{"id":"https://openalex.org/W2106893379","doi":null,"title":"(123)I-Labeled chitinase as specific radioligand for in vivo detection of fungal infections in mice.","display_name":"(123)I-Labeled chitinase as specific radioligand for in vivo detection of fungal infections in mice.","publication_year":2004,"publication_date":"2004-07-01","ids":{"openalex":"https://openalex.org/W2106893379","mag":"2106893379","pmid":"https://pubmed.ncbi.nlm.nih.gov/15235068"},"language":"en","primary_location":{"id":"pmid:15235068","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15235068","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025760331","display_name":"R Siaens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Rien Siaens","raw_affiliation_strings":["Laboratory of Radiopharmacy, Gent University, Gent, Belgium. Rien.Siaens@ugent.be"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Radiopharmacy, Gent University, Gent, Belgium. Rien.Siaens@ugent.be","institution_ids":["https://openalex.org/I32597200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052089482","display_name":"Vincent G. H. Eijsink","orcid":"https://orcid.org/0000-0002-9220-8743","observed_orcids":["https://orcid.org/0000-0002-9220-8743"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vincent G H Eijsink","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019778216","display_name":"Rudi Dierckx","orcid":"https://orcid.org/0000-0003-4971-2909","observed_orcids":["https://orcid.org/0000-0003-4971-2909"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rudi Dierckx","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109951288","display_name":"Guido Slegers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guido Slegers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2347,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.58207458,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"45","issue":"7","first_page":"1209","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12683","display_name":"Studies on Chitinases and Chitosanases","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chitinase-b","display_name":"chitinase B","score":0.8009999990463257},{"id":"https://openalex.org/keywords/serratia-marcescens","display_name":"Serratia marcescens","score":0.9769999980926514},{"id":"https://openalex.org/keywords/radioligands","display_name":"radioligands","score":0.7080000042915344},{"id":"https://openalex.org/keywords/radiopharmaceuticals","display_name":"radiopharmaceuticals","score":0.7680000066757202},{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":0.7950000166893005},{"id":"https://openalex.org/keywords/aspergillus-fumigatus","display_name":"Aspergillus fumigatus","score":1.0},{"id":"https://openalex.org/keywords/radionuclide-imaging","display_name":"scintigraphy","score":0.8100000023841858},{"id":"https://openalex.org/keywords/radiolabeling","display_name":"radiolabeling","score":0.45100000500679016},{"id":"https://openalex.org/keywords/target-to-nontarget-ratio","display_name":"target-to-nontarget ratio","score":0.7699999809265137},{"id":"https://openalex.org/keywords/invasive-fungal-infections","display_name":"invasive fungal infections","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7452468872070312},{"id":"https://openalex.org/C2779787849","wikidata":"https://www.wikidata.org/wiki/Q134359","display_name":"Aspergillus fumigatus","level":2,"score":0.7124760150909424},{"id":"https://openalex.org/C2780778831","wikidata":"https://www.wikidata.org/wiki/Q424099","display_name":"Chitinase","level":3,"score":0.7077955603599548},{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.7072129845619202},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.662426769733429},{"id":"https://openalex.org/C2776309202","wikidata":"https://www.wikidata.org/wiki/Q140004","display_name":"Serratia marcescens","level":4,"score":0.643596887588501},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47626373171806335},{"id":"https://openalex.org/C2781088250","wikidata":"https://www.wikidata.org/wiki/Q161219","display_name":"Chitin","level":3,"score":0.46936872601509094},{"id":"https://openalex.org/C179247698","wikidata":"https://www.wikidata.org/wiki/Q382799","display_name":"Affinity chromatography","level":3,"score":0.46677154302597046},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.42728492617607117},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.41709643602371216},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33726024627685547},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.3321557641029358},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.32177793979644775},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.242315411567688},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2053704559803009},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001228","descriptor_name":"Aspergillosis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001228","descriptor_name":"Aspergillosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001232","descriptor_name":"Aspergillus fumigatus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002177","descriptor_name":"Candidiasis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D002177","descriptor_name":"Candidiasis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002688","descriptor_name":"Chitinases","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004927","descriptor_name":"Escherichia coli Infections","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D004927","descriptor_name":"Escherichia coli Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007457","descriptor_name":"Iodine Radioisotopes","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009181","descriptor_name":"Mycoses","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009181","descriptor_name":"Mycoses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009220","descriptor_name":"Myositis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009220","descriptor_name":"Myositis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011877","descriptor_name":"Radionuclide Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:15235068","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15235068","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Comparative Study"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.541.6777","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.541.6777","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jnm.snmjournals.org/content/45/7/1209.full.pdf","raw_type":"text"},{"id":"mag:2106893379","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15235068","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W39725525","https://openalex.org/W78285312","https://openalex.org/W81250543","https://openalex.org/W97140654","https://openalex.org/W340502647","https://openalex.org/W586898115","https://openalex.org/W1915036617","https://openalex.org/W1980604941","https://openalex.org/W1990121552","https://openalex.org/W2003176514","https://openalex.org/W2014936174","https://openalex.org/W2040531770","https://openalex.org/W2087082796","https://openalex.org/W2090727689","https://openalex.org/W2098303032","https://openalex.org/W2117186149","https://openalex.org/W2128230458","https://openalex.org/W2133841550","https://openalex.org/W2151939702","https://openalex.org/W2155082155","https://openalex.org/W2166712052","https://openalex.org/W2192683131","https://openalex.org/W2279162372","https://openalex.org/W2291193920","https://openalex.org/W2410494606"],"related_works":["https://openalex.org/W2323792000","https://openalex.org/W2026218983","https://openalex.org/W2023565778","https://openalex.org/W3153363915","https://openalex.org/W3042334210","https://openalex.org/W2563269065","https://openalex.org/W2165517499","https://openalex.org/W2089991499","https://openalex.org/W4247460527","https://openalex.org/W7204438787"],"abstract_inverted_index":{"UNLABELLED:":[0],"Given":[1],"the":[2,11,32,105,164,217,317],"scarcity":[3],"of":[4,13,24,51,80,104,137,148,163,172,216,231],"diagnostic":[5],"tools":[6],"for":[7,22,49,53,196,209,223,248,255,263,297,313],"invasive":[8],"fungal":[9,25,33,54],"infections,":[10,258],"aim":[12],"this":[14],"project":[15],"was":[16,64,88,97,118,139,143,167],"to":[17,107,180,220,345],"develop":[18],"new,":[19],"specific":[20,161],"radiopharmaceuticals":[21],"diagnosis":[23],"infections.":[26,55],"Chitin,":[27],"which":[28],"is":[29,37],"expressed":[30],"in":[31,39,69,72,100,121,126,242,311,320,331,340],"cell":[34],"wall":[35],"but":[36,329],"absent":[38],"mammalian":[40],"and":[41,68,71,95,112,120,155,183,186,199,251,287,326],"bacterial":[42],"cells,":[43],"represents":[44],"a":[45,146,228,275,347],"potentially":[46],"selective":[47],"target":[48],"development":[50],"tracers":[52],"ChiB_E144Q":[56,81],"(ChiB":[57],"=":[58],"chitinase":[59],"B)":[60],"from":[61,82],"Serratia":[62],"marcescens":[63,84],"labeled":[65],"with":[66,128,145,227,274,323,334],"(123)I,":[67],"vitro":[70,101,312],"vivo":[73,122],"studies":[74],"were":[75,115,124,244,300],"assessed.":[76],"METHODS:":[77],"(123)I":[78],"labeling":[79],"S.":[83,264],"by":[85,90,153],"direct":[86],"iodination":[87],"characterized":[89],"high-pressure":[91],"liquid":[92],"chromatography":[93],"(HPLC),":[94],"stability":[96,147],"evaluated.":[98],"The":[99,159],"binding":[102,179],"properties":[103],"compound":[106],"living":[108],"bacteria,":[109,338],"Candida":[110],"albicans,":[111],"Aspergillus":[113],"fumigatus":[114,198,257,328],"examined.":[116],"Scintigraphy":[117],"performed":[119],"characteristics":[123],"studied":[125],"mice":[127,243],"infected":[129,322,333],"thigh":[130,269,272],"muscles.":[131],"RESULTS:":[132],"An":[133],"average":[134,160],"radiochemical":[135],"yield":[136],"35%":[138],"obtained.":[140],"Radiochemical":[141],"purity":[142],">97%":[144],">24":[149],"h":[150,236],"as":[151],"determined":[152],"HPLC":[154],"instant":[156],"thin-layer":[157],"chromatography.":[158],"activity":[162],"noncarrier-free":[165],"(123)I-chitinase":[166],"9.25":[168],"MBq/":[169],"micro":[170],"g":[171],"enzyme.":[173,233],"Binding":[174,215],"assays":[175],"showed":[176],"virtually":[177],"no":[178],"Eschericha":[181],"coli":[182],"Staphylococcus":[184],"aureus,":[185],"2.4":[187],"x":[188,193,201,206],"10(3)":[189,202],"Bq":[190,203],"per":[191,204],"1":[192,205],"10(7)":[194,207],"cells":[195,208],"A.":[197,256,327],"3.0":[200,284],"C.":[210,249,324],"albicans":[211,250,325],"(P":[212,292],"<":[213,293],"0.05).":[214,294],"tracer":[218,318],"dropped":[219],"almost":[221],"zero":[222],"organisms":[224],"previously":[225],"incubated":[226],"50-fold":[229],"excess":[230],"unlabeled":[232],"At":[234],"24":[235],"after":[237],"injection,":[238],"target-to-nontarget":[239],"(T/NT)":[240],"ratios":[241,262,296],"20.6":[245],"+/-":[246,253,282,285,289],"3.6":[247],"15.2":[252],"3.7":[254],"respectively,":[259],"whereas":[260],"T/NT":[261],"aureus":[265],"-and":[266],"E.":[267],"coli-infected":[268],"muscles":[270,273],"or":[271,336,339],"sterile":[276,341],"inflammation":[277],"did":[278],"not":[279,330],"exceed":[280],"4.9":[281],"2.6,":[283],"2.3,":[286],"5.3":[288],"2.8,":[290],"respectively":[291],"Target-to-blood":[295],"fungus-infected":[298],"thighs":[299],"always":[301],">1.":[302],"CONCLUSION:":[303],"Our":[304],"results":[305],"show":[306],"that":[307],"(123)I-ChiB_E144Q":[308],"has":[309],"affinity":[310],"fungi.":[314],"In":[315],"vivo,":[316],"accumulates":[319],"tissue":[321,332],"gram-positive":[335],"gram-negative":[337],"inflammations,":[342],"proving":[343],"it":[344],"be":[346],"valuable":[348],"SPECT":[349],"diagnostic.":[350]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}