{"id":"https://openalex.org/W2106900546","doi":"https://doi.org/10.1126/scitranslmed.3000350","title":"Gene Therapy for Dopamine Replacement in Parkinson\u00b4s Disease","display_name":"Gene Therapy for Dopamine Replacement in Parkinson\u00b4s Disease","publication_year":2009,"publication_date":"2009-10-14","ids":{"openalex":"https://openalex.org/W2106900546","doi":"https://doi.org/10.1126/scitranslmed.3000350","mag":"2106900546","pmid":"https://pubmed.ncbi.nlm.nih.gov/20368161"},"language":"en","primary_location":{"id":"doi:10.1126/scitranslmed.3000350","doi":"https://doi.org/10.1126/scitranslmed.3000350","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scitranslmed.3000350","pdf_url":null,"source":{"id":"https://openalex.org/S24207032","display_name":"Science Translational Medicine","issn_l":"1946-6234","issn":["1946-6234","1946-6242"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Translational Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047762447","display_name":"Anders Bj\u00f6rklund","orcid":"https://orcid.org/0000-0002-5676-6203","observed_orcids":["https://orcid.org/0000-0002-5676-6203"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Anders Bj\u00f6rklund","raw_affiliation_strings":["Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031631254","display_name":"Tomas Bj\u00f6rklund","orcid":"https://orcid.org/0000-0001-7968-0034","observed_orcids":["https://orcid.org/0000-0001-7968-0034"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Tomas Bj\u00f6rklund","raw_affiliation_strings":["Brain Repair and Imaging in Neural Systems (B.R.A.I.N.S), Department of Experimental Medical Science, Lund University, Lund, Sweden","Molecular Neuromodulation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Repair and Imaging in Neural Systems (B.R.A.I.N.S), Department of Experimental Medical Science, Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"Molecular Neuromodulation","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083016310","display_name":"Deniz Kirik","orcid":"https://orcid.org/0000-0002-1360-1265","observed_orcids":["https://orcid.org/0000-0002-1360-1265"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Deniz Kirik","raw_affiliation_strings":["Brain Repair and Imaging in Neural Systems (B.R.A.I.N.S), Department of Experimental Medical Science, Lund University, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Repair and Imaging in Neural Systems (B.R.A.I.N.S), Department of Experimental Medical Science, Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5047762447"],"corresponding_institution_ids":["https://openalex.org/I187531555"],"apc_list":null,"apc_paid":null,"fwci":4.5764,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.94712727,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"1","issue":"2","first_page":"2ps2","last_page":"2ps2"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9286999702453613,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9286999702453613,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.02419999986886978,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.8899999856948853},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.9950000047683716},{"id":"https://openalex.org/keywords/dopamine-replacement-therapy","display_name":"dopamine replacement therapy","score":0.8379999995231628},{"id":"https://openalex.org/keywords/l-dopa","display_name":"L-DOPA","score":0.9169999957084656},{"id":"https://openalex.org/keywords/dyskinesia","display_name":"dyskinesia","score":0.8560000061988831},{"id":"https://openalex.org/keywords/viral-vectors","display_name":"viral vectors","score":0.5440000295639038},{"id":"https://openalex.org/keywords/nonhuman-primate-model","display_name":"nonhuman primate model","score":0.8629999756813049},{"id":"https://openalex.org/keywords/enzyme-replacement-therapy","display_name":"enzyme replacement therapy","score":0.7559999823570251}],"concepts":[{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.7282629609107971},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.6978299617767334},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.5875888466835022},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5420644283294678},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4745555520057678},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4324551820755005},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4154411554336548},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.39036327600479126},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31508713960647583},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30834317207336426},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29946136474609375}],"mesh":[{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1126/scitranslmed.3000350","doi":"https://doi.org/10.1126/scitranslmed.3000350","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scitranslmed.3000350","pdf_url":null,"source":{"id":"https://openalex.org/S24207032","display_name":"Science Translational Medicine","issn_l":"1946-6234","issn":["1946-6234","1946-6242"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Translational Medicine","raw_type":"journal-article"},{"id":"pmid:20368161","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20368161","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science translational medicine","raw_type":"Journal Article"},{"id":"pmh:oai:lup.lub.lu.se:56c94388-dc90-4bab-944b-60887490136c","doi":null,"is_oa":false,"landing_page_url":"https://lup.lub.lu.se/record/1595589","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1946-6242","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1501801825","https://openalex.org/W1976143917","https://openalex.org/W1977376243","https://openalex.org/W1996813582","https://openalex.org/W2005498987","https://openalex.org/W2008119031","https://openalex.org/W2010206955","https://openalex.org/W2010723753","https://openalex.org/W2011252438","https://openalex.org/W2012111175","https://openalex.org/W2012770364","https://openalex.org/W2031906846","https://openalex.org/W2033699870","https://openalex.org/W2046510951","https://openalex.org/W2056911327","https://openalex.org/W2059378567","https://openalex.org/W2062206617","https://openalex.org/W2067920593","https://openalex.org/W2077332064","https://openalex.org/W2085518524","https://openalex.org/W2095401453","https://openalex.org/W2097863680","https://openalex.org/W2098220259","https://openalex.org/W2100097103","https://openalex.org/W2105784332","https://openalex.org/W2111837903","https://openalex.org/W2130275119","https://openalex.org/W2141311399","https://openalex.org/W2143506799","https://openalex.org/W2151497983","https://openalex.org/W2154345556","https://openalex.org/W2155284188","https://openalex.org/W2177094286","https://openalex.org/W2337142316"],"related_works":["https://openalex.org/W2170410956","https://openalex.org/W2151497983","https://openalex.org/W1868679149","https://openalex.org/W2772141956","https://openalex.org/W2490932303","https://openalex.org/W1760512867","https://openalex.org/W2047516655","https://openalex.org/W2954663760","https://openalex.org/W2575566424","https://openalex.org/W3189118405"],"abstract_inverted_index":{"The":[0],"introduction":[1],"of":[2,15,27,37,70,87,100,108],"L-dopa":[3,29],"(L-3,4-dihydroxyphenylalanine)":[4],"therapy":[5,55],"40":[6],"years":[7],"ago":[8],"was":[9],"a":[10,79,85,96],"revolution":[11],"in":[12,33,50,62,95],"the":[13,25,35,63,74,103],"treatment":[14],"patients":[16],"with":[17],"Parkinson":[18],"s":[19],"disease":[20],"(PD).":[21],"With":[22],"time,":[23],"however,":[24],"shortcomings":[26],"oral":[28],"medication":[30],"became":[31],"apparent,":[32],"particular":[34],"appearance":[36],"troublesome":[38],"side":[39],"effects,":[40],"expressed":[41],"as":[42],"involuntary":[43],"movements":[44],"(dyskinesias)":[45],"that":[46,72],"developed":[47],"over":[48],"time":[49],"many":[51],"patients.":[52],"A":[53],"gene":[54],"approach,":[56],"aimed":[57],"at":[58],"restoring":[59],"dopamine":[60],"synthesis":[61],"affected":[64],"brain":[65],"by":[66],"viral":[67],"vector":[68],"delivery":[69],"genes":[71],"encode":[73],"dopamine-synthesizing":[75],"enzymes,":[76],"may":[77],"offer":[78],"solution":[80],"to":[81],"this":[82,109],"problem.":[83],"Now,":[84],"team":[86],"French":[88],"and":[89],"UK":[90],"researchers":[91],"reports":[92],"promising":[93],"results":[94],"nonhuman":[97],"primate":[98],"model":[99],"PD,":[101],"paving":[102],"way":[104],"for":[105],"clinical":[106],"trials":[107],"enzyme-replacement":[110],"approach.":[111]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}