{"id":"https://openalex.org/W2107030003","doi":"https://doi.org/10.5402/2012/516461","title":"Influence of Calcium Ions on Cell Survival and Proliferation in the Context of an Alginate Hydrogel","display_name":"Influence of Calcium Ions on Cell Survival and Proliferation in the Context of an Alginate Hydrogel","publication_year":2012,"publication_date":"2012-05-07","ids":{"openalex":"https://openalex.org/W2107030003","doi":"https://doi.org/10.5402/2012/516461","mag":"2107030003"},"language":"en","primary_location":{"id":"doi:10.5402/2012/516461","doi":"https://doi.org/10.5402/2012/516461","is_oa":true,"landing_page_url":"https://doi.org/10.5402/2012/516461","pdf_url":"https://downloads.hindawi.com/archive/2012/516461.pdf","source":{"id":"https://openalex.org/S4210208590","display_name":"ISRN Chemical Engineering","issn_l":"2090-861X","issn":["2090-861X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ISRN Chemical Engineering","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://downloads.hindawi.com/archive/2012/516461.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015425321","display_name":"Tate Ning. Cao","orcid":"https://orcid.org/0000-0002-9159-5577","observed_orcids":["https://orcid.org/0000-0002-9159-5577"]},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"N. Cao","raw_affiliation_strings":["Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, SK, Canada S7N 5A9"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, SK, Canada S7N 5A9","institution_ids":["https://openalex.org/I32625721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100696404","display_name":"Daniel Chen","orcid":"https://orcid.org/0000-0002-4716-549X","observed_orcids":["https://orcid.org/0000-0002-4716-549X"]},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"X. B. Chen","raw_affiliation_strings":["Department of Mechanical Engineering, University of Saskatchewan, Saskatoon, SK, Canada S7N 5A9","Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, SK, Canada S7N 5A9"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, University of Saskatchewan, Saskatoon, SK, Canada S7N 5A9","institution_ids":["https://openalex.org/I32625721"]},{"raw_affiliation_string":"Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, SK, Canada S7N 5A9","institution_ids":["https://openalex.org/I32625721"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111560642","display_name":"David J. Schreyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"D. J. Schreyer","raw_affiliation_strings":["Department of Anatomy and Cell Biology, University of Saskatchewan, Saskatoon, SK, Canada S7N 5E5","Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, SK, Canada S7N 5A9"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, University of Saskatchewan, Saskatoon, SK, Canada S7N 5E5","institution_ids":["https://openalex.org/I32625721"]},{"raw_affiliation_string":"Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, SK, Canada S7N 5A9","institution_ids":["https://openalex.org/I32625721"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100696404"],"corresponding_institution_ids":["https://openalex.org/I32625721"],"apc_list":null,"apc_paid":null,"fwci":1.5222,"has_fulltext":true,"cited_by_count":140,"citation_normalized_percentile":{"value":0.78656768,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"2012","issue":null,"first_page":"1","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.03229999914765358,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcium-ions","display_name":"calcium ions","score":0.8930000066757202},{"id":"https://openalex.org/keywords/alginate-hydrogel","display_name":"alginate hydrogel","score":0.9860000014305115},{"id":"https://openalex.org/keywords/schwann-cells","display_name":"Schwann cells","score":0.906000018119812},{"id":"https://openalex.org/keywords/cell-survival","display_name":"cell survival","score":0.8289999961853027},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":1.0},{"id":"https://openalex.org/keywords/ionic-crosslinking","display_name":"ionic crosslinking","score":0.9599999785423279},{"id":"https://openalex.org/keywords/biofabrication","display_name":"biofabrication","score":0.9049999713897705},{"id":"https://openalex.org/keywords/cell-encapsulation","display_name":"cell encapsulation","score":0.7540000081062317},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.546999990940094},{"id":"https://openalex.org/keywords/alginate-concentration","display_name":"alginate concentration","score":0.8579999804496765},{"id":"https://openalex.org/keywords/cell-density","display_name":"cell density","score":0.746999979019165},{"id":"https://openalex.org/keywords/solution-viscosity","display_name":"solution viscosity","score":0.7839999794960022},{"id":"https://openalex.org/keywords/tissue-engineering-scaffolds","display_name":"tissue engineering scaffolds","score":0.8619999885559082}],"concepts":[{"id":"https://openalex.org/C2780609957","wikidata":"https://www.wikidata.org/wiki/Q108887885","display_name":"Biofabrication","level":3,"score":0.9902199506759644},{"id":"https://openalex.org/C2778713300","wikidata":"https://www.wikidata.org/wiki/Q2034064","display_name":"Calcium alginate","level":3,"score":0.7739238142967224},{"id":"https://openalex.org/C108586683","wikidata":"https://www.wikidata.org/wiki/Q17164826","display_name":"Self-healing hydrogels","level":2,"score":0.6705496907234192},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.6108495593070984},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.5818301439285278},{"id":"https://openalex.org/C193855658","wikidata":"https://www.wikidata.org/wiki/Q5058189","display_name":"Cell encapsulation","level":3,"score":0.5507286787033081},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5086530447006226},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.5018789768218994},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.491583913564682},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4891832172870636},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.47657155990600586},{"id":"https://openalex.org/C3019137385","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell survival","level":3,"score":0.45116734504699707},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4127786457538605},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4001709818840027},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.31523287296295166},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2560446262359619},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20601117610931396},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.16803580522537231},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09921565651893616},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.064512699842453},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5402/2012/516461","doi":"https://doi.org/10.5402/2012/516461","is_oa":true,"landing_page_url":"https://doi.org/10.5402/2012/516461","pdf_url":"https://downloads.hindawi.com/archive/2012/516461.pdf","source":{"id":"https://openalex.org/S4210208590","display_name":"ISRN Chemical Engineering","issn_l":"2090-861X","issn":["2090-861X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ISRN Chemical Engineering","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:f7c18a09f8774345a8b5cfebe95d71df","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/f7c18a09f8774345a8b5cfebe95d71df","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISRN Chemical Engineering, Vol 2012 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.5402/2012/516461","doi":"https://doi.org/10.5402/2012/516461","is_oa":true,"landing_page_url":"https://doi.org/10.5402/2012/516461","pdf_url":"https://downloads.hindawi.com/archive/2012/516461.pdf","source":{"id":"https://openalex.org/S4210208590","display_name":"ISRN Chemical Engineering","issn_l":"2090-861X","issn":["2090-861X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ISRN Chemical Engineering","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320319919","display_name":"Saskatchewan Health Research Foundation","ror":"https://ror.org/00trnds81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2107030003.pdf","grobid_xml":"https://content.openalex.org/works/W2107030003.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1679452661","https://openalex.org/W1981893860","https://openalex.org/W1984133636","https://openalex.org/W1984765004","https://openalex.org/W1986916145","https://openalex.org/W1987771463","https://openalex.org/W1998402731","https://openalex.org/W2013427488","https://openalex.org/W2016058943","https://openalex.org/W2044033320","https://openalex.org/W2049528384","https://openalex.org/W2062273683","https://openalex.org/W2063072775","https://openalex.org/W2069334439","https://openalex.org/W2075386107","https://openalex.org/W2093689113","https://openalex.org/W2108389906","https://openalex.org/W2111278167","https://openalex.org/W2144194420","https://openalex.org/W2168487924","https://openalex.org/W4232045221"],"related_works":["https://openalex.org/W2135990786","https://openalex.org/W2000449739","https://openalex.org/W7034773579","https://openalex.org/W1697591081","https://openalex.org/W2064558878","https://openalex.org/W4393386875","https://openalex.org/W4399045130","https://openalex.org/W2580848579","https://openalex.org/W2512482367","https://openalex.org/W1974480826"],"abstract_inverted_index":{"One":[0],"goal":[1],"of":[2,31,50,55,61,98,104,121,143,180],"biofabrication":[3,27,36,109,188],"is":[4,44],"to":[5,14,63,74,146],"incorporate":[6],"living":[7,181],"cells":[8,62,144,182],"into":[9,89],"artificial":[10],"scaffolds":[11,51],"in":[12,125,131,183,186],"order":[13],"repair":[15],"damaged":[16],"tissues":[17],"or":[18,66,80,129],"organs.":[19],"Although":[20],"there":[21],"are":[22],"many":[23],"studies":[24],"on":[25,92,165],"various":[26],"techniques,":[28],"the":[29,35,42,90,108,116,136,140,147,155,178,187],"maintenance":[30],"cell":[32,39,78,94,126,159,166,195],"viability":[33,117],"during":[34,107],"process":[37,43,189],"and":[38,96,118,133,139,158,168,170,197],"proliferation":[40,97,119],"after":[41],"still":[45,71],"a":[46],"challenging":[47],"issue.":[48],"Construction":[49],"using":[52],"hydrogels":[53],"composed":[54],"natural":[56],"materials":[57],"can":[58,70,190],"avoid":[59],"exposure":[60,73],"harsh":[64],"chemicals":[65],"temperature":[67],"extremes":[68],"but":[69],"entail":[72],"non-physiological":[75],"conditions,":[76],"causing":[77],"damage":[79],"even":[81],"death.":[82],"This":[83,175],"paper":[84],"presents":[85],"an":[86],"experimental":[87,112,151],"investigation":[88],"influence":[91,164],"Schwann":[93],"survival":[95,167,196],"calcium":[99,137,148],"used":[100],"for":[101,193],"ionic":[102],"crosslinking":[103],"alginate":[105,156],"hydrogel":[106,185],"process.":[110],"The":[111,150],"results":[113,152],"obtained":[114],"show":[115,154],"capacity":[120],"cells,":[122],"either":[123],"suspended":[124],"culture":[127],"medium":[128],"encapsulated":[130],"hydrogel,":[132],"vary":[134],"with":[135],"concentration":[138,157],"time":[141],"period":[142],"exposed":[145],"environment.":[149],"also":[153],"density,":[160],"that":[161],"have":[162],"profound":[163],"proliferation,":[169],"solution":[171],"viscosity":[172],"as":[173],"well.":[174],"study":[176],"suggests":[177],"incorporation":[179],"calcium-crosslinked":[184],"be":[191],"regulated":[192],"controlled":[194],"proliferation.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}