{"id":"https://openalex.org/W2107003449","doi":"https://doi.org/10.1210/endo-114-2-418","title":"Cyclic Adenosine Monophosphate and Ovarian Follicular Fluid Act Synergistically to Inhibit Mouse Oocyte Maturation*","display_name":"Cyclic Adenosine Monophosphate and Ovarian Follicular Fluid Act Synergistically to Inhibit Mouse Oocyte Maturation*","publication_year":1984,"publication_date":"1984-02-01","ids":{"openalex":"https://openalex.org/W2107003449","doi":"https://doi.org/10.1210/endo-114-2-418","mag":"2107003449","pmid":"https://pubmed.ncbi.nlm.nih.gov/6197295"},"language":"en","primary_location":{"id":"doi:10.1210/endo-114-2-418","doi":"https://doi.org/10.1210/endo-114-2-418","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo-114-2-418","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"STEPHEN M. DOWNS","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"STEPHEN M. DOWNS","raw_affiliation_strings":["The Jackson Laboratory Bar Harbor, Maine 04609"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory Bar Harbor, Maine 04609","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110191925","display_name":"John J. Eppig","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JOHN J. EPPIG","raw_affiliation_strings":["The Jackson Laboratory Bar Harbor, Maine 04609"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory Bar Harbor, Maine 04609","institution_ids":["https://openalex.org/I4210115256"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210115256"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":7.2303,"has_fulltext":false,"cited_by_count":86,"citation_normalized_percentile":{"value":0.985395,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"114","issue":"2","first_page":"418","last_page":"427"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11505","display_name":"Reproductive biology and impacts on aquatic species","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10584","display_name":"Reproductive Physiology in Livestock","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.9279999732971191},{"id":"https://openalex.org/keywords/follicular-fluid","display_name":"follicular fluid","score":0.8259999752044678},{"id":"https://openalex.org/keywords/mouse-oocytes","display_name":"mouse oocytes","score":0.7020000219345093},{"id":"https://openalex.org/keywords/cumulus-cells","display_name":"cumulus cells","score":0.9580000042915344},{"id":"https://openalex.org/keywords/follicle-stimulating-hormone","display_name":"follicle-stimulating hormone","score":0.7990000247955322},{"id":"https://openalex.org/keywords/forskolin","display_name":"forskolin","score":0.8389999866485596},{"id":"https://openalex.org/keywords/synergistic-inhibition","display_name":"synergistic inhibition","score":0.5609999895095825},{"id":"https://openalex.org/keywords/germinal-vesicle-breakdown","display_name":"germinal vesicle breakdown","score":0.9160000085830688}],"concepts":[{"id":"https://openalex.org/C2776690073","wikidata":"https://www.wikidata.org/wiki/Q3246226","display_name":"Oocyte","level":3,"score":0.7616285085678101},{"id":"https://openalex.org/C2776188440","wikidata":"https://www.wikidata.org/wiki/Q3746826","display_name":"Follicular fluid","level":4,"score":0.7170201539993286},{"id":"https://openalex.org/C2779276759","wikidata":"https://www.wikidata.org/wiki/Q412747","display_name":"Forskolin","level":3,"score":0.6540648341178894},{"id":"https://openalex.org/C2994119143","wikidata":"https://www.wikidata.org/wiki/Q3246226","display_name":"Germinal vesicle","level":4,"score":0.5956919193267822},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5716512203216553},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5427693128585815},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5108615756034851},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3586728274822235},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3309710621833801},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.2731964588165283},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.13263505697250366},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08507946133613586},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.07713642716407776}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003994","descriptor_name":"Bucladesine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004224","descriptor_name":"Diterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005576","descriptor_name":"Colforsin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006080","descriptor_name":"Ovarian Follicle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013806","descriptor_name":"Theophylline","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D015056","descriptor_name":"1-Methyl-3-isobutylxanthine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1210/endo-114-2-418","doi":"https://doi.org/10.1210/endo-114-2-418","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo-114-2-418","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:6197295","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6197295","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:mouseion.jax.org:stfb1980_1989-1555","doi":null,"is_oa":false,"landing_page_url":"https://mouseion.jax.org/stfb1980_1989/556","pdf_url":null,"source":{"id":"https://openalex.org/S4377196421","display_name":"The Mouseion at the JAXlibrary (Jackson Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115256","host_organization_name":"Jackson Laboratory","host_organization_lineage":["https://openalex.org/I4210115256"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Research 1980 - 1989","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4000000059604645,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1965978191","https://openalex.org/W1971087119","https://openalex.org/W1971506156","https://openalex.org/W1976220201","https://openalex.org/W1984305127","https://openalex.org/W1986086454","https://openalex.org/W1986140299","https://openalex.org/W1998772563","https://openalex.org/W2002801349","https://openalex.org/W2010184839","https://openalex.org/W2024364788","https://openalex.org/W2025879433","https://openalex.org/W2046781755","https://openalex.org/W2049717556","https://openalex.org/W2061027592","https://openalex.org/W2063374950","https://openalex.org/W2095713377","https://openalex.org/W2103750154","https://openalex.org/W2131338581","https://openalex.org/W2150083639","https://openalex.org/W2158794650","https://openalex.org/W2295074165","https://openalex.org/W2328940672","https://openalex.org/W2410961661"],"related_works":["https://openalex.org/W1977764079","https://openalex.org/W2080329211","https://openalex.org/W2046781755","https://openalex.org/W2045201130","https://openalex.org/W2019928137","https://openalex.org/W55500349","https://openalex.org/W7099315455","https://openalex.org/W2131338581","https://openalex.org/W2109850843","https://openalex.org/W2060085097"],"abstract_inverted_index":{"The":[0,23,88,132,146,260],"relationship":[1],"between":[2],"cAMP":[3],"and":[4,44,78,246],"the":[5,53,72,99,107,190,216,241,255,265],"capacity":[6],"of":[7,11,41,52,71,74,90,98,106,110,134,159,167,218,243,258],"two":[8],"partially-purified":[9],"fractions":[10,24,101,239],"porcine":[12,63],"follicular":[13],"fluid":[14],"(PFF)":[15],"to":[16,94,195,230,253],"suppress":[17],"mouse":[18,80],"oocyte":[19,232],"maturation":[20,73,233,242],"was":[21,136,149,179],"investigated.":[22],"used":[25],"were:":[26],"1)":[27],"a":[28,46,68,121,154,199,219,227,269,280],"low":[29],"molecular":[30,156],"weight":[31,157],"filtrate":[32,55],"(less":[33],"than":[34,142,205,274],"10,000)":[35],"derived":[36],"from":[37,48],"Amicon":[38],"PM10":[39,54,65,168],"filtration":[40],"PFF":[42,100,111,127,222,238,266],"(PM10),":[43],"2)":[45],"fraction":[47,128],"Bio-Gel":[49],"P2":[50],"chromatography":[51],"(Bio-Gel)":[56],"that":[57,206,223,264],"has":[58],"meiotic":[59],"inhibitory":[60,108,173,256],"activity":[61,257],"in":[62,103,113,129,139,143,198,208,221,234],"oocytes.":[64,116,131,145],"alone":[66,112],"produced":[67],"transient":[69],"inhibition":[70,135,178],"both":[75,244],"cumulus":[76,114,140,247,250],"cell-enclosed":[77,115,141,248],"denuded":[79,130,144,245],"oocytes,":[81,249],"as":[82],"manifested":[83],"by":[84,182],"germinal":[85],"vesicle":[86],"breakdown.":[87],"addition":[89],"FSH":[91],"or":[92,118,164,282],"(Bu)2cAMP":[93,119],"medium":[95,197],"containing":[96],"either":[97,126],"resulted":[102],"dramatic":[104],"synergism":[105,174,192],"effect":[109],"Forskolin":[117],"promoted":[120],"similar":[122],"synergistic":[123],"response":[124],"with":[125,175,226],"degree":[133],"consistently":[137],"greater":[138,204],"putative":[147],"inhibitor":[148,267],"dialyzable":[150],"through":[151],"tubing":[152],"having":[153],"nominal":[155],"cutoff":[158],"1,000.":[160],"Proteolysis,":[161],"acid":[162],"hydrolysis,":[163],"ether":[165],"extraction":[166],"did":[169,187],"not":[170,188,279],"reduce":[171],"its":[172],"(Bu)2cAMP.":[176],"However,":[177],"completely":[180],"abolished":[181],"charcoal":[183],"extraction.":[184],"Steroid":[185],"hormones":[186],"mimic":[189],"PM10-induced":[191],"when":[193],"added":[194],"(Bu)2cAMP-containing":[196],"concentration":[200],"at":[201],"least":[202],"14-fold":[203],"present":[207],"PM10-supplemented":[209],"medium.":[210],"In":[211],"conclusion,":[212],"our":[213],"results":[214],"demonstrate":[215],"presence":[217],"factor(s)":[220],"acts":[224],"synergistically":[225],"cAMP-dependent":[228],"process":[229],"inhibit":[231],"vitro.":[235],"Furthermore,":[236],"although":[237],"suppressed":[240],"cells":[251],"appear":[252],"mediate":[254],"PFF.":[259],"data":[261],"also":[262],"suggest":[263],"is":[268],"small":[270],"(mol":[271],"wt":[272],"less":[273],"1,000)":[275],"hydrophobic":[276],"molecule":[277],"but":[278],"peptide":[281],"nonpolar":[283],"lipid.":[284]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
