{"id":"https://openalex.org/W2106882229","doi":null,"title":"NMDA receptors and PCREB: their role in brain and behavioral changes after stress","display_name":"NMDA receptors and PCREB: their role in brain and behavioral changes after stress","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2106882229","mag":"2106882229"},"language":"en","primary_location":{"id":"pmh:oai:research.library.mun.ca:10167","doi":null,"is_oa":false,"landing_page_url":"http://research.library.mun.ca/10167/1/Blundell_JacquelineJ.pdf","pdf_url":"http://research.library.mun.ca/10167/1/Blundell_JacquelineJ.pdf","source":{"id":"https://openalex.org/S4306401319","display_name":"Memorial University Research Repository (Memorial University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130438778","host_organization_name":"Memorial University of Newfoundland","host_organization_lineage":["https://openalex.org/I130438778"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://memorial.scholaris.ca/bitstreams/9dd226c8-0eff-4736-81f8-918293a70629/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067457118","display_name":"Jacqueline J. Blundell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jacqueline Blundell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5067457118"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.4189000129699707,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.4189000129699707,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.24130000174045563,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.18970000743865967,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.9890000224113464},{"id":"https://openalex.org/keywords/pcreb","display_name":"pCREB","score":0.6970000267028809},{"id":"https://openalex.org/keywords/predator-stress","display_name":"predator stress","score":0.8270000219345093},{"id":"https://openalex.org/keywords/anxiety-like-behavior","display_name":"anxiety-like behavior","score":0.8420000076293945},{"id":"https://openalex.org/keywords/cpp","display_name":"CPP","score":0.6399999856948853},{"id":"https://openalex.org/keywords/neuroplasticity","display_name":"neuroplasticity","score":0.8610000014305115},{"id":"https://openalex.org/keywords/elevated-plus-maze","display_name":"elevated plus maze","score":0.8600000143051147},{"id":"https://openalex.org/keywords/social-avoidance","display_name":"social avoidance","score":0.5059999823570251},{"id":"https://openalex.org/keywords/acoustic-startle-response","display_name":"acoustic startle response","score":0.7319999933242798},{"id":"https://openalex.org/keywords/social-interaction","display_name":"social interaction","score":0.546999990940094},{"id":"https://openalex.org/keywords/stress-sensitization","display_name":"stress sensitization","score":0.32100000977516174},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.3479999899864197},{"id":"https://openalex.org/keywords/amygdala","display_name":"amygdala","score":0.574999988079071},{"id":"https://openalex.org/keywords/medial-prefrontal-cortex","display_name":"medial prefrontal cortex","score":0.6499999761581421},{"id":"https://openalex.org/keywords/dorsal-raphe-nucleus","display_name":"dorsal raphe nucleus","score":0.47600001096725464}],"concepts":[{"id":"https://openalex.org/C173586616","wikidata":"https://www.wikidata.org/wiki/Q5359685","display_name":"Elevated plus maze","level":3,"score":0.7021239399909973},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.6652264595031738},{"id":"https://openalex.org/C96857902","wikidata":"https://www.wikidata.org/wiki/Q2138108","display_name":"Predator","level":3,"score":0.5732832551002502},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5353097915649414},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4840089976787567},{"id":"https://openalex.org/C205044023","wikidata":"https://www.wikidata.org/wiki/Q4778117","display_name":"Anxiogenic","level":4,"score":0.48293372988700867},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.45962488651275635},{"id":"https://openalex.org/C125370674","wikidata":"https://www.wikidata.org/wiki/Q1527480","display_name":"Stressor","level":2,"score":0.45726853609085083},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.4455319046974182},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4145164489746094},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3907014727592468},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.33307623863220215},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23717111349105835},{"id":"https://openalex.org/C2777765862","wikidata":"https://www.wikidata.org/wiki/Q62903","display_name":"Anxiolytic","level":3,"score":0.19148635864257812},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15451860427856445},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.09818682074546814},{"id":"https://openalex.org/C188382862","wikidata":"https://www.wikidata.org/wiki/Q170430","display_name":"Predation","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:research.library.mun.ca:10167","doi":null,"is_oa":false,"landing_page_url":"http://research.library.mun.ca/10167/1/Blundell_JacquelineJ.pdf","pdf_url":"http://research.library.mun.ca/10167/1/Blundell_JacquelineJ.pdf","source":{"id":"https://openalex.org/S4306401319","display_name":"Memorial University Research Repository (Memorial University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130438778","host_organization_name":"Memorial University of Newfoundland","host_organization_lineage":["https://openalex.org/I130438778"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:oai:memorial.scholaris.ca:20.500.14783/2481","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.14783/2481","pdf_url":"https://memorial.scholaris.ca/bitstreams/9dd226c8-0eff-4736-81f8-918293a70629/download","source":{"id":"https://openalex.org/S4306401319","display_name":"Memorial University Research Repository (Memorial University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130438778","host_organization_name":"Memorial University of Newfoundland","host_organization_lineage":["https://openalex.org/I130438778"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Doctoral thesis"},{"id":"mag:2106882229","doi":null,"is_oa":false,"landing_page_url":"https://research.library.mun.ca/10167/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:memorial.scholaris.ca:20.500.14783/2481","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.14783/2481","pdf_url":"https://memorial.scholaris.ca/bitstreams/9dd226c8-0eff-4736-81f8-918293a70629/download","source":{"id":"https://openalex.org/S4306401319","display_name":"Memorial University Research Repository (Memorial University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130438778","host_organization_name":"Memorial University of Newfoundland","host_organization_lineage":["https://openalex.org/I130438778"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Doctoral thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323319","display_name":"Memorial University of Newfoundland","ror":"https://ror.org/04haebc03"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2106882229.pdf","grobid_xml":"https://content.openalex.org/works/W2106882229.grobid-xml"},"referenced_works_count":85,"referenced_works":["https://openalex.org/W66138198","https://openalex.org/W98302833","https://openalex.org/W206623842","https://openalex.org/W1262613349","https://openalex.org/W1694363227","https://openalex.org/W1821106912","https://openalex.org/W1842711843","https://openalex.org/W1967318820","https://openalex.org/W1975190631","https://openalex.org/W1979684634","https://openalex.org/W1982284863","https://openalex.org/W1982442335","https://openalex.org/W1985748807","https://openalex.org/W1994003304","https://openalex.org/W1994122020","https://openalex.org/W1996260345","https://openalex.org/W2001628402","https://openalex.org/W2005022730","https://openalex.org/W2005076206","https://openalex.org/W2005102053","https://openalex.org/W2006928106","https://openalex.org/W2007266319","https://openalex.org/W2009637177","https://openalex.org/W2010269783","https://openalex.org/W2010564515","https://openalex.org/W2010811464","https://openalex.org/W2014168974","https://openalex.org/W2014308812","https://openalex.org/W2018312069","https://openalex.org/W2020443900","https://openalex.org/W2025247587","https://openalex.org/W2026721213","https://openalex.org/W2027398184","https://openalex.org/W2031956214","https://openalex.org/W2032721791","https://openalex.org/W2032997748","https://openalex.org/W2035071372","https://openalex.org/W2036025389","https://openalex.org/W2037024587","https://openalex.org/W2040278623","https://openalex.org/W2040442376","https://openalex.org/W2041850455","https://openalex.org/W2042734298","https://openalex.org/W2042847262","https://openalex.org/W2045393710","https://openalex.org/W2046641175","https://openalex.org/W2047867886","https://openalex.org/W2050006242","https://openalex.org/W2053385743","https://openalex.org/W2054498332","https://openalex.org/W2057167096","https://openalex.org/W2057317784","https://openalex.org/W2057618472","https://openalex.org/W2057912465","https://openalex.org/W2057983666","https://openalex.org/W2061011435","https://openalex.org/W2068575458","https://openalex.org/W2070623386","https://openalex.org/W2074707688","https://openalex.org/W2075199276","https://openalex.org/W2079768227","https://openalex.org/W2086465627","https://openalex.org/W2087519774","https://openalex.org/W2088582596","https://openalex.org/W2089031800","https://openalex.org/W2089770153","https://openalex.org/W2091697313","https://openalex.org/W2103953803","https://openalex.org/W2106625755","https://openalex.org/W2110385209","https://openalex.org/W2120023340","https://openalex.org/W2125823313","https://openalex.org/W2136827845","https://openalex.org/W2138718238","https://openalex.org/W2141050240","https://openalex.org/W2146747402","https://openalex.org/W2152390421","https://openalex.org/W2153062715","https://openalex.org/W2154836288","https://openalex.org/W2159011576","https://openalex.org/W2165245677","https://openalex.org/W2219191873","https://openalex.org/W2296042795","https://openalex.org/W4406059073","https://openalex.org/W7098841198"],"related_works":["https://openalex.org/W2054498332","https://openalex.org/W2079689934","https://openalex.org/W2048103638","https://openalex.org/W2014308812","https://openalex.org/W1994455743","https://openalex.org/W2037024587","https://openalex.org/W2035071372","https://openalex.org/W2316141587","https://openalex.org/W2042734298","https://openalex.org/W2153062715"],"abstract_inverted_index":{"In":[0,124,273,523,547,565,704],"this":[1,54,311],"dissertation,":[2],"we":[3,56,127,360,526,549],"employed":[4,170],"the":[5,13,39,63,67,78,101,108,129,173,205,217,220,227,231,236,243,250,267,286,362,390,398,416,423,428,431,443,450,456,460,477,480,537,551,563,573,598,632,638,647,652,657,661,713,718,721,725],"ecologically":[6],"valid":[7],"predator":[8,71,84,145,190,206,221,237,253,275,307,358,367,417,432,444,483,507,614,641,699,726],"stress":[9,16,72,85,191,254,276,484,556,684,700,752],"model":[10],"to":[11,29,95,111,166,171,176,189,294,499,532,562,572,581,631,637],"assess":[12,172],"effects":[14,69,130,251,363,552],"of":[15,26,66,70,131,179,182,230,242,252,297,303,310,313,338,364,397,427,447,462,495,553,651,660,682,717,750],"on":[17,140,280,318,366,557],"brain":[18,381,540],"and":[19,164,198,213,234,269,351,386,406,441,458,466,479,545,587,601,628,654,720],"behavior.":[20,504,731],"A":[21],"five":[22],"minute":[23],"unprotected":[24,263],"exposure":[25,94,571,636],"a":[27,30,112,132,295,301,488,582,680,748],"rat":[28,40],"cat":[31,583],"induces":[32],"long-lasting":[33],"changes":[34,80,91,305,315,319,369,485,501,509,516,529,612,694,706],"in":[35,38,116,209,216,224,240,248,262,266,320,370,372,380,384,420,422,435,437,449,455,487,502,510,517,530,539,543,559,575,640,646,656,677,695,707,709,729,745],"anxiety-like":[36,141,194,503,511,696,730],"behaviors":[37,195],"(Adamec":[41],"&":[42],"Shallow,":[43],"1993;":[44],"Adamec":[45],"et":[46,50],"al.,":[47,51],"2001;":[48],"Cohen":[49],"2004).":[52],"Using":[53],"model,":[55],"addressed":[57],"four":[58],"main":[59],"questions.":[60],"First,":[61],"are":[62,77,492,604,701],"various":[64],"manifestations":[65],"anxiogenic":[68],"N-methyl-D-aspartate":[73],"(NMDA)":[74],"receptor-dependent?":[75,87],"Second,":[76],"neuroplastic":[79,90,109,496],"that":[81,118,300,413,473,577,607,618,692],"occur":[82,92],"after":[83,93,201,357,570,613],"NMDA":[86,133,326,349,489,520,609,702],"Third,":[88],"do":[89],"other,":[96],"milder":[97],"stressors,":[98,534],"such":[99,535],"as":[100,283,328,330,536],"elevated":[102,154,644],"plus":[103,155],"maze":[104,156],"(EPM)?":[105],"Finally,":[106],"is":[107,346,355],"response":[110,165,175,341,531],"mild":[113,675,743],"stressor":[114],"enhanced":[115],"animals":[117,560,678,746],"have":[119],"been":[120,579],"previously":[121],"stressed?":[122],"--":[123,335,522,686],"Chapter":[125,373,524],"2,":[126],"assessed":[128,377],"receptor":[134],"antagonist":[135],"[(3-(2-carboxypiperazin4-yl)propyl-l-phosphonic":[136],"acid)":[137],"-":[138],"CPP]":[139],"behavior":[142,388,697],"produced":[143],"by":[144,258,325,331,348,673,741],"stress.":[146,177,202,308,615],"An":[147],"affect":[148],"test":[149],"battery":[150],"including":[151,389],"hole":[152],"board,":[153],"(EPM),":[157],"light/dark":[158,232],"box,":[159,233],"social":[160,162,271,281],"interaction,":[161],"avoidance,":[163],"acoustic":[167,244],"startle":[168,245],"was":[169,277,376,464,568],"behavioral":[174,304,314],"Doses":[178],"1-10":[180],"mg/kg":[181],"CPP":[183,203,259,365,414],"administered":[184],"ip":[185],"30":[186],"min":[187],"prior":[188,554],"blocked":[192,204,219,235,257,415,430],"most":[193,693],"measured":[196,284],"eight":[197],"nine":[199],"days":[200,585],"stress-induced":[207,222,238,368,418,433,445,508,515,727],"reduction":[208,261],"open":[210],"arm":[211,229],"exploration":[212],"risk":[214],"assessment":[215],"EPM,":[218,538],"decrease":[223],"entries":[225],"into":[226],"lighted":[228],"delay":[239],"habituation":[241],"response.":[246],"Behaviors":[247],"which":[249,603],"were":[255,519,620],"not":[256,513],"included":[260,597],"head":[264],"dips":[265],"EPM":[268,574,633,639],"reduced":[270],"interaction.":[272],"addition,":[274,548,705],"without":[278],"effect":[279],"avoidance":[282],"with":[285,667,679,735,747],"Haller":[287],"test.":[288],"Taken":[289,687],"together,":[290,688],"these":[291,689],"findings":[292],"add":[293],"body":[296],"evidence":[298],"showing":[299],"syndrome":[302,312],"follows":[306],"Components":[309],"likely":[316],"depend":[317],"separable":[321],"neural":[322],"substrates":[323],"initiated":[324],"receptors":[327,350],"well":[329],"other":[332,533],"neurochemical":[333],"means.":[334],"Since":[336],"phosphorylation":[337],"cyclic":[339],"AMP":[340],"element":[342],"binding":[343],"protein":[344],"(CREB)":[345],"regulated":[347],"pCREB-like":[352],"immunoreactivity":[353],"(lir)":[354],"increased":[356],"stress,":[359],"examined":[361,527,569],"pCREB-lir":[371,375,421,436,448,463,486,518,558,567,611,622,645,708],"3.":[374],"using":[378],"immunocytochemistry":[379],"areas":[382,494,541,592,606],"implicated":[383,542],"fearful":[385],"anxious":[387],"amygdala,":[391,599],"periaqueductal":[392],"gray":[393],"(PAG),":[394],"bed":[395],"nucleus":[396],"stria":[399],"terminalis":[400],"(BNST),":[401],"anterior":[402],"cingulate":[403],"cortex":[404],"(ACC),":[405],"dorsal":[407,658],"medial":[408],"hypothalamus":[409],"(DMH).":[410],"Results":[411,616],"showed":[412,617],"increase":[419,434],"right":[424,648,714],"lateral":[425,649,715],"column":[426,650,659,716],"PAG,":[429,459,478,600],"several":[438,474,710],"amygdala":[439,457,475,711],"nuclei,":[440,476,712],"reversed":[442],"suppression":[446],"BNST.":[451],"Importantly,":[452],"at":[453],"least":[454],"pattern":[461],"hemisphere-":[465],"anterior-posterior":[467],"(AP)":[468],"plane-dependent.":[469],"Our":[470],"results":[471,690],"suggest":[472,664,691],"BNST,":[481,602],"where":[482],"receptor-dependent":[490,610],"manner,":[491],"candidate":[493],"change":[497],"contributing":[498],"lasting":[500],"However,":[505,635],"like":[506],"behavior,":[512],"all":[514,605],"receptor-dependent.":[521,703],"4,":[525],"pCREB":[528],"fear":[544],"anxiety.":[546],"investigated":[550,593],"traumatic":[555],"exposed":[561,580,630],"EPM.":[564],"particular,":[566],"rats":[576,627,629,643],"had":[578],"seven":[584],"earlier":[586],"naive":[588,625],"(handled)":[589],"controls.":[590],"Brain":[591],"for":[594],"both":[595],"experiments":[596],"show":[608],"there":[619],"no":[621],"differences":[623],"between":[624],"control":[626],"only.":[634],"stressed":[642],"PAG":[653,719],"bilaterally":[655],"PAG.":[662],"Findings":[663],"mechanisms":[665,733],"associated":[666,734],"neuroplasticity":[668,736],"may":[669,723,737],"be":[670,738],"further":[671,739],"engaged":[672],"relatively":[674,742],"stresses":[676,744],"history":[681,749],"severe":[683,751],"exposure.":[685,753],"following":[698],"BNST":[722],"mediate":[724],"increases":[728],"Furthermore,":[732],"activated":[740]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
