{"id":"https://openalex.org/W2106911287","doi":"https://doi.org/10.1196/annals.1347.003","title":"Depression, the Perimenopause, and Estrogen Therapy","display_name":"Depression, the Perimenopause, and Estrogen Therapy","publication_year":2005,"publication_date":"2005-06-01","ids":{"openalex":"https://openalex.org/W2106911287","doi":"https://doi.org/10.1196/annals.1347.003","mag":"2106911287","pmid":"https://pubmed.ncbi.nlm.nih.gov/16024748"},"language":"en","primary_location":{"id":"doi:10.1196/annals.1347.003","doi":"https://doi.org/10.1196/annals.1347.003","is_oa":false,"landing_page_url":"https://doi.org/10.1196/annals.1347.003","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049359413","display_name":"Peter J. Schmidt","orcid":"https://orcid.org/0000-0002-6565-0181","observed_orcids":["https://orcid.org/0000-0002-6565-0181"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"PETER J. SCHMIDT","raw_affiliation_strings":["Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bldg. 10-CRC, Rm. 6-5340, 10 Center Dr., MSC 1276, Bethesda, MD 20892-1276, USA. peterschmidt@mail.nih.gov","Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bldg. 10-CRC, Rm. 6-5340, 10 Center Dr., MSC 1276, Bethesda, MD 20892-1276, USA. peterschmidt@mail.nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"]},{"raw_affiliation_string":"Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5049359413"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"],"apc_list":{"value":5080,"currency":"USD","value_usd":5080},"apc_paid":null,"fwci":0.5176,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.52716049,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"1052","issue":"1","first_page":"27","last_page":"40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10459","display_name":"Sexual function and dysfunction studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.781000018119812},{"id":"https://openalex.org/keywords/perimenopause","display_name":"perimenopause","score":0.9990000128746033},{"id":"https://openalex.org/keywords/estrogen-therapy","display_name":"estrogen therapy","score":0.8960000276565552},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.8690000176429749},{"id":"https://openalex.org/keywords/menopause","display_name":"menopause","score":0.7870000004768372},{"id":"https://openalex.org/keywords/gonadotropins","display_name":"gonadotropins","score":0.7919999957084656},{"id":"https://openalex.org/keywords/follicle-stimulating-hormone","display_name":"follicle-stimulating hormone","score":0.9940000176429749},{"id":"https://openalex.org/keywords/ovarian-function","display_name":"ovarian function","score":0.8399999737739563},{"id":"https://openalex.org/keywords/antidepressant-efficacy","display_name":"antidepressant efficacy","score":0.6159999966621399},{"id":"https://openalex.org/keywords/reproductive-events","display_name":"reproductive events","score":0.6159999966621399},{"id":"https://openalex.org/keywords/women-s-mental-health","display_name":"women's mental health","score":0.7770000100135803}],"concepts":[{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.7165513038635254},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.6686815023422241},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5939881205558777},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5647662281990051},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5291137099266052},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4612821936607361},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.42268872261047363},{"id":"https://openalex.org/C2777395788","wikidata":"https://www.wikidata.org/wiki/Q647630","display_name":"Premature ovarian failure","level":2,"score":0.4150194823741913},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3530743718147278},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.34362369775772095},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015914","descriptor_name":"Estrogen Replacement Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047648","descriptor_name":"Perimenopause","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1196/annals.1347.003","doi":"https://doi.org/10.1196/annals.1347.003","is_oa":false,"landing_page_url":"https://doi.org/10.1196/annals.1347.003","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:16024748","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16024748","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":98,"referenced_works":["https://openalex.org/W3240440","https://openalex.org/W12622730","https://openalex.org/W33803201","https://openalex.org/W91600810","https://openalex.org/W100295546","https://openalex.org/W1509868652","https://openalex.org/W1581536415","https://openalex.org/W1593555368","https://openalex.org/W1687311161","https://openalex.org/W1761997414","https://openalex.org/W1922363637","https://openalex.org/W1950744654","https://openalex.org/W1969680120","https://openalex.org/W1969852349","https://openalex.org/W1971723070","https://openalex.org/W1972523301","https://openalex.org/W1972737331","https://openalex.org/W1973125755","https://openalex.org/W1979680135","https://openalex.org/W1979870292","https://openalex.org/W1980679596","https://openalex.org/W1985033275","https://openalex.org/W1985501998","https://openalex.org/W1988369035","https://openalex.org/W1992284534","https://openalex.org/W1993050841","https://openalex.org/W1993239654","https://openalex.org/W1996300933","https://openalex.org/W2002741313","https://openalex.org/W2003838450","https://openalex.org/W2004641165","https://openalex.org/W2005571121","https://openalex.org/W2010269783","https://openalex.org/W2011620025","https://openalex.org/W2012571604","https://openalex.org/W2013409806","https://openalex.org/W2016961635","https://openalex.org/W2021451131","https://openalex.org/W2022361277","https://openalex.org/W2024239675","https://openalex.org/W2026135720","https://openalex.org/W2031812230","https://openalex.org/W2031917138","https://openalex.org/W2034416729","https://openalex.org/W2034891565","https://openalex.org/W2034993146","https://openalex.org/W2036474396","https://openalex.org/W2036891077","https://openalex.org/W2039045651","https://openalex.org/W2044870186","https://openalex.org/W2044965575","https://openalex.org/W2047150120","https://openalex.org/W2047934167","https://openalex.org/W2048183366","https://openalex.org/W2048595403","https://openalex.org/W2048804437","https://openalex.org/W2053467054","https://openalex.org/W2057775869","https://openalex.org/W2058389392","https://openalex.org/W2059865238","https://openalex.org/W2062586571","https://openalex.org/W2071392303","https://openalex.org/W2071716550","https://openalex.org/W2078607970","https://openalex.org/W2079637016","https://openalex.org/W2083183508","https://openalex.org/W2087955490","https://openalex.org/W2092726363","https://openalex.org/W2099346933","https://openalex.org/W2099782016","https://openalex.org/W2111811285","https://openalex.org/W2112338121","https://openalex.org/W2118436200","https://openalex.org/W2123035989","https://openalex.org/W2126962932","https://openalex.org/W2127363947","https://openalex.org/W2131830842","https://openalex.org/W2134358770","https://openalex.org/W2134817776","https://openalex.org/W2142604492","https://openalex.org/W2149487349","https://openalex.org/W2149747644","https://openalex.org/W2151041365","https://openalex.org/W2151553159","https://openalex.org/W2155750205","https://openalex.org/W2159061031","https://openalex.org/W2163076876","https://openalex.org/W2164150248","https://openalex.org/W2165399071","https://openalex.org/W2168408572","https://openalex.org/W2169615651","https://openalex.org/W2304591280","https://openalex.org/W2317060418","https://openalex.org/W2472195961","https://openalex.org/W4240757079","https://openalex.org/W4285719527","https://openalex.org/W4295836678","https://openalex.org/W4300921406"],"related_works":["https://openalex.org/W2083857481","https://openalex.org/W4234662353","https://openalex.org/W2029224686","https://openalex.org/W1992713777","https://openalex.org/W190583300","https://openalex.org/W4298089367","https://openalex.org/W4409812390","https://openalex.org/W2089227492","https://openalex.org/W4288902457","https://openalex.org/W3200700457"],"abstract_inverted_index":{"The":[0,22],"focus":[1],"of":[2,11,19,27,93,128,142,156],"this":[3],"chapter":[4],"is":[5,24,72,151],"the":[6,9,16,20,52,76,83,91,107,126,136,157],"relationship":[7],"between":[8],"onset":[10,127],"depression":[12,150],"in":[13,30,35,61,78,90,116,125,144,160,165],"women":[14,37,101,162],"and":[15,67,175],"reproductive":[17,31,120],"events":[18,121],"perimenopause.":[21],"perimenopause":[23,84],"a":[25,86,123,153],"time":[26],"considerable":[28],"variability":[29,77],"function,":[32],"which":[33],"appears":[34],"some":[36,117,161],"to":[38,45,178],"be":[39],"associated":[40],"with":[41,55,63],"an":[42],"increased":[43],"susceptibility":[44],"depression.":[46,94,129,180],"Elevated":[47],"gonadotropin":[48],"levels":[49,59],"occur":[50],"during":[51,82,106],"late":[53],"perimenopause,":[54],"plasma":[56],"follicle-stimulating":[57],"hormone":[58,80],"increasing":[60],"association":[62],"impaired":[64],"ovarian":[65,79,166],"function":[66,174],"decreased":[68],"estradiol":[69,143],"secretion.":[70],"It":[71],"unclear,":[73],"however,":[74],"whether":[75],"secretion":[81],"has":[85],"substantial":[87],"causal":[88],"role":[89,124],"development":[92],"Epidemiologic":[95],"studies":[96,113],"have":[97,134],"documented":[98,135],"that":[99,115],"most":[100],"do":[102],"not":[103,152],"become":[104],"depressed":[105,145],"menopausal":[108,158],"transition.":[109],"However,":[110],"recent":[111],"longitudinal":[112],"suggest":[114],"women,":[118],"perimenopause-related":[119],"play":[122],"Additionally,":[130],"randomized":[131],"controlled":[132],"trials":[133],"short-term":[137],"(3-6":[138],"weeks)":[139],"antidepressant":[140],"efficacy":[141],"perimenopausal":[146],"women.":[147],"Thus,":[148],"although":[149],"uniform":[154],"accompaniment":[155],"transition,":[159],"age-related":[163],"changes":[164],"estrogen":[167],"production":[168],"may":[169],"alter":[170],"central":[171],"nervous":[172],"system":[173],"predispose":[176],"them":[177],"develop":[179]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}