{"id":"https://openalex.org/W2107190331","doi":"https://doi.org/10.1146/annurev.physiol.010908.163156","title":"Sex-Based Cardiac Physiology","display_name":"Sex-Based Cardiac Physiology","publication_year":2008,"publication_date":"2008-10-02","ids":{"openalex":"https://openalex.org/W2107190331","doi":"https://doi.org/10.1146/annurev.physiol.010908.163156","mag":"2107190331","pmid":"https://pubmed.ncbi.nlm.nih.gov/18828746"},"language":"en","primary_location":{"id":"doi:10.1146/annurev.physiol.010908.163156","doi":"https://doi.org/10.1146/annurev.physiol.010908.163156","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.physiol.010908.163156","pdf_url":null,"source":{"id":"https://openalex.org/S196366644","display_name":"Annual Review of Physiology","issn_l":"0066-4278","issn":["0066-4278","1545-1585"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Physiology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056993823","display_name":"Elizabeth D. Luczak","orcid":"https://orcid.org/0000-0002-7753-089X","observed_orcids":["https://orcid.org/0000-0002-7753-089X"]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth D. Luczak","raw_affiliation_strings":["Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309;,","Department of Molecular Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309;,","institution_ids":["https://openalex.org/I188538660"]},{"raw_affiliation_string":"Department of Molecular Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085095319","display_name":"Leslie Anne Leinwand","orcid":"https://orcid.org/0000-0003-1470-4810","observed_orcids":["https://orcid.org/0000-0003-1470-4810"]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leslie A. Leinwand","raw_affiliation_strings":["Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309;,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309;,","institution_ids":["https://openalex.org/I188538660"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I188538660"],"apc_list":null,"apc_paid":null,"fwci":0.9478,"has_fulltext":false,"cited_by_count":145,"citation_normalized_percentile":{"value":0.66904145,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"71","issue":"1","first_page":"1","last_page":"18"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13252","display_name":"Sex and Gender in Healthcare","score":0.6791999936103821,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13252","display_name":"Sex and Gender in Healthcare","score":0.6791999936103821,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.274399995803833,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.8119999766349792},{"id":"https://openalex.org/keywords/cardiac-physiology","display_name":"cardiac physiology","score":0.9800000190734863},{"id":"https://openalex.org/keywords/sex-hormones","display_name":"sex hormones","score":0.7080000042915344},{"id":"https://openalex.org/keywords/estrogen","display_name":"estrogen","score":0.9110000133514404},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.9980000257492065},{"id":"https://openalex.org/keywords/phytoestrogens","display_name":"phytoestrogens","score":0.8980000019073486},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":0.9039999842643738},{"id":"https://openalex.org/keywords/heart-disease","display_name":"heart disease","score":0.6029999852180481},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.8190000057220459}],"concepts":[{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.7407432198524475},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.6901959776878357},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6546909809112549},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.6516324281692505},{"id":"https://openalex.org/C183683566","wikidata":"https://www.wikidata.org/wiki/Q5038741","display_name":"Cardiovascular physiology","level":2,"score":0.6376856565475464},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.5813558101654053},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5124969482421875},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5038048624992371},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.503032386302948},{"id":"https://openalex.org/C2780074459","wikidata":"https://www.wikidata.org/wiki/Q389735","display_name":"Heart disease","level":2,"score":0.4963560700416565},{"id":"https://openalex.org/C2778270713","wikidata":"https://www.wikidata.org/wiki/Q414496","display_name":"Phytoestrogens","level":3,"score":0.4325066804885864},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3985552489757538},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.14806464314460754}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006331","descriptor_name":"Heart Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012727","descriptor_name":"Sex Characteristics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D048789","descriptor_name":"Phytoestrogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1146/annurev.physiol.010908.163156","doi":"https://doi.org/10.1146/annurev.physiol.010908.163156","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.physiol.010908.163156","pdf_url":null,"source":{"id":"https://openalex.org/S196366644","display_name":"Annual Review of Physiology","issn_l":"0066-4278","issn":["0066-4278","1545-1585"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Physiology","raw_type":"journal-article"},{"id":"pmid:18828746","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18828746","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual review of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":133,"referenced_works":["https://openalex.org/W2512104","https://openalex.org/W19125468","https://openalex.org/W334540905","https://openalex.org/W370902999","https://openalex.org/W620227789","https://openalex.org/W1433990362","https://openalex.org/W1482473767","https://openalex.org/W1485589572","https://openalex.org/W1497938403","https://openalex.org/W1526356963","https://openalex.org/W1593442063","https://openalex.org/W1595294120","https://openalex.org/W1676540962","https://openalex.org/W1877307747","https://openalex.org/W1963742461","https://openalex.org/W1964422900","https://openalex.org/W1965657782","https://openalex.org/W1970781523","https://openalex.org/W1973520084","https://openalex.org/W1975707648","https://openalex.org/W1979501382","https://openalex.org/W1981428805","https://openalex.org/W1984353351","https://openalex.org/W1985542200","https://openalex.org/W1989197624","https://openalex.org/W1989273144","https://openalex.org/W1989348345","https://openalex.org/W1990374532","https://openalex.org/W1993113568","https://openalex.org/W1993183130","https://openalex.org/W1995359445","https://openalex.org/W1998616342","https://openalex.org/W1999251970","https://openalex.org/W2000506136","https://openalex.org/W2000857746","https://openalex.org/W2001397664","https://openalex.org/W2006281459","https://openalex.org/W2007442480","https://openalex.org/W2008676804","https://openalex.org/W2009527950","https://openalex.org/W2011868056","https://openalex.org/W2014062820","https://openalex.org/W2015639803","https://openalex.org/W2015698023","https://openalex.org/W2024652271","https://openalex.org/W2026171294","https://openalex.org/W2030436321","https://openalex.org/W2031563805","https://openalex.org/W2034359758","https://openalex.org/W2037008271","https://openalex.org/W2037680193","https://openalex.org/W2038608961","https://openalex.org/W2040201215","https://openalex.org/W2045062814","https://openalex.org/W2049967922","https://openalex.org/W2051135818","https://openalex.org/W2053357967","https://openalex.org/W2054267961","https://openalex.org/W2054371281","https://openalex.org/W2054959315","https://openalex.org/W2057931548","https://openalex.org/W2062913102","https://openalex.org/W2063254774","https://openalex.org/W2068242526","https://openalex.org/W2069165194","https://openalex.org/W2070660975","https://openalex.org/W2078748771","https://openalex.org/W2082315136","https://openalex.org/W2085245450","https://openalex.org/W2086876168","https://openalex.org/W2087750804","https://openalex.org/W2087994415","https://openalex.org/W2088381487","https://openalex.org/W2089586054","https://openalex.org/W2090667046","https://openalex.org/W2092093656","https://openalex.org/W2094138142","https://openalex.org/W2094151606","https://openalex.org/W2097704819","https://openalex.org/W2103042940","https://openalex.org/W2105014609","https://openalex.org/W2105330325","https://openalex.org/W2105777690","https://openalex.org/W2106564874","https://openalex.org/W2107063713","https://openalex.org/W2107207858","https://openalex.org/W2111092938","https://openalex.org/W2113865982","https://openalex.org/W2114379216","https://openalex.org/W2121596388","https://openalex.org/W2121604817","https://openalex.org/W2122221269","https://openalex.org/W2125743928","https://openalex.org/W2125931795","https://openalex.org/W2128242453","https://openalex.org/W2128517839","https://openalex.org/W2131032307","https://openalex.org/W2131782993","https://openalex.org/W2132378701","https://openalex.org/W2134270245","https://openalex.org/W2139967865","https://openalex.org/W2140206052","https://openalex.org/W2142458023","https://openalex.org/W2144450331","https://openalex.org/W2147237245","https://openalex.org/W2148254721","https://openalex.org/W2148993268","https://openalex.org/W2151007116","https://openalex.org/W2152323915","https://openalex.org/W2153106405","https://openalex.org/W2154587590","https://openalex.org/W2155598737","https://openalex.org/W2155975969","https://openalex.org/W2156995088","https://openalex.org/W2159940503","https://openalex.org/W2160776746","https://openalex.org/W2163064472","https://openalex.org/W2164641172","https://openalex.org/W2167550154","https://openalex.org/W2168000106","https://openalex.org/W2169328139","https://openalex.org/W2171377757","https://openalex.org/W2171434441","https://openalex.org/W2171834186","https://openalex.org/W2292249227","https://openalex.org/W2324476825","https://openalex.org/W2325814559","https://openalex.org/W2333702587","https://openalex.org/W2340630441","https://openalex.org/W2405144088","https://openalex.org/W2407168779","https://openalex.org/W2460651783","https://openalex.org/W4251876242"],"related_works":["https://openalex.org/W2046604548","https://openalex.org/W2063177494","https://openalex.org/W2337656162","https://openalex.org/W2038944991","https://openalex.org/W2037662832","https://openalex.org/W4409143935","https://openalex.org/W1967717319","https://openalex.org/W136431067","https://openalex.org/W1539195752","https://openalex.org/W2249429402"],"abstract_inverted_index":{"Biological":[0],"sex":[1,39],"plays":[2],"an":[3],"important":[4],"role":[5],"in":[6,13,31,59,69,101],"normal":[7],"cardiac":[8,18,24,35,53,70,99],"physiology":[9,100],"as":[10,12,94],"well":[11],"the":[14,32],"heart's":[15],"response":[16],"to":[17,66,77,84,87],"disease.":[19],"Women":[20],"generally":[21,75],"have":[22],"better":[23],"function":[25],"and":[26,105],"survival":[27],"than":[28],"do":[29],"men":[30],"face":[33],"of":[34,52],"disease;":[36],"however,":[37],"this":[38],"difference":[40],"is":[41,57,74,82],"lost":[42],"when":[43],"comparing":[44],"postmenopausal":[45],"women":[46],"with":[47],"age-matched":[48],"men.":[49],"Animal":[50],"models":[51],"disease":[54,71],"mirror":[55],"what":[56],"seen":[58],"humans.":[60],"Sex":[61],"steroid":[62],"hormones":[63],"contribute":[64],"significantly":[65],"sex-based":[67],"differences":[68],"outcomes.":[72],"Estrogen":[73],"considered":[76],"be":[78,85],"cardioprotective,":[79],"whereas":[80],"testosterone":[81],"thought":[83],"detrimental":[86],"heart":[88],"function.":[89],"Environmental":[90],"estrogen-like":[91],"molecules,":[92],"such":[93],"phytoestrogens,":[95],"can":[96],"also":[97],"affect":[98],"both":[102],"a":[103,106],"positive":[104],"negative":[107],"manner.":[108]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
