{"id":"https://openalex.org/W2106913534","doi":"https://doi.org/10.1182/blood-2013-12-544924","title":"The formin DIAPH1 (mDia1) regulates megakaryocyte proplatelet formation by remodeling the actin and microtubule cytoskeletons","display_name":"The formin DIAPH1 (mDia1) regulates megakaryocyte proplatelet formation by remodeling the actin and microtubule cytoskeletons","publication_year":2014,"publication_date":"2014-10-09","ids":{"openalex":"https://openalex.org/W2106913534","doi":"https://doi.org/10.1182/blood-2013-12-544924","mag":"2106913534","pmid":"https://pubmed.ncbi.nlm.nih.gov/25298036"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2013-12-544924","doi":"https://doi.org/10.1182/blood-2013-12-544924","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2013-12-544924","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112897812","display_name":"Jiajia Pan","orcid":"https://orcid.org/0000-0003-3829-6671","observed_orcids":["https://orcid.org/0000-0003-3829-6671"]},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jiajia Pan","raw_affiliation_strings":["Institut Gustave Roussy, Plateforme Imagerie et Cytom\u00e9trie, Villejuif, France;","Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 1009, Institut Gustave Roussy, Villejuif, France;","Universit\u00e9 Paris-Sud, Le Kremlin-Bic\u00eatre, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Gustave Roussy, Plateforme Imagerie et Cytom\u00e9trie, Villejuif, France;","institution_ids":["https://openalex.org/I2801843802"]},{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 1009, Institut Gustave Roussy, Villejuif, France;","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2801843802"]},{"raw_affiliation_string":"Universit\u00e9 Paris-Sud, Le Kremlin-Bic\u00eatre, France;","institution_ids":["https://openalex.org/I102197404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071767949","display_name":"Larissa Lordier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Larissa Lordier","raw_affiliation_strings":["Institut Gustave Roussy, Plateforme Imagerie et Cytom\u00e9trie, Villejuif, France;","Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 1009, Institut Gustave Roussy, Villejuif, France;","Universit\u00e9 Paris-Sud, Le Kremlin-Bic\u00eatre, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Gustave Roussy, Plateforme Imagerie et Cytom\u00e9trie, Villejuif, France;","institution_ids":["https://openalex.org/I2801843802"]},{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 1009, Institut Gustave Roussy, Villejuif, France;","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2801843802"]},{"raw_affiliation_string":"Universit\u00e9 Paris-Sud, Le Kremlin-Bic\u00eatre, France;","institution_ids":["https://openalex.org/I102197404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043292171","display_name":"D\u00e9borah Meyran","orcid":"https://orcid.org/0000-0003-2723-8185","observed_orcids":["https://orcid.org/0000-0003-2723-8185"]},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Deborah Meyran","raw_affiliation_strings":["Institut Gustave Roussy, Plateforme Imagerie et Cytom\u00e9trie, Villejuif, France;","Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 1009, Institut Gustave Roussy, Villejuif, France;","Universit\u00e9 Paris-Sud, Le Kremlin-Bic\u00eatre, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Gustave Roussy, Plateforme Imagerie et Cytom\u00e9trie, Villejuif, France;","institution_ids":["https://openalex.org/I2801843802"]},{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 1009, Institut Gustave Roussy, Villejuif, France;","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2801843802"]},{"raw_affiliation_string":"Universit\u00e9 Paris-Sud, Le Kremlin-Bic\u00eatre, France;","institution_ids":["https://openalex.org/I102197404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061634572","display_name":"Philippe Rameau","orcid":"https://orcid.org/0000-0001-6060-0049","observed_orcids":["https://orcid.org/0000-0001-6060-0049"]},"institutions":[{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Philippe Rameau","raw_affiliation_strings":["Institut Gustave Roussy, Plateforme Imagerie et Cytom\u00e9trie, Villejuif, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Gustave Roussy, Plateforme Imagerie et Cytom\u00e9trie, Villejuif, France;","institution_ids":["https://openalex.org/I2801843802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082404845","display_name":"Yann L\u00e9cluse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Yann Lecluse","raw_affiliation_strings":["Institut Gustave Roussy, Plateforme Imagerie et Cytom\u00e9trie, Villejuif, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Gustave Roussy, Plateforme Imagerie et Cytom\u00e9trie, Villejuif, France;","institution_ids":["https://openalex.org/I2801843802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065580138","display_name":"Susan M. Kitchen-Goosen","orcid":"https://orcid.org/0000-0001-9291-056X","observed_orcids":["https://orcid.org/0000-0001-9291-056X"]},"institutions":[{"id":"https://openalex.org/I1317189400","display_name":"Van Andel Institute","ror":"https://ror.org/00wm07d60","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1317189400"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan Kitchen-Goosen","raw_affiliation_strings":["Laboratory of Cell Structure and Signal Integration, Van Andel Research Institute, Grand Rapids, MI; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cell Structure and Signal Integration, Van Andel Research Institute, Grand Rapids, MI; and","institution_ids":["https://openalex.org/I1317189400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034050398","display_name":"Idinath Badirou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Idinath Badirou","raw_affiliation_strings":["Institut Gustave Roussy, Plateforme Imagerie et Cytom\u00e9trie, Villejuif, France;","Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 1009, Institut Gustave Roussy, Villejuif, France;","Universit\u00e9 Paris-Sud, Le Kremlin-Bic\u00eatre, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Gustave Roussy, Plateforme Imagerie et Cytom\u00e9trie, Villejuif, France;","institution_ids":["https://openalex.org/I2801843802"]},{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 1009, Institut Gustave Roussy, Villejuif, France;","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2801843802"]},{"raw_affiliation_string":"Universit\u00e9 Paris-Sud, Le Kremlin-Bic\u00eatre, France;","institution_ids":["https://openalex.org/I102197404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012832340","display_name":"Hayat Mokrani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Hayat Mokrani","raw_affiliation_strings":["Institut Gustave Roussy, Plateforme Imagerie et Cytom\u00e9trie, Villejuif, France;","Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 1009, Institut Gustave Roussy, Villejuif, France;","Universit\u00e9 Paris-Sud, Le Kremlin-Bic\u00eatre, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Gustave Roussy, Plateforme Imagerie et Cytom\u00e9trie, Villejuif, France;","institution_ids":["https://openalex.org/I2801843802"]},{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 1009, Institut Gustave Roussy, Villejuif, France;","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2801843802"]},{"raw_affiliation_string":"Universit\u00e9 Paris-Sud, Le Kremlin-Bic\u00eatre, France;","institution_ids":["https://openalex.org/I102197404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024624058","display_name":"Shuh Narumiya","orcid":"https://orcid.org/0000-0001-8062-6529","observed_orcids":["https://orcid.org/0000-0001-8062-6529"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shuh Narumiya","raw_affiliation_strings":["Department of Pharmacology, Kyoto University, Faculty of Medicine, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Kyoto University, Faculty of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023869395","display_name":"Arthur S. Alberts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1317189400","display_name":"Van Andel Institute","ror":"https://ror.org/00wm07d60","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1317189400"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arthur S. Alberts","raw_affiliation_strings":["Laboratory of Cell Structure and Signal Integration, Van Andel Research Institute, Grand Rapids, MI; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cell Structure and Signal Integration, Van Andel Research Institute, Grand Rapids, MI; and","institution_ids":["https://openalex.org/I1317189400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081008172","display_name":"William Vainchenker","orcid":"https://orcid.org/0000-0003-4705-202X","observed_orcids":["https://orcid.org/0000-0003-4705-202X"]},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"William Vainchenker","raw_affiliation_strings":["Institut Gustave Roussy, Plateforme Imagerie et Cytom\u00e9trie, Villejuif, France;","Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 1009, Institut Gustave Roussy, Villejuif, France;","Universit\u00e9 Paris-Sud, Le Kremlin-Bic\u00eatre, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Gustave Roussy, Plateforme Imagerie et Cytom\u00e9trie, Villejuif, France;","institution_ids":["https://openalex.org/I2801843802"]},{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 1009, Institut Gustave Roussy, Villejuif, France;","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2801843802"]},{"raw_affiliation_string":"Universit\u00e9 Paris-Sud, Le Kremlin-Bic\u00eatre, France;","institution_ids":["https://openalex.org/I102197404"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060108689","display_name":"Yunhua Chang","orcid":"https://orcid.org/0000-0001-8890-9726","observed_orcids":["https://orcid.org/0000-0001-8890-9726","https://orcid.org/0000-0001-7160-6569"]},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Yunhua Chang","raw_affiliation_strings":["Institut Gustave Roussy, Plateforme Imagerie et Cytom\u00e9trie, Villejuif, France;","Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 1009, Institut Gustave Roussy, Villejuif, France;","Universit\u00e9 Paris-Sud, Le Kremlin-Bic\u00eatre, France;"],"raw_orcid":"https://orcid.org/0000-0001-7160-6569","affiliations":[{"raw_affiliation_string":"Institut Gustave Roussy, Plateforme Imagerie et Cytom\u00e9trie, Villejuif, France;","institution_ids":["https://openalex.org/I2801843802"]},{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 1009, Institut Gustave Roussy, Villejuif, France;","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2801843802"]},{"raw_affiliation_string":"Universit\u00e9 Paris-Sud, Le Kremlin-Bic\u00eatre, France;","institution_ids":["https://openalex.org/I102197404"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":4.6669,"has_fulltext":false,"cited_by_count":80,"citation_normalized_percentile":{"value":0.95480667,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"124","issue":"26","first_page":"3967","last_page":"3977"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diaph1","display_name":"DIAPH1","score":0.9670000076293945},{"id":"https://openalex.org/keywords/mdia1","display_name":"mDia1","score":0.9779999852180481},{"id":"https://openalex.org/keywords/megakaryocytes","display_name":"megakaryocytes","score":0.8569999933242798},{"id":"https://openalex.org/keywords/proplatelet-formation","display_name":"proplatelet formation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.9150000214576721},{"id":"https://openalex.org/keywords/microtubule-dynamics","display_name":"microtubule dynamics","score":0.8889999985694885},{"id":"https://openalex.org/keywords/rho-gtpase-signaling","display_name":"Rho GTPase signaling","score":0.8970000147819519},{"id":"https://openalex.org/keywords/rho-kinase","display_name":"Rho kinase","score":0.7739999890327454},{"id":"https://openalex.org/keywords/myosin-ii","display_name":"myosin II","score":0.9950000047683716},{"id":"https://openalex.org/keywords/stress-fibers","display_name":"stress fibers","score":0.7670000195503235},{"id":"https://openalex.org/keywords/megakaryopoiesis","display_name":"megakaryopoiesis","score":0.7049999833106995},{"id":"https://openalex.org/keywords/cytoskeletal-remodeling","display_name":"cytoskeletal remodeling","score":0.7200000286102295}],"concepts":[{"id":"https://openalex.org/C53195969","wikidata":"https://www.wikidata.org/wiki/Q5470213","display_name":"Formins","level":5,"score":0.8336225152015686},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.6432012319564819},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.638228178024292},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.6299026608467102},{"id":"https://openalex.org/C2779705218","wikidata":"https://www.wikidata.org/wiki/Q821701","display_name":"Megakaryocyte","level":4,"score":0.5690286755561829},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48665839433670044},{"id":"https://openalex.org/C3620293","wikidata":"https://www.wikidata.org/wiki/Q14908027","display_name":"Actin remodeling","level":5,"score":0.4708245098590851},{"id":"https://openalex.org/C59999672","wikidata":"https://www.wikidata.org/wiki/Q21497084","display_name":"MDia1","level":5,"score":0.4681040942668915},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.4596753418445587},{"id":"https://openalex.org/C2993400109","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Actin cytoskeleton","level":4,"score":0.41392916440963745},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2804673910140991},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14181816577911377},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.13548722863197327},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.0730365514755249},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000080865","descriptor_name":"Formins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008533","descriptor_name":"Megakaryocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013926","descriptor_name":"Thrombopoietin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016086","descriptor_name":"Lentivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018952","descriptor_name":"Antigens, CD34","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020558","descriptor_name":"GTP Phosphohydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024462","descriptor_name":"Myosin Type II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood-2013-12-544924","doi":"https://doi.org/10.1182/blood-2013-12-544924","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2013-12-544924","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:25298036","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25298036","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.849.7430","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.849.7430","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.bloodjournal.org/content/bloodjournal/124/26/3967.full.pdf?sso-checked%3Dtrue","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W34270861","https://openalex.org/W1489785912","https://openalex.org/W1508311780","https://openalex.org/W1523601423","https://openalex.org/W1527650585","https://openalex.org/W1838062783","https://openalex.org/W1897742525","https://openalex.org/W1950490249","https://openalex.org/W1965271672","https://openalex.org/W1969318465","https://openalex.org/W1975287998","https://openalex.org/W1978402743","https://openalex.org/W1984374880","https://openalex.org/W1986667319","https://openalex.org/W1990356394","https://openalex.org/W1990630282","https://openalex.org/W1990974808","https://openalex.org/W2009996200","https://openalex.org/W2011343310","https://openalex.org/W2012587910","https://openalex.org/W2022948593","https://openalex.org/W2029042183","https://openalex.org/W2030222262","https://openalex.org/W2030598357","https://openalex.org/W2034352781","https://openalex.org/W2040611486","https://openalex.org/W2043017862","https://openalex.org/W2044571671","https://openalex.org/W2050998289","https://openalex.org/W2053655134","https://openalex.org/W2058180077","https://openalex.org/W2060296307","https://openalex.org/W2062852486","https://openalex.org/W2077498847","https://openalex.org/W2079337167","https://openalex.org/W2082084638","https://openalex.org/W2082851874","https://openalex.org/W2083436950","https://openalex.org/W2088071645","https://openalex.org/W2093723806","https://openalex.org/W2095106591","https://openalex.org/W2095404261","https://openalex.org/W2096243643","https://openalex.org/W2102640342","https://openalex.org/W2107789427","https://openalex.org/W2111395938","https://openalex.org/W2122257200","https://openalex.org/W2127735672","https://openalex.org/W2133788606","https://openalex.org/W2137240240","https://openalex.org/W2142663972","https://openalex.org/W2152462023","https://openalex.org/W2155766871","https://openalex.org/W2161007761"],"related_works":["https://openalex.org/W7099713659","https://openalex.org/W4256354554","https://openalex.org/W2597355035","https://openalex.org/W7096676401","https://openalex.org/W7147189725","https://openalex.org/W181967100","https://openalex.org/W2040926299","https://openalex.org/W1992510208","https://openalex.org/W2102791712","https://openalex.org/W2809193267"],"abstract_inverted_index":{"Megakaryocytes":[0],"are":[1,100],"highly":[2],"specialized":[3],"precursor":[4],"cells":[5],"that":[6,30,39,65,87],"produce":[7],"platelets":[8],"via":[9,79],"cytoplasmic":[10],"extensions":[11],"called":[12],"proplatelets.":[13],"Proplatelet":[14],"formation":[15],"(PPF)":[16],"requires":[17],"profound":[18],"changes":[19],"in":[20,104,111],"microtubule":[21,60,115],"and":[22,59,70,97,117],"actin":[23,58],"organization.":[24],"In":[25],"this":[26],"work,":[27],"we":[28,63],"demonstrated":[29],"DIAPH1":[31,69],"(mDia1),":[32],"a":[33],"mammalian":[34],"homolog":[35],"of":[36,44,56,67,81,91,114],"Drosophila":[37],"diaphanous":[38],"works":[40],"as":[41],"an":[42],"effector":[43],"the":[45,54,57,71,92,112],"small":[46],"GTPase":[47,94],"Rho,":[48],"negatively":[49],"regulates":[50],"PPF":[51,78],"by":[52],"controlling":[53],"dynamics":[55,118],"cytoskeletons.":[61,83],"Moreover,":[62],"showed":[64],"inhibition":[66],"both":[68,82],"Rho-associated":[72],"protein":[73],"kinase":[74],"(Rock)/myosin":[75],"pathway":[76,95],"increased":[77],"coordination":[80],"We":[84],"provide":[85],"evidence":[86],"2":[88],"major":[89],"effectors":[90],"Rho":[93],"(DIAPH1":[96],"Rock/myosin":[98],"II)":[99],"involved":[101],"not":[102],"only":[103],"Rho-mediated":[105],"stress":[106],"fibers":[107],"assembly,":[108],"but":[109],"also":[110],"regulation":[113],"stability":[116],"during":[119],"PPF.":[120]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}