{"id":"https://openalex.org/W2107022380","doi":"https://doi.org/10.1073/pnas.0709419104","title":"Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice","display_name":"Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice","publication_year":2007,"publication_date":"2007-11-14","ids":{"openalex":"https://openalex.org/W2107022380","doi":"https://doi.org/10.1073/pnas.0709419104","mag":"2107022380","pmid":"https://pubmed.ncbi.nlm.nih.gov/18003893","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2141846"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0709419104","doi":"https://doi.org/10.1073/pnas.0709419104","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0709419104","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2141846","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050160250","display_name":"Roberto Carlos Ag\u00eds\u2010Balboa","orcid":"https://orcid.org/0000-0001-9899-9569","observed_orcids":["https://orcid.org/0000-0001-9899-9569"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roberto C. Ag\u00eds-Balboa","raw_affiliation_strings":["Psychiatric Institute, Department of Psychiatry, School of Medicine, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612","Psychiatric Institute, Department of Psychiatry, School of Medicine, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychiatric Institute, Department of Psychiatry, School of Medicine, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Psychiatric Institute, Department of Psychiatry, School of Medicine, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001147683","display_name":"Graziano Pinna","orcid":"https://orcid.org/0000-0001-7541-4855","observed_orcids":["https://orcid.org/0000-0001-7541-4855"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Graziano Pinna","raw_affiliation_strings":["Psychiatric Institute, Department of Psychiatry, School of Medicine, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychiatric Institute, Department of Psychiatry, School of Medicine, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042503656","display_name":"Fabio Pibiri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fabio Pibiri","raw_affiliation_strings":["Psychiatric Institute, Department of Psychiatry, School of Medicine, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychiatric Institute, Department of Psychiatry, School of Medicine, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053936847","display_name":"Bashkim Kadriu","orcid":"https://orcid.org/0000-0002-3809-9451","observed_orcids":["https://orcid.org/0000-0002-3809-9451"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bashkim Kadriu","raw_affiliation_strings":["Psychiatric Institute, Department of Psychiatry, School of Medicine, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychiatric Institute, Department of Psychiatry, School of Medicine, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109119057","display_name":"Erminio Costa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erminio Costa","raw_affiliation_strings":["Psychiatric Institute, Department of Psychiatry, School of Medicine, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychiatric Institute, Department of Psychiatry, School of Medicine, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048825104","display_name":"Alessandro Guidotti","orcid":"https://orcid.org/0000-0003-4480-0010","observed_orcids":["https://orcid.org/0000-0003-4480-0010"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alessandro Guidotti","raw_affiliation_strings":["Psychiatric Institute, Department of Psychiatry, School of Medicine, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychiatric Institute, Department of Psychiatry, School of Medicine, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612","institution_ids":["https://openalex.org/I39422238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I39422238"],"apc_list":null,"apc_paid":null,"fwci":2.7377,"has_fulltext":false,"cited_by_count":173,"citation_normalized_percentile":{"value":0.90307044,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"104","issue":"47","first_page":"18736","last_page":"18741"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.6410999894142151,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.6410999894142151,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.3034999966621399,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.019999999552965164,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allopregnanolone","display_name":"allopregnanolone","score":0.871999979019165},{"id":"https://openalex.org/keywords/neurosteroidogenesis","display_name":"neurosteroidogenesis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/3alpha-hydroxysteroid-dehydrogenase","display_name":"3\u03b1-hydroxysteroid dehydrogenase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/social-isolation","display_name":"social isolation","score":0.9649999737739563},{"id":"https://openalex.org/keywords/corticolimbic-circuits","display_name":"corticolimbic circuits","score":0.9750000238418579},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.8389999866485596},{"id":"https://openalex.org/keywords/amygdala","display_name":"amygdala","score":0.9049999713897705},{"id":"https://openalex.org/keywords/prefrontal-cortex","display_name":"prefrontal cortex","score":0.8209999799728394},{"id":"https://openalex.org/keywords/gaba-a-receptor-modulation","display_name":"GABA-A receptor modulation","score":0.6710000038146973},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.5120000243186951},{"id":"https://openalex.org/keywords/aggression","display_name":"aggression","score":0.6299999952316284},{"id":"https://openalex.org/keywords/gene-downregulation","display_name":"gene downregulation","score":0.7080000042915344}],"concepts":[{"id":"https://openalex.org/C44796713","wikidata":"https://www.wikidata.org/wiki/Q2659374","display_name":"Neuroactive steroid","level":4,"score":0.6754491925239563},{"id":"https://openalex.org/C2775941552","wikidata":"https://www.wikidata.org/wiki/Q25212305","display_name":"Isolation (microbiology)","level":2,"score":0.5222804546356201},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.5216370224952698},{"id":"https://openalex.org/C2776893239","wikidata":"https://www.wikidata.org/wiki/Q1778765","display_name":"Social isolation","level":2,"score":0.501396894454956},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3905121684074402},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3711259365081787},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34987151622772217},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3316560387611389},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2668381929397583},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.22526231408119202},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16433420777320862},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1570781171321869},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.12974143028259277},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0858604907989502},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0},{"id":"https://openalex.org/C168258287","wikidata":"https://www.wikidata.org/wiki/Q60147","display_name":"GABAA receptor","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012934","descriptor_name":"Social Isolation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D013741","descriptor_name":"3-Oxo-5-alpha-Steroid 4-Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013741","descriptor_name":"3-Oxo-5-alpha-Steroid 4-Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045002","descriptor_name":"3-alpha-Hydroxysteroid Dehydrogenase (B-Specific)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045002","descriptor_name":"3-alpha-Hydroxysteroid Dehydrogenase (B-Specific)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.0709419104","doi":"https://doi.org/10.1073/pnas.0709419104","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0709419104","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2141846","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2141846","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:18003893","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18003893","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2141846","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2141846","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G375046713","display_name":"Reelin and GAD67 Downregulation","funder_award_id":"R01MH062090","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G8409054204","display_name":null,"funder_award_id":"MH5680","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320309257","display_name":"McLean Hospital","ror":"https://ror.org/01kta7d96"},{"id":"https://openalex.org/F4320326069","display_name":"Regione Autonoma della Sardegna","ror":"https://ror.org/041vg2t58"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W146465976","https://openalex.org/W435769191","https://openalex.org/W598007856","https://openalex.org/W1492103690","https://openalex.org/W1522048223","https://openalex.org/W1561736958","https://openalex.org/W1728222780","https://openalex.org/W1864733621","https://openalex.org/W1961476520","https://openalex.org/W1965169456","https://openalex.org/W1971685472","https://openalex.org/W1973115552","https://openalex.org/W1976707885","https://openalex.org/W1980882938","https://openalex.org/W1988418074","https://openalex.org/W1989257227","https://openalex.org/W1998236920","https://openalex.org/W2018831144","https://openalex.org/W2023634197","https://openalex.org/W2026720425","https://openalex.org/W2027449969","https://openalex.org/W2040579648","https://openalex.org/W2041000222","https://openalex.org/W2057387160","https://openalex.org/W2060589548","https://openalex.org/W2068222511","https://openalex.org/W2075312117","https://openalex.org/W2086519799","https://openalex.org/W2147502381","https://openalex.org/W2161364208","https://openalex.org/W2226450706","https://openalex.org/W2477848304","https://openalex.org/W2489126218","https://openalex.org/W2777548161","https://openalex.org/W4242976046","https://openalex.org/W4250700855","https://openalex.org/W4290856831","https://openalex.org/W4388295527","https://openalex.org/W7096203747"],"related_works":["https://openalex.org/W1989257227","https://openalex.org/W2324145200","https://openalex.org/W1985772728","https://openalex.org/W2029899890","https://openalex.org/W2030314043","https://openalex.org/W2160759787","https://openalex.org/W2040579648","https://openalex.org/W2045756579","https://openalex.org/W2036002298","https://openalex.org/W2055971647"],"abstract_inverted_index":{"Allopregnanolone":[0],"(ALLO),":[1],"synthesized":[2,30],"by":[3,33,201],"pyramidal":[4,137,151,171,176,236],"neurons,":[5,138,172,175,185],"is":[6,29,224,231],"a":[7],"potent":[8],"positive":[9],"allosteric":[10],"modulator":[11],"of":[12,15,37,128,145,153,178,216,220,228,259],"the":[13,26,34,49,125,146,218,225,241,257],"action":[14,36],"GABA":[16],"at":[17],"GABA(A)":[18],"receptors":[19],"expressing":[20],"specific":[21],"neurosteroid":[22],"binding":[23],"sites.":[24],"In":[25,48,120,161,248],"brain,":[27],"ALLO":[28,229],"from":[31,243],"progesterone":[32],"sequential":[35],"two":[38],"enzymes:":[39],"5alpha-reductase":[40],"type":[41],"I":[42],"(5alpha-RI)":[43],"and":[44,52,94,102,111,149,186,190,245,266],"3alpha-hydroxysteroid":[45],"dehydrogenase":[46],"(3alpha-HSD).":[47],"cortex,":[50],"hippocampus,":[51],"amygdala,":[53,148],"these":[54,121],"enzymes":[55],"are":[56,86],"colocalized":[57],"in":[58,89,95,108,112,133,169,210,234],"principal":[59],"glutamatergic":[60,136,143,150,235],"output":[61],"neurons":[62,144,152,177,237],"[Ag\u00eds-Balboa":[63],"RC,":[64],"Pinna":[65],"G,":[66],"Zhubi":[67],"A,":[68],"Maloku":[69],"E,":[70,74],"Veldic":[71],"M,":[72],"Costa":[73],"Guidotti":[75],"A":[76],"(2006)":[77],"Proc":[78],"Natl":[79],"Acad":[80],"Sci":[81],"USA":[82],"103:14602-14607],":[83],"but":[84],"they":[85],"not":[87],"detectable":[88],"GABAergic":[90],"interneurons.":[91],"Using":[92],"RT-PCR":[93],"situ":[96],"hybridization,":[97],"this":[98,252],"study":[99],"compares":[100],"5alpha-RI":[101,129,163,221],"3alpha-HSD":[103,196],"mRNA":[104,126,164,197],"brain":[105],"expression":[106,127,165,198,219],"levels":[107],"group":[109],"housed":[110],"socially":[113,122,249],"isolated":[114,123,250],"male":[115,211],"mice":[116],"for":[117,256],"4":[118,214],"weeks.":[119],"mice,":[124,212,251],"was":[130,199],"dramatically":[131],"decreased":[132],"hippocampal":[134,246],"CA3":[135],"dentate":[139],"gyrus":[140],"granule":[141],"cells,":[142],"basolateral":[147],"layer":[154,179],"V/VI":[155],"frontal":[156],"(prelimbic,":[157],"infralimbic)":[158],"cortex":[159],"(FC).":[160],"contrast,":[162],"failed":[166],"to":[167],"change":[168],"CA1":[170],"central":[173],"amygdala":[174,242],"II/III":[180],"FC,":[181],"ventromedial":[182],"thalamic":[183,192],"nucleus":[184,193],"striatal":[187],"medium":[188],"spiny":[189],"reticular":[191],"neurons.":[194],"Importantly,":[195],"unchanged":[200],"protracted":[202],"social":[203],"isolation":[204],"(Si).":[205],"These":[206],"data":[207],"suggest":[208],"that,":[209],"after":[213],"weeks":[215],"Si,":[217],"mRNA,":[222],"which":[223],"rate-limiting-step":[226],"enzyme":[227],"biosynthesis,":[230],"specifically":[232],"down-regulated":[233],"that":[238],"converge":[239],"on":[240],"cortical":[244],"regions.":[247],"down-regulation":[253],"may":[254],"account":[255],"appearance":[258],"behavioral":[260],"disorders":[261],"such":[262],"as":[263],"anxiety,":[264],"aggression,":[265],"cognitive":[267],"dysfunction.":[268]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}