{"id":"https://openalex.org/W2106929505","doi":"https://doi.org/10.1373/clinchem.2007.100818","title":"Evaluation of a Prolonged Prothrombin Time","display_name":"Evaluation of a Prolonged Prothrombin Time","publication_year":2008,"publication_date":"2008-03-28","ids":{"openalex":"https://openalex.org/W2106929505","doi":"https://doi.org/10.1373/clinchem.2007.100818","mag":"2106929505","pmid":"https://pubmed.ncbi.nlm.nih.gov/18375491"},"language":"en","primary_location":{"id":"doi:10.1373/clinchem.2007.100818","doi":"https://doi.org/10.1373/clinchem.2007.100818","is_oa":false,"landing_page_url":"https://doi.org/10.1373/clinchem.2007.100818","pdf_url":null,"source":{"id":"https://openalex.org/S139212996","display_name":"Clinical Chemistry","issn_l":"0009-9147","issn":["0009-9147","1530-8561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320272","host_organization_name":"American Association for Clinical Chemistry","host_organization_lineage":["https://openalex.org/P4310320272"],"host_organization_lineage_names":["American Association for Clinical Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057105893","display_name":"Joshua L. Hood","orcid":"https://orcid.org/0000-0003-3998-4118","observed_orcids":["https://orcid.org/0000-0003-3998-4118"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua L Hood","raw_affiliation_strings":["Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5106134852","display_name":"Charles S. Eby","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Charles S Eby","raw_affiliation_strings":["Address correspondence to this author at: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110. E-mail","Laboratory and Genomic Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Address correspondence to this author at: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110. E-mail","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Laboratory and Genomic Medicine","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5106134852"],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":{"value":4636,"currency":"USD","value_usd":4636},"apc_paid":null,"fwci":0.4181,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.68005844,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"54","issue":"4","first_page":"765","last_page":"768"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.01899999938905239,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.01119999960064888,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prolonged-prothrombin-time","display_name":"prothrombin time prolongation","score":0.9670000076293945},{"id":"https://openalex.org/keywords/coagulation-screening","display_name":"coagulation screening","score":0.5580000281333923},{"id":"https://openalex.org/keywords/coagulation-factor-deficiency","display_name":"coagulation factor deficiency","score":0.6370000243186951},{"id":"https://openalex.org/keywords/factor-vii-deficiency","display_name":"factor VII deficiency","score":0.6449999809265137},{"id":"https://openalex.org/keywords/factor-x-deficiency","display_name":"factor X deficiency","score":0.5720000267028809},{"id":"https://openalex.org/keywords/factor-v-deficiency","display_name":"factor V deficiency","score":0.7369999885559082},{"id":"https://openalex.org/keywords/factor-ii-deficiency","display_name":"factor II deficiency","score":0.7490000128746033},{"id":"https://openalex.org/keywords/fibrinogen-deficiency","display_name":"fibrinogen deficiency","score":0.6919999718666077},{"id":"https://openalex.org/keywords/heparin-contamination","display_name":"heparin contamination","score":0.7519999742507935},{"id":"https://openalex.org/keywords/coagulation-pathway","display_name":"coagulation pathway","score":0.4399999976158142},{"id":"https://openalex.org/keywords/menorrhagia","display_name":"menorrhagia","score":0.7239999771118164},{"id":"https://openalex.org/keywords/hip-arthroplasty","display_name":"total hip arthroplasty","score":0.7049999833106995},{"id":"https://openalex.org/keywords/bleeding-risk-assessment","display_name":"bleeding risk assessment","score":0.33799999952316284},{"id":"https://openalex.org/keywords/anticoagulation","display_name":"anticoagulation","score":0.42800000309944153}],"concepts":[{"id":"https://openalex.org/C2780434524","wikidata":"https://www.wikidata.org/wiki/Q1144385","display_name":"Prothrombin time","level":2,"score":0.7036208510398865},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3809339106082916},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.34021562337875366},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.31690722703933716},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2917637825012207}],"mesh":[{"descriptor_ui":"D005168","descriptor_name":"Factor VII Deficiency","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011517","descriptor_name":"Prothrombin Time","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1373/clinchem.2007.100818","doi":"https://doi.org/10.1373/clinchem.2007.100818","is_oa":false,"landing_page_url":"https://doi.org/10.1373/clinchem.2007.100818","pdf_url":null,"source":{"id":"https://openalex.org/S139212996","display_name":"Clinical Chemistry","issn_l":"0009-9147","issn":["0009-9147","1530-8561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320272","host_organization_name":"American Association for Clinical Chemistry","host_organization_lineage":["https://openalex.org/P4310320272"],"host_organization_lineage_names":["American Association for Clinical Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry","raw_type":"journal-article"},{"id":"pmid:18375491","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18375491","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical chemistry","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W177906890","https://openalex.org/W187464087","https://openalex.org/W1979763475","https://openalex.org/W1983967234","https://openalex.org/W2010534123","https://openalex.org/W2010643709","https://openalex.org/W2036986942","https://openalex.org/W2043573822","https://openalex.org/W2090080882","https://openalex.org/W2118814044","https://openalex.org/W2400827470"],"related_works":["https://openalex.org/W7099626299","https://openalex.org/W4230823186","https://openalex.org/W2921531057","https://openalex.org/W2291421224","https://openalex.org/W2902588570","https://openalex.org/W1967926990","https://openalex.org/W4381249783","https://openalex.org/W2090080882","https://openalex.org/W2484657664","https://openalex.org/W3204486486"],"abstract_inverted_index":{"A":[0,779,846,861,1277],"47-year-old":[1],"African":[2],"American":[3],"woman":[4],"was":[5,113,547,587,688,1018,1161,1224,1239,1250],"evaluated":[6],"for":[7,67,643,1029,1363,1469],"a":[8,38,52,110,166,188,218,246,262,276,316,325,335,367,386,486,490,509,530,535,541,552,578,596,620,633,644,681,696,724,1076,1189,1290,1353,1458],"prolonged":[9,84,293,387,435,447,478,718,1077,1272,1285],"prothrombin":[10,1343,1426,1462],"time":[11,76,388],"(PT)":[12],"result":[13,108,183,451,553],"obtained":[14,1106],"before":[15],"she":[16,36,1216,1223],"underwent":[17],"right":[18],"total":[19],"hip":[20],"arthroplasty.":[21],"The":[22,440,640,693,1003,1167,1389],"patient":[23,494,645,694,1073,1168,1278],"had":[24,51],"no":[25,517,700,1218],"history":[26,55,1475],"of":[27,56,109,128,144,155,192,196,222,240,250,275,307,338,343,363,375,395,406,467,493,511,555,685,726,740,749,768,781,806,852,899,958,972,999,1015,1038,1109,1123,1134,1143,1154,1172,1188,1198,1202,1243,1352,1378,1410],"gastrointestinal":[28,1480,1502],"or":[29,33,190,194,220,248,261,264,318,425,458,513,518,534,674,737,775,818,1370,1493,1501],"intracranial":[30],"bleeding,":[31,1481,1503],"epistaxis,":[32,1478],"hemarthrosis.":[34],"However,":[35,1208],"reported":[37],"tendency":[39],"toward":[40],"easy":[41],"limb":[42],"bruising":[43],"and":[44,72,92,106,117,138,150,157,175,211,232,243,259,328,385,393,399,437,496,516,544,564,632,703,717,746,809,822,831,834,838,847,882,890,926,960,1079,1105,1132,1176,1222,1245,1254,1274,1284,1297,1346,1387,1396,1434,1439,1454,1465,1483,1507,1514],"menorrhagia,":[45,1479],"which":[46,410,1035],"required":[47],"iron":[48],"supplementation.":[49],"She":[50],"negative":[53,1295],"family":[54,1298],"abnormal":[57],"bleeding.":[58,1051,1516],"Initial":[59],"laboratory":[60],"studies":[61],"included":[62],"findings":[63,722,1083],"within":[64,502,1281],"reference":[65,80,88,98,504,616,628,1282],"intervals":[66,1283],"complete":[68],"blood":[69,313,351,1121,1220],"cell":[70],"count":[71],"activated":[73,795],"partial":[74,519],"thromboplastin":[75,585,1065,1104,1405],"(aPTT)":[77],"(30.8":[78],"s,":[79,87,551,627],"interval":[81,89,99,505,590,617,629],"23\u201336":[82],"s),":[83,91,631],"PT":[85,112,116,156,215,244,296,332,400,436,450,459,546,719,980,1078,1275,1286],"(20.3":[86],"11.0\u201315.0":[90],"International":[93],"Normalized":[94],"Ratio":[95],"(INR)":[96],"(1.78,":[97],"0.9\u20131.2).":[100],"No":[101],"preanalytical":[102,305,358,468,1267],"artifacts":[103],"were":[104,1085],"identified,":[105],"the":[107,126,153,197,223,251,273,298,361,407,412,456,471,480,503,545,569,663,747,850,870,893,908,970,997,1013,1039,1097,1114,1129,1135,1148,1155,1177,1183,1209,1236,1350,1379],"repeat":[111,455],"also":[114,236],"prolonged.":[115],"aPTT":[118,158,185,242,294,396,438,448,457,570,1273,1280],"are":[119,235,744,751,888,938,967,1265,1360,1457],"commonly":[120],"requested":[121],"screening":[122,472],"tests.":[123],"In":[124,760,969,1111,1349],"vivo,":[125],"initiation":[127],"coagulation":[129,161,254,473,658,871],"depends":[130],"on":[131,489,577,1012],"tissue":[132,287,974,1001,1016,1485,1506],"factor\u2013mediated":[133],"factor":[134,162,229,269,604,607,659,836,1017],"VII":[135],"(FVII)":[136],"activation,":[137],"sustained":[139],"thrombin":[140,622,1256],"generation":[141,274],"requires":[142,1374],"activation":[143,163,270],"factors":[145,201,207,255,1430],"XI,":[146,209],"IX,":[147,210,1432],"VIII,":[148],"X,":[149,230,257,1431],"V.":[151],"For":[152],"interpretation":[154],"results,":[159],"however,":[160],"culminating":[164,271],"in":[165,272,417,428,443,671,690,763,829,842,869,892,918,961,977,996,1044,1263,1336,1451],"fibrin":[167,277],"clot":[168,382,580],"can":[169,347,1270,1322,1417],"be":[170,348,453,735,816,1310,1418],"organized":[171],"into":[172],"intrinsic,":[173],"extrinsic,":[174],"common":[176,252,326,562,598],"pathways":[177],"(Fig.":[178,1413],"1":[179,1233],").":[180,1415],"An":[181,213,404],"isolated":[182,214,648,683],"showing":[184],"prolongation":[186,216],"suggests":[187,217,245],"deficiency":[189,219,247,510,558,612,650,733,743,785,801,854,1293],"inhibitor":[191,524,623,635,1257],"one":[193,512],"more":[195,514],"intrinsic":[198],"pathway":[199,225,253,599],"clotting":[200],"(prekallikrein,":[202],"high":[203,280,422],"molecular":[204,281],"weight":[205,282],"kininogen,":[206],"XII,":[208],"VIII).":[212],"inhibition":[221,249],"extrinsic":[224],"(FVII),":[226],"but":[227,896,990],"mild":[228,1091],"V,":[231,258],"II":[233,608,1435],"deficiencies":[234,840],"possible":[237],"causes.":[238],"Prolongation":[239],"both":[241],"(factor":[256,601],"II),":[260],"qualitative":[263],"quantitative":[265],"fibrinogen":[266,565,611],"defect.":[267],"Coagulation":[268],"clot.":[278],"HMWK,":[279],"kininogen;":[283],"PK,":[284],"prekallikrein;":[285],"TF,":[286],"factor.":[288],"When":[289,1331],"evaluating":[290,444,1067],"an":[291,445,528,556,647,803,1055,1107,1230,1397],"unexpected":[292,446],"and/or":[295,449,756,1490,1510],"result,":[297],"first":[299,1004],"step":[300,442,482],"is":[301,324,352,483,506,521,651,666,810,855,1024,1315,1334],"to":[302,312,454,463,476,484,501,527,549,950,1006,1026,1049,1128,1151,1193,1309,1324,1488],"rule":[303],"out":[304,595],"causes":[306],"inaccuracy(1).":[308],"Anticoagulant":[309],"contamination":[310],"due":[311,526,1025,1127,1192,1487],"collection":[314,364,392,430],"from":[315,354,419,707,948,1047,1437],"venous":[317],"arterial":[319],"line":[320],"flushed":[321],"with":[322,380,421,508,523,583,646,699,753,787,793,844,858,876,934,945,1069,1075,1089,1101,1113,1140,1279,1317,1402,1461],"heparin":[323],"artifact,":[327],"although":[329],"most":[330,1357],"commercial":[331,979],"reagents":[333],"contain":[334],"substance":[336],"capable":[337],"neutralizing":[339,532],"approximately":[340,993,1124,1152],"2":[341,708,1170,1414],"U/mL":[342],"heparin,":[344,1253],"this":[345,691],"capacity":[346],"overwhelmed":[349],"if":[350,1163],"collected":[353,427],"heparin-containing":[355],"catheters.":[356],"Other":[357],"variables":[359,1268],"include":[360,1340],"use":[362,1062],"tubes":[365],"containing":[366,1429],"higher":[368],"sodium":[369],"citrate":[370],"anticoagulant":[371,638],"concentration":[372,415],"(3.8%":[373],"instead":[374],"3.2%),":[376],"hemolyzed":[377],"samples":[378,418,426],"interfering":[379],"photo-optical":[381],"detection":[383,581],"methods,":[384],"lapse":[389],"between":[390,1382],"specimen":[391],"performance":[394],"(>4":[397],"hours)":[398,402],"(>24":[401],"assays.":[403],"increase":[405],"citrate:plasma":[408],"ratio,":[409],"decreases":[411],"ionized":[413],"calcium":[414],"[e.g.,":[416],"patients":[420,954,1068,1359],"hematocrit":[423],"(>55%)":[424],"underfilled":[429],"tubes]":[431],"may":[432,734,815,914,991,1288,1447],"produce":[433,679,927,1448],"erroneously":[434],"results.":[439,720,1276],"second":[441],"should":[452,1060],"assay,":[460],"taking":[461],"care":[462],"eliminate":[464],"potential":[465,1459],"sources":[466],"artifact.":[469],"If":[470],"test":[474],"continues":[475],"show":[477,985,992],"times,":[479],"third":[481],"perform":[485],"mixing":[487,542],"study":[488],"50:50":[491],"mixture":[492],"plasma":[495,1146,1157,1445],"normal":[497,712,715,1180],"pooled":[498],"plasma.":[499],"Correction":[500],"consistent":[507,522,1088],"factors,":[515],"correction":[520],"activity":[525,574,774,989,995,1099,1108,1248,1307,1399],"anticoagulant,":[529,561],"factor-specific":[531],"antibody,":[533],"nonspecific":[536,634],"lupus":[537,560,637],"anticoagulant.":[538],"We":[539],"performed":[540,576,1316,1401],"study,":[543],"corrected":[548],"14.5":[550],"suggestive":[554],"FVII":[557,573,649,686,727,729,732,742,773,784,796,800,853,872,878,928,956,988,1009,1020,1070,1081,1098,1292,1306,1329,1332,1385,1398,1411,1416,1471],"because":[559,653,1377],"pathway,":[563],"defects":[566],"usually":[567,827,939],"prolong":[568,662],"as":[571,687,1259,1261],"well.":[572],"measurement":[575],"mechanical":[579],"instrument":[582],"rabbit":[584,973],"activator":[586],"5%":[588,1080],"(reference":[589],"60%\u2013150%).":[591],"Additional":[592],"investigations":[593],"ruled":[594],"coexisting":[597],"defect":[600],"V":[602],"144%,":[603],"X":[605],"86%,":[606],"not":[609,1086],"done),":[610],"(fibrinogen,":[613],"3700":[614],"mg/L,":[615],"1800\u20134000":[618],"mg/L),":[619],"direct":[621,1255],"(thrombin":[624],"time,":[625],"18.4":[626],"16\u201322":[630],"(negative":[636],"screen).":[639],"differential":[641],"diagnosis":[642,725],"limited,":[652],"conditions":[654],"that":[655,668,770,1084,1269],"substantially":[656],"reduce":[657],"synthesis":[660],"additionally":[661],"aPTT.":[664],"It":[665],"unlikely":[667],"subtle":[669],"changes":[670],"hepatic":[672,713],"function":[673],"vitamin":[675],"K":[676],"metabolism":[677],"would":[678],"such":[680],"profound,":[682],"decrease":[684],"seen":[689],"case.":[692],"described":[695,1179],"varied":[697],"diet":[698],"alcohol":[701],"consumption,":[702],"her":[704,1090,1246],"medical":[705],"records":[706],"years":[709],"earlier":[710],"documented":[711],"function,":[714],"aPTT,":[716],"These":[721],"support":[723],"deficiency.":[728,1071,1472],"Deficiency.":[730],"Isolated":[731],"acquired":[736,741,783],"inherited.":[738],"Reports":[739],"rare,":[745],"majority":[748],"cases":[750,963],"associated":[752,786,877,933],"malignancy,":[754],"sepsis,":[755],"bone":[757],"marrow":[758],"transplantation(2).":[759],"some":[761,978,982],"cases,":[762],"vitro":[764],"evidence":[765,1242],"supports":[766],"production":[767],"autoantibodies":[769],"either":[771],"neutralize":[772],"accelerate":[776],"its":[777],"clearance.":[778],"case":[780,1373],"transient":[782],"surgery":[788,1184,1369],"has":[789,802],"been":[790,902],"successfully":[791],"treated":[792],"recombinant":[794,1063,1102,1347,1403,1440],"(rFVIIa,":[797],"NovoSeven)(2).":[798],"Congenital":[799],"estimated":[804,1119],"prevalence":[805],"1:500":[807],"000(3)":[808],"often":[811],"discovered":[812],"incidentally.":[813],"Patients":[814],"asymptomatic":[817,1048],"have":[819,901,955,1289],"spontaneous":[820,1504],"joint":[821,1482,1508],"cerebral":[823],"hemorrhages.":[824],"Bleeding":[825],"complications":[826,1365,1456],"occur":[828,891],"homozygotes":[830],"compound":[832],"heterozygotes,":[833],"unlike":[835],"VIII":[837],"IX":[839],"(found":[841],"males":[843],"hemophilia":[845],"B,":[848],"respectively),":[849],"degree":[851],"poorly":[856],"correlated":[857],"bleeding":[859,883,936,1092,1244,1299,1355,1391,1474,1486,1491,1497],"tendency.":[860],"public":[862],"database":[863],"(europium.csc.mrc.ac.uk)":[864],"lists":[865],"136":[866],"unique":[867],"mutations":[868,887,900,913,921,932,941,966,984,1304],"(F7)":[873],"gene,":[874],"along":[875],"activity,":[879,1058,1082,1386],"antigen":[880],"concentration,":[881],"severity.":[884],"Most":[885],"F7":[886,909,912,931,965,983,1302,1383],"missense":[889,940],"catalytic":[894],"domain,":[895],"various":[897],"types":[898],"identified":[903],"at":[904,1031,1361],"sites":[905],"scattered":[906],"throughout":[907],"gene.":[910],"Uncommon":[911],"cause":[915,1271,1305],"life-threatening":[916,1499],"hemorrhages":[917],"neonates.":[919],"Such":[920],"typically":[922],"prevent":[923],"protein":[924],"expression":[925],"activities":[929,946,957,1010],"<2%.":[930],"mild-to-moderate":[935],"histories":[937],"affecting":[942],"circulating":[943],"FVII,":[944],"ranging":[947,1046],"1%":[949],"50%.":[951],"Asymptomatic":[952],"FVII-deficient":[953,1358],"4%\u201361%,":[959],"these":[962],"all":[964],"missense.":[968],"presence":[971,998],"factor,":[975],"used":[976],"reagents,":[981],"only":[986,1366],"negligible":[987],"30%":[994],"human":[1000,1064,1103,1404],"factor(4).":[1002],"variant":[1005,1023],"display":[1007],"different":[1008],"depending":[1011],"source":[1014],"named":[1019],"Padua(5).":[1021],"This":[1022,1320],"glutamine":[1027],"substitution":[1028],"arginine":[1030],"position":[1032],"304":[1033],"(R304Q),":[1034],"impairs":[1036],"formation":[1037,1187],"FVIIa\u2013tissue":[1040],"factor\u2013FX":[1041],"complex(6),":[1042],"resulting":[1043],"phenotypes\u2019":[1045],"moderate":[1050],"To":[1052],"avoid":[1053],"reporting":[1054],"inaccurately":[1056],"low":[1057],"laboratories":[1059],"always":[1061],"when":[1066,1313],"Our":[1072],"presented":[1074],"entirely":[1087],"history.":[1093],"Therefore,":[1094],"we":[1095,1137],"repeated":[1096],"assay":[1100,1400],"31%.":[1110],"consultation":[1112],"patient\u2019s":[1115,1156,1210,1237,1390],"orthopedic":[1116],"surgeon,":[1117],"who":[1118],"intraoperative":[1120],"requirements":[1122],"4\u20136":[1125],"units":[1126,1142,1171,1201],"anticipated":[1130],"duration":[1131],"complexity":[1133],"surgery,":[1136],"recommended":[1138],"transfusion":[1139,1197],"5":[1141,1199],"fresh":[1144,1423],"frozen":[1145,1424,1444],"during":[1147,1492],"operation,":[1149],"equivalent":[1150],"20%":[1153],"volume.":[1158],"Recombinant":[1159],"FVIIa":[1160,1441],"available":[1162],"severe":[1164,1354],"hemorrhage":[1165],"developed.":[1166],"received":[1169,1217],"red":[1173,1203],"cells":[1174,1204],"intraoperatively,":[1175],"surgeon":[1178],"hemostasis.":[1181],"Postoperatively,":[1182],"team":[1185],"suspected":[1186],"deep":[1190],"hematoma":[1191],"persistent":[1194],"anemia":[1195],"despite":[1196,1294],"additional":[1200,1219],"over":[1205],"6":[1206],"days.":[1207],"hemoglobin":[1211],"stabilized,":[1212],"wound":[1213],"drainage":[1214],"stopped,":[1215],"components,":[1221],"discharged":[1225],"12":[1226],"days":[1227],"postsurgery.":[1228],"At":[1229],"outpatient":[1231],"visit":[1232],"month":[1234],"later,":[1235],"incision":[1238],"healed":[1240],"without":[1241],"physical":[1247],"level":[1249],"improving.":[1251],"Polycythemia,":[1252],"anticoagulants,":[1258],"well":[1260],"delays":[1262],"testing,":[1264],"important":[1266],"results":[1287,1308],"congenital":[1291],"personal":[1296],"histories.":[1300],"Some":[1301],"gene":[1303],"much":[1311],"lower":[1312],"testing":[1314],"nonhuman":[1318],"thromboplastins.":[1319],"situation":[1321],"lead":[1323],"inappropriate":[1325],"management":[1326,1376,1409],"decisions":[1327],"regarding":[1328],"replacement.":[1330],"replacement":[1333],"necessary":[1335],"deficient":[1337],"patients,":[1338,1453],"options":[1339],"fresh-frozen":[1341],"plasma,":[1342,1425,1438],"complex":[1344,1427,1463],"concentrates,":[1345],"FVIIa.":[1348],"absence":[1351],"history,":[1356,1392],"risk":[1362,1460],"hemorrhagic":[1364],"following":[1367],"major":[1368],"trauma(8).":[1371],"Each":[1372],"individual":[1375],"poor":[1380],"correlation":[1381],"mutations,":[1384],"phenotype(7).":[1388],"current":[1393],"clinical":[1394],"situation,":[1395],"must":[1406],"guide":[1407],"initial":[1408],"deficiency(8)(9)":[1412],"temporarily":[1419],"supplemented":[1420],"by":[1421],"infusing":[1422],"concentrates":[1428,1464],"VII,":[1433],"derived":[1436],"(NovoSeven\u00ae).":[1442],"Fresh":[1443],"infusion":[1446],"volume":[1449],"overload":[1450],"susceptible":[1452],"thrombotic":[1455],"NovoSeven\u00ae":[1466],"therapy.":[1467],"Algorithm":[1468],"managing":[1470],"*Mild":[1473],"includes":[1476,1498],"minor":[1477],"soft":[1484,1505],"trauma,":[1489],"after":[1494],"surgery.":[1495],"\u2020Severe":[1496],"mucosal":[1500],"bleeds,":[1509],"central":[1511],"nervous":[1512],"system":[1513],"ocular":[1515],"Grant/Funding":[1517],"Support:":[1518],"None":[1519,1523],"declared.":[1520,1524],"Financial":[1521],"Disclosures:":[1522]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}