[118],"vector":[119,123],"(left":[120],"flank)":[121,126],"or":[122,185],"only":[124],"(right":[125],"mixed":[127],"with":[128,153],"liposome":[129],"followed":[130,182],"administration.":[134],"Both":[135],"i.p.":[136],"and":[137,160],"i.t.":[138,178,186],"administration":[139,189],"profoundly":[143],"reduced":[144],"growth":[146],"plasmid-injected":[149],"tumors,":[151],"compared":[152],"control.":[154],"Innate":[155],"immune":[156],"cells,":[157],"including":[158],"macrophages":[159],"neutrophils,":[161],"were":[162],"found":[163],"infiltrate":[165],"at":[166],"regressing":[168],"site.":[170],"This":[171],"study":[172],"provides":[173],"proof":[174],"principle":[176],"plasmid":[180],"injection":[181],"systemic":[184],"may":[190],"be":[191],"useful":[193],"strategy":[194],"for":[195],"treatment":[197]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}