{"id":"https://openalex.org/W2107022720","doi":"https://doi.org/10.3109/14647273.2014.940003","title":"\u2018TheBRCAClock is Ticking!\u2019: Negotiating medical concerns and reproductive goals in preimplantation genetic diagnosis","display_name":"\u2018TheBRCAClock is Ticking!\u2019: Negotiating medical concerns and reproductive goals in preimplantation genetic diagnosis","publication_year":2014,"publication_date":"2014-08-08","ids":{"openalex":"https://openalex.org/W2107022720","doi":"https://doi.org/10.3109/14647273.2014.940003","mag":"2107022720","pmid":"https://pubmed.ncbi.nlm.nih.gov/25105219"},"language":"en","primary_location":{"id":"doi:10.3109/14647273.2014.940003","doi":"https://doi.org/10.3109/14647273.2014.940003","is_oa":false,"landing_page_url":"https://doi.org/10.3109/14647273.2014.940003","pdf_url":null,"source":{"id":"https://openalex.org/S51346222","display_name":"Human Fertility","issn_l":"1464-7273","issn":["1464-7273","1742-8149"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Fertility","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114060057","display_name":"Lisa R. Rubin","orcid":"https://orcid.org/0009-0008-5702-0308","observed_orcids":["https://orcid.org/0009-0008-5702-0308"]},"institutions":[{"id":"https://openalex.org/I102179633","display_name":"The New School","ror":"https://ror.org/02tvcev59","country_code":"US","type":"education","lineage":["https://openalex.org/I102179633"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lisa R. Rubin","raw_affiliation_strings":["Department of Psychology, New School for Social Research, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, New School for Social Research, New York, NY, USA","institution_ids":["https://openalex.org/I102179633"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027076246","display_name":"Allison Werner\u2010Lin","orcid":"https://orcid.org/0000-0003-3133-820X","observed_orcids":["https://orcid.org/0000-0003-3133-820X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allison Werner-Lin","raw_affiliation_strings":["The School of Social Policy and Practice, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The School of Social Policy and Practice, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111761375","display_name":"Michal Sagi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Michal Sagi","raw_affiliation_strings":["Department of Human Genetics, Hadassah Hebrew University Medical Center, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Hadassah Hebrew University Medical Center, Jerusalem, Israel","institution_ids":["https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040765979","display_name":"Ina N. Cholst","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]},{"id":"https://openalex.org/I4405272987","display_name":"Weill Cornell Medical Center","ror":"https://ror.org/052v90092","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466","https://openalex.org/I4405272987"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ina Cholst","raw_affiliation_strings":["Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, New York Presbyterian Hospital, Weill Cornell Medical Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, New York Presbyterian Hospital, Weill Cornell Medical Center, New York, NY, USA","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I4405272987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051096116","display_name":"Rikki Stern","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rikki Stern","raw_affiliation_strings":["School of Law, New York University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Law, New York University, New York, NY, USA","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045098501","display_name":"Debra Lilienthal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]},{"id":"https://openalex.org/I4405272987","display_name":"Weill Cornell Medical Center","ror":"https://ror.org/052v90092","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466","https://openalex.org/I4405272987"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Debra Lilienthal","raw_affiliation_strings":["Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, New York Presbyterian Hospital, Weill Cornell Medical Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, New York Presbyterian Hospital, Weill Cornell Medical Center, New York, NY, USA","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I4405272987"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108789317","display_name":"Karen E. Hurley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen Hurley","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center and Clinical Psychologist Private Practice, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center and Clinical Psychologist Private Practice, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5114060057"],"corresponding_institution_ids":["https://openalex.org/I102179633"],"apc_list":null,"apc_paid":null,"fwci":2.3471,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.8806959,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"17","issue":"3","first_page":"159","last_page":"164"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":0.5576000213623047,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":0.5576000213623047,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.24650000035762787,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11156","display_name":"Reproductive Health and Technologies","score":0.14970000088214874,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/preimplantation-genetic-diagnosis","display_name":"preimplantation genetic diagnosis","score":1.0},{"id":"https://openalex.org/keywords/brca1-2-mutation-carriers","display_name":"BRCA1/2 mutation carriers","score":0.875},{"id":"https://openalex.org/keywords/reproductive-decision-making","display_name":"reproductive decision-making","score":0.7870000004768372},{"id":"https://openalex.org/keywords/reproductive-goals","display_name":"reproductive goals","score":0.8100000023841858},{"id":"https://openalex.org/keywords/embryo-screening","display_name":"embryo screening","score":0.5009999871253967}],"concepts":[{"id":"https://openalex.org/C2778805741","wikidata":"https://www.wikidata.org/wiki/Q1501356","display_name":"Preimplantation genetic diagnosis","level":3,"score":0.88158118724823},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5843751430511475},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4755163788795471},{"id":"https://openalex.org/C150966472","wikidata":"https://www.wikidata.org/wiki/Q3410145","display_name":"Psychosocial","level":2,"score":0.462696373462677},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.44613510370254517},{"id":"https://openalex.org/C199776023","wikidata":"https://www.wikidata.org/wiki/Q202875","display_name":"Negotiation","level":2,"score":0.4257148206233978},{"id":"https://openalex.org/C199033989","wikidata":"https://www.wikidata.org/wiki/Q1318295","display_name":"Narrative","level":2,"score":0.4141954779624939},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.38108593225479126},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2076244056224823},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.20215526223182678},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.18181157112121582},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12495294213294983},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11753848195075989},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019313","descriptor_name":"BRCA1 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019313","descriptor_name":"BRCA1 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019836","descriptor_name":"Preimplantation Diagnosis","qualifier_ui":"Q000941","qualifier_name":"ethics","is_major_topic":true},{"descriptor_ui":"D024682","descriptor_name":"BRCA2 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024682","descriptor_name":"BRCA2 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3109/14647273.2014.940003","doi":"https://doi.org/10.3109/14647273.2014.940003","is_oa":false,"landing_page_url":"https://doi.org/10.3109/14647273.2014.940003","pdf_url":null,"source":{"id":"https://openalex.org/S51346222","display_name":"Human Fertility","issn_l":"1464-7273","issn":["1464-7273","1742-8149"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Fertility","raw_type":"journal-article"},{"id":"pmid:25105219","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25105219","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human fertility (Cambridge, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1904189051","display_name":null,"funder_award_id":"R03 HG0004528","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"}],"funders":[{"id":"https://openalex.org/F4320310702","display_name":"National Cancer Research Institute","ror":"https://ror.org/02mp0vf47"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1514473043","https://openalex.org/W1594291205","https://openalex.org/W1605824561","https://openalex.org/W1999933852","https://openalex.org/W2005016057","https://openalex.org/W2016035370","https://openalex.org/W2019983958","https://openalex.org/W2031885519","https://openalex.org/W2038847731","https://openalex.org/W2053264391","https://openalex.org/W2056330418","https://openalex.org/W2059938162","https://openalex.org/W2087025655","https://openalex.org/W2097188465","https://openalex.org/W2115802526","https://openalex.org/W2116743346","https://openalex.org/W2119401330","https://openalex.org/W2124489512","https://openalex.org/W2132309919","https://openalex.org/W2135514612","https://openalex.org/W2141429353","https://openalex.org/W2150111967","https://openalex.org/W2328105863","https://openalex.org/W2936069350","https://openalex.org/W4205738534"],"related_works":["https://openalex.org/W2005016057","https://openalex.org/W2167661484","https://openalex.org/W2119327768","https://openalex.org/W4281626217","https://openalex.org/W2000645633","https://openalex.org/W2806095229","https://openalex.org/W2089192431","https://openalex.org/W2289293828","https://openalex.org/W2947727299","https://openalex.org/W2568250722"],"abstract_inverted_index":{"Despite":[0,142],"research":[1],"on":[2,56,67,145],"BRCA1/2":[3,26,61],"mutation":[4,27,62],"carriers":[5],"attitudes":[6],"towards":[7],"preimplantation":[8],"genetic":[9],"diagnosis":[10],"(PGD),":[11],"considerably":[12],"less":[13,158],"is":[14,43,196],"known":[15],"about":[16],"individuals'":[17],"experience":[18,114],"with":[19,59,80,154,198],"its":[20],"use.":[21],"Through":[22],"case":[23,172],"reports":[24,82,173],"of":[25,41,50,70,83,89,105,112,126,132,180],"carriers'":[28],"thoughts":[29],"on,":[30],"and":[31,45,52,86,98,117,131,167,189,191],"use":[32],"of,":[33],"PGD,":[34,79,97],"this":[35,64],"paper":[36],"highlights":[37],"how":[38],"the":[39,48,90,103,106,164],"option":[40],"PGD":[42,120,130,181],"experienced":[44],"negotiated":[46],"in":[47,148],"context":[49],"reproductive":[51,138,200],"life-course":[53],"goals.":[54,201],"Drawing":[55],"qualitative":[57],"interviews":[58],"38":[60],"carriers,":[63],"article":[65],"focuses":[66],"a":[68],"subsample":[69],"10":[71],"interviewees":[72],"who":[73],"sought":[74],"consultation":[75],"for,":[76],"and/or":[77],"attempted,":[78],"in-depth":[81],"3":[84],"cases":[85],"summary":[87],"decisions":[88,188],"remaining":[91],"7.":[92],"Three":[93],"couples":[94],"decided":[95],"against":[96],"one":[99],"was":[100],"deciding":[101],"at":[102],"time":[104],"interview.":[107],"Interviewees":[108],"discuss":[109],"key":[110],"aspects":[111],"their":[113,137,199],"prior":[115],"to,":[116],"going":[118],"through,":[119],"for":[121,151,182,185],"BRCA1/2,":[122],"including":[123],"potential":[124],"challenges":[125],"becoming":[127],"pregnant":[128],"through":[129],"heightened":[133],"pressure":[134],"to":[135,163],"achieve":[136],"goals":[139],"more":[140],"quickly.":[141],"considerable":[143],"focus":[144],"ethical":[146],"issues":[147],"screening":[149],"embryos":[150],"mutations":[152],"associated":[153],"adult-onset":[155],"cancer":[156],"risk,":[157],"attention":[159],"has":[160],"been":[161],"paid":[162],"technical,":[165],"logistical,":[166],"related":[168],"psychosocial":[169],"issues.":[170],"Narrative":[171],"may":[174],"help":[175],"individuals":[176],"develop":[177],"appropriate":[178],"expectations":[179],"BRCA":[183],"prepare":[184],"possibly":[186],"challenging":[187],"outcomes,":[190],"ultimately":[192],"determine":[193],"whether":[194],"it":[195],"compatible":[197]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
