{"id":"https://openalex.org/W2107034706","doi":"https://doi.org/10.1530/eje.0.1490601","title":"Sex hormones, inflammation and the metabolic syndrome: a population-based study","display_name":"Sex hormones, inflammation and the metabolic syndrome: a population-based study","publication_year":2003,"publication_date":"2003-12-01","ids":{"openalex":"https://openalex.org/W2107034706","doi":"https://doi.org/10.1530/eje.0.1490601","mag":"2107034706","pmid":"https://pubmed.ncbi.nlm.nih.gov/14641004"},"language":"en","primary_location":{"id":"doi:10.1530/eje.0.1490601","doi":"https://doi.org/10.1530/eje.0.1490601","is_oa":false,"landing_page_url":"https://doi.org/10.1530/eje.0.1490601","pdf_url":null,"source":{"id":"https://openalex.org/S4210218062","display_name":"European Journal of Endocrinology","issn_l":"0804-4643","issn":["0804-4643","1479-683X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109247978","display_name":"David Elliot Laaksonen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]},{"id":"https://openalex.org/I4210092991","display_name":"Kuopio University Hospital","ror":"https://ror.org/00fqdfs68","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210092991","https://openalex.org/I4405278559"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"DE Laaksonen","raw_affiliation_strings":["Department of Medicine, Kuopio University Hospital, Kuopio, Finland","Department of Physiology, University of Kuopio, Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Kuopio University Hospital, Kuopio, Finland","institution_ids":["https://openalex.org/I4210092991"]},{"raw_affiliation_string":"Department of Physiology, University of Kuopio, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048168425","display_name":"LEO K. NISKANEN","orcid":"https://orcid.org/0000-0003-1503-7060","observed_orcids":["https://orcid.org/0000-0003-1503-7060"]},"institutions":[{"id":"https://openalex.org/I4210092991","display_name":"Kuopio University Hospital","ror":"https://ror.org/00fqdfs68","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210092991","https://openalex.org/I4405278559"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"L Niskanen","raw_affiliation_strings":["Department of Medicine, Kuopio University Hospital, Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Kuopio University Hospital, Kuopio, Finland","institution_ids":["https://openalex.org/I4210092991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073998688","display_name":"Kari R.A. Punnonen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092991","display_name":"Kuopio University Hospital","ror":"https://ror.org/00fqdfs68","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210092991","https://openalex.org/I4405278559"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"K Punnonen","raw_affiliation_strings":["Department of Clinical Chemistry, Kuopio University Hospital, Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry, Kuopio University Hospital, Kuopio, Finland","institution_ids":["https://openalex.org/I4210092991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113532209","display_name":"K. Nyyss\u00f6nen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"K Nyyssonen","raw_affiliation_strings":["Department of Public Health and General Practice, University of Kuopio, Kuopio, Finland","Research Institute of Public Health, University of Kuopio, Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health and General Practice, University of Kuopio, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]},{"raw_affiliation_string":"Research Institute of Public Health, University of Kuopio, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066034213","display_name":"TP Tuomainen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"TP Tuomainen","raw_affiliation_strings":["Research Institute of Public Health, University of Kuopio, Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Public Health, University of Kuopio, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":null,"display_name":"R Salonen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"R Salonen","raw_affiliation_strings":["Department of Public Health and General Practice, University of Kuopio, Kuopio, Finland","Research Institute of Public Health, University of Kuopio, Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health and General Practice, University of Kuopio, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]},{"raw_affiliation_string":"Research Institute of Public Health, University of Kuopio, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108210030","display_name":"Rainer Rauramaa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092991","display_name":"Kuopio University Hospital","ror":"https://ror.org/00fqdfs68","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210092991","https://openalex.org/I4405278559"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"R Rauramaa","raw_affiliation_strings":["Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland","Kuopio Research Institute of Exercise Medicine, Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland","institution_ids":["https://openalex.org/I4210092991"]},{"raw_affiliation_string":"Kuopio Research Institute of Exercise Medicine, Kuopio, Finland","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112998042","display_name":"J T Salonen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"JT Salonen","raw_affiliation_strings":["Department of Public Health and General Practice, University of Kuopio, Kuopio, Finland","Inner Savo Health Center, Suonenjoki, Finland","Research Institute of Public Health, University of Kuopio, Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health and General Practice, University of Kuopio, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]},{"raw_affiliation_string":"Inner Savo Health Center, Suonenjoki, Finland","institution_ids":[]},{"raw_affiliation_string":"Research Institute of Public Health, University of Kuopio, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5112998042"],"corresponding_institution_ids":["https://openalex.org/I175532246"],"apc_list":{"value":3798,"currency":"EUR","value_usd":4292},"apc_paid":null,"fwci":5.4093,"has_fulltext":false,"cited_by_count":438,"citation_normalized_percentile":{"value":0.96595391,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"149","issue":"6","first_page":"601","last_page":"608"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.9769999980926514},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.5870000123977661},{"id":"https://openalex.org/keywords/sex-hormone-binding-globulin","display_name":"sex hormone-binding globulin","score":0.9819999933242798},{"id":"https://openalex.org/keywords/free-testosterone","display_name":"free testosterone","score":0.8040000200271606},{"id":"https://openalex.org/keywords/hypoandrogenism","display_name":"hypoandrogenism","score":0.8830000162124634},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9200000166893005},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.996999979019165},{"id":"https://openalex.org/keywords/ferritin","display_name":"ferritin","score":0.9860000014305115},{"id":"https://openalex.org/keywords/iron-stores","display_name":"iron stores","score":0.656000018119812},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.4690000116825104},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.7300000190734863},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.8690000176429749},{"id":"https://openalex.org/keywords/middle-aged-men","display_name":"middle-aged men","score":0.9010000228881836},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.6809999942779541},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C30092816","wikidata":"https://www.wikidata.org/wiki/Q419613","display_name":"Sex hormone-binding globulin","level":4,"score":0.8803308010101318},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.8659710884094238},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8111163377761841},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7757598161697388},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.6829798221588135},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.600805401802063},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5915536284446716},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5636237859725952},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4574853479862213},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4225844442844391},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.21027782559394836},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005387","descriptor_name":"Finland","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012738","descriptor_name":"Sex Hormone-Binding Globulin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019314","descriptor_name":"Dehydroepiandrosterone Sulfate","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D044967","descriptor_name":"Serum","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1530/eje.0.1490601","doi":"https://doi.org/10.1530/eje.0.1490601","is_oa":false,"landing_page_url":"https://doi.org/10.1530/eje.0.1490601","pdf_url":null,"source":{"id":"https://openalex.org/S4210218062","display_name":"European Journal of Endocrinology","issn_l":"0804-4643","issn":["0804-4643","1479-683X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Endocrinology","raw_type":"journal-article"},{"id":"pmid:14641004","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14641004","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of endocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.325.6386","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.325.6386","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.eje.org/content/149/6/601.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G8780156136","display_name":"MECHANISMS UNDERLYING PSYCHOSOCIAL ASSOCIATIONS WITH IHD","funder_award_id":"R01HL044199","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1554762746","https://openalex.org/W1961916049","https://openalex.org/W1973562485","https://openalex.org/W1986349550","https://openalex.org/W1999094333","https://openalex.org/W2008618446","https://openalex.org/W2016392921","https://openalex.org/W2018403770","https://openalex.org/W2021943148","https://openalex.org/W2023513779","https://openalex.org/W2026857524","https://openalex.org/W2028670915","https://openalex.org/W2032187052","https://openalex.org/W2036707886","https://openalex.org/W2036791565","https://openalex.org/W2037112420","https://openalex.org/W2049240571","https://openalex.org/W2049608785","https://openalex.org/W2060449981","https://openalex.org/W2066946777","https://openalex.org/W2069402323","https://openalex.org/W2076551208","https://openalex.org/W2086247313","https://openalex.org/W2094613204","https://openalex.org/W2096773810","https://openalex.org/W2098247759","https://openalex.org/W2109494488","https://openalex.org/W2110825938","https://openalex.org/W2117268230","https://openalex.org/W2124041132","https://openalex.org/W2132837172","https://openalex.org/W2134293572","https://openalex.org/W2136049176","https://openalex.org/W2140921420","https://openalex.org/W2145528838","https://openalex.org/W2146511410","https://openalex.org/W2149040949","https://openalex.org/W2316831615","https://openalex.org/W2320228217","https://openalex.org/W2409907277","https://openalex.org/W2413208704"],"related_works":["https://openalex.org/W7097900658","https://openalex.org/W2165913105","https://openalex.org/W2018549749","https://openalex.org/W846693761","https://openalex.org/W7095413690","https://openalex.org/W2116785242","https://openalex.org/W135008947","https://openalex.org/W1974191136","https://openalex.org/W1960677498","https://openalex.org/W1985373991"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Mild":[1],"hypoandrogenism":[2],"in":[3,47,69,125,144,227,241,246],"men":[4,70,165],"is":[5],"associated":[6,100,115,194,219],"with":[7,16,31,71,101,116,121,166,179,197,205,220],"features":[8],"of":[9,51,103,164,177,199,211,230],"the":[10,14,17,32,72,126,141,172,180,200,206,228,247],"metabolic":[11,18,33,73,142,181,201,207,248],"syndrome,":[12,202,249],"but":[13,203],"association":[15,176],"syndrome":[19,34,74,143,182,208],"itself":[20],"using":[21],"an":[22],"accepted":[23],"definition":[24],"has":[25],"not":[26,170,195],"been":[27],"described.":[28],"DESIGN:":[29],"Men":[30,120],"were":[35,45,63,98,129,192,218],"identified":[36],"and":[37,39,61,65,84,88,93,96,110,113,147,189,222,236,250],"testosterone":[38,60,95,123,188],"sex":[40,216,242],"hormone-binding":[41],"globulin":[42],"(SHBG)":[43],"levels":[44,124,191],"determined":[46],"a":[48],"population-based":[49],"cohort":[50],"1896":[52],"non-diabetic":[53],"middle-aged":[54],"Finnish":[55],"men.":[56],"RESULTS:":[57],"Calculated":[58],"free":[59,94,122],"SHBG":[62,97,178,190],"11%":[64],"18%":[66],"lower":[67],"(P<0.001)":[68],"(n=345,":[75],"World":[76],"Health":[77],"Organisation":[78],"definition).":[79],"After":[80],"categorisation":[81],"by":[82],"tertiles":[83],"adjusting":[85,158],"for":[86,159],"age":[87],"body":[89,160,212,223],"mass":[90,161,213],"index,":[91],"total":[92],"inversely":[99],"concentrations":[102],"insulin,":[104],"glucose,":[105],"triglycerides,":[106],"C-reactive":[107],"protein":[108],"(CRP)":[109],"CRP-adjusted":[111],"ferritin":[112],"positively":[114],"high-density":[117],"lipoprotein":[118],"cholesterol.":[119],"lowest":[127],"third":[128],"2.7":[130],"(95%":[131,149],"confidence":[132],"interval":[133],"(CI)":[134],"2.0-3.7)":[135],"times":[136,152],"more":[137,153],"likely":[138,154],"to":[139,253],"have":[140],"age-adjusted":[145],"analyses,":[146],"1.7":[148],"CI":[150],"1.2-2.4)":[151],"even":[155],"after":[156],"further":[157],"index.":[162,214],"Exclusion":[163],"cardiovascular":[167,237],"disease":[168],"did":[169],"alter":[171],"association.":[173],"The":[174],"inverse":[175],"was":[183],"somewhat":[184],"stronger.":[185],"CONCLUSIONS:":[186],"Low":[187],"strongly":[193],"only":[196],"components":[198],"also":[204],"itself,":[209],"independently":[210],"Furthermore,":[215],"hormones":[217,243],"inflammation":[221],"iron":[224],"stores.":[225],"Even":[226],"absence":[229],"late-stage":[231],"consequences":[232],"such":[233],"as":[234],"diabetes":[235],"disease,":[238],"subtle":[239],"derangements":[240],"are":[244],"present":[245],"may":[251],"contribute":[252],"its":[254],"pathogenesis.":[255]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":21},{"year":2017,"cited_by_count":22},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":22},{"year":2014,"cited_by_count":24},{"year":2013,"cited_by_count":32},{"year":2012,"cited_by_count":37}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}