{"id":"https://openalex.org/W2107045802","doi":"https://doi.org/10.1183/09031936.02.00238702","title":"Improved health outcomes in patients with COPD during 1 yr's treatment with tiotropium","display_name":"Improved health outcomes in patients with COPD during 1 yr's treatment with tiotropium","publication_year":2002,"publication_date":"2002-02-01","ids":{"openalex":"https://openalex.org/W2107045802","doi":"https://doi.org/10.1183/09031936.02.00238702","mag":"2107045802","pmid":"https://pubmed.ncbi.nlm.nih.gov/11871363"},"language":"en","primary_location":{"id":"doi:10.1183/09031936.02.00238702","doi":"https://doi.org/10.1183/09031936.02.00238702","is_oa":true,"landing_page_url":"https://doi.org/10.1183/09031936.02.00238702","pdf_url":"https://erj.ersjournals.com/content/erj/19/2/209.full.pdf","source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Respiratory Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://erj.ersjournals.com/content/erj/19/2/209.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081466012","display_name":"Walter Vincken","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]},{"id":"https://openalex.org/I4210126764","display_name":"Universitair Ziekenhuis Brussel","ror":"https://ror.org/038f7y939","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210126764"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"W. Vincken","raw_affiliation_strings":["Respiratory Division, AZ VUB (Academic Hospital University of Brussels), Belgium","Vrije Universiteit Brussel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory Division, AZ VUB (Academic Hospital University of Brussels), Belgium","institution_ids":["https://openalex.org/I13469542","https://openalex.org/I4210126764"]},{"raw_affiliation_string":"Vrije Universiteit Brussel","institution_ids":["https://openalex.org/I13469542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111537363","display_name":"Jan Arie van Noord","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J.A. van Noord","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028300999","display_name":"A.P.M. Greefhorst","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A.P.M. Greefhorst","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018129559","display_name":"Th.A. Bantje","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Th.A. Bantje","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090459826","display_name":"Steven Kesten","orcid":"https://orcid.org/0000-0002-5522-7910","observed_orcids":["https://orcid.org/0000-0002-5522-7910"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Kesten","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039698736","display_name":"Larry Korducki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]},{"id":"https://openalex.org/I4210160255","display_name":"Boehringer Ingelheim (United States)","ror":"https://ror.org/05kffp613","country_code":"US","type":"company","lineage":["https://openalex.org/I1330995197","https://openalex.org/I4210160255"]}],"countries":["BE","US"],"is_corresponding":false,"raw_author_name":"L. Korducki","raw_affiliation_strings":["Boehringer Ingelheim , Ridgefield , CT , USA","Respiratory Division , Academic Hos- pital University of Brussels (AZ VUB) , Brussels , Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boehringer Ingelheim , Ridgefield , CT , USA","institution_ids":["https://openalex.org/I4210160255"]},{"raw_affiliation_string":"Respiratory Division , Academic Hos- pital University of Brussels (AZ VUB) , Brussels , Belgium","institution_ids":["https://openalex.org/I13469542"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110075277","display_name":"P. J. G. Cornelissen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P.J.G. Cornelissen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":55.7684,"has_fulltext":true,"cited_by_count":728,"citation_normalized_percentile":{"value":0.99950025,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":100},"biblio":{"volume":"19","issue":"2","first_page":"209","last_page":"216"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tiotropium","display_name":"tiotropium","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9760000109672546},{"id":"https://openalex.org/keywords/ipratropium-bromide","display_name":"ipratropium bromide","score":0.9700000286102295},{"id":"https://openalex.org/keywords/inhaled-anticholinergics","display_name":"inhaled anticholinergics","score":0.8429999947547913},{"id":"https://openalex.org/keywords/acute-exacerbation-of-copd","display_name":"COPD exacerbations","score":0.8320000171661377},{"id":"https://openalex.org/keywords/lung-function","display_name":"lung function","score":0.8920000195503235},{"id":"https://openalex.org/keywords/fev1","display_name":"FEV1","score":0.8140000104904175},{"id":"https://openalex.org/keywords/peak-expiratory-flow","display_name":"peak expiratory flow","score":0.9300000071525574},{"id":"https://openalex.org/keywords/dyspnea","display_name":"dyspnea","score":0.8980000019073486},{"id":"https://openalex.org/keywords/health-related-quality-of-life","display_name":"health-related quality of life","score":0.9990000128746033},{"id":"https://openalex.org/keywords/salbutamol-use","display_name":"salbutamol use","score":0.9620000123977661},{"id":"https://openalex.org/keywords/hospitalization","display_name":"hospitalization","score":0.6129999756813049},{"id":"https://openalex.org/keywords/xerostomia","display_name":"xerostomia","score":0.6579999923706055}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9038280248641968},{"id":"https://openalex.org/C2909577894","wikidata":"https://www.wikidata.org/wiki/Q424294","display_name":"Ipratropium","level":4,"score":0.8844324350357056},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.8130166530609131},{"id":"https://openalex.org/C2776968687","wikidata":"https://www.wikidata.org/wiki/Q424316","display_name":"Tiotropium bromide","level":4,"score":0.775179386138916},{"id":"https://openalex.org/C2777014857","wikidata":"https://www.wikidata.org/wiki/Q1383410","display_name":"Exacerbation","level":2,"score":0.7228692770004272},{"id":"https://openalex.org/C2777394947","wikidata":"https://www.wikidata.org/wiki/Q410358","display_name":"Salbutamol","level":3,"score":0.6715936064720154},{"id":"https://openalex.org/C2776719499","wikidata":"https://www.wikidata.org/wiki/Q424333","display_name":"Salmeterol","level":3,"score":0.5824205279350281},{"id":"https://openalex.org/C2780333948","wikidata":"https://www.wikidata.org/wiki/Q653305","display_name":"Spirometry","level":3,"score":0.485486775636673},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41806942224502563},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4047636091709137},{"id":"https://openalex.org/C3018587741","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung function","level":3,"score":0.28809142112731934},{"id":"https://openalex.org/C2781018748","wikidata":"https://www.wikidata.org/wiki/Q927234","display_name":"Bronchodilator","level":3,"score":0.27449607849121094},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.22454461455345154},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.18618911504745483}],"mesh":[{"descriptor_ui":"D000069447","descriptor_name":"Tiotropium Bromide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001993","descriptor_name":"Bronchodilator Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005541","descriptor_name":"Forced Expiratory Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009241","descriptor_name":"Ipratropium","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010366","descriptor_name":"Peak Expiratory Flow Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012602","descriptor_name":"Scopolamine Derivatives","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014797","descriptor_name":"Vital Capacity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018680","descriptor_name":"Cholinergic Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1183/09031936.02.00238702","doi":"https://doi.org/10.1183/09031936.02.00238702","is_oa":true,"landing_page_url":"https://doi.org/10.1183/09031936.02.00238702","pdf_url":"https://erj.ersjournals.com/content/erj/19/2/209.full.pdf","source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Respiratory Journal","raw_type":"journal-article"},{"id":"pmid:11871363","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11871363","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The European respiratory journal","raw_type":"Clinical Trial"}],"best_oa_location":{"id":"doi:10.1183/09031936.02.00238702","doi":"https://doi.org/10.1183/09031936.02.00238702","is_oa":true,"landing_page_url":"https://doi.org/10.1183/09031936.02.00238702","pdf_url":"https://erj.ersjournals.com/content/erj/19/2/209.full.pdf","source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Respiratory Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2107045802.pdf","grobid_xml":"https://content.openalex.org/works/W2107045802.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W283336396","https://openalex.org/W1892949664","https://openalex.org/W1961645094","https://openalex.org/W1963710622","https://openalex.org/W1970629614","https://openalex.org/W1978457536","https://openalex.org/W1992410603","https://openalex.org/W1993643657","https://openalex.org/W1998547311","https://openalex.org/W1998819769","https://openalex.org/W1999498873","https://openalex.org/W2007810665","https://openalex.org/W2019621692","https://openalex.org/W2035236156","https://openalex.org/W2037377025","https://openalex.org/W2056765555","https://openalex.org/W2066161938","https://openalex.org/W2075487269","https://openalex.org/W2079777289","https://openalex.org/W2083436606","https://openalex.org/W2088022718","https://openalex.org/W2112318617","https://openalex.org/W2133119676","https://openalex.org/W2138312725","https://openalex.org/W2149849734","https://openalex.org/W2156146671","https://openalex.org/W2166780351","https://openalex.org/W2197553214","https://openalex.org/W2994597783","https://openalex.org/W4292806894"],"related_works":["https://openalex.org/W2149199480","https://openalex.org/W2150866838","https://openalex.org/W2158530076","https://openalex.org/W2047229555","https://openalex.org/W4239080780","https://openalex.org/W2412416006","https://openalex.org/W2112318617","https://openalex.org/W2160426586","https://openalex.org/W1981197711","https://openalex.org/W2104616045"],"abstract_inverted_index":{"Tiotropium,":[0],"a":[1,14,170],"novel":[2],"once-daily":[3,230],"inhaled":[4],"anticholinergic,":[5],"has":[6],"been":[7],"shown":[8],"to":[9,19,160,166],"improve":[10],"lung":[11,207],"function":[12,208],"over":[13,26],"24-h":[15],"period.":[16],"In":[17],"order":[18],"extend":[20],"these":[21],"findings,":[22],"health-outcomes":[23],"were":[24,56,88,143,191],"evaluated":[25],"1":[27,106],"yr":[28,107],"in":[29,58,84,124,185,198,209,235],"chronic":[30,212,238],"obstructive":[31,213,239],"pulmonary":[32,214,240],"disease":[33],"(COPD)":[34],"patients.":[35],"Spirometric":[36],"results,":[37],"peak":[38],"expiratory":[39,82],"flow":[40],"rate":[41],"(PEFR),":[42],"salbutamol":[43,126],"use":[44,227],"and":[45,53,97,114,133,140,157,164,206,216],"effects":[46],"on":[47],"dyspnoea,":[48,200],"health-related":[49,202],"quality":[50,203],"of":[51,66,92,152,182,204,228],"life":[52,205],"COPD":[54,171],"exacerbations":[55,153],"assessed":[57],"two":[59],"identical":[60],"1-yr":[61],"randomized":[62],"double-blind":[63],"double-dummy":[64],"studies":[65],"tiotropium":[67,113,146,187,229],"18":[68],"microg":[69,77],"once":[70],"daily":[71],"(n=356)":[72],"compared":[73,174],"with":[74,112,119,145,175,211,221,237],"ipratropium":[75,120],"40":[76],"q.i.d.":[78],"(n=179).":[79],"Screening":[80],"forced":[81],"volume":[83],"one":[85],"second":[86],"(FEV1)":[87],"1.25+/-0.43":[89],"L":[90,99,111,118],"(41.9+/-12.7%":[91],"the":[93,134,150,186,218,226],"predicted":[94],"value)":[95],"(tiotropium)":[96],"1.18+/-0.37":[98],"(39.4+/-10.7%":[100],"pred)":[101],"(ipratropium).":[102],"Trough":[103],"FEV1":[104],"at":[105],"improved":[108],"by":[109,116],"0.12+/-0.01":[110],"declined":[115],"0.03+/-0.02":[117],"(p<0.001).":[121],"Significant":[122],"improvement":[123],"PEFR,":[125],"use,":[127],"Transition":[128],"Dyspnea":[129],"Index":[130],"focal":[131],"score,":[132],"St":[135],"George's":[136],"Respiratory":[137],"Questionnaire":[138],"total":[139],"impact":[141],"scores":[142],"seen":[144,220],"(p<0.01).":[147],"Tiotropium":[148,195],"reduced":[149],"number":[151],"(by":[154],"24%,":[155],"p<0.01),":[156],"increased":[158,180],"time":[159,165],"first":[161,167],"exacerbation":[162,172],"(p<0.01)":[163],"hospitalization":[168],"for":[169],"(p<0.05)":[173],"ipratropium.":[176,222],"Apart":[177],"from":[178],"an":[179],"incidence":[181],"dry":[183],"mouth":[184],"group,":[188],"adverse":[189],"events":[190],"similar":[192],"between":[193],"treatments.":[194],"was":[196],"effective":[197],"improving":[199],"exacerbations,":[201],"patients":[210,236],"disease,":[215],"exceeds":[217],"benefits":[219],"The":[223],"data":[224],"support":[225],"as":[231],"first-line":[232],"maintenance":[233],"treatment":[234],"disease.":[241]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":21},{"year":2015,"cited_by_count":26},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":30},{"year":2012,"cited_by_count":35}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}