{"id":"https://openalex.org/W2107060975","doi":"https://doi.org/10.1093/clinchem/33.1.87","title":"On the albumin-dependence of measurements of free thyroxin. II. Patients with non-thyroidal illness.","display_name":"On the albumin-dependence of measurements of free thyroxin. II. Patients with non-thyroidal illness.","publication_year":1987,"publication_date":"1987-01-01","ids":{"openalex":"https://openalex.org/W2107060975","doi":"https://doi.org/10.1093/clinchem/33.1.87","mag":"2107060975","pmid":"https://pubmed.ncbi.nlm.nih.gov/3100099"},"language":"en","primary_location":{"id":"doi:10.1093/clinchem/33.1.87","doi":"https://doi.org/10.1093/clinchem/33.1.87","is_oa":false,"landing_page_url":"https://doi.org/10.1093/clinchem/33.1.87","pdf_url":null,"source":{"id":"https://openalex.org/S139212996","display_name":"Clinical Chemistry","issn_l":"0009-9147","issn":["0009-9147","1530-8561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320272","host_organization_name":"American Association for Clinical Chemistry","host_organization_lineage":["https://openalex.org/P4310320272"],"host_organization_lineage_names":["American Association for Clinical Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027032991","display_name":"Gy\u00f6rgy Cs\u00e1k\u00f3","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Csako","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046689484","display_name":"MARK H. ZWEIG","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M H Zweig","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057697494","display_name":"Carol B. Benson","orcid":"https://orcid.org/0000-0003-2639-2703","observed_orcids":["https://orcid.org/0000-0003-2639-2703"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Benson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5015575563","display_name":"Mark E. Ruddel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Ruddel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4636,"currency":"USD","value_usd":4636},"apc_paid":null,"fwci":2.3969,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.8900578,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"33","issue":"1","first_page":"87","last_page":"92"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.011599999852478504,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/free-thyroxine","display_name":"free thyroxine","score":0.9869999885559082},{"id":"https://openalex.org/keywords/non-thyroidal-illness","display_name":"low T3 syndrome","score":0.9340000152587891},{"id":"https://openalex.org/keywords/thyroxine-binding-proteins","display_name":"thyroxine-binding proteins","score":0.8240000009536743},{"id":"https://openalex.org/keywords/serum-albumin","display_name":"serum albumin","score":0.9319999814033508},{"id":"https://openalex.org/keywords/radioimmunoassay-interference","display_name":"radioimmunoassay interference","score":0.722000002861023},{"id":"https://openalex.org/keywords/equilibrium-dialysis","display_name":"equilibrium dialysis","score":0.8309999704360962}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.620735228061676},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5925682783126831},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.49695566296577454},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4688096344470978},{"id":"https://openalex.org/C165616093","wikidata":"https://www.wikidata.org/wiki/Q424232","display_name":"Serum albumin","level":2,"score":0.4336254298686981},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32697683572769165}],"mesh":[{"descriptor_ui":"D003951","descriptor_name":"Diagnostic Errors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003956","descriptor_name":"Dialysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006331","descriptor_name":"Heart Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013223","descriptor_name":"Statistics as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013959","descriptor_name":"Thyroid Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013975","descriptor_name":"Thyroxine-Binding Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D014284","descriptor_name":"Triiodothyronine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/clinchem/33.1.87","doi":"https://doi.org/10.1093/clinchem/33.1.87","is_oa":false,"landing_page_url":"https://doi.org/10.1093/clinchem/33.1.87","pdf_url":null,"source":{"id":"https://openalex.org/S139212996","display_name":"Clinical Chemistry","issn_l":"0009-9147","issn":["0009-9147","1530-8561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320272","host_organization_name":"American Association for Clinical Chemistry","host_organization_lineage":["https://openalex.org/P4310320272"],"host_organization_lineage_names":["American Association for Clinical Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry","raw_type":"journal-article"},{"id":"pmid:3100099","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3100099","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical chemistry","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1894161363","https://openalex.org/W1928162041","https://openalex.org/W1993358990","https://openalex.org/W2014643405","https://openalex.org/W2074101844","https://openalex.org/W2086711676","https://openalex.org/W2111351495","https://openalex.org/W2117931087","https://openalex.org/W2121297836","https://openalex.org/W2136335064","https://openalex.org/W2163480387","https://openalex.org/W4246472814","https://openalex.org/W4302771188"],"related_works":["https://openalex.org/W1801162136","https://openalex.org/W7097299493","https://openalex.org/W2166034218","https://openalex.org/W1963324156","https://openalex.org/W1952077050","https://openalex.org/W2123158805","https://openalex.org/W7095448667","https://openalex.org/W1818796228","https://openalex.org/W1928162041","https://openalex.org/W4299615917"],"abstract_inverted_index":{"We":[0],"studied":[1],"the":[2,32,38,131,141,151],"relation":[3],"between":[4],"thyroxin-binding":[5],"proteins":[6],"and":[7,16,31,60,68,94,145],"free":[8],"thyroxin":[9],"(FT4)":[10],"measurements":[11],"by":[12,44],"five":[13],"radioimmunoassays":[14],"(RIA)":[15],"an":[17],"FT4":[18,29,40,55,99,120,143],"index":[19],"(FT4I)":[20],"in":[21,101,130],"patients":[22,80,103,113],"with":[23,57,64,81,104,114,122],"non-thyroidal":[24],"illness":[25],"(NTI).":[26],"The":[27,91],"one-step":[28,58,142],"RIAs":[30,59,93,144],"FT4I":[33,61,146],"frequently":[34],"failed":[35],"to":[36],"identify":[37],"true":[39],"status":[41,153],"(as":[42],"determined":[43],"equilibrium":[45,95],"dialysis)":[46],"of":[47,111,133,154],"NTI":[48,79,112,155],"patients.":[49,156],"In":[50],"these":[51,123],"patients,":[52],"falsely":[53],"low":[54,84],"results":[56,121],"were":[62],"associated":[63],"decreasing":[65,74],"total":[66],"T3":[67,116],"T4":[69,85],"concentrations,":[70],"which,":[71],"furthermore,":[72],"paralleled":[73],"serum":[75],"albumin":[76,89,136],"concentrations.":[77],"All":[78],"\"low":[82,115],"T3,":[83],"syndrome\"":[86,117],"had":[87],"subnormal":[88,135],"concentration.":[90],"two-step":[92],"dialysis":[96],"showed":[97],"normal":[98],"concentrations":[100],"most":[102],"NTI.":[105],"However,":[106],"sera":[107],"from":[108],"a":[109,134],"subset":[110],"gave":[118],"above-normal":[119],"methods.":[124],"From":[125],"their":[126],"predictably":[127],"poor":[128],"performance":[129],"presence":[132],"concentration,":[137],"we":[138],"conclude":[139],"that":[140],"are":[147],"inappropriate":[148],"for":[149],"testing":[150],"thyrometabolic":[152]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
