{"id":"https://openalex.org/W2107315155","doi":"https://doi.org/10.1111/j.1751-1097.1982.tb04410.x","title":"MODE OF ACTION OF \u03b1\u2010TERTHIENYL ON ESCHERICHIA COLI: EVIDENCE FOR A PHOTODYNAMIC EFFECT ON MEMBRANES","display_name":"MODE OF ACTION OF \u03b1\u2010TERTHIENYL ON ESCHERICHIA COLI: EVIDENCE FOR A PHOTODYNAMIC EFFECT ON MEMBRANES","publication_year":1982,"publication_date":"1982-11-01","ids":{"openalex":"https://openalex.org/W2107315155","doi":"https://doi.org/10.1111/j.1751-1097.1982.tb04410.x","mag":"2107315155"},"language":"en","primary_location":{"id":"doi:10.1111/j.1751-1097.1982.tb04410.x","doi":"https://doi.org/10.1111/j.1751-1097.1982.tb04410.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1751-1097.1982.tb04410.x","pdf_url":null,"source":{"id":"https://openalex.org/S61245073","display_name":"Photochemistry and Photobiology","issn_l":"0031-8655","issn":["0031-8655","1751-1097"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Photochemistry and Photobiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021341587","display_name":"Kelsey R. Downum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"K. R. Downum","raw_affiliation_strings":["Department of Botany and Microbiology, University of British Columbia. Vancouver, BC. Canada V6T 2B1","T. H. Morgan School of Biological Sciences, University of Kentucky, Lexington, KY 40506, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Botany and Microbiology, University of British Columbia. Vancouver, BC. Canada V6T 2B1","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"T. H. Morgan School of Biological Sciences, University of Kentucky, Lexington, KY 40506, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066530115","display_name":"Robert E. W. Hancock","orcid":"https://orcid.org/0000-0001-5989-8503","observed_orcids":["https://orcid.org/0000-0001-5989-8503","https://orcid.org/0000-0003-2231-4716","https://orcid.org/0000-0001-5465-3814"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"R. E. W. Hancock","raw_affiliation_strings":["Department of Botany and Microbiology, University of British Columbia. Vancouver, BC. Canada V6T 2B1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Botany and Microbiology, University of British Columbia. Vancouver, BC. Canada V6T 2B1","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105885645","display_name":"G.H.N. Towers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"G. H. N. Towers","raw_affiliation_strings":["Department of Botany and Microbiology, University of British Columbia. Vancouver, BC. Canada V6T 2B1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Botany and Microbiology, University of British Columbia. Vancouver, BC. Canada V6T 2B1","institution_ids":["https://openalex.org/I141945490"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4330,"currency":"USD","value_usd":4330},"apc_paid":null,"fwci":7.4301,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.97308847,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"36","issue":"5","first_page":"517","last_page":"523"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-terthienyl","display_name":"\u03b1-terthienyl","score":0.9819999933242798},{"id":"https://openalex.org/keywords/photodynamic-effect","display_name":"photodynamic effect","score":0.871999979019165},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9490000009536743},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.9739999771118164},{"id":"https://openalex.org/keywords/near-uv-light","display_name":"near-UV light","score":0.6779999732971191},{"id":"https://openalex.org/keywords/photosensitizers","display_name":"photosensitizers","score":0.7929999828338623},{"id":"https://openalex.org/keywords/plasma-membrane","display_name":"plasma membrane","score":0.7580000162124634},{"id":"https://openalex.org/keywords/oxygen-dependence","display_name":"oxygen dependence","score":0.7519999742507935},{"id":"https://openalex.org/keywords/bactericidal-activity","display_name":"bactericidal activity","score":0.7910000085830688},{"id":"https://openalex.org/keywords/dna-repair-mutants","display_name":"DNA repair mutants","score":0.7440000176429749},{"id":"https://openalex.org/keywords/8-methoxypsoralen","display_name":"8-methoxypsoralen","score":0.7639999985694885},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.4569999873638153}],"concepts":[{"id":"https://openalex.org/C2781469039","wikidata":"https://www.wikidata.org/wiki/Q18388377","display_name":"Photosensitizer","level":2,"score":0.8473589420318604},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.7763127684593201},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.6420522928237915},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6272029280662537},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5427392721176147},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.4702528715133667},{"id":"https://openalex.org/C2778910516","wikidata":"https://www.wikidata.org/wiki/Q380136","display_name":"Enterobacteriaceae","level":4,"score":0.46717649698257446},{"id":"https://openalex.org/C2778913249","wikidata":"https://www.wikidata.org/wiki/Q422241","display_name":"Sodium dodecyl sulfate","level":2,"score":0.42867642641067505},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.4182373881340027},{"id":"https://openalex.org/C2781323092","wikidata":"https://www.wikidata.org/wiki/Q1428072","display_name":"Photodynamic therapy","level":2,"score":0.4156338572502136},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2696637511253357},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19231674075126648},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06347543001174927},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1111/j.1751-1097.1982.tb04410.x","doi":"https://doi.org/10.1111/j.1751-1097.1982.tb04410.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1751-1097.1982.tb04410.x","pdf_url":null,"source":{"id":"https://openalex.org/S61245073","display_name":"Photochemistry and Photobiology","issn_l":"0031-8655","issn":["0031-8655","1751-1097"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Photochemistry and Photobiology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1520097912","https://openalex.org/W1964896899","https://openalex.org/W1987958173","https://openalex.org/W1994687185","https://openalex.org/W1995528247","https://openalex.org/W2017818082","https://openalex.org/W2021364670","https://openalex.org/W2027933897","https://openalex.org/W2030662954","https://openalex.org/W2037469485","https://openalex.org/W2061107573","https://openalex.org/W2063127584","https://openalex.org/W2064603855","https://openalex.org/W2072918524","https://openalex.org/W2080876747","https://openalex.org/W2081225050","https://openalex.org/W2101848104","https://openalex.org/W2131882560","https://openalex.org/W2148458578","https://openalex.org/W2148643960","https://openalex.org/W4231001051","https://openalex.org/W4402019245"],"related_works":["https://openalex.org/W2021364670","https://openalex.org/W4402036613","https://openalex.org/W1986955921","https://openalex.org/W2037469485","https://openalex.org/W2114801378","https://openalex.org/W2166070469","https://openalex.org/W7033187854","https://openalex.org/W1967463513","https://openalex.org/W1981026787","https://openalex.org/W2015918225"],"abstract_inverted_index":{"Abstract":[0],"The":[1,98,168],"photodynamic":[2,177],"effects":[3],"of":[4,19,49,82,96,100,122,149,157,165,187],"\u03b1\u2010terthienyl":[5],"(\u03b1T)":[6],"in":[7,57,135],"near\u2010UV":[8],"light":[9,17],"(UV\u2010A)":[10],"onEscherichia":[11],"colishowed":[12],"close":[13],"agreement":[14],"with":[15,38,112,159],"the":[16,28,34,46,61,94,120,125,131,185,188],"absorption":[18],"\u03b1T":[20,26,123,174],"at":[21,116,184],"different":[22],"wavelengths":[23],"suggesting":[24,118],"that":[25,45,80,119,173],"is":[27,139,175],"primary":[29,182],"absorbing":[30],"molecule":[31],"responsible":[32],"for":[33,143],"photosensitized":[35],"reaction.":[36],"Studies":[37],"DNA":[39,55],"repair":[40],"deficient":[41],"mutants":[42],"ofE.":[43,128],"coliindicated":[44],"bactericidal":[47],"action":[48],"\u03b1T/UV\u2010A":[50,103,160],"was":[51,78,90],"not":[52,130,140],"mediated":[53],"by":[54,102],"damage,":[56],"direct":[58],"contrast":[59],"to":[60],"well\u2010known":[62],"photosensitizer,":[63],"8\u2010methoxypsoralen.":[64],"By":[65],"using":[66],"a":[67,85,105,176],"closed":[68],"borosilicate":[69],"glass":[70],"reaction":[71],"vessel":[72],"and":[73,137,155],"various":[74],"gas":[75],"mixtures,":[76],"it":[77],"demonstrated":[79],"photosensitization":[81],"bothE.":[83],"coliand":[84],"more":[86],"resistant":[87],"bacterium,Pseudomonas":[88],"aeruginosa,":[89],"absolutely":[91],"dependent":[92],"on":[93,109],"presence":[95],"oxygen.":[97],"rate":[99,132],"killing":[101,115,136],"showed":[104,161],"rather":[106],"small":[107],"dependence":[108],"preincubation":[110],"temperatures,":[111],"quite":[113],"rapid":[114],"5\u00b0C,":[117],"movement":[121],"across":[124],"cytoplasmic":[126,189],"membrane":[127,151],"coliis":[129],"limiting":[133],"step":[134],"perhaps":[138],"even":[141],"necessary":[142],"killing.":[144],"Sodium":[145],"dodecyl":[146],"sulphate\u2010polyacrylamide":[147],"gels":[148],"cell":[150],"proteins":[152],"after":[153],"15":[154],"30min":[156],"treatment":[158],"substantial":[162],"random":[163],"crosslinking":[164],"these":[166],"proteins.":[167],"results":[169],"taken":[170],"overall":[171],"suggest":[172],"photosensitizer":[178],"which":[179],"exerts":[180],"its":[181],"effect":[183],"level":[186],"membrane.":[190]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}