{"id":"https://openalex.org/W2107024161","doi":"https://doi.org/10.1677/joe.0.1580359","title":"Modulation of human thyrotropin oligosaccharide structures--enhanced proportion of sialylated and terminally galactosylated serum thyrotropin isoforms in subclinical and overt primary hypothyroidism","display_name":"Modulation of human thyrotropin oligosaccharide structures--enhanced proportion of sialylated and terminally galactosylated serum thyrotropin isoforms in subclinical and overt primary hypothyroidism","publication_year":1998,"publication_date":"1998-09-01","ids":{"openalex":"https://openalex.org/W2107024161","doi":"https://doi.org/10.1677/joe.0.1580359","mag":"2107024161","pmid":"https://pubmed.ncbi.nlm.nih.gov/9846165"},"language":"en","primary_location":{"id":"doi:10.1677/joe.0.1580359","doi":"https://doi.org/10.1677/joe.0.1580359","is_oa":true,"landing_page_url":"https://doi.org/10.1677/joe.0.1580359","pdf_url":"https://joe.bioscientifica.com/downloadpdf/journals/joe/158/3/359.pdf","source":{"id":"https://openalex.org/S34842069","display_name":"Journal of Endocrinology","issn_l":"0022-0795","issn":["0022-0795","1479-6805"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://joe.bioscientifica.com/downloadpdf/journals/joe/158/3/359.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056028552","display_name":"J\u00f6rg Trojan","orcid":"https://orcid.org/0000-0003-4110-2647","observed_orcids":["https://orcid.org/0000-0003-4110-2647"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210132578","display_name":"University Hospital Frankfurt","ror":"https://ror.org/03f6n9m15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210132578"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J Trojan","raw_affiliation_strings":["Zentrum der Inneren Medizin, Klinikum der Johann Wolfgang Goethe-Universit\u00e4t, Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zentrum der Inneren Medizin, Klinikum der Johann Wolfgang Goethe-Universit\u00e4t, Frankfurt, Germany","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210132578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083622583","display_name":"Marily Theodoropoulou","orcid":"https://orcid.org/0000-0002-7378-4374","observed_orcids":["https://orcid.org/0000-0002-7378-4374"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210145969","display_name":"Max Planck Institute of Psychiatry","ror":"https://ror.org/04dq56617","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M Theodoropoulou","raw_affiliation_strings":["Max-Planck-Institut fu\u00a8r Psychiatrie ,","AG Stalla, G\u00fcnter, Florian Holsboer (Direktor), Max Planck Institute of Psychiatry, Max Planck Society"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck-Institut fu\u00a8r Psychiatrie ,","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]},{"raw_affiliation_string":"AG Stalla, G\u00fcnter, Florian Holsboer (Direktor), Max Planck Institute of Psychiatry, Max Planck Society","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109194209","display_name":"K. H. Usadel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210132578","display_name":"University Hospital Frankfurt","ror":"https://ror.org/03f6n9m15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210132578"]},{"id":"https://openalex.org/I4210145969","display_name":"Max Planck Institute of Psychiatry","ror":"https://ror.org/04dq56617","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"KH Usadel","raw_affiliation_strings":["Zentrum der Inneren Medizin , Klinikum der Johann Wolfgang Goethe-Universita\u00a8t , D-60590 Frankfurt a.M. , Germany and","Max-Planck-Institut fu\u00a8r Psychiatrie, Kraepelinstr. 10, D-80804 Mu\u00a8nchen, Germany","Zentrum der Inneren Medizin, Klinikum der Johann Wolfgang Goethe-Universita\u00a8t, D-60590 Frankfurt a.M., Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zentrum der Inneren Medizin , Klinikum der Johann Wolfgang Goethe-Universita\u00a8t , D-60590 Frankfurt a.M. , Germany and","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210132578"]},{"raw_affiliation_string":"Max-Planck-Institut fu\u00a8r Psychiatrie, Kraepelinstr. 10, D-80804 Mu\u00a8nchen, Germany","institution_ids":["https://openalex.org/I4210145969"]},{"raw_affiliation_string":"Zentrum der Inneren Medizin, Klinikum der Johann Wolfgang Goethe-Universita\u00a8t, D-60590 Frankfurt a.M., Germany","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210132578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055608939","display_name":"G\u00fcnter Karl Stalla","orcid":"https://orcid.org/0000-0002-1975-3294","observed_orcids":["https://orcid.org/0000-0002-1975-3294"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210145969","display_name":"Max Planck Institute of Psychiatry","ror":"https://ror.org/04dq56617","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"GK Stalla","raw_affiliation_strings":["Max-Planck-Institut fu\u00a8r Psychiatrie,","Max-Planck-Institut fu\u00a8r Psychiatrie , Kraepelinstr. 10 , D-80804 Mu\u00a8nchen , Germany","Endokrinologie und Klinische Chemie, D-80804 Mu\u00a8nchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck-Institut fu\u00a8r Psychiatrie,","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]},{"raw_affiliation_string":"Max-Planck-Institut fu\u00a8r Psychiatrie , Kraepelinstr. 10 , D-80804 Mu\u00a8nchen , Germany","institution_ids":["https://openalex.org/I4210145969"]},{"raw_affiliation_string":"Endokrinologie und Klinische Chemie, D-80804 Mu\u00a8nchen, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108203381","display_name":"Ludwig Schaaf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210145969","display_name":"Max Planck Institute of Psychiatry","ror":"https://ror.org/04dq56617","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"L Schaaf","raw_affiliation_strings":["Max-Planck-Institut fu\u00a8r Psychiatrie ,","AG Stalla, G\u00fcnter, Florian Holsboer (Direktor), Max Planck Institute of Psychiatry, Max Planck Society"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck-Institut fu\u00a8r Psychiatrie ,","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]},{"raw_affiliation_string":"AG Stalla, G\u00fcnter, Florian Holsboer (Direktor), Max Planck Institute of Psychiatry, Max Planck Society","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6256,"has_fulltext":true,"cited_by_count":45,"citation_normalized_percentile":{"value":0.69496949,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"158","issue":"3","first_page":"359","last_page":"365"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.6807000041007996,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.6807000041007996,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.31200000643730164,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sialylation","display_name":"sialylation","score":0.8429999947547913},{"id":"https://openalex.org/keywords/primary-hypothyroidism","display_name":"primary hypothyroidism","score":0.8539999723434448},{"id":"https://openalex.org/keywords/subclinical-hypothyroidism","display_name":"subclinical hypothyroidism","score":1.0},{"id":"https://openalex.org/keywords/thyrotropin-releasing-hormone","display_name":"thyrotropin-releasing hormone","score":0.9440000057220459},{"id":"https://openalex.org/keywords/sialic-acid","display_name":"sialic acid","score":0.7509999871253967},{"id":"https://openalex.org/keywords/metabolic-clearance-rate","display_name":"metabolic clearance rate","score":0.7360000014305115}],"concepts":[{"id":"https://openalex.org/C2777195454","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Euthyroid","level":3,"score":0.868468701839447},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8678522706031799},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8633030652999878},{"id":"https://openalex.org/C113280763","wikidata":"https://www.wikidata.org/wiki/Q2326546","display_name":"Subclinical infection","level":2,"score":0.5721648931503296},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47623756527900696},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.453536719083786},{"id":"https://openalex.org/C184760221","wikidata":"https://www.wikidata.org/wiki/Q3304865","display_name":"Thyrotropic cell","level":5,"score":0.42490410804748535},{"id":"https://openalex.org/C4134927","wikidata":"https://www.wikidata.org/wiki/Q7671336","display_name":"TRH stimulation test","level":4,"score":0.41699835658073425},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.397521048784256},{"id":"https://openalex.org/C2776216936","wikidata":"https://www.wikidata.org/wiki/Q24726011","display_name":"Thyrotropin-releasing hormone","level":3,"score":0.3532488942146301},{"id":"https://openalex.org/C2777658017","wikidata":"https://www.wikidata.org/wiki/Q156871","display_name":"Pituitary gland","level":3,"score":0.33471962809562683},{"id":"https://openalex.org/C94984642","wikidata":"https://www.wikidata.org/wiki/Q3015605","display_name":"Somatotropic cell","level":4,"score":0.1429695188999176}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005690","descriptor_name":"Galactose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007536","descriptor_name":"Isomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009844","descriptor_name":"Oligosaccharides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013972","descriptor_name":"Thyrotropin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013972","descriptor_name":"Thyrotropin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013972","descriptor_name":"Thyrotropin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013973","descriptor_name":"Thyrotropin-Releasing Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019158","descriptor_name":"N-Acetylneuraminic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1677/joe.0.1580359","doi":"https://doi.org/10.1677/joe.0.1580359","is_oa":true,"landing_page_url":"https://doi.org/10.1677/joe.0.1580359","pdf_url":"https://joe.bioscientifica.com/downloadpdf/journals/joe/158/3/359.pdf","source":{"id":"https://openalex.org/S34842069","display_name":"Journal of Endocrinology","issn_l":"0022-0795","issn":["0022-0795","1479-6805"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinology","raw_type":"journal-article"},{"id":"pmid:9846165","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9846165","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of endocrinology","raw_type":"Comparative Study"},{"id":"pmh:oai:edoc.mpg.de:323064","doi":null,"is_oa":false,"landing_page_url":"http://edoc.mpg.de/323064","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Endocrinology, v.158, 359-365 (1998)","raw_type":"Article"},{"id":"pmh:oai:pure.mpg.de:item_1646201","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11858/00-001M-0000-000E-A882-F","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Endocrinology","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1677/joe.0.1580359","doi":"https://doi.org/10.1677/joe.0.1580359","is_oa":true,"landing_page_url":"https://doi.org/10.1677/joe.0.1580359","pdf_url":"https://joe.bioscientifica.com/downloadpdf/journals/joe/158/3/359.pdf","source":{"id":"https://openalex.org/S34842069","display_name":"Journal of Endocrinology","issn_l":"0022-0795","issn":["0022-0795","1479-6805"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320868","display_name":"Boehringer Ingelheim Fonds","ror":"https://ror.org/00dkye506"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2107024161.pdf","grobid_xml":"https://content.openalex.org/works/W2107024161.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W590561559","https://openalex.org/W1566783700","https://openalex.org/W1965718451","https://openalex.org/W1973265924","https://openalex.org/W1980044073","https://openalex.org/W1985678689","https://openalex.org/W1997516973","https://openalex.org/W2002975921","https://openalex.org/W2003778443","https://openalex.org/W2015074009","https://openalex.org/W2015097208","https://openalex.org/W2018906259","https://openalex.org/W2040819480","https://openalex.org/W2042375192","https://openalex.org/W2042576269","https://openalex.org/W2051024047","https://openalex.org/W2051621035","https://openalex.org/W2059494528","https://openalex.org/W2062175236","https://openalex.org/W2111307336","https://openalex.org/W2120640580","https://openalex.org/W2129915992","https://openalex.org/W2331220651","https://openalex.org/W4252474431"],"related_works":["https://openalex.org/W7030137202","https://openalex.org/W1965718451","https://openalex.org/W1989800794","https://openalex.org/W2054025748","https://openalex.org/W2032971297","https://openalex.org/W3127098572","https://openalex.org/W2140592058","https://openalex.org/W2106485066","https://openalex.org/W2040819480","https://openalex.org/W1993126334"],"abstract_inverted_index":{"Enhanced":[0],"sialylation":[1,37],"of":[2,38,44,64,67,77,122,135,160,187,222,267,305,339,359,364,370,382],"thyrotropin":[3],"(TSH)":[4],"prolongs":[5],"its":[6,55],"metabolic":[7],"clearance":[8],"rate":[9],"and":[10,25,61,91,105,116,126,139,199,213,245,287,308,315,330,346],"thus":[11],"increases":[12],"the":[13,36,62,185,264,320,356,380],"hormone's":[14],"in":[15,84,155,195,235,241,255,319],"vivo":[16],"bioactivity.":[17],"This":[18],"has":[19],"been":[20],"shown":[21],"for":[22,26,229,273,279,288,355],"hypothyroid":[23],"rats":[24],"recombinant":[27],"human":[28,39,52,106],"TSH,":[29,54,231],"but":[30,375],"there":[31],"are":[32],"few":[33],"data":[34,324],"on":[35,71],"serum":[40,53,82,340],"TSH.":[41],"The":[42,133,219,303],"aim":[43],"this":[45],"work":[46],"was":[47,113,128,146,166,189,225,269],"to":[48,372],"further":[49,357],"study":[50],"sialylated":[51,136,383],"precursors":[56],"bearing":[57,141,343],"terminal":[58,142,344],"galactose":[59,143,345],"residues,":[60,349],"role":[63],"pharmacological":[65],"doses":[66,363],"thyrotropin-releasing":[68],"hormone":[69],"(TRH)":[70],"their":[72],"secretion":[73],"under":[74],"different":[75],"degrees":[76],"primary":[78,93,201,259,292,332],"hypothyroidism.":[79,260],"We":[80],"analyzed":[81],"TSH":[83,109,127,138,164,173,176,194,224,263,341,371,387],"patients":[85,196,242,256,280,289,327],"with":[86,99,157,197,243,257,281,290,328],"subclinical":[87,198,282,329],"(n":[88,95,102],"=":[89,96,103],"9)":[90],"overt":[92,200,258,291,331],"hypothyroidism":[94,202,283,293,333],"13)":[97],"compared":[98],"euthyroid":[100,183,211,236,253,274,301],"individuals":[101,184,275,321],"12)":[104],"standard":[107],"pituitary":[108,230,262],"(IRP":[110],"80/558).":[111],"Blood":[112],"drawn":[114],"before":[115,314],"30":[117],"min":[118],"after":[119,316],"intravenous":[120],"administration":[121,318],"200":[123],"micrograms":[124],"TRH,":[125],"purified":[129],"by":[130,148,168],"immunoaffinity":[131],"concentration.":[132],"content":[134],"(sialo-)":[137],"isoforms":[140,342],"(Gal-TSH,":[144],"asialo-Gal-TSH)":[145],"measured":[147,167],"Ricinus":[149],"communis":[150],"(RCA":[151],"120)":[152],"affinity":[153],"chromatography":[154],"combination":[156],"enzymatic":[158],"cleavage":[159],"sialic":[161,347],"acid":[162,348],"residues.":[163],"immunoreactivity":[165],"an":[169,367],"automated":[170],"second":[171],"generation":[172],"immunoassay.":[174],"Pituitary":[175],"contained":[177,203],"16.5":[178],"+/-":[179,191,205,215,227,233,239,247,271,277,285,295],"0.8%":[180],"Gal-TSH.":[181],"In":[182],"proportion":[186,266,338,381],"Gal-TSH":[188,217],"14.6":[190],"1.9%,":[192],"whereas":[193],"23.9":[204],"3.5%":[206],"(P":[207,249,297],"<":[208,250,298],"0.05":[209],"vs":[210,252,300],"individuals)":[212,254],"21.1":[214],"1.7%":[216],"respectively.":[218],"mean":[220],"ratio":[221],"asialo-Gal":[223],"23.8":[226],"0.6%":[228],"35.7":[232],"4.2%":[234],"individuals,":[237],"48.0":[238],"3.3%":[240],"subclinical,":[244],"61.5":[246],"3.8%":[248],"0.001":[251,299],"For":[261],"calculated":[265],"sialo-TSH":[268,309],"6.5":[270],"0.2%,":[272],"20.3":[276],"2.8%,":[278],"24.1":[284],"3.0%,":[286],"40.7":[294],"3.0%":[296],"individuals).":[302],"proportions":[304],"Gal-TSH,":[306],"asialo-Gal-TSH,":[307],"did":[310],"not":[311,377],"differ":[312],"significantly":[313,378],"TRH":[317,365],"studied.":[322],"Our":[323],"show":[325],"that":[326],"have":[334],"a":[335,353],"markedly":[336],"increased":[337,368],"which":[350],"may":[351],"represent":[352],"mechanism":[354],"stimulation":[358],"thyroid":[360],"function.":[361],"Pharmacological":[362],"cause":[366],"quantity":[369],"be":[373],"released,":[374],"do":[376],"alter":[379],"or":[384],"terminally":[385],"galactosylated":[386],"isoforms.":[388]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
