{"id":"https://openalex.org/W2107248308","doi":"https://doi.org/10.1002/hep.1840220408","title":"Antipyrine clearance and response to interferon treatment in patients with chronic active hepatitis C","display_name":"Antipyrine clearance and response to interferon treatment in patients with chronic active hepatitis C","publication_year":1995,"publication_date":"1995-10-01","ids":{"openalex":"https://openalex.org/W2107248308","doi":"https://doi.org/10.1002/hep.1840220408","mag":"2107248308","pmid":"https://pubmed.ncbi.nlm.nih.gov/7557852"},"language":"en","primary_location":{"id":"doi:10.1002/hep.1840220408","doi":"https://doi.org/10.1002/hep.1840220408","is_oa":false,"landing_page_url":"https://doi.org/10.1002/hep.1840220408","pdf_url":null,"source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081634079","display_name":"Shirley A Coverdale","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2803024705","display_name":"Westmead Hospital","ror":"https://ror.org/04gp5yv64","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2803024705","https://openalex.org/I4405259172"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Shirley Coverdale","raw_affiliation_strings":["Storr Liver Unit, Department of Medicine, University of Sydney, and the Department of Gastroenterology and Hepatology, Westmead Hospital, Westmead, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Storr Liver Unit, Department of Medicine, University of Sydney, and the Department of Gastroenterology and Hepatology, Westmead Hospital, Westmead, NSW, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I2803024705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056297299","display_name":"Karen Byth","orcid":"https://orcid.org/0000-0002-1253-6393","observed_orcids":["https://orcid.org/0000-0002-1253-6393"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2803024705","display_name":"Westmead Hospital","ror":"https://ror.org/04gp5yv64","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2803024705","https://openalex.org/I4405259172"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Karen Byth","raw_affiliation_strings":["Storr Liver Unit, Department of Medicine, University of Sydney, and the Department of Gastroenterology and Hepatology, Westmead Hospital, Westmead, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Storr Liver Unit, Department of Medicine, University of Sydney, and the Department of Gastroenterology and Hepatology, Westmead Hospital, Westmead, NSW, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I2803024705"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jacqueline Field","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2803024705","display_name":"Westmead Hospital","ror":"https://ror.org/04gp5yv64","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2803024705","https://openalex.org/I4405259172"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jacqueline Field","raw_affiliation_strings":["Storr Liver Unit, Department of Medicine, University of Sydney, and the Department of Gastroenterology and Hepatology, Westmead Hospital, Westmead, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Storr Liver Unit, Department of Medicine, University of Sydney, and the Department of Gastroenterology and Hepatology, Westmead Hospital, Westmead, NSW, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I2803024705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049828619","display_name":"Christopher Liddle","orcid":"https://orcid.org/0000-0003-3936-6790","observed_orcids":["https://orcid.org/0000-0003-3936-6790"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2803024705","display_name":"Westmead Hospital","ror":"https://ror.org/04gp5yv64","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2803024705","https://openalex.org/I4405259172"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Christopher Liddle","raw_affiliation_strings":["Storr Liver Unit, Department of Medicine, University of Sydney, and the Department of Gastroenterology and Hepatology, Westmead Hospital, Westmead, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Storr Liver Unit, Department of Medicine, University of Sydney, and the Department of Gastroenterology and Hepatology, Westmead Hospital, Westmead, NSW, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I2803024705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113007156","display_name":"Rita Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2803024705","display_name":"Westmead Hospital","ror":"https://ror.org/04gp5yv64","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2803024705","https://openalex.org/I4405259172"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Rita Lin","raw_affiliation_strings":["Storr Liver Unit, Department of Medicine, University of Sydney, and the Department of Gastroenterology and Hepatology, Westmead Hospital, Westmead, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Storr Liver Unit, Department of Medicine, University of Sydney, and the Department of Gastroenterology and Hepatology, Westmead Hospital, Westmead, NSW, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I2803024705"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109955079","display_name":"Geoffrey C. Farrell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2803024705","display_name":"Westmead Hospital","ror":"https://ror.org/04gp5yv64","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2803024705","https://openalex.org/I4405259172"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Geoffrey C. Farrell","raw_affiliation_strings":["Storr Liver Unit, Department of Medicine, University of Sydney, and the Department of Gastroenterology and Hepatology, Westmead Hospital, Westmead, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Storr Liver Unit, Department of Medicine, University of Sydney, and the Department of Gastroenterology and Hepatology, Westmead Hospital, Westmead, NSW, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I2803024705"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5109955079"],"corresponding_institution_ids":["https://openalex.org/I129604602","https://openalex.org/I2803024705"],"apc_list":{"value":2900,"currency":"USD","value_usd":2900},"apc_paid":null,"fwci":2.928,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.91152236,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"22","issue":"4","first_page":"1065","last_page":"1071"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antipyrine-clearance","display_name":"antipyrine clearance","score":0.9390000104904175},{"id":"https://openalex.org/keywords/chronic-hepatitis-c","display_name":"chronic hepatitis C","score":0.8489999771118164},{"id":"https://openalex.org/keywords/interferon-therapy","display_name":"interferon therapy","score":0.8700000047683716},{"id":"https://openalex.org/keywords/treatment-response-prediction","display_name":"treatment response prediction","score":0.878000020980835},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.8370000123977661},{"id":"https://openalex.org/keywords/alanine-transaminase-normalization","display_name":"alanine transaminase normalization","score":0.9210000038146973},{"id":"https://openalex.org/keywords/relapse","display_name":"relapse","score":0.7879999876022339},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6349999904632568},{"id":"https://openalex.org/keywords/interferon-resistance","display_name":"interferon resistance","score":0.48399999737739563},{"id":"https://openalex.org/keywords/viral-clearance","display_name":"viral clearance","score":0.33799999952316284},{"id":"https://openalex.org/keywords/liver-function-tests","display_name":"liver function tests","score":0.33000001311302185},{"id":"https://openalex.org/keywords/interferon-free-therapy","display_name":"interferon-free therapy","score":0.3490000069141388}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7529337406158447},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.7400965690612793},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.6956577301025391},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6920799016952515},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.691033124923706},{"id":"https://openalex.org/C2778606649","wikidata":"https://www.wikidata.org/wiki/Q305481","display_name":"Alanine transaminase","level":2,"score":0.575385332107544},{"id":"https://openalex.org/C2776877979","wikidata":"https://www.wikidata.org/wiki/Q424288","display_name":"Transaminase","level":3,"score":0.47583794593811035},{"id":"https://openalex.org/C2909179924","wikidata":"https://www.wikidata.org/wiki/Q6046488","display_name":"Alpha interferon","level":3,"score":0.4253961443901062},{"id":"https://openalex.org/C2992208098","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver function","level":2,"score":0.41293513774871826},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3131939172744751},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11106514930725098},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.08626991510391235},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077190","descriptor_name":"Interferon alpha-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000410","descriptor_name":"Alanine Transaminase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000983","descriptor_name":"Antipyrine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006521","descriptor_name":"Hepatitis, Chronic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006521","descriptor_name":"Hepatitis, Chronic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/hep.1840220408","doi":"https://doi.org/10.1002/hep.1840220408","is_oa":false,"landing_page_url":"https://doi.org/10.1002/hep.1840220408","pdf_url":null,"source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},{"id":"doi:10.1016/0270-9139(95)90610-x","doi":"https://doi.org/10.1016/0270-9139(95)90610-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0270-9139(95)90610-x","pdf_url":null,"source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},{"id":"pmid:7557852","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7557852","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology (Baltimore, Md.)","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W114438298","https://openalex.org/W245952103","https://openalex.org/W1472309296","https://openalex.org/W1648420719","https://openalex.org/W1976899994","https://openalex.org/W1977593695","https://openalex.org/W1980323412","https://openalex.org/W1989920801","https://openalex.org/W2002067704","https://openalex.org/W2004134475","https://openalex.org/W2005246694","https://openalex.org/W2014932366","https://openalex.org/W2023083968","https://openalex.org/W2023875365","https://openalex.org/W2046012912","https://openalex.org/W2061208588","https://openalex.org/W2123122673","https://openalex.org/W2155510029","https://openalex.org/W2159820198","https://openalex.org/W2321510787","https://openalex.org/W2334197314","https://openalex.org/W2336799715","https://openalex.org/W2911538489","https://openalex.org/W4214822228","https://openalex.org/W4232270597","https://openalex.org/W4300820655"],"related_works":["https://openalex.org/W3023435089","https://openalex.org/W245952103","https://openalex.org/W2091651577","https://openalex.org/W2086977019","https://openalex.org/W2046012912","https://openalex.org/W2018370670","https://openalex.org/W2058821735","https://openalex.org/W2094137204","https://openalex.org/W2061188466","https://openalex.org/W2017424173"],"abstract_inverted_index":null,"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
