{"id":"https://openalex.org/W2107154530","doi":"https://doi.org/10.1194/jlr.m400181-jlr200","title":"Novel fatty acid elongases and their use for the reconstitution of docosahexaenoic acid biosynthesis","display_name":"Novel fatty acid elongases and their use for the reconstitution of docosahexaenoic acid biosynthesis","publication_year":2004,"publication_date":"2004-08-02","ids":{"openalex":"https://openalex.org/W2107154530","doi":"https://doi.org/10.1194/jlr.m400181-jlr200","mag":"2107154530","pmid":"https://pubmed.ncbi.nlm.nih.gov/15292371"},"language":"en","primary_location":{"id":"doi:10.1194/jlr.m400181-jlr200","doi":"https://doi.org/10.1194/jlr.m400181-jlr200","is_oa":true,"landing_page_url":"https://doi.org/10.1194/jlr.m400181-jlr200","pdf_url":"http://www.jlr.org/article/S0022227520312645/pdf","source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jlr.org/article/S0022227520312645/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111678711","display_name":"Astrid Meyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Astrid Meyer","raw_affiliation_strings":["Biozentrum Klein Flottbek, Universit\u00e4t Hamburg, D-22609 Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biozentrum Klein Flottbek, Universit\u00e4t Hamburg, D-22609 Hamburg, Germany","institution_ids":["https://openalex.org/I159176309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037117108","display_name":"Helene Kirsch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Helene Kirsch","raw_affiliation_strings":["Biozentrum Klein Flottbek, Universit\u00e4t Hamburg, D-22609 Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biozentrum Klein Flottbek, Universit\u00e4t Hamburg, D-22609 Hamburg, Germany","institution_ids":["https://openalex.org/I159176309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031581061","display_name":"Fr\u00e9d\u00e9ric Domergue","orcid":"https://orcid.org/0000-0002-0183-7000","observed_orcids":["https://orcid.org/0000-0002-0183-7000"]},"institutions":[{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Fr\u00e9d\u00e9ric Domergue","raw_affiliation_strings":["Biozentrum Klein Flottbek, Universit\u00e4t Hamburg, D-22609 Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biozentrum Klein Flottbek, Universit\u00e4t Hamburg, D-22609 Hamburg, Germany","institution_ids":["https://openalex.org/I159176309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040876659","display_name":"Amine Abbadi","orcid":"https://orcid.org/0000-0002-2389-978X","observed_orcids":["https://orcid.org/0000-0002-2389-978X"]},"institutions":[{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Amine Abbadi","raw_affiliation_strings":["Biozentrum Klein Flottbek, Universit\u00e4t Hamburg, D-22609 Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biozentrum Klein Flottbek, Universit\u00e4t Hamburg, D-22609 Hamburg, Germany","institution_ids":["https://openalex.org/I159176309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111364954","display_name":"Petra Sperling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Petra Sperling","raw_affiliation_strings":["Biozentrum Klein Flottbek, Universit\u00e4t Hamburg, D-22609 Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biozentrum Klein Flottbek, Universit\u00e4t Hamburg, D-22609 Hamburg, Germany","institution_ids":["https://openalex.org/I159176309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107253298","display_name":"J\u00f6rg Bauer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107087","display_name":"BASF (Germany)","ror":"https://ror.org/01q8f6705","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210107087"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J\u00f6rg Bauer","raw_affiliation_strings":["BASF Plant Science GmbH, D-67056 Ludwigshafen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BASF Plant Science GmbH, D-67056 Ludwigshafen, Germany","institution_ids":["https://openalex.org/I4210107087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046282466","display_name":"Petra Cirpus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107087","display_name":"BASF (Germany)","ror":"https://ror.org/01q8f6705","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210107087"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Petra Cirpus","raw_affiliation_strings":["BASF Plant Science GmbH, D-67056 Ludwigshafen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BASF Plant Science GmbH, D-67056 Ludwigshafen, Germany","institution_ids":["https://openalex.org/I4210107087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091449014","display_name":"Thorsten K. Zank","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107087","display_name":"BASF (Germany)","ror":"https://ror.org/01q8f6705","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210107087"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thorsten K. Zank","raw_affiliation_strings":["BASF Plant Science GmbH, D-67056 Ludwigshafen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BASF Plant Science GmbH, D-67056 Ludwigshafen, Germany","institution_ids":["https://openalex.org/I4210107087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003307709","display_name":"Herv\u00e9 Moreau","orcid":"https://orcid.org/0000-0003-2554-5536","observed_orcids":["https://orcid.org/0000-0003-2554-5536"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210144707","display_name":"Observatoire Oc\u00e9anologique de Banyuls-sur-Mer","ror":"https://ror.org/05gz4kr37","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I39804081","https://openalex.org/I4210144707"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Herv\u00e9 Moreau","raw_affiliation_strings":["Laboratoire Arago, Unit\u00e9 Mixte de Recherche 7628, Centre National de la Recherche Scientifique, F-66651 Banyuls sur mer, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire Arago, Unit\u00e9 Mixte de Recherche 7628, Centre National de la Recherche Scientifique, F-66651 Banyuls sur mer, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210144707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042844879","display_name":"Thomas James Roscoe","orcid":"https://orcid.org/0000-0002-5477-3725","observed_orcids":["https://orcid.org/0000-0002-5477-3725"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210130438","display_name":"Laboratoire G\u00e9nome et D\u00e9veloppement des Plantes","ror":"https://ror.org/038207k30","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I151295451","https://openalex.org/I4210096427","https://openalex.org/I4210130438"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Thomas J. Roscoe","raw_affiliation_strings":["Laboratoire de G\u00e9nome et D\u00e9veloppement des Plantes, Unit\u00e9 Mixte de Recherche 5096, Centre National de la Recherche Scientifique, F-66860 Perpignan, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de G\u00e9nome et D\u00e9veloppement des Plantes, Unit\u00e9 Mixte de Recherche 5096, Centre National de la Recherche Scientifique, F-66860 Perpignan, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210130438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090327349","display_name":"Ulrich Z\u00e4hringer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128097","display_name":"Research Center Borstel - Leibniz Lung Center","ror":"https://ror.org/036ragn25","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210128097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ulrich Z\u00e4hringer","raw_affiliation_strings":["Forschungszentrum Borstel, D-23845 Borstel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Forschungszentrum Borstel, D-23845 Borstel, Germany","institution_ids":["https://openalex.org/I4210128097"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111530592","display_name":"Ernst Heinz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Ernst Heinz","raw_affiliation_strings":["Biozentrum Klein Flottbek, Universit\u00e4t Hamburg, D-22609 Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biozentrum Klein Flottbek, Universit\u00e4t Hamburg, D-22609 Hamburg, Germany","institution_ids":["https://openalex.org/I159176309"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5111530592"],"corresponding_institution_ids":["https://openalex.org/I159176309"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.9793,"has_fulltext":true,"cited_by_count":185,"citation_normalized_percentile":{"value":0.92272618,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"45","issue":"10","first_page":"1899","last_page":"1909"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.8237000107765198,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.8237000107765198,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.1421000063419342,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10450","display_name":"Aquaculture Nutrition and Growth","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/docosahexaenoic-acid-biosynthesis","display_name":"docosahexaenoic acid biosynthesis","score":0.9660000205039978},{"id":"https://openalex.org/keywords/fatty-acid-elongase","display_name":"fatty acid elongase","score":0.9319999814033508},{"id":"https://openalex.org/keywords/omega-3-polyunsaturated-fatty-acids","display_name":"omega-3 polyunsaturated fatty acids","score":0.7739999890327454},{"id":"https://openalex.org/keywords/ostreococcus-tauri","display_name":"Ostreococcus tauri","score":0.8870000243186951},{"id":"https://openalex.org/keywords/thalassiosira-pseudonana","display_name":"Thalassiosira pseudonana","score":1.0}],"concepts":[{"id":"https://openalex.org/C2777171753","wikidata":"https://www.wikidata.org/wiki/Q423345","display_name":"Docosahexaenoic acid","level":4,"score":0.8559402227401733},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.6966018676757812},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5895400643348694},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5311511754989624},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.4981868267059326},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.3286851644515991},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13234984874725342}],"mesh":[{"descriptor_ui":"D000081031","descriptor_name":"Fatty Acid Elongases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000123","descriptor_name":"Acetyltransferases","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000123","descriptor_name":"Acetyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000123","descriptor_name":"Acetyltransferases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002938","descriptor_name":"Ciona intestinalis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004281","descriptor_name":"Docosahexaenoic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004281","descriptor_name":"Docosahexaenoic Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005231","descriptor_name":"Fatty Acids, Unsaturated","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008722","descriptor_name":"Methods","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015003","descriptor_name":"Yeasts","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017686","descriptor_name":"Oncorhynchus mykiss","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019068","descriptor_name":"Bryopsida","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056890","descriptor_name":"Eukaryota","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1194/jlr.m400181-jlr200","doi":"https://doi.org/10.1194/jlr.m400181-jlr200","is_oa":true,"landing_page_url":"https://doi.org/10.1194/jlr.m400181-jlr200","pdf_url":"http://www.jlr.org/article/S0022227520312645/pdf","source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},{"id":"pmid:15292371","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15292371","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of lipid research","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:945884e7e5494e2fae904ddd108057ed","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/945884e7e5494e2fae904ddd108057ed","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Lipid Research, Vol 45, Iss 10, Pp 1899-1909 (2004)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1194/jlr.m400181-jlr200","doi":"https://doi.org/10.1194/jlr.m400181-jlr200","is_oa":true,"landing_page_url":"https://doi.org/10.1194/jlr.m400181-jlr200","pdf_url":"http://www.jlr.org/article/S0022227520312645/pdf","source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2107154530.pdf","grobid_xml":"https://content.openalex.org/works/W2107154530.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1486477932","https://openalex.org/W1504719529","https://openalex.org/W1527575436","https://openalex.org/W1656523635","https://openalex.org/W1907473378","https://openalex.org/W1972549325","https://openalex.org/W1974401020","https://openalex.org/W1986450487","https://openalex.org/W1990045070","https://openalex.org/W1990876848","https://openalex.org/W1995813003","https://openalex.org/W1996358681","https://openalex.org/W2009344085","https://openalex.org/W2012716766","https://openalex.org/W2013344341","https://openalex.org/W2026103104","https://openalex.org/W2026478921","https://openalex.org/W2033302572","https://openalex.org/W2055008532","https://openalex.org/W2055043387","https://openalex.org/W2068176739","https://openalex.org/W2069280266","https://openalex.org/W2073866295","https://openalex.org/W2078490695","https://openalex.org/W2081493241","https://openalex.org/W2084588202","https://openalex.org/W2102424101","https://openalex.org/W2107873244","https://openalex.org/W2116420692","https://openalex.org/W2120328280","https://openalex.org/W2132200710","https://openalex.org/W2140090951","https://openalex.org/W2157520090","https://openalex.org/W2395017497"],"related_works":["https://openalex.org/W2090575415","https://openalex.org/W2438035631","https://openalex.org/W2990601725","https://openalex.org/W2254050763","https://openalex.org/W2162229958","https://openalex.org/W2026203662","https://openalex.org/W3083569359","https://openalex.org/W2110355285","https://openalex.org/W2091443668","https://openalex.org/W2099922768"],"abstract_inverted_index":{"In":[0],"algae,":[1],"the":[2,11,27,33,48,56,61,67,76,81,90,118,151,163],"biosynthesis":[3],"of":[4,13,89,107,120,150],"docosahexaenoic":[5],"acid":[6,15],"(22:6omega3;":[7],"DHA)":[8],"proceeds":[9],"via":[10],"elongation":[12,119],"eicosapentaenoic":[14],"(20:5omega3;":[16],"EPA)":[17],"to":[18,191],"22:5omega3,":[19],"which":[20],"is":[21],"required":[22],"as":[23,73],"a":[24,74],"substrate":[25],"for":[26,36,98,117,125],"final":[28],"Delta4":[29],"desaturation.":[30],"To":[31],"isolate":[32],"elongase":[34,77,92],"specific":[35,116,124],"this":[37,193],"step,":[38],"we":[39,103,171],"searched":[40],"expressed":[41,95],"sequence":[42,78,195],"tag":[43],"and":[44,52,65,112,122,140,146,153,158,165],"genomic":[45],"databases":[46],"from":[47,55,60,66,80,109,135,155,167],"algae":[49,170],"Ostreococcus":[50],"tauri":[51,111],"Thalassiosira":[53],"pseudonana,":[54],"fish":[57],"Oncorhynchus":[58],"mykiss,":[59,137],"frog":[62],"Xenopus":[63],"laevis,":[64,139],"sea":[68],"squirt":[69],"Ciona":[70],"intestinalis":[71,142],"using":[72],"query":[75],"PpPSE1":[79],"moss":[82],"Physcomitrella":[83],"patens.":[84],"The":[85,132],"open":[86],"reading":[87],"frames":[88],"identified":[91,104],"candidates":[93],"were":[94],"in":[96,176,188],"yeast":[97],"functional":[99],"characterization.":[100],"By":[101,148],"this,":[102],"two":[105,168],"types":[106],"elongases":[108],"O.":[110,136,159],"T.":[113,156],"pseudonana:":[114],"one":[115,123],"(Delta6-)C18-PUFAs":[121],"(Delta5-)C20-PUFAs,":[126],"showing":[127],"highest":[128],"activity":[129],"with":[130,162],"EPA.":[131],"clones":[133],"isolated":[134],"X.":[138],"C.":[141],"accepted":[143],"both":[144],"C18-":[145],"C20-PUFAs.":[147],"coexpression":[149],"Delta6-":[152],"Delta5-elongases":[154],"pseudonana":[157],"tauri,":[160],"respectively,":[161],"Delta5-":[164],"Delta4-desaturases":[166],"other":[169],"successfully":[172],"implemented":[173],"DHA":[174],"synthesis":[175],"stearidonic":[177],"acid-fed":[178],"yeast.":[179],"This":[180],"may":[181],"be":[182],"considered":[183],"an":[184],"encouraging":[185],"first":[186],"step":[187],"future":[189],"efforts":[190],"implement":[192],"biosynthetic":[194],"into":[196],"transgenic":[197],"oilseed":[198],"crops.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":13}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}