{"id":"https://openalex.org/W2107237644","doi":"https://doi.org/10.1074/jbc.m602516200","title":"Induction of Krox-24 by Endogenous Cannabinoid Type 1 Receptors in Neuro2A Cells Is Mediated by the MEK-ERK MAPK Pathway and Is Suppressed by the Phosphatidylinositol 3-Kinase Pathway","display_name":"Induction of Krox-24 by Endogenous Cannabinoid Type 1 Receptors in Neuro2A Cells Is Mediated by the MEK-ERK MAPK Pathway and Is Suppressed by the Phosphatidylinositol 3-Kinase Pathway","publication_year":2006,"publication_date":"2006-07-25","ids":{"openalex":"https://openalex.org/W2107237644","doi":"https://doi.org/10.1074/jbc.m602516200","mag":"2107237644","pmid":"https://pubmed.ncbi.nlm.nih.gov/16864584"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m602516200","doi":"https://doi.org/10.1074/jbc.m602516200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m602516200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m602516200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013805162","display_name":"E. Scott Graham","orcid":"https://orcid.org/0000-0002-2925-9126","observed_orcids":["https://orcid.org/0000-0002-2925-9126"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"E. Scott Graham","raw_affiliation_strings":["Department of Pharmacology, University of Auckland, Private Bag 92019, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Auckland, Private Bag 92019, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075729167","display_name":"Nicola Ball","orcid":"https://orcid.org/0000-0001-7575-5422","observed_orcids":["https://orcid.org/0000-0001-7575-5422"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Nicola Ball","raw_affiliation_strings":["Department of Pharmacology, University of Auckland, Private Bag 92019, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Auckland, Private Bag 92019, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089619118","display_name":"Emma L. Scotter","orcid":"https://orcid.org/0000-0003-4064-3599","observed_orcids":["https://orcid.org/0000-0003-4064-3599"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Emma L. Scotter","raw_affiliation_strings":["Department of Pharmacology, University of Auckland, Private Bag 92019, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Auckland, Private Bag 92019, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005763658","display_name":"Pritika J. Narayan","orcid":"https://orcid.org/0000-0002-8713-1470","observed_orcids":["https://orcid.org/0000-0002-8713-1470"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Pritika Narayan","raw_affiliation_strings":["Department of Pharmacology, University of Auckland, Private Bag 92019, Auckland, New Zealand","National Research Centre for Growth and Development, University of Auckland, Private Bag 92019, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Auckland, Private Bag 92019, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]},{"raw_affiliation_string":"National Research Centre for Growth and Development, University of Auckland, Private Bag 92019, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043163123","display_name":"Mike Dragunow","orcid":"https://orcid.org/0000-0003-1711-1631","observed_orcids":["https://orcid.org/0000-0003-1711-1631"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Mike Dragunow","raw_affiliation_strings":["Department of Pharmacology, University of Auckland, Private Bag 92019, Auckland, New Zealand","National Research Centre for Growth and Development, University of Auckland, Private Bag 92019, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Auckland, Private Bag 92019, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]},{"raw_affiliation_string":"National Research Centre for Growth and Development, University of Auckland, Private Bag 92019, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052855527","display_name":"Michelle Glass","orcid":"https://orcid.org/0000-0002-5997-6898","observed_orcids":["https://orcid.org/0000-0002-5997-6898"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":true,"raw_author_name":"Michelle Glass","raw_affiliation_strings":["Department of Pharmacology, University of Auckland, Private Bag 92019, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Auckland, Private Bag 92019, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5052855527"],"corresponding_institution_ids":["https://openalex.org/I154130895"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.5058,"has_fulltext":false,"cited_by_count":59,"citation_normalized_percentile":{"value":0.88404013,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"281","issue":"39","first_page":"29085","last_page":"29095"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/krox-24","display_name":"Krox-24","score":0.9509999752044678},{"id":"https://openalex.org/keywords/cb1-receptor","display_name":"CB1 receptor","score":0.8429999947547913},{"id":"https://openalex.org/keywords/endocannabinoid-signaling","display_name":"endocannabinoid signaling","score":0.8379999995231628},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9100000262260437},{"id":"https://openalex.org/keywords/neuro-2a-cells","display_name":"N2a cells","score":0.7879999876022339},{"id":"https://openalex.org/keywords/hu-210","display_name":"HU-210","score":0.7900000214576721},{"id":"https://openalex.org/keywords/signaling-crosstalk","display_name":"signaling crosstalk","score":0.7329999804496765},{"id":"https://openalex.org/keywords/creb-phosphorylation","display_name":"CREB phosphorylation","score":0.9390000104904175},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.7419999837875366},{"id":"https://openalex.org/keywords/uo126","display_name":"UO126","score":0.7440000176429749},{"id":"https://openalex.org/keywords/ly294002","display_name":"LY294002","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.779294490814209},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6455379128456116},{"id":"https://openalex.org/C2780610907","wikidata":"https://www.wikidata.org/wiki/Q2273248","display_name":"Phosphatidylinositol","level":3,"score":0.5950068235397339},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5574684143066406},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.5035755038261414},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5008811950683594},{"id":"https://openalex.org/C3018449070","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signalling pathways","level":3,"score":0.4413915276527405},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3976976275444031},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2861059308052063},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18878930807113647}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020930","descriptor_name":"MAP Kinase Kinase Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043882","descriptor_name":"Receptors, Cannabinoid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051766","descriptor_name":"Early Growth Response Protein 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1074/jbc.m602516200","doi":"https://doi.org/10.1074/jbc.m602516200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m602516200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:16864584","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16864584","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:researchspace.auckland.ac.nz:2292/18788","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2292/18788","pdf_url":null,"source":{"id":"https://openalex.org/S7407055463","display_name":"ResearchSpace (University of Auckland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I154130895","host_organization_name":"University of Auckland","host_organization_lineage":["https://openalex.org/I154130895"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m602516200","doi":"https://doi.org/10.1074/jbc.m602516200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m602516200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W646114512","https://openalex.org/W1494186970","https://openalex.org/W1548409859","https://openalex.org/W1812356957","https://openalex.org/W1847398151","https://openalex.org/W1966040289","https://openalex.org/W1971727526","https://openalex.org/W1978047956","https://openalex.org/W1979688023","https://openalex.org/W1983212364","https://openalex.org/W1985278508","https://openalex.org/W1988633934","https://openalex.org/W1989915314","https://openalex.org/W2004836039","https://openalex.org/W2006878208","https://openalex.org/W2017244291","https://openalex.org/W2017292900","https://openalex.org/W2017323313","https://openalex.org/W2023300694","https://openalex.org/W2025367674","https://openalex.org/W2025543167","https://openalex.org/W2037155998","https://openalex.org/W2047064684","https://openalex.org/W2054259191","https://openalex.org/W2055705346","https://openalex.org/W2061958711","https://openalex.org/W2064128689","https://openalex.org/W2072800347","https://openalex.org/W2073891278","https://openalex.org/W2085300294","https://openalex.org/W2086764120","https://openalex.org/W2087036930","https://openalex.org/W2087170439","https://openalex.org/W2087367550","https://openalex.org/W2097448914","https://openalex.org/W2112213092","https://openalex.org/W2113960469","https://openalex.org/W2116247944","https://openalex.org/W2121330267","https://openalex.org/W2126436185","https://openalex.org/W2126766019","https://openalex.org/W2128269809","https://openalex.org/W2133702956","https://openalex.org/W2134429437","https://openalex.org/W2138417680","https://openalex.org/W2139794765","https://openalex.org/W2143173753","https://openalex.org/W2146141725","https://openalex.org/W2148381523","https://openalex.org/W2164485911","https://openalex.org/W2167604659","https://openalex.org/W2171637070"],"related_works":["https://openalex.org/W1812356957","https://openalex.org/W4387938632","https://openalex.org/W2100507781","https://openalex.org/W1979688023","https://openalex.org/W2086573308","https://openalex.org/W40016481","https://openalex.org/W2121330267","https://openalex.org/W1746387032","https://openalex.org/W2084701475","https://openalex.org/W1607901775"],"abstract_inverted_index":{"Neuro2a":[0],"cells":[1],"endogenously":[2],"express":[3],"cannabinoid":[4],"type":[5],"1":[6],"(CB1)":[7],"receptors.":[8],"CB1":[9,48],"stimulation":[10,50],"with":[11,91],"HU210":[12],"activated":[13],"ERK":[14],"and":[15,43,82,98,122],"induced":[16],"the":[17,61,111,119],"transcription":[18,113],"factor":[19,114],"Krox-24.":[20,47,87],"A":[21],"functional":[22],"MEK-ERK":[23],"pathway":[24,121],"is":[25,115],"an":[26],"important":[27,132],"requirement":[28],"for":[29],"CB1-mediated":[30,44,84,108],"Krox-24":[31,80,112],"induction":[32,85],"as":[33],"blockade":[34,71],"of":[35,46,72,86,110,126],"MEK":[36],"signaling":[37,74,127],"by":[38,75],"UO126":[39],"reduces":[40],"both":[41],"basal":[42,79],"activation":[45,109],"receptor":[49],"did":[51],"not":[52],"activate":[53],"either":[54],"JNK":[55],"or":[56,60,70],"p38":[57],"MAPK":[58],"pathways":[59],"pro-proliferation":[62],"phosphatidylinositol":[63],"3-kinase":[64],"(PI3K)-Akt":[65],"pathway.":[66],"However,":[67],"serum":[68],"removal":[69],"PI3K":[73,102],"LY294002":[76],"transiently":[77],"stimulated":[78],"expression":[81],"increased":[83],"This":[88],"was":[89],"consistent":[90],"a":[92],"transient":[93],"increase":[94],"in":[95],"pMEK,":[96],"pERK,":[97],"pCREB":[99],"levels":[100],"following":[101],"blockade.":[103],"These":[104],"data":[105],"demonstrate":[106],"that":[107],"negatively":[116],"regulated":[117],"through":[118],"PI3K-Akt":[120],"reveals":[123],"several":[124],"points":[125],"cross-talk":[128],"between":[129],"these":[130],"two":[131],"kinase":[133],"pathways.":[134]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}