{"id":"https://openalex.org/W2106972194","doi":"https://doi.org/10.1093/hmg/ddu050","title":"A genome-wide association study of intra-ocular pressure suggests a novel association in the gene FAM125B in the TwinsUK cohort","display_name":"A genome-wide association study of intra-ocular pressure suggests a novel association in the gene FAM125B in the TwinsUK cohort","publication_year":2014,"publication_date":"2014-02-11","ids":{"openalex":"https://openalex.org/W2106972194","doi":"https://doi.org/10.1093/hmg/ddu050","mag":"2106972194","pmid":"https://pubmed.ncbi.nlm.nih.gov/24518671","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4030784"},"language":"en","primary_location":{"id":"doi:10.1093/hmg/ddu050","doi":"https://doi.org/10.1093/hmg/ddu050","is_oa":true,"landing_page_url":"https://doi.org/10.1093/hmg/ddu050","pdf_url":"https://academic.oup.com/hmg/article-pdf/23/12/3343/2061118/ddu050.pdf","source":{"id":"https://openalex.org/S166515463","display_name":"Human Molecular Genetics","issn_l":"0964-6906","issn":["0964-6906","1460-2083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Molecular Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/hmg/article-pdf/23/12/3343/2061118/ddu050.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035009040","display_name":"Abhishek Nag","orcid":"https://orcid.org/0000-0002-4638-2433","observed_orcids":["https://orcid.org/0000-0002-4638-2433","https://orcid.org/0000-0003-2129-8873"]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. Nag","raw_affiliation_strings":["Department of Twin Research and Genetic Epidemiology, King's College London, St. Thomas' Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Twin Research and Genetic Epidemiology, King's College London, St. Thomas' Hospital, London, UK","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004878569","display_name":"Cristina Venturini","orcid":"https://orcid.org/0000-0002-4769-7912","observed_orcids":["https://orcid.org/0000-0002-4769-7912","https://orcid.org/0000-0002-6948-2963"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C. Venturini","raw_affiliation_strings":["UCL Institute of Ophthalmology, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCL Institute of Ophthalmology, London, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002134134","display_name":"Kerrin S. Small","orcid":"https://orcid.org/0000-0003-4566-0005","observed_orcids":["https://orcid.org/0000-0003-4566-0005"]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"K. S. Small","raw_affiliation_strings":["Department of Twin Research and Genetic Epidemiology, King's College London, St. Thomas' Hospital, London, UK","1Department of Twin Research and Genetic Epidemiology, King's College London, St. Thomas\u2019 Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Twin Research and Genetic Epidemiology, King's College London, St. Thomas' Hospital, London, UK","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I183935753"]},{"raw_affiliation_string":"1Department of Twin Research and Genetic Epidemiology, King's College London, St. Thomas\u2019 Hospital, London, UK","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001007771","display_name":"Terri L. Young","orcid":"https://orcid.org/0000-0001-6994-9941","observed_orcids":["https://orcid.org/0000-0001-6994-9941"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. L. Young","raw_affiliation_strings":["Center for Human Genetics, Duke University Medical Center, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Genetics, Duke University Medical Center, Durham, NC, USA","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105819907","display_name":"Ananth C. Viswanathan","orcid":"https://orcid.org/0009-0000-1519-7908","observed_orcids":["https://orcid.org/0009-0000-1519-7908","https://orcid.org/0009-0001-8127-3419"]},"institutions":[{"id":"https://openalex.org/I4210088407","display_name":"NIHR Moorfields Biomedical Research Centre","ror":"https://ror.org/004hydx84","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I1325675289","https://openalex.org/I34931013","https://openalex.org/I4210088407","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I4210150574","display_name":"Moorfields Eye Hospital","ror":"https://ror.org/03tb37539","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325675289","https://openalex.org/I4210150574"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. C. Viswanathan","raw_affiliation_strings":["NIHR Biomedical Research Centre at Moorfields Eye Hospital NHSFT and UCL Institute of Ophthalmology, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIHR Biomedical Research Centre at Moorfields Eye Hospital NHSFT and UCL Institute of Ophthalmology, London, UK","institution_ids":["https://openalex.org/I4210088407","https://openalex.org/I4210150574","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045241030","display_name":"David Anthony Mackey","orcid":"https://orcid.org/0000-0001-7914-4709","observed_orcids":["https://orcid.org/0000-0001-7914-4709"]},"institutions":[{"id":"https://openalex.org/I104628220","display_name":"Lions Eye Institute","ror":"https://ror.org/006vyay97","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I104628220"]},{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"D. A. Mackey","raw_affiliation_strings":["Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Australia","institution_ids":["https://openalex.org/I104628220","https://openalex.org/I177877127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016454136","display_name":"Pirro G. Hysi","orcid":"https://orcid.org/0000-0001-5752-2510","observed_orcids":["https://orcid.org/0000-0001-5752-2510"]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P. G. Hysi","raw_affiliation_strings":["Department of Twin Research and Genetic Epidemiology, King's College London, St. Thomas' Hospital, London, UK","1Department of Twin Research and Genetic Epidemiology, King's College London, St. Thomas\u2019 Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Twin Research and Genetic Epidemiology, King's College London, St. Thomas' Hospital, London, UK","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I183935753"]},{"raw_affiliation_string":"1Department of Twin Research and Genetic Epidemiology, King's College London, St. Thomas\u2019 Hospital, London, UK","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101683595","display_name":"Christopher J. Hammond","orcid":"https://orcid.org/0000-0002-3227-2620","observed_orcids":["https://orcid.org/0000-0002-3227-2620"]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"C. Hammond","raw_affiliation_strings":["Department of Twin Research and Genetic Epidemiology, King's College London, St. Thomas' Hospital, London, UK chris.hammond@kcl.ac.uk","Department of Twin Research and Genetic Epidemiology, King's College London, St. Thomas' Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Twin Research and Genetic Epidemiology, King's College London, St. Thomas' Hospital, London, UK chris.hammond@kcl.ac.uk","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I183935753"]},{"raw_affiliation_string":"Department of Twin Research and Genetic Epidemiology, King's College London, St. Thomas' Hospital, London, UK","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022464374","display_name":"Tin Aung","orcid":"https://orcid.org/0000-0002-7916-0589","observed_orcids":["https://orcid.org/0000-0002-7916-0589","https://orcid.org/0000-0002-4187-0788"]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"T. Aung","raw_affiliation_strings":["Department of Twin Research and Genetic Epidemiology, King's College London, St. Thomas' Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Twin Research and Genetic Epidemiology, King's College London, St. Thomas' Hospital, London, UK","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032933669","display_name":"Ching\u2010Yu Cheng","orcid":"https://orcid.org/0000-0003-0655-885X","observed_orcids":["https://orcid.org/0000-0003-0655-885X","https://orcid.org/0000-0002-4916-6074"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C.-Y. Cheng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019310337","display_name":"Brian W. Fleck","orcid":"https://orcid.org/0000-0003-1524-7682","observed_orcids":["https://orcid.org/0000-0003-1524-7682"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. W. Fleck","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"J. Gibson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Gibson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037433676","display_name":"Alex William Hewitt","orcid":"https://orcid.org/0000-0002-5123-5999","observed_orcids":["https://orcid.org/0000-0002-5123-5999"]},"institutions":[{"id":"https://openalex.org/I4210088407","display_name":"NIHR Moorfields Biomedical Research Centre","ror":"https://ror.org/004hydx84","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I1325675289","https://openalex.org/I34931013","https://openalex.org/I4210088407","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I4210150574","display_name":"Moorfields Eye Hospital","ror":"https://ror.org/03tb37539","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325675289","https://openalex.org/I4210150574"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. W. Hewitt","raw_affiliation_strings":["NIHR Biomedical Research Centre at Moorfields Eye Hospital NHSFT and UCL Institute of Ophthalmology, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIHR Biomedical Research Centre at Moorfields Eye Hospital NHSFT and UCL Institute of Ophthalmology, London, UK","institution_ids":["https://openalex.org/I4210088407","https://openalex.org/I4210150574","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107836650","display_name":"Albert Hofman","orcid":"https://orcid.org/0009-0007-3564-3267","observed_orcids":["https://orcid.org/0009-0007-3564-3267"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Hofman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010641221","display_name":"Ren\u00e9 H\u00f6hn","orcid":"https://orcid.org/0000-0003-2870-1469","observed_orcids":["https://orcid.org/0000-0003-2870-1469"]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R. Hohn","raw_affiliation_strings":["Department of Twin Research and Genetic Epidemiology, King's College London, St. Thomas' Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Twin Research and Genetic Epidemiology, King's College London, St. Thomas' Hospital, London, UK","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082561940","display_name":"Jost Bruno Jonas","orcid":"https://orcid.org/0000-0003-2972-5227","observed_orcids":["https://orcid.org/0000-0003-2972-5227"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. B. Jonas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080847227","display_name":"Chiea Chuen Khor","orcid":"https://orcid.org/0000-0002-1128-4729","observed_orcids":["https://orcid.org/0000-0002-1128-4729"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C.-C. Khor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029529953","display_name":"Caroline C. W. Klaver","orcid":"https://orcid.org/0000-0002-2355-5258","observed_orcids":["https://orcid.org/0000-0002-2355-5258"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. C. Klaver","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011555439","display_name":"Hans G. Lemij","orcid":"https://orcid.org/0000-0001-8508-8985","observed_orcids":["https://orcid.org/0000-0001-8508-8985"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. G. Lemij","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046585715","display_name":"Jiemin Liao","orcid":"https://orcid.org/0000-0001-6848-5532","observed_orcids":["https://orcid.org/0000-0001-6848-5532"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Liao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072541133","display_name":"Andrew John Lotery","orcid":"https://orcid.org/0000-0001-5541-4305","observed_orcids":["https://orcid.org/0000-0001-5541-4305"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. J. Lotery","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012302685","display_name":"Yi Lu","orcid":"https://orcid.org/0000-0001-9933-3654","observed_orcids":["https://orcid.org/0000-0001-9933-3654"]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Y. Lu","raw_affiliation_strings":["1Department of Twin Research and Genetic Epidemiology, King's College London, St. Thomas\u2019 Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Twin Research and Genetic Epidemiology, King's College London, St. Thomas\u2019 Hospital, London, UK","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029948119","display_name":"Stuart MacGregor","orcid":"https://orcid.org/0000-0001-6731-8142","observed_orcids":["https://orcid.org/0000-0001-6731-8142"]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S. Macgregor","raw_affiliation_strings":["Department of Twin Research and Genetic Epidemiology, King's College London, St. Thomas' Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Twin Research and Genetic Epidemiology, King's College London, St. Thomas' Hospital, London, UK","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113465880","display_name":"Paul Mitchell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P. Mitchell","raw_affiliation_strings":["Department of Twin Research and Genetic Epidemiology, King's College London, St. Thomas' Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Twin Research and Genetic Epidemiology, King's College London, St. Thomas' Hospital, London, UK","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012019655","display_name":"Wishal D. Ramdas","orcid":"https://orcid.org/0000-0002-1780-5281","observed_orcids":["https://orcid.org/0000-0002-1780-5281"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W. D. Ramdas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077089543","display_name":"Henri\u00ebt Springelkamp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"H. Springelkamp","raw_affiliation_strings":["Department of Twin Research and Genetic Epidemiology, King's College London, St. Thomas' Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Twin Research and Genetic Epidemiology, King's College London, St. Thomas' Hospital, London, UK","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049068947","display_name":"E Shyong Tai","orcid":"https://orcid.org/0000-0003-2929-8966","observed_orcids":["https://orcid.org/0000-0003-2929-8966"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E.-S. Tai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101851184","display_name":"Yik\u2010Ying Teo","orcid":"https://orcid.org/0000-0002-7522-0601","observed_orcids":["https://orcid.org/0000-0002-7522-0601"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y.-Y. Teo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031530236","display_name":"Andr\u00e9 Gerardus Uitterlinden","orcid":"https://orcid.org/0000-0002-7276-3387","observed_orcids":["https://orcid.org/0000-0002-7276-3387"]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. G. Uitterlinden","raw_affiliation_strings":["1Department of Twin Research and Genetic Epidemiology, King's College London, St. Thomas\u2019 Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Twin Research and Genetic Epidemiology, King's College London, St. Thomas\u2019 Hospital, London, UK","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017009749","display_name":"Cornelia M. van Duijn","orcid":"https://orcid.org/0000-0002-2374-9204","observed_orcids":["https://orcid.org/0000-0002-2374-9204","https://orcid.org/0000-0001-8766-6224"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. M. van Duijn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073411351","display_name":"Leonieke M. E. van Koolwijk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. M. van Koolwijk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105776643","display_name":"Johannes R. Vingerling","orcid":"https://orcid.org/0000-0002-0441-2809","observed_orcids":["https://orcid.org/0000-0002-0441-2809"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. R. Vingerling","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071827492","display_name":"V\u00e9ronique Vitart","orcid":"https://orcid.org/0000-0002-4991-3797","observed_orcids":["https://orcid.org/0000-0002-4991-3797"]},"institutions":[{"id":"https://openalex.org/I104628220","display_name":"Lions Eye Institute","ror":"https://ror.org/006vyay97","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I104628220"]},{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"V. Vitart","raw_affiliation_strings":["Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Australia","institution_ids":["https://openalex.org/I104628220","https://openalex.org/I177877127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085332370","display_name":"Eranga N. Vithana","orcid":"https://orcid.org/0000-0002-8898-0095","observed_orcids":["https://orcid.org/0000-0002-8898-0095"]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"E. Vithana","raw_affiliation_strings":["Department of Twin Research and Genetic Epidemiology, King's College London, St. Thomas' Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Twin Research and Genetic Epidemiology, King's College London, St. Thomas' Hospital, London, UK","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023239227","display_name":"J. J. Wang","orcid":"https://orcid.org/0000-0002-8394-5979","observed_orcids":["https://orcid.org/0000-0002-8394-5979"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. J. Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002448265","display_name":"Katie M Williams","orcid":"https://orcid.org/0000-0003-4596-3938","observed_orcids":["https://orcid.org/0000-0003-4596-3938"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. M. Williams","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012703227","display_name":"Robert Wojciechowski","orcid":"https://orcid.org/0000-0002-9593-4652","observed_orcids":["https://orcid.org/0000-0002-9593-4652"]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R. Wojciechowski","raw_affiliation_strings":["Department of Twin Research and Genetic Epidemiology, King's College London, St. Thomas' Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Twin Research and Genetic Epidemiology, King's College London, St. Thomas' Hospital, London, UK","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072258594","display_name":"Tien Yin Wong","orcid":"https://orcid.org/0000-0002-8448-1264","observed_orcids":["https://orcid.org/0000-0002-8448-1264"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T.-Y. Wong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065029045","display_name":"WTCCC WTCCC","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"WTCCC","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101545243","display_name":"Lizhen Xu","orcid":"https://orcid.org/0000-0003-4921-7238","observed_orcids":["https://orcid.org/0000-0003-4921-7238"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Xu","raw_affiliation_strings":["Center for Human Genetics; Duke University Medical Center; Durham, NC USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Genetics; Duke University Medical Center; Durham, NC USA","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108090928","display_name":"Ekaterina Yonova\u2010Doing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"E. Yonova-Doing","raw_affiliation_strings":["Department of Twin Research and Genetic Epidemiology, King's College London, St. Thomas' Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Twin Research and Genetic Epidemiology, King's College London, St. Thomas' Hospital, London, UK","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I183935753"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046127730","display_name":"Tanja Zeller","orcid":"https://orcid.org/0000-0003-3379-2641","observed_orcids":["https://orcid.org/0000-0003-3379-2641"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Z. Tanja","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5101683595"],"corresponding_institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I183935753"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":{"value":2565,"currency":"EUR","value_usd":2766},"fwci":6.8718,"has_fulltext":true,"cited_by_count":48,"citation_normalized_percentile":{"value":0.97180823,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"23","issue":"12","first_page":"3343","last_page":"3348"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12989","display_name":"Ocular Disorders and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intraocular-pressure","display_name":"intraocular pressure","score":0.9760000109672546},{"id":"https://openalex.org/keywords/glaucoma","display_name":"glaucoma","score":0.8759999871253967},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.878000020980835},{"id":"https://openalex.org/keywords/expression-quantitative-trait-loci","display_name":"expression quantitative trait loci","score":0.9039999842643738},{"id":"https://openalex.org/keywords/vesicular-trafficking","display_name":"vesicle trafficking","score":0.8259999752044678},{"id":"https://openalex.org/keywords/caveolin","display_name":"caveolin","score":0.7490000128746033},{"id":"https://openalex.org/keywords/primary-open-angle-glaucoma","display_name":"primary open-angle glaucoma","score":0.9110000133514404},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.5709999799728394}],"concepts":[{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.7982096672058105},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.6777188181877136},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.6678916215896606},{"id":"https://openalex.org/C168393362","wikidata":"https://www.wikidata.org/wiki/Q5421706","display_name":"Expression quantitative trait loci","level":5,"score":0.6655982136726379},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.6247376203536987},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5838305354118347},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5438729524612427},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.49377450346946716},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.4561036229133606},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.4397546350955963},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4055370092391968},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.3433963656425476},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002899","descriptor_name":"Chromosomes, Human, Pair 9","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006113","descriptor_name":"United Kingdom","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007429","descriptor_name":"Intraocular Pressure","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014427","descriptor_name":"Twins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D033921","descriptor_name":"Vesicular Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D033921","descriptor_name":"Vesicular Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044465","descriptor_name":"White People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1093/hmg/ddu050","doi":"https://doi.org/10.1093/hmg/ddu050","is_oa":true,"landing_page_url":"https://doi.org/10.1093/hmg/ddu050","pdf_url":"https://academic.oup.com/hmg/article-pdf/23/12/3343/2061118/ddu050.pdf","source":{"id":"https://openalex.org/S166515463","display_name":"Human Molecular Genetics","issn_l":"0964-6906","issn":["0964-6906","1460-2083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Molecular Genetics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3008989","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4030784","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4030784","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4030784","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hum Mol Genet","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:openaire/ba59e040-45c8-4033-9c01-502b3506ec09","doi":null,"is_oa":true,"landing_page_url":"https://admin.research-repository.uwa.edu.au/en/publications/ba59e040-45c8-4033-9c01-502b3506ec09","pdf_url":null,"source":{"id":"https://openalex.org/S4306402492","display_name":"UWA Profiles and Research Repository (UWA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177877127","host_organization_name":"The University of Western Australia","host_organization_lineage":["https://openalex.org/I177877127"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nag, A, Venturini, C, Small, K S, Young, T L, Viswanathan, A C, Mackey, D, Hysi, P G & Hammond, C J 2014, 'A genome-wide association study of intra-ocular pressure suggests a novel association in the gene FAM125b in the TwinsUK cohort', Human Molecular Genetics, vol. 23, no. 12, pp. 3343-3348. https://doi.org/10.1093/hmg/ddu050","raw_type":"info:eu-repo/semantics/article"},{"id":"pmid:24518671","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24518671","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human molecular genetics","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.soton.ac.uk:368924","doi":null,"is_oa":false,"landing_page_url":"http://doi.org/10.1093/hmg/ddu050>).","pdf_url":null,"source":{"id":"https://openalex.org/S4306401019","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/256473","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11343/256473","pdf_url":"http://hdl.handle.net/11343/256473","source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1450527","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1450527/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"HUMAN MOLECULAR GENETICS , 23 (12) pp. 3343-3348. (2014)","raw_type":"Article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:openaire/b564d75b-e0e7-4f6c-b4a5-77a9d947196a","doi":null,"is_oa":true,"landing_page_url":"http://hmg.oxfordjournals.org/content/23/12/3343","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nag, A, Venturini, C, Small, K S, Young, T L, Viswanathan, A C, Mackey, D A, Hysi, P G, Hammond, C J 2014, 'A genome-wide association study of intra-ocular pressure suggests a novel association in the gene FAM125B in the TwinsUK cohort', Human Molecular Genetics, vol. 23, no. 12, pp. 3343-3348. https://doi.org/10.1093/hmg/ddu050","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1093/hmg/ddu050","doi":"https://doi.org/10.1093/hmg/ddu050","is_oa":true,"landing_page_url":"https://doi.org/10.1093/hmg/ddu050","pdf_url":"https://academic.oup.com/hmg/article-pdf/23/12/3343/2061118/ddu050.pdf","source":{"id":"https://openalex.org/S166515463","display_name":"Human Molecular Genetics","issn_l":"0964-6906","issn":["0964-6906","1460-2083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Molecular Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1933023605","display_name":null,"funder_award_id":"MR/K023721/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G2078188668","display_name":"International Collaborative Twin Study of Refractive and Glaucoma Endophenotypes","funder_award_id":"R01EY018246","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G7340196846","display_name":null,"funder_award_id":"WT081878MA","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2106972194.pdf","grobid_xml":"https://content.openalex.org/works/W2106972194.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1513948303","https://openalex.org/W1968210590","https://openalex.org/W1972698844","https://openalex.org/W1972929463","https://openalex.org/W1981747825","https://openalex.org/W2019232525","https://openalex.org/W2042863127","https://openalex.org/W2051417851","https://openalex.org/W2052130695","https://openalex.org/W2052202737","https://openalex.org/W2057925970","https://openalex.org/W2065005955","https://openalex.org/W2069490704","https://openalex.org/W2078528120","https://openalex.org/W2081381892","https://openalex.org/W2081714395","https://openalex.org/W2091151219","https://openalex.org/W2100341629","https://openalex.org/W2105306382","https://openalex.org/W2110308463","https://openalex.org/W2110754749","https://openalex.org/W2114068481","https://openalex.org/W2123215356","https://openalex.org/W2135185351","https://openalex.org/W2148890166","https://openalex.org/W2151459533","https://openalex.org/W2151773390","https://openalex.org/W2164531652","https://openalex.org/W2166925937","https://openalex.org/W2559028527"],"related_works":["https://openalex.org/W805738436","https://openalex.org/W2063300800","https://openalex.org/W2884990155","https://openalex.org/W2075077772","https://openalex.org/W2794617952","https://openalex.org/W2110754749","https://openalex.org/W2052202737","https://openalex.org/W2106529000","https://openalex.org/W2771217310","https://openalex.org/W2097610995"],"abstract_inverted_index":{"Glaucoma":[0,93],"is":[1],"a":[2,20,28,88,129,161,208,211,219,243],"major":[3],"cause":[4],"of":[5,23,32,44,78,90,102,131,154,164,170,187,193,200,210,224,264],"blindness":[6],"in":[7,50,73,160,215,248,252,267],"the":[8,45,51,91,103,112,121,142,151,155,194,197,201,225,253,261],"world.":[9],"To":[10],"date,":[11],"common":[12],"genetic":[13],"variants":[14],"associated":[15,105,127,145,235],"with":[16,128,236],"glaucoma":[17,268],"only":[18],"explain":[19],"small":[21],"proportion":[22],"its":[24],"heritability.":[25],"We":[26],"performed":[27,108],"genome-wide":[29],"association":[30,58,174,245],"study":[31,46,241],"intra-ocular":[33],"pressure":[34],"(IOP),":[35],"an":[36,184],"underlying":[37],"endophenotype":[38],"for":[39,140,178,183,191,207],"glaucoma.":[40,239],"The":[41,69],"discovery":[42],"phase":[43],"was":[47,125,189],"carried":[48],"out":[49],"TwinsUK":[52,122,254],"cohort":[53],"(N":[54],"=":[55,83,136,176],"2774)":[56],"analyzing":[57],"between":[59,246],"IOP":[60,124,251],"and":[61,172,229,250],"single":[62],"nucleotide":[63],"polymorphisms":[64],"(SNPs)":[65],"imputed":[66],"to":[67,222,259],"HapMap2.":[68],"results":[70],"were":[71,87,107],"validated":[72],"12":[74,165],"independent":[75],"replication":[76,159],"cohorts":[77,166],"European":[79],"ancestry":[80],"(combined":[81],"N":[82],"22":[84],"789)":[85],"that":[86,223],"part":[89],"International":[92],"Genetics":[94],"Consortium.":[95],"Expression":[96,116],"quantitative":[97],"trait":[98],"locus":[99],"(eQTL)":[100],"analyses":[101],"significantly":[104,126,144],"SNPs":[106,132,247],"using":[109],"data":[110],"from":[111],"Multiple":[113],"Tissue":[114],"Human":[115],"Resource":[117],"(MuTHER)":[118],"Study.":[119],"In":[120],"cohort,":[123,255],"number":[130],"at":[133,147],"9q33.3":[134],"(P":[135,175],"3.48":[137],"\u00d7":[138],"10(-8)":[139],"rs2286885,":[141],"most":[143],"SNP":[146],"this":[148,265],"locus),":[149],"within":[150],"genomic":[152],"sequence":[153],"FAM125B":[156,202,249],"gene.":[157,203],"Independent":[158],"composite":[162],"panel":[163],"revealed":[167],"consistent":[168],"direction":[169],"effect":[171,186],"significant":[173],"0.003,":[177],"fixed-effect":[179],"meta-analysis).":[180],"Suggestive":[181],"evidence":[182],"eQTL":[185],"rs2286885":[188],"observed":[190],"one":[192],"probes":[195],"targeting":[196],"coding":[198],"region":[199],"This":[204,240],"gene":[205,266],"codes":[206],"component":[209],"membrane":[212],"complex":[213],"involved":[214],"vesicular":[216],"trafficking":[217],"process,":[218],"function":[220],"similar":[221],"Caveolin":[226],"genes":[227],"(CAV1":[228],"CAV2)":[230],"which":[231],"have":[232],"previously":[233],"been":[234],"primary":[237],"open-angle":[238],"suggests":[242],"novel":[244],"though":[256],"further":[257],"studies":[258],"elucidate":[260],"functional":[262],"role":[263],"are":[269],"necessary.":[270]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":6}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}